So what is the most important signaling pathway in all life forms for longevity and for optimal health? That is the subject of this blog. The short is answer is the redox potential stored in the membranes, organelles and the exclusion zone of water in cells. I will be bold to say that maintenance of intracellular redox homeostasis is the most important thing to get right to get Optimal.Continue Reading
Most of the science that gets done today gets done within a rigid set of rules applied, where you know exactly who your peers are, and things get evaluated according to a very strict set of standards. That works, when you’re not trying to change the structure. But when you try to change the structure or paradigm of science, that system doesn’t work very well. In fact, you usually make some enemies. Gilbert Ling is an example of somebody who didn’t follow the rules and pissed a lot of people off. He pissed off so many people that they alienated his work, made sure he had no funding to continue on, and then allowed somebody to steal his work and gave that person the Nobel Prize in 2003. Today, we are going to unfold that story, because fundamentally this is why millions are dying from neolithic diseases today.Continue Reading
Today, I am going to show you how sleep mechanistically really happens in you and all humans. In my view, the modern biology of sleep can be viewed as an emergent property of the physical laws of chemistry, which, in turn, can be viewed as an emergent property of subatomic particle physics and how those particle interact. The interaction of these particles often causes consternation and confusion in people who have a “biologic bent” in their mind’s eye. I suggest if you are one of these people, you begin to embrace the complexity and paradox. Because when you do, you begin to see quantum actions specifically, not driving your own “consensus in thought.”Continue Reading
Thirty years ago, autism affected 1 in 500 children. In recent years, scientists have made extraordinary advances in understanding the causes of autism. Autism now is estimated to afflict 1 in 88 children in the USA. In certain parts of the USA, it is found in 1 in 44 births. But remarkably little of this understanding has percolated into popular awareness, which often remains fixated on vaccination linkage to the disease.Continue Reading
The human genome is the first draft of what we might be, but our life experience within the environment we choose to exist is where the final draft of our book is written. An architect far smarter than us has given us that epigenetic toolbox, and we now have the ability to use it by altering our behaviors to change our lives and reverse diseases.Continue Reading
This will probably be the most important blog in the entire Quilt. It is how I see the three fundamental laws of nature integrating and coordinating the physiologic function of animating life. It is how all life works as a collective phenomena.Continue Reading
Today’s blog post is about the three laws of nature for all life anywhere on our planet. These are axiomatic laws not subject to debate, research or your beliefs. All decisions that life has made revolve around these three things. Reducing things to these three things is simple, but the application in how life and evolution has done it is very complex. Today, we begin to unravel the mysteries.Continue Reading
“Reality is that which, when you stop believing in it, doesn’t go away.” This quote by Philip K. Dick serves a great purpose today. Most people in alternative healthcare believe that the cause of autoimmunity is tied to something heinous in our food supply. I do not. In fact, a recent article about gluten and celiac disease in the New York Times raises this point. So what causes celiac disease? That is the topic of today’s installment. Let us begin.Continue Reading
We are all products of our environment. Our genes are the first draft of what we are created to be, but the experience those genes face (epigenetics) is how the novel of our life is really written. This blog is about how this experience begins to unfold in our species.Continue Reading
Today, we begin to examine levee’s 6, 14, and 26 in the Quilt document for the first time. We begin to show examples of these levee’s by examining how the human brain forms and functions in an infant. This example will act as an analogy to help us understand many other processes as the blog series rolls on.
There are many countervailing influences in life that on the surface confuse our intellect. They create the appearance of paradox, enigma, and myths, and mysteries. I find when we look at the world through the hull of a glass-bottom ship, to look through a kaleidoscope at the galaxies that exist on the edge of our mind, we begin to see the sense that nature makes from the chaos of the world. I like the irony that mysteries often create. Today, we are going to use some “other observations” we have all made to show you how the mysteries of our modern world might be solved asking better questions instead of settling for the answers we have been given.
