The Rewarding Feeling of Safe Starches

The Rewarding Feeling of Safe Starches








I took a stroll through some of my favorite sites last night because I could not sleep well (added back a safe starch ironically yesterday, too) because I have some big things on my mind, and it seems some of the doubters are beginning to see the magic in my Quilt document.  I remember when I posted it and how I was ridiculed in some places.  I just sat back and took it all in because I fully expected that response.  In fact, I told one of my internet friends, Dexter Yard, that I did this by design for a reason.  I went as far as emailing a copy of the document to him to look over before it ever was posted on the Internet.  His reply was much more kind and subdued than what I faced publicly when I launched the document.  He told me he felt that this was not going to help people that it may in fact, confuse them even more.  He told me it was all too complex for most people.  I remember reading his reply and just smiling.  He was trying to help a friend out and not allow me make a fool of myself.  I smiled because I anticipated his response and I knew Dex was the kind of person who I want on my team because of the compassion and sincerity in his reply for my feelings.

What Dexter and many others did not know was the method of my madness.  What I have stumbled upon is incredibly important not only to me, but for my patients, and mainly for you, the readers of these words.  It is also some really complex and deep stuff.  Our neolithic modern world desires everything in sound bites and 140 character tweets these days.  I cannot and do not believe  that I can convey what I think I have found with modern neolithic methods of communications.  I have been told by countless people like Dex, PH Patrik, and even Mark Sisson, recently that we have to tell the world what we know in a way they will best understand.  In fact, many Paleohackers told and scolded me the same warnings.  They took my responses as aloof and arrogant.  Typical of a CW doc, they said.  Never once did they think about the paradox of choice or of doubt. Maybe using your own doubt and paradox of choice is precisely what I had in mind. Maybe, just maybe, I decided to show some of us why we should remain consciously aware of how doubt can be the currency for the changes I seek in my world.  It might seem like insanity, initially, until you understand why things happen. When it came to my Quilt.I made it tough by design to optimally teach all of you how to become the change we all seek.


There is a thread on PaleoHacks commenting about my cold thermogenesis protocol and a long time poster and doubter named Marie, who posted,  “I’ve been reading his blog with great skepticism for some time…however, each “patch” of the Quilt he adds explains more, and more, why my 72 y/o mother has a 6 pack and I do not. Yes, Mom swims in cold water 3x a week for an hour and has done for the last 35 years. There is a fine line between genius and insanity and only time will tell upon which side Dr. K walks… – Marie 5 hours ago”





Elizabeth Miller wrote this on my FB wall (, ” I’ve been wandering down the path of the role climate plays — I once saw a documentary of an expedition to the arctic where all the members had to do was deal with the cold — no work. And even though they ate thousands of calories more than usual — especially meat and fat — every single one of them lost gobs of weight. So I wonder if the diet one should eat should reflect not only one’s DNA (cold weather alleles) but also the climate one currently experiences. Maybe in a warm weather place like where I live (Los Angeles) where one does not need to generate as much heat as one would in a cold weather place, that too much fat in the diet might not be warranted. Here’s an interesting article:”


Dave Mayo made the following observations after reading the PH comments I made in response and I quote, ” Interesting point. I think that the great deal of plasticity our DNA gives us is why we thrive, but what happens when the change in environment is greater than that which our epigenome allows or it occurs over a shorter period of time than it appears that epigenetic plasticity allows the programming to change (mother to child as opposed to grandmother to grandchild).”

I think Dave’s version of reality generally jives with what most think and what is published in our scientific literature.  But I think my response to him opened a discussion on choice, the paradox of choice, and how the human brain actually works compared to how most think it works.  Moreover, because of this misunderstanding of how our brains really work from an evolutionary functional standpoint, there can be a mismatch that is in our blind spot. It is at the core why our neolithic brains allow us to make decisions that subjugate out paleolithic genes all too often.  I use the reward theory of obesity and the safe starches theories in the blogosphere as my analogies to visualize the points for you here in this blog.

He followed that one up this, “From the research I’m reading (I’m a strength coach), you have to provide the proper resistance training stimulus if you want any of the starches to be safe and you have an easy time putting on weight. If you look at the research, obese people/Type 2 Diabetics tend to carry more Type IIx muscle fibers. It makes perfect sense because they tend to be primarily glycolytic and are rarely used in our current environment. They atrophy which leaves less active sites for glucose metabolism. Even better, a nice way to hasten the process if you are this genotype is to perform high intensity aerobic training chronically.”


I told Dave and the other commenters that I was going to hit on this topic in my new Paleo Summit podcast that is due to air on February 27th with Sean Croxton.  You can register for it right here on my site so you won’t miss it.


Someone else brought up food reward and safe starches and that is when I chimed in. (I added some blackberries to my diet yesterday and the immediate effect was no sleep last night so I wrote this blog. So I’m back to my old plan today)


I said, “Dave, you do react to these things if what those studies are based upon are using biochemistry that we use today…what if I told you biochemistry can rewire just like the leptin receptor? Might that shock you?  Moreover what does it mean for all your studies that you currently believe to be true for your clients?  Might there is a better way? A way evolution figured out how to use the laws of quantum mechanics more efficiently to make biochemistry appear to rewire? And show you an more Optimal way?  FACTOR X….GET SOME! Question everything and always ask why…always embrace paradox.”

Karen Vaughn quickly jumped in and reported, “I’ve fallen off the low carb wagon and have been struggling to get back on. I’ve noticed that since eating more bad carbs I feel more cold than I did a few weeks ago. Is this a coincidence or some sort of bad carb side affect? HMMM.”

I told her that she could go to the PHD or the reward method of” feeling” her way toward optimal, or she can use the Primal Rx to optimal as I will lay out. I am going to show you precisely why the ketogenic paleo diet is the optimal diet.

Long time reader, Daniel Han jumped in and said, “I’m excited for the Paleo Summit and hearing you lecture Dr. Kruse! IMO the optimal diet for nutrition and a low reward diet are two totally separate things, each with their own importance. one can be thin but not healthy by eating a bland diet, or eating healthy ingredients but not thin. I think that if one is overweight while eating a full Paleo diet, they should reduce the food reward by cooking plainly.”


My response was pretty cutting, but I was after all rewarded by safe starches last night and replied, “Reward is a dead concept to me….” And I felt I owed him an explanation for why I said it.




Now that quantum mechanics has crashed into modern biologic theory, we have finally figured out why we think the way we do with our brain. The neo-cortex of humans is the most amazing micro machine evolution has ever created. With its creation, comes the ability of being consciously aware of our unconscious self, and of new realities available to us. Quantum mechanics actually predicted this mathematically in the 1920′s, but no one thought until recently to apply it to how our brain functions. Having these abilities allows us to change our direction in any environment. The real human miracle of our minds is not that we can see the world as it is, but that we can see it as it is not, and then change it. We must however be mindful that the conscious, deliberative mind is not the author of our most important decisions, such as what diet to eat or what exercise should I do and who should I date.

