So what is the most important signaling pathway in all life forms for longevity and for optimal health? That is the subject of this blog. The short is answer is the redox potential stored in the membranes, organelles and the exclusion zone of water in cells. I will be bold to say that maintenance of intracellular redox homeostasis is the most important thing to get right to get Optimal.Continue Reading
Most of the science that gets done today gets done within a rigid set of rules applied, where you know exactly who your peers are, and things get evaluated according to a very strict set of standards. That works, when you’re not trying to change the structure. But when you try to change the structure or paradigm of science, that system doesn’t work very well. In fact, you usually make some enemies. Gilbert Ling is an example of somebody who didn’t follow the rules and pissed a lot of people off. He pissed off so many people that they alienated his work, made sure he had no funding to continue on, and then allowed somebody to steal his work and gave that person the Nobel Prize in 2003. Today, we are going to unfold that story, because fundamentally this is why millions are dying from neolithic diseases today.Continue Reading
Today, I am going to show you how sleep mechanistically really happens in you and all humans. In my view, the modern biology of sleep can be viewed as an emergent property of the physical laws of chemistry, which, in turn, can be viewed as an emergent property of subatomic particle physics and how those particle interact. The interaction of these particles often causes consternation and confusion in people who have a “biologic bent” in their mind’s eye. I suggest if you are one of these people, you begin to embrace the complexity and paradox. Because when you do, you begin to see quantum actions specifically, not driving your own “consensus in thought.”Continue Reading
Thirty years ago, autism affected 1 in 500 children. In recent years, scientists have made extraordinary advances in understanding the causes of autism. Autism now is estimated to afflict 1 in 88 children in the USA. In certain parts of the USA, it is found in 1 in 44 births. But remarkably little of this understanding has percolated into popular awareness, which often remains fixated on vaccination linkage to the disease.Continue Reading
This will probably be the most important blog in the entire Quilt. It is how I see the three fundamental laws of nature integrating and coordinating the physiologic function of animating life. It is how all life works as a collective phenomena.Continue Reading
Today’s blog post is about the three laws of nature for all life anywhere on our planet. These are axiomatic laws not subject to debate, research or your beliefs. All decisions that life has made revolve around these three things. Reducing things to these three things is simple, but the application in how life and evolution has done it is very complex. Today, we begin to unravel the mysteries.Continue Reading
“Reality is that which, when you stop believing in it, doesn’t go away.” This quote by Philip K. Dick serves a great purpose today. Most people in alternative healthcare believe that the cause of autoimmunity is tied to something heinous in our food supply. I do not. In fact, a recent article about gluten and celiac disease in the New York Times raises this point. So what causes celiac disease? That is the topic of today’s installment. Let us begin.Continue Reading
We are all products of our environment. Our genes are the first draft of what we are created to be, but the experience those genes face (epigenetics) is how the novel of our life is really written. This blog is about how this experience begins to unfold in our species.Continue Reading
Today, we begin to examine levee’s 6, 14, and 26 in the Quilt document for the first time. We begin to show examples of these levee’s by examining how the human brain forms and functions in an infant. This example will act as an analogy to help us understand many other processes as the blog series rolls on.
There are many countervailing influences in life that on the surface confuse our intellect. They create the appearance of paradox, enigma, and myths, and mysteries. I find when we look at the world through the hull of a glass-bottom ship, to look through a kaleidoscope at the galaxies that exist on the edge of our mind, we begin to see the sense that nature makes from the chaos of the world. I like the irony that mysteries often create. Today, we are going to use some “other observations” we have all made to show you how the mysteries of our modern world might be solved asking better questions instead of settling for the answers we have been given.
The Human Infant
It is clear in modern medicine now that we can not have optimal human brain development unless we have a secure nutrient rich food supply for both mother and child. This relationship also needs to be maintained postnatally for several years after birth until neuralation is successful. It does appear in modern neurosurgery research that human brain development is programmed genetically to a certain extent, but is more malleable then we thought because of the new science findings of epigenetics. This is also more apparent in humans than other mammals because our brain is so complex that even small changes in functional regions can lead to massive clinical changes that become apparent as the child develops. Autism and spectrum disorders are a good example of this phenomena.Continue Reading
Two years ago I gave you the Hormone 101: Clinical thoughts revealed blog post. That was a small dose of reality at the beginning of this journey. There was some foundational hormone biochemistry there given to you in simple terms. Most people jumped all over the free T3 link to pregnenolone in the post. They thought that “their cure” for hypothyroidism and/or chronic pregnenolone steal syndrome was increasing free T3 or just lowering reverse T3 to raise pregnenolone. So what was not observed?