The Human Infant
It is clear in modern medicine now that we can not have optimal human brain development unless we have a secure nutrient rich food supply for both mother and child. This relationship also needs to be maintained postnatally for several years after birth until neuralation is successful. It does appear in modern neurosurgery research that human brain development is programmed genetically to a certain extent, but is more malleable then we thought because of the new science findings of epigenetics. This is also more apparent in humans than other mammals because our brain is so complex that even small changes in functional regions can lead to massive clinical changes that become apparent as the child develops. Autism and spectrum disorders are a good example of this phenomena.Continue Reading
If you remember my podcast several years back, I told you the disease that got me interested in all this was osteoporosis. This is a disease I treat a lot as a spine surgeon. I discussed Wolff’s law in detail in the EMF 1 blog. When I realized that Wolff’s law was null and void in leptin resistance states in bone, something else radical appeared to me. I knew that Leptin Resistance signaled inflammation, and inflammation could be seen as a positive charge and loss of a negative charge on MRI’s, fMRI, and MEG studies. I also realized that MRI or NMR should show an increased flair signal on T2 weighted MRI images signifying an intracellular water loss coupled with a loss of collagen and of ATP. Collagen makes up the main protein of connective tissues in all mammals, typically 60–70% by weight. The water and collagen constitute a liquid crystalline matrix in which every cell in the body is embedded, making this system the ideal medium for intercommunication in eutherian mammals. Within this matrix we have learned about proton and electron superconduction that not only feed the underlying mechanistic pathways that most biochemistry recite but they also feed a rich “wet chemistry” that is fundamentally based upon special qualities of water. It turns out water has some prodigious quantum flexibility when it is confined in closed spaces that make it do some unique quirky things that no classic chemist would predict. These things are all predicted by quantum electrodynamic field theory. One such quirk is the use of water reverse micelles around proteins that increase enzyme action and kinetics by the order 10 to the 10th power based upon the pioneering work of Frank Mayer and Jim Clegg. Classic physics and chemistry thinks of water in its bulk form only because that is all the classic sciences can explain about it. In quantum coherence, where water acts as a total cohesive unit because it has infinite chemical freedom, water becomes highly structured chemically, from its bulk form to do some amazing things, to become extremely flexible in phase transitions between ice crystals and liquid crystals and gas vapor as it gets confined in small diameter nanotubes in our cells. Water dynamics and actions are quantumly altered as it is confined within nanotubes it develops properties that allow it to collectively work dynamically within reverse micelles and in proton superconducting cables that align along collagen in the cells cytoarchitecture to allow for super fast semiconduction. This has been reproduced by many physics and molecular biology researchers in electron photomicrographs and X-ray diffraction studies. The most amazing property water develops as it is confined in these nanotubes, it becomes a super catalyst that organic chemistry has missed, because it accounts for the energy of activation of biochemical reactions and enzymatic kinetics. It is not ATP that does this, ever!! ATP has another more critical function. It unfolds protein in cells to open water binding sites to form these super conduction cables to create 100% energy efficiency.Continue Reading
What is Adrenal Fatigue at its core? Many websites will tell you it is an adrenal gland function problem that is best assayed by a salivary adrenal stress panel. I wont and I do not. The cause of adrenal fatigue is a brain injury at the hypothalamus all caused by bad signaling. My Adrenal Fatigue Rx is best called Metabolic Neurosurgery: It is all about energy and energy utilization that allows for perfect signaling of environmental signals. When your energy is bad your signaling falls off a cliff. The ASI is just like a gauge on a car. It tells you some info but it does not tell you why it is happening. How we understand adrenal dysfunction in 2012 has radically changed because of a relatively new science called neurohumoral-immunology. What does this mean?
It means adrenal fatigue at its core is a brain illness and not an adrenal gland problem.