Instead, our ancient paleolithic brain based in the basal ganglia (paleo-cortex), is part of our old neural networked circuits that consciousness cannot access at all! It can however, pull the strings of all of our behaviors, and more importantly, our thoughts!  This part of the paleolithic brain runs on dopamine. This is the true reward part of the real story that you were not told. This part of our brain predicts how rewarding a choice will be. The word predicts means something is being left up to chance. This is where Heisenberg principle shows up in modern biology. For example, if I pick this vegan sandwich, how rewarded might I become? (Not very) Our neolithic brain, however, evaluates the current state of what has been experienced and coded for in our entire cortex over a life time and informs the paleolithic brain about the best course of action or options we have. Here, choice comes into our equation again. This means all thinking is based upon probabilities based upon what is in our current understanding of reality.

This implies if you do not have a good foundation of experiences; your decisions will be shoddy! This means that intelligence is a function of chance. It is not a function of genetics or anything else you have been told it was. This is why Alzheimer’s patients improve cognition with exercise and movement. The brain is experiencing new things to add to it new reality. This is in complete alignment with Heisenberg’s uncertainty principle of quantum mechanics from 1925 that stumped Einstein. Even the master mind could not fathom it, even though his magnificent organ was using it in his head as he thought it. That is the paradox of choice. Our neolithic brain leaves many things up to chance, but decides things based upon the best reality it can contemplate based on what is has wired into it. When we become consciously aware of our unconscious paleolithic brain’s existence it can then be used to transform our reality.  This is how transformation occurs. This introduces another effect of quantum mechanics called a quantum leap or an alternative reality. Many do not appreciate how it applies to biology or thought, but this is the spark of insight that people get before transforming events. It occurs when the neolithic brain becomes aware of a new truth and it opens new rabbit holes in our imagination. It creates the possibility of a new reality. All these things are mathematically worked out now. Biochemistry, however, has not worked any of it out.

It is precisely how the human brain is designed to work. Here is the paradox of the design most remain blind too all their life. It is only later that people construct an explanation of their paleolithic brain’s snap choices using their neolithic brain ability to conceive of a new reality that may or may not be true…actually convincing themselves incorrectly that volition and logic were responsible for their beliefs or decisions when in reality, they were not. They were always subject to the basic biology of the snap decision of their paleolithic brain and the rewards it was wired for. Malcolm Gladwell wrote a book about this called Blink.




The reward theory of obesity is the neolithic brain of a blogger trying to explain how the paleolithic chemistry of obesity operates. It is trying to make sense out of the multitudes of papers that are published. All of them are based upon reductive thinking too. The worse kind, mind you. The paleocortex includes the hypothalamus for those of you keeping score here. My concept of obesity is a bit simpler, it concerns itself with how we account for electrons from food at the leptin receptor. This is present in every eutherian mammal on this planet today. That means evolution had a blueprint design for it. End of report. Now what is it is another story….

In my clinical and personal experience, obesity is an inflammatory disease of the brain, the paleolithic brain called the hypothalamus that damages the leptin receptor. Once you become consciously aware that my reality might be true, all things change. WHY? Because this is how we account for electrons from food! The reward tracts are fed afferent signal from the leptin receptor. This is not a bidirectional neural circuit as some think it is. It is a one way street. This means that the reward tracts have zero influence on how we account for electrons from food. You should think of the implications of that when you ponder the food reward theory. Biology requires it, and it is mandated by quantum mechanics and built into organic chemistries equations. This also explains why people are getting better on my Leptin Rx reset and using cold thermogenesis. If you use food reward by itself it, solves no clinical problems. I know this because I have tried it several times. This is how reductive thinking might lead to a miscalculation.  That is how I view it after deep reflection.


Thoughts form all our decisions, but our experiences hardwired into our neocortex determine our current reality of beliefs. This can trip us up if those experiences turn out wrong. Think statins, cholesterol, government spending….you getting were I am headed now huh? This is why CW is so common, and yet so often wrong.  What we experience in our life socializes us to a belief system that is the jumping off point for how we view reality.  The coolest thing about how quantum physics impacts biology is it mathematically showed that alternate realities were mathematically possible but no one quite fathomed it.  All one has to do is look at how the human brain works to see that evolution assimilated this into our brain by design.  Anything present in an organ level must be true on a subatomic level too.  So, quantum mechanics theory wins again.  We are just beginning to see how the application of quantum biology impacts human physiology.  The FACTOR X concept is tied to this phenomenon too.




Why can thinking change your DNA?  Consider the things I just wrote about, and then consider this mental juxtaposition. What if we’re all dead wrong and our biochemistry is best adapted for cold environment, yet we live presently in a relatively warm world? What if evolution to a cold thermogenic environment is our primordial condition? Cold-adapted, or psychrophilic organisms are able to thrive at low temperatures and in permanently cold environments.  What if we adapted to the warm of the modern world the last 2.5 million years, but we are best adapted to live like the 90% of living things on this planet that live on it?  Yes 90% of life on our planet is cold adapted. Let me be clear here.  I am not saying humans did not evolve out of Africa from Miocene Ape lineage (Dryopithecus ).  I believe they did.  However, I think a case can be made that their best survival blueprint might be for a cold environment in spite of what the paleo hominid fossil records current report.  Why?   What if Mother Nature’s evolutionary blueprints plans differ from your thoughts as they exist today? To see a glimpse of why you might be off, consider that all scientists still believe modern day earth is in an ice age,all be it at the end in the warming cycle that began 11,000 years ago. We know of many that have occurred since we evolved. What if I told you that your proteins and enzymes react completely 180 degrees opposite their current actions when you change a few things?  Might that change the picture of your understanding today?


Maybe modern day life is the ultimate biologic mismatch that we are currently unaware of? Yes, a thought could change your DNA if you ponder a reality that is not currently in your conscious awareness.


My profession usually does not try to eliminate the impossible, because we are trained to be logical and reductive thinkers. When I am stumped, I think about the impossible and the links to the knowns. Then I deduce and I use connective thoughts. In my view, when you have eliminated the impossible whatever remains however improbable, must be the truth. I think your neolithic brain could allow all of us to be making the same error, a modern day Paleohacker error. I aim to show you why this might be case as I roll it out this year…

Hey sign up for the Paleo Summit where I talk about this very issue with Sean Croxton on February 27th!  The registration box is on my site on the top right!

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  1. Pat Palmese February 19, 2012 at 8:06 am - Reply

    Awesome stuff Jackie, understanding why we do and choose things is a big step to total transformation.

    • Jack February 19, 2012 at 8:16 am - Reply

      @ Pat…….the roll out has to be slow. I have to make you consciously aware of how your unconscious brain works and thinks. Once you get this ultimate mismatch………well the Road to Optimal becomes a yellow brick road. Still pissed I ate those damn blackberries last night. I hate missing sleep. This is how transformation happens……it is a process no one understand well but its why humans find change so difficult…….so I use some techniques that appear counterintuitive to make you a better learner than you could be if I just dumbed it down for you……….And I am not dumbing it down. I am going to elevate you to a level you were not was even possible in your brain…….because I know it is and that is where Optimal Living lies.