A trip down memory lane for the hormone cascade
Leptin resistance occurs first in the brain. Then insulin resistance happens soon their after in the liver, gut, and peripheral tissues. This eventually leads to adrenal resistance. This resistance occurs at the PVN in the brain. (Brain Gut 16: Adrenal Fatigue Rx) It does not happen in the adrenal gland. What happens is that the outflow from our sympathetic system in the brainstem overwhelms the parasympathetic nervous system. This increase in overall cortisol initially, is the stress hormone that allows for fight or flight syndrome (life or death). As this condition persists chronically over time, cortisol levels decrease and flatline on adrenal stress index testing.Continue Reading
There is so much buzz now in modern healthcare and on the internet about Vitamin D but does anyone really know how it is integrated into our physiology? Most people understand that Vitamin D is tied into our bone’s metabolism and our immune system’s function but there is a lot more to this story. Vitamin D and its receptor, along with Vitamin A and its RXR receptor are among the oldest chemicals life has used to exist in evolutionary biology. This alone tells you how important Vitamin D is for function. Vitamin D is directly modulated by photoelectric effect, which is a foundational law of nature and quantum mechanics. The skin and brain are both derived from neuroectoderm in all animals. In EMF 2, we saw how obesity might be related to an inflammatory condition found in the brain due to a lack of electrons and photons. Today, we are going to examine how Vitamin D works in a quantized fashion.
Many physicians have confided in me that just do not believe that Vitamin D levels are that big of a deal for most patients. When they say that to me, I return a smile. It is not that big a deal for the doctor, but it is a huge clue about what is going on with the patient. For me, it is one of the most critical lab ‘thermostat values’ that tell me about the “preload of their semiconductors” in their skin and body. Yes, it is a quantum signal, to me as a physician. If you remember from the video’s made at Paleo Fx 2011 and our Optimal reset challenge, that I said we can do a quick “biohack” using three labs and tell a lot about the person’s current conditions of existence and where they need to go. Those three labs were the HS-CRP, DHEA, and Vitamin D. So far we covered DHEA in detail in the CPC blog of 6/30/2012 and in the back half of EMF 7. We have covered HS CRP in multiple places. Inflammation is the major signal that all biologic processes and respond to. It is what the hormone panel responds to and it dictates the thermostat for mitochondrial efficiency, signaling, and control of the cell cycle. The inflammatory signal also sets the tone for “tight” circadian control via the adenosine signal.Continue Reading
If you remember my podcast several years back, I told you the disease that got me interested in all this was osteoporosis. This is a disease I treat a lot as a spine surgeon. I discussed Wolff’s law in detail in the EMF 1 blog. When I realized that Wolff’s law was null and void in leptin resistance states in bone, something else radical appeared to me. I knew that Leptin Resistance signaled inflammation, and inflammation could be seen as a positive charge and loss of a negative charge on MRI’s, fMRI, and MEG studies. I also realized that MRI or NMR should show an increased flair signal on T2 weighted MRI images signifying an intracellular water loss coupled with a loss of collagen and of ATP. Collagen makes up the main protein of connective tissues in all mammals, typically 60–70% by weight. The water and collagen constitute a liquid crystalline matrix in which every cell in the body is embedded, making this system the ideal medium for intercommunication in eutherian mammals. Within this matrix we have learned about proton and electron superconduction that not only feed the underlying mechanistic pathways that most biochemistry recite but they also feed a rich “wet chemistry” that is fundamentally based upon special qualities of water. It turns out water has some prodigious quantum flexibility when it is confined in closed spaces that make it do some unique quirky things that no classic chemist would predict. These things are all predicted by quantum electrodynamic field theory. One such quirk is the use of water reverse micelles around proteins that increase enzyme action and kinetics by the order 10 to the 10th power based upon the pioneering work of Frank Mayer and Jim Clegg. Classic physics and chemistry thinks of water in its bulk form only because that is all the classic sciences can explain about it. In quantum coherence, where