What is the PVN? How do we know if our PVN is shut off? What are some of the symptoms? We can’t sleep, our guts do not work, our body composition goes way off, we sweat at the wrong times, we develop cognitive haze, blurred vision, migraines, and reactive hypoglycemia. Many times fatigue is only relieved by eating foods we should not. It also means we have lost allosteric control of leptin!Continue Reading
[show_if has_tag="No-Webinar-2012-08-August"]Buy Webinar[/show_if][show_if has_tag="Webinar-2012-08-August"]ACCESS YOUR WEBINAR[/show_if] We talk a lot on the blog about the brain-gut axis and the implications our gut has on our overall health, including: Most brain disease and neurodegenerative disorders start in the gut (tumors, autism, depression, high blood pressure, Alzheimer’s, hypertension, heart disease) start in the gut. Autoimmune diseases like MS starts in the gut when your gut flora is changed to a more simplified flora, allowing inflammation to pass from your gut into your liver and to flood your brain blood barrier. Infertility starts in the gut by allowing inflammation to overwhelm your system and affect your HPA, destroying its ability to make the releasing hormone that releases sex hormones. Obesity is caused by inflammation getting through the gut, simpifying the gut flora, and invading the blood brain barrier to destroy the HPA and hypocretin neurons, which is equivalent to driving on the Long Island Expressway with mud on your windshield, no wipers, no windshield wiper fluids and your car only goes 20 mph. Your body is essentially in-operational, unable to keep up with the demands of a taxing environment; needless to say, this is very dangerous. Everyone thinks that things like bacteria, candida and carbohydrates are what screws your gut […]Continue Reading
Today, we are going to dive into the gut flora story a bit deeper than we did in our first gut flora post to help you understand how a a change in gut flora might lead to changes in your health by altering your hormone panel. Obesity is an inflammatory brain condition. Where does the infection come from? The gut flora actually is what causes humans to become fat. It has to due with shear numbers and the species of bacteria in our gut. There is a particular flora that produces adiposity and obesity in humans. These bacteria make something called FIAF (Fasting induced adipose factor) that control this process. This factor blocks lipoprotein lipase (LPL) in fat cells. LPL allows us to convert dietary Free Fatty Acids carried in lipoproteins into neutral fats that are stored in adipocytes.
Non Geeks: Our gut bacteria makes humans fat.
Geek Alert: The FIAF is made by our liver, muscles, and our small bowel wall when food sources are in short supply. This is the signal to stop storing fat in our fat cells when food is scarce. What is not well appreciated by many is that the FIAF in our intestinal wall is controlled 100% by our gut flora. When we have a simplified gut flora it favors fat cell creation. When our gut flora is complex and healthy, it has 100 trillion cells with 250 species. We tend not to make fat in this instance either! Moreover, when the bacteria are active metabolically due to the presence of simple sugars, production of FIAF ceases, and fat creation is signaled. This implies that our gut flora is directly tied to fat creation in humans. The gut flora’s action is directly signaled to the brain via the afferent nerve fibers in the vagus nerve. In those newly created fat cells, a protein called leptin is also produced, and acts as a score keeper for the brain of how much fat is stored in the body. This messenger is sent to the brain around midnight when we are sleeping allowing the brain to assess total energy balance in the body.Continue Reading
This blog post was created for my members who just heard my webinar on bioidentical and synthetic hormone replacement. It is specifically designed to further our discussions in that talk.
DHEA has been an enigma to the public and to most physicians. I never once heard about this hormone in four years of medical school, seven years of residency or in any endocrinology lecture from my training. The general public did not learn about DHEA until 1996, when its benefits were mentioned in the media and several popular books that showed up on daytime TV shows. Most in mainstream medicine continued to ignore the science these books contained because they were not found in the usual ways via journals and continuing education classes. You actually had to be on the lookout for this information. With a busy medical practice, this is no easy task. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book called DHEA and Aging. That book provided scientific validation for the many life-extending effects of DHEA.Continue Reading
Buy Teleseminar If you struggle with eating disorders, obesity or diabetes; or if you have a family history of Alzheimer’s or Parkinson’s, this webinar is especially for you. The Epi-Paleo diet is different from the traditional Paleo template – it is rich in iodine and magnesium and gives you complete, optimal brain function. Remember, HEALTH STARTS IN THE BRAIN. The way the brain goes, your health goes. In this teleseminar, we’re going to explore: The epi-paleo diet and how it affects the gut microflora. As you know from the leaky gut series, a healthy gut is imperative to reversing disease and experiencing a great quality of life. Iodine and it’s relationship with thyroid functioning. Iodine is the most important mineral in human optimization. Learn why fish oil and seafood and shellfish are NOT the same (quantum electron tunneling) — it’s the difference that “creates” consciousness (gamma coherence) and reveals why anesthesia works. We’ll also talk about fish oil, its antioxidant properties, and why it’s been conserved by evolution for 600 million years by every nervous system and every animal on this planet, including dinosaurs. The importance of DHA. When its levels fall in the brain, so does cognition, making way for diseases like Alzheimer’s, Parkinsons and Eating Disorders. […]Continue Reading
Now that you understand that I believe cold environments were how life first evolved, what implications does this hold for all life and humans today? I think with this thought experiment we need to begin to talk about another aspect of evolution to fully conceptualize how cold works for biology. Let’s talk about sleep for 4 short minutes. First, I want you to watch this video before you proceed.