  2. Jan February 19, 2012 at 8:53 am - Reply

    Hi Jack, Dex was probably right. He was thinking of me as I'm not the brightest button in the box. And you are probably right too – you are certainly onto something with the cold (aka thermowhatsit!). Pre-Paleo I was cold all the time. But I have just been through a very cold winter without a coat. I haven't needed it. There is some correlation somewhere. Look forward to trying to learn more although may have to call on Dex for translation. Good Luck!

  3. Erica February 19, 2012 at 8:57 am - Reply

    Jack, I am very grateful for your Leptin Rx/Quilt. Today is the start of my fourth wk on the Leptin Reset and it's going great. In August I started a primal/paleo diet went from 176 lbs – 158 in about 6 wks. Then I started struggling. I kept messing with my macro amounts and even tried to add in exercise just in case. Nothing worked. Every two lbs I had to fight for and would stall for wks. I finally got to 153 (my lowest) at the beginning of december. I just kept fluctuating b/w 153-156. It was so frustrating as I had changed my entire way of eating.. as before I ate crap constantly. My diet was 1000% better than it had been in my entire life yet I was having such a hard time losing.

    It was so confusing to me as growing up I never had a weight problem and never "dieted" before trying paleo. I ate constant junk food and never gained weight until I was about 19. It just didn't add up to me.

    So, over xmas and new yrs I started eating bad food again. I didn't go crazy as my ability to eat as much junk has changed since going paleo. But, I did eat bread and a lot of other junk food. Luckily, I only gained a few lbs and was about 156. I also had noticed starting in end of Nov – beginning of Dec my hair had started falling out way too much. My mother has hypothyroidism so I was worried. Unfortunately, (or fortunately) I have no insurance or money to go to the doctor. So, I started searching online as to what I could do with diet. I wondered if maybe that is what had stalled my weight loss as well.

    This is when I happened upon your Leptin Reset. It made so much sense. Especially to why I could eat whatever I wanted growing up and not gain any weight. Also, why I loved the cold and wouldn't wear a jacket until I was about 14. I even used to take cold showers growing up because I couldn't handle hot or even warm water. My dad used to tell me that as a baby I would scream bloody murder if they tried to bathe me in anything warmer than tepid water.

    Since I am a female I wasn't expecting to lose much weight on your reset. After all I've read in the MDA threads it seems women have other things happen first. Well, I'm lucky I guess. Since starting I have lost 8 lbs in 3 wks! My sleep is slowly getting better. I had to change my sleep around completely as I have always been a night person where I go to bed around 4 am and get up around 12-1 pm. My sex drive which had waned drastically is slowly starting to resurface. Not that it's that helpful without a partner, but I'm sure it's healthier. I've always been hotter feeling than most people, but it's even better now. My house is always at 66 for monetary purposes, but I have a heater in my room. Which I almost never turn on now and I've kept my window open all winter so far. (I live in Ohio) The best part is my hair has started to not fall out as much. It's still a little more than normal, but massively better than it was.

    Since your mention of the cold protocol I have been adding some in. I have already tried a few times the Tim Feriss way with the ice on my neck area. It didn't seem to do much before. I started with the water on my face. I'm still working on that as I can keep it under until I need a breath multiple times, but often my forehead starts hurting. I'm guessing an O3 issue. I have a good amount of my weight on my mid-lower stomach area. So, I've started putting my ice packs on it at night before bed for about 45m-1hr. And I also put it on my upper chest upper back/neck area and where my thyroid is to try to help that. It's working! I did it 3 days and each day I lost weight. I even ate slightly higher than I should have carbs one of those days (from chocolate from v-day) and still lost 1 lb! The last two days I haven't done it and I haven't lost weight. It could be a coincidence, but tonight I'm going to test it again and see if I wake up with weight loss.

    I can't say I'm a complete success story yet as I'm only part way through. I also am very poor so I have no labs to go by and I can't afford supplements at this time. I eat brazil nuts for selenium, liver once a wk, and I eat tuna every morning (I know bad for mercury, but only way I can get fish and easy 50g). I'm trying to work in something fermented next month for k2 which I desperately need.

    I just wanted to thank you as this is helping me get through my plateau and possibly helping my thyroid. This is how easy I thought it should be to lose weight and keep it off with food. Thank you! 🙂

    • Jack February 19, 2012 at 9:10 am - Reply

      @Erica…….once you come upon a new reality you did not anticipate……..amazing things can happen. Keep it up

  4. Casey February 19, 2012 at 10:39 am - Reply

    "The coolest thing about how quantum physics impacts biology…… mathematically showed that alternate realities were mathematically possible but no one quite fathomed it."

    A post digging into this concept would be most welcome!

    • Jack February 19, 2012 at 1:18 pm - Reply

      @Casey………trust me its coming. I would not be talking if I did not think I could cash the check.

  5. Ryan February 19, 2012 at 11:21 am - Reply

    Dr. Kruse,

    This article reminded me of what you said here:

    • Jack February 19, 2012 at 1:17 pm - Reply

      @Ryan……..I promise you the smartest people among us learn from the mistakes of others. Since you are at your beginning in this world, I would suggest you check all what you believe and think you know and consider some of my thoughts…….assimilate the info and then make your decision. You will find your entire life is better. I wish somebody would have told me that back then because I doubt I would have become a physician………..And I have to say that is one of my own personal regrets in life that I did not follow my passion because I listened to many who told why I could not do it……..instead of listening to the voice in my head and my gut. I am going to leave you with this thought……..someone very wise gave me when I was 20 yrs old and I did not listen…….What an amateur calls pure genius, the master professional calls practice. Always improve your craft to improve yourself no matter what you choose to do. Never forget that because 99% of the world dies with their potential in their heads unused.

  6. Suni February 19, 2012 at 11:52 am - Reply

    Jack, I've been following you since mid-2011, and am having more fun than a barrel of monkeys! I'm 63, now weigh the same as in high school, and getting younger by the day. Many thanks from me and my slim and happy husband. Please keep it up.

    • Jack February 19, 2012 at 1:09 pm - Reply

      @Suni Glad to hear it…….but we are just scratching the surface. There is a lot more to the story and these thoughts.

  7. akman February 19, 2012 at 11:57 am - Reply

    I'm very glad you stick to the science and don't get into a God vs. Evolution debate. As soon as you clearly take one side, you will alienate some and skew the discussion. Well done!

    Living in the arctic, I can attest to much of what you say on cold environments. At -55 deg, chickadees that weigh only ounces still visit my bird feeder. With only 2 hours of daylight, they must get enough calories to last for 22 hours without eating! Muskrats and beavers live under the ice in near absolute darkness at 33 deg for 6 months, in the spring they are fat and healthy.