water acts as a total cohesive unit because it has infinite chemical freedom, water becomes highly structured chemically, from its bulk form to do some amazing things, to become extremely flexible in phase transitions between ice crystals and liquid crystals and gas vapor as it gets confined in small diameter nanotubes in our cells. Water dynamics and actions are quantumly altered as it is confined within nanotubes it develops properties that allow it to collectively work dynamically within reverse micelles and in proton superconducting cables that align along collagen in the cells cytoarchitecture to allow for super fast semiconduction. This has been reproduced by many physics and molecular biology researchers in electron photomicrographs and X-ray diffraction studies. The most amazing property water develops as it is confined in these nanotubes, it becomes a super catalyst that organic chemistry has missed, because it accounts for the energy of activation of biochemical reactions and enzymatic kinetics. It is not ATP that does this, ever!! ATP has another more critical function. It unfolds protein in cells to open water binding sites to form these super conduction cables to create 100% energy efficiency.Continue Reading
“The miracle of your mind isn’t that you can see the world as it is. It’s that you can see the world as it isn’t.” – Kathryn Schulz
Without risk, life is worthless; without risk, biology does not work. Evolutionary biology is based upon the random risk of natural selection and and the conditions of existence. Darwin coined both of these terms but only explained the first well. The second idea was his better one, but he simply could not explain what conditions of existence meant. The reason was simple. He did not understand quantum field physics. Of the two, he said he knew, the latter was the most powerful force in biology. He was dead right, but since his time evolutionary biology and my critics have believed natural selection is the most important. It is not true. Today, we know “conditions of existence” meant epigenetics. Darwin spent the rest of of life looking for ‘epigenetics’ in an idea labeled “Pangenes”. He believed that Pangenes were responsible for translated environmental influences that have now become known as epigenetics today. Today we know that small frequency EMF’s called the Schumann resonance imprints water and creates life where their was none by using the power of quantum coherence of water. Evolution is in large part, about how these electromagnetic epigenetic signals are transferred to the living organism to living organism by bioelectrical cellular communication; it’s comparing quantum resonance notes and frequency notes and copying and pasting new epigenetic signals on RNA and DNA to make new genetic recipes to create a survival solution from life’s current condition of chaos. When we understand how that dish was created, we gain deep insight of how to keep that dish tasting fresh every time a generation is replicated. Today trans-generational epigenetics tells us something is badly off in our species.Continue Reading
“If you are out to describe the truth, leave elegance to the tailor.” —Einstein
The implications of the last blog, EMF 2 are massive for biology. Those two space experiments show us that time contractions when we lose the sensation of magnetism, and it dilates when we increase it. This implies we can die faster or reverse disease if we understand how it affects us. With this knowledge I knew I could help reverse many neolithic diseases. But it dawned on me on the plane ride home it also might explain how life really began in our oceans.
The irony here, is two days before, I was standing in Rome in the Sistine Chapel showing my son the center panel of Michelangelo’s masterpiece ceiling. It was then I realized I might want to know God’s thoughts. I want to know God’s thoughts in a biologic way……..and the path to that way used an alphabet called evolution.Continue Reading
“You’ve got to work at living… when 99% of the globe works at dying daily; Denial of the truth will lead you into blind alleys. Let go of your paradigm, accept what nature designed, and embrace your ultimate potential” -Gretchen Bronson (starfish)
Why is the clock the most important part of the story of life?
Have you ever had a dream that seems so large in scope, it just seems like it just possibly cannot come to fruition? I have for the last 7 years. Today, I am going to share it with you.
It is time. I believe all dreams come true, if we have the courage to pursue them. It is always easier to make a dollar off a dream, but it is a lot tougher to make a difference with one. I think EMF-2, is going to do just that for everyone.