Recently, one of my readers pointed out he was confused by Dr. Gamble when she said the normal pattern of sleep in a natural environment had two cycles. He wanted to know why her version and my version for sleep as written in my post “Rx for the Leptin Rx” were not congruent. It was a great question that really opens the discussion to the idea of evolutionary mismatches. These mismatches occur in many modern systems of biology, and they are actually increasing in frequency and severity as time elapses. The reason is quite simple. Evolution is constantly getting faster as time goes on, relative to the current state of our genome. This is really how the “cellular theory of relativity” is currently affecting our own genome today. The speed of evolutionary change has far out stripped the ability of our paleolithic genes to catch up. This mismatch causes major problems for modern humans. When they further exacerbate the system with choices not congruent with our biology, the results are magnified in disease incidence and prevalence.
She also mentioned in passing, early in her talk, that people who went deep into the ground have been found to be “very productive” while in a cold dark environment. She did not expand on this concept at all, but I would strongly suggest you remember this as the cold thermogenesis series progresses on. There is a deep biologic reason this occurs. As we use this pathway, lots of things improve that we do not expect.Continue Reading
READERS SUMMARY: WHY SHOULD WE QUESTION EVERYTHING? WHAT IS THE SOURCE OF ALL CHOICE? WHERE MIGHT THE REWARD IN SAFE STARCHES TRULY LIE? HOW GOOD IS YOUR NEOLITHIC BRAIN AT SENSING YOUR PALEOLITHIC BRAIN? DOES QUANTUM MECHANICS PROVIDE AN EXPLANATION FOR THE PARADOX OF CHOICE? I took a stroll through some of my favorite sites last night because I could not sleep well (added back a safe starch ironically yesterday, too) because I have some big things on my mind, and it seems some of the doubters are beginning to see the magic in my Quilt document. I remember when I posted it and how I was ridiculed in some places. I just sat back and took it all in because I fully expected that response. In fact, I told one of my internet friends, Dexter Yard, that I did this by design for a reason. I went as far as emailing a copy of the document to him to look over before it ever was posted on the Internet. His reply was much more kind and subdued than what I faced publicly when I launched the document. He told me he felt that this was not going to […]Continue Reading
I was in a lounge watching the news last week and began to over hear a group of dermatologists talk about the new FDA rules set down for sunblocks that will go into effect in January of 2012. There was unanimous agreement among them all that sunlight was the source of everything that was bad in their world. One of the doctors said to another that, “no human should be out in the sun and they should just take vitamin D3 from the drug store instead of getting it from the sun.” It was at that point I knew this was going to make a blog post about this. Apparently no one realizes that photosynthesis supports most of the food chain on this planet? And we are the mammal who has an energy hog in our head that needs energy. Since our skin is derived from neuro-ectoderm and we too use photosynthesis to make Vitamin D for our protection from poor electron dense foods in summer maybe we better re think this position.
It is beyond me why the sun is so vilified. We could not have evolved past single cells organisms without it. We all learned that simple fact in school. But now with advanced degrees and plaques on our wall, are we going to blame all skin diseases all on the sun now? I definitely don’t buy this conventional wisdom. So I decided to begin to add pieces to the immunity levee in the QUILT because of this conversation. And before we start let me be clear. It is better to get Vitamin D3 from the natural sources before a supplement in my opinion. But there is a catch to this pearl of wisdom. First, review this link on natural Vitamin D production.Continue Reading