    All ancient cultures that lived in cold climates wrapped themselves in heavy animal furs and had fire for heat. The clothing they wore was better insulated in some instances than what we have today. What they didn't have were thermostats and a constant heat source. They also had to be outside more, breathing in the cold air. By all accounts, they ate zero carb for most of the year.

    Great stuff, can't wait for the book!

  8. John Sorrentino February 19, 2012 at 12:30 pm - Reply

    You gave us a lot to think about here. First of all, correct me if I am wrong, but I consider your quilt a living document. By that I mean it's not set in stone and may be changed based on new data. It should not be simplified, anyone dipping their toe in these waters better be prepared to digest some college level information if they truly want to reach an understanding. To carry my sperm whale metaphor from this morning forward you can't find out how deep they dive just looking at them on the surface.

    Einstein is a current metaphor for genius. If he were alive he would be the first to tell you that Relativity is an incomplete theory. It does not jive with quantum mechanics. The person who overcomes these conflicts will become the new metaphor for genius and Einstein will be relegated to a back bencher. No one (except perhaps me) talks about the genius of Newton or Aristotle anymore.

    Finally, looking at evolutionary biology ((forgive me if you covered this already, I have not read everything, yet) the Earth is currently about 12,000 years into an interglacial warm period. For about 100,000 years before that we were in an ice age. Yes we evolved in the tropics but Out of Africa occurred about 65,000 years ago so I do believe we have a great deal of evolutionary experience and hence adaptation to cold weather environments. Studying this migration and its position in climatological time will provide many answers.

    • Jack February 19, 2012 at 2:24 pm - Reply

      @Dr Sorrentino………I have a lot more. When this whole mess with safe starches came up I just thought about the implications of it for most people and got angry the more I thought about it. This is the kind of thing that allows for mismatches to continue. So if people choose to do it…….Im fine with it as long as they take the thought experiment out to the last possibility. To see where and why the assumption made in this theory might be wrong. The modern world is filled with people who think they are close to perfect and exercise like mad and they continue to chase their tail and wonder why. Somebody comes by and tells them precisely what they want to hear and it matches most of what CW says……because the carbs will make them feel better short term and sacrifice their long term optimal health. There is no evolutionary history that show we ever needed carbs. There was an article in the seventies I remember reading in SA about coprolites (fosil turds of humans) and how there was no evidence science could find that our ancestors ate any plant based material in any know hominid species. That kind of struck me as odd back then. I have read since then, that they still have not found any! That tells me something, because we are rapidly finding more human evolutionary evidence yearly.

      Starches are safe for modern humans who are already sick, and may not know it, and this supports their neolithic beliefs. Look here….. <a href="http://.″ target=”_blank”>. <a href="” target=”_blank”>

      As clinicians we focus in on sick humans and see how this slippery slope might lead to epic fail as time progresses. I would not and do not expect a researcher or a non clinican to get this, but when you pen a work and it contains the word Perfect in it and say starches are 100% safe………sorry, you lose me at hello. There is much data to support that carbs are completely unnecessary for any human, much less than be safe for 100% of the population. Yes, some more modern HG's like the Kitavans, tolerate them but they are the exception and not the our primordial status. Moreover, there is no good data on them saying that their good could not be better if they ate more coconut?

      The longevity argument is not even preserved on safe starches. We can easily open the oncology literature or the aging literature to see what they say about safe starches or carbs. Our biology is descended from animals called eutherian mammals. They, by definition are ketogenic fat burners and their placenta's run best on high fat and moderate protein diets. They dont run best on carbs. In fact that is why i in 7 couples in the USA are infertile. The data on osteoporsis is clear, carbs are not safe at all. I am an expert in this area, and I see the short and long term effects of safe starches. I have seen thousands of people in my career suffer with this disese, and none thrive on carbs long term. Why is that if it is the safe for 100% of people? Should not safe and perfect lead to optimal in all people or is that just for those without spines?

      People point to athlete…….really lets take a look at how they do past 55 years old. Especially the endurance athletes. Not too damn well. 99% of people are not high performance athletes, they are weekend warriors. They keep my ortho buddies busy. If you want to sacrifice life span for fame by all means do so…….but realize the rice, potatoes, pasta you eat now, will take you sooner than you would have if you ate the diet evolution sculpted through eons. The concept of natural selection over the last 2.5 million years of human history for safe starches is reasonable to have because we know where humans came from, Africa. But where we first evolved does not confer optimal or perfect. Epigenetics shows us that logical fallacy can no longer be accepted. So let's move to the hominid fossil record……but the hominid fossil records do not support it either! Neither does the dental records that you know well. I'd love for you to get Ungar in this discussion from Un. of Arkansas. Dental morphology strongly supports a different dietary construct.

      Many people cite literature that we need "some glycation" of the Golgi bodies and RER in cells to prevent normal autophagy…….all true but these glucose needs are controlled by strict enzymatic processes that are independent of dietary carbohydrate sources. You don't need extra starches/sugar, period ever because we make what we need. Evolution has that covered. There is no obligate carbohydrate for humans period. That study was done right here at Vanderbilt.

      Potatoes have been called safe recently……but they have toxins in them and they are a nightshade. Cordain's new book shows it. and he is pretty clear on how safe they are. They are nutritionally devoid according to him too. Is that safe or perfect? Rice shows cross reactivity with gluten (even in Asians because i have many in my practice here who show it) and it can induced changes in our mitochondrial and mRNA that alter our epigenetic signaling and not for our benefit. Can some handle it…….sure, but then you cant use the word safe………because it carries a connotation for the unwaring public that safe is 100%. They just do not get the nuance. Just because humans and asians can eat them does not equate with them being safe. Safe = tolerated…….not optimal or perfect!

      If you want to really prove safety lets call in the immunologists and GI specialist I have at metametrix, cyrex, or genova and bring them to the table. These are the guys who run the test that I order on patients who believe they are safe food. Why do I test them and find out they are sick? And many time patients do feel better eating them initially…….WHY? Because they are adapted to a bad habit. Its like smoking or drinking……people can do it a long time before the shit hits the fan. Does that make it safe?

      The neurohumeral response that these companies are finding out are nothing short of stagggering. I talk to them weekly about these findings. And you want to know what JS………..this community is in the dark about it! Why? They don't have the problem yet and foster the idea it has to be safe if its not biting me in the ass. This is why they do not realize it. I challenge anyone who doubts this to call any of the three companies up to speak with their research scientists about what they have found regarding this issue. Its published work and they can send it to you.

      If we are unaware of it, it means it does not exist in our brain until we become consciously aware its true. That is why this post was written. You can hate on me all you want but here is a prime example of where our neolithic mind subjugates our paleolithic genes. This is why we see so many with leaky guts, shitty immunity, and horrible adrenal fatigue that lasts for decades and often lifetimes. No one is doing functional testing and looking! Why? They dont know to look. Those who do……are CLINICIANS who see it daily.