I told you all last March, on Sean Croxton’s underground internet radio show, and at Paleo FX 2012, that environmental mismatches all cause inflammation. Many of you found it a bold and interesting statement, but I never told you WHY. The reason I did not, was because I did not feel you were ready to understand my perspective, yet. Today that changes. When you do not understand someone’s perspective often times what they say sometimes sounds a bit ‘bizarre’ to you. The reason it does is because you have no frame of reference for understanding, primarily because you were never taught that space/time, might be the most critical factor in understanding trans-generational epigenetic biology today. That is going to change today as well.Continue Reading
READERS SUMMARY: 1. WHY IS DHA IN ITS EVOLUTIONARY PACKAGE THE KEY TO THE MASSIVE METABOLIC RATE OF THE HUMAN BRAIN AND HEART? 2. WHAT EVER MAKES CELLULAR SIGNALING “CLEAN” FOR AN ORGANISM LEADS TO OPTIMAL HEALTH. 3. WHAT THE BIOCHEMISTRY OF NEURAL LIPIDS MEANS FOR HOMO’s SOLUTION? 4. WHAT ARE THE KEY METABOLIC NEUROLOGIC KEYS TO OUR REAL SOLUTION FOR HEALTH? 5. WHY METABOLIC NEUROPHYSIOLOGY = OPTIMAL HEALTH? Many have asked me how I have the physical and mental ability to do all I do. It is pretty simple. On my own journey to Optimal I stumbled into some neural science that showed me where optimal nutrition meets optimal performance of all types. Since I found this evolutionary use, all my abilities have increased exponentially. I can do things now that I could not do even in my prime years when I was in college, medical school, or in neurosurgical residency. I mentioned this when I was in Austin in March. This blog series is my goal of fulfilling a promise I made in March 2012 at Paleo Fx that there was a lot more to the paleolithic template than the current tribe believed. It was there, […]Continue Reading
[show_if has_tag="No-Webinar-2012-08-August"]Buy Webinar[/show_if][show_if has_tag="Webinar-2012-08-August"]ACCESS YOUR WEBINAR[/show_if] We talk a lot on the blog about the brain-gut axis and the implications our gut has on our overall health, including: Most brain disease and neurodegenerative disorders start in the gut (tumors, autism, depression, high blood pressure, Alzheimer’s, hypertension, heart disease) start in the gut. Autoimmune diseases like MS starts in the gut when your gut flora is changed to a more simplified flora, allowing inflammation to pass from your gut into your liver and to flood your brain blood barrier. Infertility starts in the gut by allowing inflammation to overwhelm your system and affect your HPA, destroying its ability to make the releasing hormone that releases sex hormones. Obesity is caused by inflammation getting through the gut, simpifying the gut flora, and invading the blood brain barrier to destroy the HPA and hypocretin neurons, which is equivalent to driving on the Long Island Expressway with mud on your windshield, no wipers, no windshield wiper fluids and your car only goes 20 mph. Your body is essentially in-operational, unable to keep up with the demands of a taxing environment; needless to say, this is very dangerous. Everyone thinks that things like bacteria, candida and carbohydrates are what screws your gut […]Continue Reading
Many of you know I believe obesity if an inflammatory disease of the brain. Where this disease begins may surprise some of you. It begins in our gut flora. How does this happen? Read this link! Sub optimal bacteria which contain bacterial toxins called lipopolysaccharides (LPS) which are found in bacterial cell membranes. As gut LPS rises, it has been shown to cause a rise in serum leptin levels. Once leptin levels are raised high enough it stimulates SOCS 3 signaling in the hypothalamus to cause LR.Continue Reading
Geeks: The implications of Brain Gut 4 mean that to develop a brain seafood is required part of the program to maintain it. Nutrients and many other environmental factors have also been found to influence epigenetic programing of our DNA either directly or indirectly via metabolic sensors. Peroxisomal proliferator-activated receptors (PPAR’s), the vitamin D receptors, and the retinoid X receptors (RXR), and the retinoic acid receptors (RAR) are all examples of the nuclear receptors that interact with the brain cell membranes to control inflammation and metabolism all over our bodies. It turns out that PPAR’s are the receptors that are at the crossroads of where inflammation and metabolism actually cross. These are specialized lipid sensors that pay attention to our balance of omega 6 and 3 levels. 3% of the human genome is directly or indirectly controlled by the endocrine functions of the Vitamin D system. This shows you how environmental signals are intertwined into the expression of DNA in humans. The Epi-Paleo Rx controls inflammation at a hormonal level in the brain better than the more famous paleo diet.
Non Geeks: What we eat is really damn important when you have 3 lbs of lipid in your head called a brain. If you eat outside our design you get sick.Continue Reading
READERS SUMMARY: 1. How does the fossil record prove that epigenetics is the most dominant factor in biology today? 2. How does this lack of insight create a huge mismatch for patients trying to get to Optimal? 3. Does epigenetics change they way we think? 4. Does the way we think alter our biology and can it alter the medicine we practice? 5. How do we make this actionable for patients? In the famous equation E=mc2 we all know that the speed of light is the most important variable in the power of the equation. This has become the logical syntax of science the last 100 years. This is why a nuclear weapon has the energy it does from two small blocks of metals that get exploded into us. The equation is now being challenged by new wave scientists. In fact, one of them spoke at the TEDx Nashville event I participated in and I found his talk fascination on many levels. I love people who challenge scientific dogma. Might there be a similar ‘weighted or squared factor’ in biology that does the same thing to a biologic system? Might that one factor have the same magnitude on modern man? […]Continue Reading