      And really that is where I get kinda of chapped about it. Because modern neolithic humans are completely in the dark about most of this. They have been taught and socialized for hundreds of years that grains and all carbs are OK in moderation. How often have we heard it? You hear it long enough it becomes part of your mental fabric and you become a sugar burner and you lose the ability to be an apex fat burner……..and you slowly decline into mediocrity and subcumb to neolithic disease.

      What we need to worry about is what happens to glycation after the enzymatic processes are saturated. We know those answers now. The ACCORD trial should have put the debate to bed. It has not. In my opinion it is a decent debate to have because we should question everything……..but there is no good evolutionary data, biologic data, fossil data to support it.

      With respect to brain growth and the composition of breast milk, I think I know a little bit about what is best for a growing brain. Its requirements need fat not carbs. Children are born with ketototic metabolisms, and any neonatology book will show it. The infant brain does not need ANY GLUCOSE to survive. This is total bullshit that is constantly said like it was ultimate truth. I used to take care of these sick kids all the time and all of them were running ketotoic in the first few days or life and even after breast feeding occurred. There is some glucose in breast milk because human children are mammals born without hair for warmth and they have limited fat supplies. Moreover, just because carbs are present in small amounts in breast milk, doesn't automatically mean humans are best adapted to it. there is likely a purpose for it. Babies have different metabolic needs than at any other stage of life and compared to other mammals they are born in a pretty sad state because all placental life is about brain growth at the detriment to somatic growth. Composition of moms milk has evolved to solve that……….Babies do not equal teenagers or young adults or adults in my line of thinking.

      If this were true we should see the majority of people thriving on this approach. We do not. I think most clinicians will agree with me. Feeding safe starches to world has not exactly been a great idea based on the data. The data on low carb diets I think is pretty solid. Requirements change and the situation has to be brought into proper context. In my view the safest starch for humans is the ones you avoid outside of the ones we manufacture by design. I have little trouble with carbs in long light cycles and higher temps. That is when evolution prescribed them to be present and I think eating them there makes some good sense. Doing it in the dead of the winter makes none. When I see good credible evolutionary data for obligate carbohydrate needs for humans I will reconsider my opinion. For 35 years I have not seen one shred of evidence and I probably do more functional testing than most clinicians to back up my primal instincts here. Sorry about the rant Dr. S but you touched a nerve……….with your drill.

  9. Dave Dixon February 19, 2012 at 2:10 pm - Reply

    Hey Jack. I have a feeling you don't really mean "Heisenberg Uncertainty Principle" here. Despite all of the press it gets, the Uncertainty Principle is (IMHO) a fairly boring technical aspect around the mathematical structure of quantum physics. I expect you're actually thinking more along the lines of the Many Worlds interpretation of QM, leading to this sort of thing:

  10. Lauren February 19, 2012 at 2:32 pm - Reply

    Jon Kabat Zinn explains that the Latin name for humans is 'homo sapiens sapiens' roughly meaning 'the one who knows that they know." He then points out that we haven't lived up to this – that we get to knowing, but not knowing about our knowing. I think this is akin to what we are saying. Thinking is not enough. We have to understand why and how we think and then open to what we don't know, can't imagine but still may be possible. I love the advice to always embrace paradox! (I work in mental health and in a lecture last week actually said that I believe the biggest feature of mental wellness is the ability to understand paradox as truth.) Thanks for confusing me and forcing me to continually readjust, reconsider, question and move forward! (Don't dumb down your book – we need this.)

    • Jack February 19, 2012 at 2:33 pm - Reply

      @Lauren you know I believe this…….I think it is our ultimate neolithic mismatch. Having DaVinci, Michaelangelo, and Einstein as mentor is why I love ambiguity and paradox. They were masters of it by example of their work and teachings. I did not learn this from my kin.

  11. Joyce Soos February 19, 2012 at 2:36 pm - Reply

    I find that the only food that will warm me up is beef and lamb. My blood vessels in my hands actually pop up! Carbs do it temporarily but then I get cold afterwards. High starches make me warm but make me dizzy with all the sugar. Thanks for your articles!

    • Jack February 19, 2012 at 2:58 pm - Reply

      @Joyce I cant really recall anyone telling me they have done well on carbs long term…….even the high performance athletes are socialize to buy the CW that carbs means fast energy or glycogen replenishment. Kind of amazing how the Native Inuit never had access to this stuff and even Weston A Price marveled at their fitness and health in his masterpiece. Albert Schweitzer too……….

  12. Jack February 19, 2012 at 2:52 pm - Reply
  13. Terry F February 19, 2012 at 3:16 pm - Reply

    "Question everything," good point and this is the reason to have the science and background information for us. It's difficult to ask the right questions unless one has some basic understanding. I had wanted to study anthropology from the time I was in early grade school. At age 50 or so I was able to finish college in anthro. The last class of the last term is where I finally had enough background to question and understand the reason for anthro was not the one I thought it was. Thankfully it didn't take til the end of a PhD study.

    Rewards, if ones body chemistry is not working right one can 'reward' for the wrong things(like carbs every 2 hours). I finally decided to treat this body like a prized race horse. The owner having spent hundreds of thousands of dollars and hoping to make much more is not going to let the horse eat just anything. So in consultation with your website this 'horse body' eats what I give it. I smile when I cut into half an apple, feed it to myself for a treat and think about my analogy. I can tell that the body feels more secure with this method. It is assured that nourishment is coming in a timely manner and because I am fat adapted it is still secure when I IF because there is a ready supply accessible internally. This has been the best thing I have done for my self. For once I feel secure and cared for.

    I even felt secure enough to get some labs drawn. Not too bad. CRP was .26, TSH 2.1,need (.3 to .6) Homocysteine was 11.1. (need this below 6) I can add some more B Vits. Rest of lab WNL. However, DHEA was only 135 and should be 350-430. I am following the LEF protocol for DHEA supplementation and will get labs done again in 6 weeks or so. This will help bring the TSH into line I think.

    Sometime, I hope you can discuss the role of DHEA and pregnenolone in older people. Of course DHEA starts to decline in the late 30s. According to the lit. DHEA decreases by some 90% by the time one is 70. I read that people who meditate have higher DHEA. I know how I feel with a low DHEA level. Might cold thermogenisis keep DHEA and other hormone levels higher as one gets older? There was no supplementation for this until recently. I'll start the cold adaptation in 2-3 weeks. Thanks again.

    • Jack February 19, 2012 at 7:02 pm - Reply

      @Terry not might……..consider it does.

  14. Dave Dixon February 19, 2012 at 3:35 pm - Reply
    • Jack February 19, 2012 at 7:02 pm - Reply

      @Dave you only show up when I go QM on here! LOL Thanks for the read. I love reads.

  15. Lauren February 19, 2012 at 3:39 pm - Reply

    For you, Dr K.

    "Tell a wise person, or else keep silent,

    because the mass man will mock it right away.

    I praise what is truly alive,

    what longs to be burned to death.

    In the calm water of the love-nights,

    where you were begotten, where you have begotten,

    a strange feeling comes over you,

    when you see the silent candle burning.

    Now you are no longer caught

    in the obsession with darkness,

    and a desire for higher love-making

    sweeps you upward.

    Distance does not make you falter.

    Now, arriving in magic, flying,

    and finally, insane for the light,

    you are the butterfly and you are gone.

    And so long as you haven't experienced

    this: to die and so to grow,

    you are only a troubled guest

    on the dark earth."

    ― Johann Wolfgang von Goethe

    • Jack February 19, 2012 at 6:57 pm - Reply

      @Lauren I like Goethe…….a lot. But you seem to sense this.

  16. John Sorrentino February 19, 2012 at 4:27 pm - Reply

    Actually, I enjoyed the rant. It reminded me of a conversation I had with a physical therapist when my article came out. He started by saying, "I take exception to your phrase carbohydrates are not an obligate nutrient, you NEED carbohydrates…." He got more than an ear full from me.

    I will see Unger next month, email me any questions you want me to ask him. I plan on going to the AHS in August so I will see you there if not before. (Must remember to buy ticket.)

    • Jack February 19, 2012 at 8:06 pm - Reply

      @JS there is no question we have adapted to carbs via natural selection……….you just have to walk into to Walmart once to know that…….but adaptation does not mean optimal, safe perfect or just OK either. I think Rosedale has made that point well. My beef is more basic. It fosters the neolithic belief that may in fact be false. There in lies the rub, medicine is on a continuum scale and not all or none. No diet is perfect….that i why there are 250 diet books published per year in the USA…..but I think the case that one diet is optimal can be made. I think it is where paleo splits……I have felt that way for some time now. I think what we are calling paleo today is the modern rendition painted by neolithic beliefs and has been socialized into the national consciousness.

      Many are adapted to grains too without any noticeable problems too……..but does eating them make it correct? Cordain's new book is a great book to tackle those issues for patients. If your goal is optimal living I think you have to question what the assumptions. It seems pretty clear to me that evolution has scullted out some blueprint for the optimal path to live. The key question remains what might that path be………..

  17. John Sorrentino February 19, 2012 at 4:29 pm - Reply

    and if I am not hitting a nerve in you, I am not doing my job properly.

  18. akman February 19, 2012 at 5:59 pm - Reply

    So have you changed your thoughts on cycling carbs along with hours of daylight, ie. ZC at Winter solstice

    • Jack February 19, 2012 at 6:48 pm - Reply

      @akman…….no this yr has been an outlayer for a reason.

  19. Santiago February 19, 2012 at 6:36 pm - Reply


    some questions/comments to learn a bit more

    i) I understand the problem with carbohydrates (well, sort of), I understand fruits contain evil fructose… but apart from that black/blue/wild/cran-berries contain varied polyphenols, which seemingly have a very positive effect on the health, I've read somewhere they are sirtuin activators.

    Probably this is heresy… but one single blueberry have much more micronutrients, minerals, vitamints, etc. than a 1 kilo of coconut oil.

    ii) Vegetables are CH as well. Brocolli, Kale are really evils?. Hard to believe.

    iii) Out of curiosity. After a meal, if obligated to choose, you would rather take an apple or a cappuccino (with his overheated pasteurized milk) ?. Scared about the answer here…. 😉

    Best. Santiago

    • Jack February 19, 2012 at 6:52 pm - Reply

      @Santiago. I kilo of coconut oil will do far more for human biology than one blueberry ever could…….in fact it would do more than a barrel load of berries. I never said veggies are evil and fruit is bad, I leave that for other bloggers to say about what they think I said or meant……………they are good, in a correct biologic context. Find that context becomes the main goal.

      But the question remains, if your healthy today do you need something that is just good for you that you can tolerate or should you focus on the things in your health that guarantee optimal if you know that biologic context?………or do you just settle for good because you have been socialized to believe that you absolutely need a certain food to live?

      See people who are sick already have a different situation………their decisions should not be the same as yours. Dr Terry Wahl's version of her paleo diet uses that context well. When you say you are the perfect diet does not that mean it is perfect in all contexts to you? What if I biology and evolution say it is not. Should we continue to believe that things are safe when they are not?……..When you do not question these things mediocrity creeps in……….and then people begin to question what is wrong but never look to the the real problem because the perception is that it can not be that because………well its perfect and I feel fine with that?……..The reason this happens is because our modern world has adapted these beliefs and most have been socialized to believe that blueberries are better than fats………especially MCT fats. All mammals were made to burn fats first and foremost. That is how placental biology works. Babies are born into ketosis. Any Neonatolgy book will show it. The problems begin when the child cant breast feed because the mother's milk does not come in because she has been consuming safe starches all pregnancy long………….May be we need to look closer at assumptions made at what is really perfect and safe…….

      I would take the coffee plain or go without either.

  20. Gladina February 19, 2012 at 6:41 pm - Reply

    Can you really not tolerate even some low sugary fruits such as berries? I know it makes sense evolutionary to not have such fruits available during winter time, but it still seems a bit frustrating if you cannot have even a small amount.

    • Jack February 19, 2012 at 8:06 pm - Reply

      @Gladina……tolerate them yes. But they wont get me where I need to be. There in lies the rub for me. So I adapt.

  21. v February 19, 2012 at 7:14 pm - Reply

    Dr. K said: "…And I have to say that is one of my own personal regrets in life that I did not follow my passion because I listened to many who told why I could not do it……"

    May I ask what your passion was?

    Also, I remember you said you started adding in carbs in April. Is you new position that carbs are totally non-optimal, and so you will never eat them again (except when you slip up vis a vis the blackberry incident)?

    How about the argument that carbs (like leafy greens) are needed to keep us from getting to acidic?

    Thanks -v

    • Jack February 19, 2012 at 7:17 pm - Reply

      @V the acid CW needs to go die a slow death…….I have some different variables this yr going on so I decided to try to test the system……the test lasted one meal. As for my passion I will keep that quiet.

  22. The Paleo Rag | The Rewarding Feeling of Safe Starches February 19, 2012 at 2:14 pm - Reply

    […] Read More » […]

  23. Myree February 19, 2012 at 11:52 pm - Reply

    I have a confession… I'm in love with your blogs!!! I'm startin slow on the cold but started. This is REALLY a leap of faith for me because of my hypothyroidism when I get chilled I have a very difficult time getting warm! Cold is very painful but when I started down this path in July I was icing my back and hip multiple times a day and was losing over a pound a day and started feeling better and stopped. Now I'm starting again. I'm going outside every hour and wearing a coat but have thin pants on plus I'm icing my low back and hips several times a day. I did go pick up some CoQ10, magnesium malate along with supplements I was already taking and finally I'm sleeping again. I haven't had 3 nights in a row of 8 hours of sleep since September but I chalk that up to grief and stress of moving… then getting what I'm sure was food poisoning didn't help… I'll keep you posted… you haven't steered me wrong yet!!! I've known for a long time I do better vlc but always thought I had a wheat allergy well getting tummy sick and eating oatmeal made my skin break out and me very bloated so I'm sure I have celiacs! My old doctor agreed but also agreed a test wouldn't show it since I've been off grains for so long.

    It's 10:00 now and I'm going to bed! Yay I'm tired at 10:00 now hopefully I'll sleep till 7 or maybe even 8 hehe!

    • Jack February 20, 2012 at 8:30 am - Reply

      @Myree I do what I can. If you find help here I am happy. Im not everyone's cup of tea.

  24. Santiago February 20, 2012 at 3:56 am - Reply


    thanks for the feedback. A question about coconut oil. In a contest of a healthy paleo-style person, what amount of coconut oil is reasonable to ingest on a daily basis?.

    Personally, I used coconut oil for all the cooking, but never sure how much should I ingest apart from that. I use it sometimes as a dessert mixing it cocoa powder, or some bccas, which even tastes good.


    • Jack February 20, 2012 at 8:29 am - Reply

      @Santiago I think this depends upon the person and the health of their gut. FOr me…..I use 4-6 large tablespoons per day Sept 1-April 1. In Dec a lot more…..In June not much at all.

      • Shane January 8, 2017 at 12:06 pm - Reply

        Dr. Kruse,

        I was thinking I read somewhere that you said that during the cold months it was best to consume animal fats and avoid CO until the warmer months? Have I misunderstood you or have you changed positions?


        • Jack Kruse January 8, 2017 at 2:23 pm - Reply

          This is true.

          • Shane January 9, 2017 at 11:01 am

            I apologize for being dense, but which of my questions is true?


  25. Erik February 20, 2012 at 6:44 am - Reply

    Thank you once again for your fantastic blog posts!

    I am a bit surprised to read that you are in the ketogenic camp. From your earlier blogs, I have got the impression that "once you are LS, macronutrients don't matter". But I take it that that is if you settle for a C, not an A, right Doc? 😉

    Two questions:

    1. How about serotonin synthesis while in ketosis?

    2. How about carb re-feeds combined with weight lifting?

    • Jack February 20, 2012 at 8:27 am - Reply

      @Erik I am ketogenic all the time in fall and winter…….we are headed to spring so I thought I was "safe" because of the time and my labs I got back Saturday. I was wrong. SO i got pissed at myself for making an error in judgement. In this failure, I decided to write about why it happened and I thought it might help people realize how one can make errors……..with thought. My rant came out of JS hitting a nerve about something we have been talking about for sometime now. So it came out………with some of my thoughts on what really is safe or not. We need to question everything for ourself. Nothing is axiomatic and we all live on a clinical continuum. You have to find your own continuum.

  26. Erik February 20, 2012 at 6:48 am - Reply

    Forgot to elaborate question 2. "How about carb re-feeds combined with weight lifting?"

    I mean, do they come at a price? Lowered longevity? Higher inflammation? I.e. can they be optimal?

    • Jack February 20, 2012 at 8:24 am - Reply

      @Erik Loaded question that I expect to be examined at Paleo Fx……where the theory of paleo meets the clinical practice.

  27. Matt February 20, 2012 at 7:01 am - Reply

    Jack, you may be interested to know that blackberries do not contain starch and so cannot be considered a "safe starch".

    • Jack February 20, 2012 at 8:23 am - Reply

      @Matt……I think I get that, but some how I think your point had another intention. The point of the blog was to think about what you're really doing…… was not about starches or fruit. They were used as examples. It just so happens that I used some fruit to test things out on me and immediately had a nasty reaction. I guess I was aggravated with myself for "caving" into a feeling…….when I knew better. Hence the blog post was written at 3:30 AM in the morning while I was hot at myself for making an error in thinking…………..

  28. Mark February 20, 2012 at 7:03 am - Reply

    So it seems that It comes down to living like we're in an ice age:

    -eat mostly fat and meat

    -get some sun

    -expose yourself to the cold

    -lift some heavy stuff every once in awhile

    -sleep good

    Sound about right?

    • Jack February 20, 2012 at 8:19 am - Reply

      @Mark This is my Primal Rx for health.

  29. v February 20, 2012 at 8:30 am - Reply

    Dr. Kruse said, "@V the acid CW needs to go die a slow death.."

    Dr. Cordain puts forth this CW in his books. Does he repudiate the acid CW which he helped to propagate in his new book? If yes, then it doesn't seem such a good buy after all.

    • Jack February 20, 2012 at 10:17 am - Reply

      @ V…….overall the book (The Paleo Answer) is great…….that is not an endorsement that everything in it I agree with. Cordain also said ten yrs ago Saturated fat was bad…… this book he has evolved his thinking. Did I discount everything Cordain said ten yrs ago because he was dead wrong? No. I do not think like that. Others do and they try to apply their thought to my intents. When someone does not have your own reality they do not know where your thought come from. They use their own reality to formulate their response and often it reflects badly upon them. You always can tell the true essence of someone from how they think. How they think is translated best in their actions. I think the actions of Cordain, Jaminet, and most others in the blogosphere speak volumes for the quality of minds working on the same goal via different pathways.

      I suggest you do the same with regard to acid issue. It is a moot point. We need to all find the ability to disagree with one and another without disqualifying our individual efforts or great ideas. I'll give you a perfect example. I recommend Paul Jaminet's book by writing Rx with the name of the book on it for my patients. 95% of of what is in it is excellent advice for them to use as a guide. I tell them I completely disagree with him about safe starches.

      This disagreement does not disqualify all the good that Paul and his wife's idea have provided the public. That is how I view things. Sadly few others get that angle because they think everything is a zero sum game or all or none, because of how THEY think. I can not control how they think I can only control how I think. I will not allow people to frame my thoughts. I do that quite well here for all to see.

      …………As a surgeon clinician experience has taught me a valuable lesson. That is, all clinical problems occur on a continuum and are never static. If you think statically you can hurt people. If you dynamic think across knowledge you know and tie it all together to get to a better place than we are today. We always need to be mindful of this before we make a decision………..I see this mistake daily in many blogs, thoughts, and forums. When I see it I try to get people back on point. This is precisely what I have been doing at MDA for 8 months. I think it provides a valuable resource. Some dont………That is why I wrote this post. I fell victim to it myself and called myself out on it publicly. I am constantly aware of how my neolithic brain can undercut my paleolithic genes. This is precisely what my Paleo Summit talk is all about.

  30. Jonathan Goins February 20, 2012 at 8:52 am - Reply

    JK, what labs "should" be changing. I want to grab new ones but would rather not just stab in the dark as it will be on my own limited dime.

    Also as noted elswhere 14 days 12 pounds


    • Jack February 20, 2012 at 10:09 am - Reply

      @Jon T rising E2 lowering…..insulin cratering. CRP crashing Diurnal cortisol normalizing are great trends to follow.

  31. Erik February 20, 2012 at 8:54 am - Reply

    Thank you for your comments to my questions. I know they are loaded and there might not be any obvious answers. I am most of the time in a ketogenic state despite doing weight lifting (once or twice a week). This is because my gut feeling is that the benefits of being in keto outweighs the increased strength at the gym a non-keto diet would give me.

    However, all this talk about safe starches made me a bit unsure and another thing that added to that (should have been question 3 above) was your comment about selenium deficiency after long time keto.

    • Jack February 20, 2012 at 10:10 am - Reply

      @Erik I am with you on this………this is where I move from dogmatic paleo principles as stated in Paleo 1.0 books. I have uncovered a lot of science why that may be a prudent move longer term.

  32. Lee February 20, 2012 at 10:27 am - Reply

    You can eat blubber on an empty stomach, I'm guessing…really guessing. If so, is it ok to do coconut oil on an empty stomach?

    • Jack February 20, 2012 at 10:28 am - Reply

      @Lee I do……..I put it in my optimal coffee every day.

  33. Lee February 20, 2012 at 11:10 am - Reply

    I'm sorry, but between meals? I want to keep the eleven hour gap and I wonder if fat is immune to the insulin rule/guideline?

  34. Lee February 20, 2012 at 11:12 am - Reply

    Sorry, an empty stomach is automatically between meals. just the eleven hour rule I wonder about.

  35. akman February 20, 2012 at 11:20 am - Reply

    If we evolved to live in an ice age, cold exposure and a ketogenic diet would be part of our DNA. Seems to follow that we'd have a lowered Vitamin D level during the coldest parts of the year. Maybe we should rethink supplementing with D3 all winter long.

    • Jack February 20, 2012 at 8:34 pm - Reply

      @Akman…….I love that your mind is thinking……..i promise the curveball will surprise you. Evolution has a special switch for the polar regions. That will answer your question.

  36. v February 20, 2012 at 11:24 am - Reply

    Dr. Kruse said: " I think the actions of Cordain, Jaminet, and most others in the blogosphere speak volumes for the quality of minds working on the same goal via different pathways.

    I suggest you do the same with regard to acid issue. It is a moot point."

    I do the same what?

    I'm not a scientist, although i do experiment on myself and look at correlations. i don't agree with you about bioidentical hormones, but i still value what you have to say- so i get what you're saying about not throwing the baby out with the bath water and whole sale discounting what someone has to say based on a few areas of disagreements.

    i hope you have time to refer me to the evidence that led to your rejecting the acid CW.

    for us laypeople, we depend on experts and then muddle around with experiments on ourselves. i respect both you are professor devany, but i get a headache trying to figure out whether to lean towards the clinician who has seen many patients and labs in these past 5 years including his own, and the theorist who has lived pale for 25 years, but never started out from an unhealthy place and hasn't worked first hand with many outside of his family.

    thankfully, my health is pretty good and these questions have not reached the critical point for me as they have for others in my family. i'm very excited about the future in medicine because of what people like you are doing. i can't wait for the pale summit. i hope you have time to talk about the acid cw more in depth. i thinking of how to test it out for myself…

    • Jack February 20, 2012 at 8:33 pm - Reply

      @V Robb Wolf has like 4 podcasts debunking the acid base crap argument. Go to his podcasts and look at the archives. You will find them. I also believe Matt LaLonde has talked about this as well.

  37. v February 20, 2012 at 11:32 am - Reply

    ps just another think on the radar- both of my taiwanese brother-in-laws who mainly eat a traditional chinese diet, but who live in nyc, are coming down with serious h.pylori infections. one has a perforation and had to have emergency surgery, the other was diagnosed with gastritis but also had a tumor on his adrenal gland. they were going to remove it laproscopically, but they inadvertently "nicked the IVC", so he has a huge scar across his abdomen. he's just a so-called immigrant on medicaid, so they lied to him and told him they needed to cut him open so wide cuz he was so fat. they probably didn't think he would have a relative who could read the medical report.

  38. Lee February 20, 2012 at 11:50 am - Reply

    So I'm confused, we eat fruit for vitamin C or we need more vitamin c because we eat fruit? I feel like I've used unreasonable amounts of both at times for regularity. Then I hear I'll get a kidney stone and stop.

  39. Matt February 20, 2012 at 12:15 pm - Reply

    Jack, I really don't feel you need to be aggravated with yourself for "caving" into a feeling.

    It is perhaps more likely that you are unaccustomed to a large dose of fruit after a period of eating very low-carb over the autumn and winter. Fruit like blackberries are quite high in soluble fiber among other things that cause some alterations in your gut. Perhaps you just need a little time to adapt to eating fruit and you will be sleeping just fine again.

    • Jack February 20, 2012 at 8:29 pm - Reply

      @Matt I do not accept failure in my own thoughts. Fruit is only meant to be eaten in season. Biology planned it this way and evolutionary Rx should follow this. Just because our neolithic brain figured out a way to circumvent mother nature does not make it correct……..even if some other people FEEL its OK………its not OK if biology and evolution do not plan for it. That is the primary reason for my pissed "offness" at my self. I know it and I still allowed it to happen.

  40. Paul February 20, 2012 at 1:57 pm - Reply

    One can think back to the "EPR (Einstein,Podolsky,and Rosen)Paradox," a critique intended to show the incompleteness of quantum theory and support Einstein's theory of an algebraic representation of reality. Most physicists today believe the EPR Paradox, based squarely on intuitive classical ideas of reality, resulted in "paradoxically" illustrating the new logic that was required to better and more accurately understand physical reality.

  41. BR February 20, 2012 at 4:26 pm - Reply

    I am still with you. I have read every post & most comments. Wikipedia is getting a work out from me and I am learning a lot of new biology and medical terms. You are very exciting to me. Keep it up. I will let you know how the cold adaption works for me and my wife.

    • Jack February 20, 2012 at 8:14 pm - Reply

      @BR look at the comment I just posted in the NEw evolution blog about the Sweedish guy……..somebody just sent it to me. Physicians told me today that they thought what is reported here is physically impossible. Maybe we know something they do not?

      Stay tuned.

  42. Christy February 20, 2012 at 6:10 pm - Reply

    @ Dr. Kruse, re: "I put it in my optimal coffee every day"

    optimal coffee? elaborate please



    • Jack February 20, 2012 at 8:12 pm - Reply

      @Christy This is my concoction that I make every morning. It will be on my website soon in my e cookbook that should be done as soon as my website gets updated.

  43. Jenny February 20, 2012 at 6:11 pm - Reply

    Thinking about the fats versus cold weather problem – is there also a link with low iodine/hypothyroidism. Many of the peoples in the very cold climates also eat lots of fish or mammals who eat fish – eg seals. They are getting lots of iodine with their fat.

    Secondly, last week I was travelling and stuck with more carbs than normal – potato – but still carb – and was the one starting to feel very cold. I just assumed I was tired…

  44. Jenny February 20, 2012 at 6:18 pm - Reply

    I've just noticed you pass comment on something I was trying to look up this evening – about rice being cross reactive to gluten. Being coeliac, I had wondered about this before. Do you have any reference to this, or is it your observations?

    • Jack February 20, 2012 at 8:07 pm - Reply

      @Jenny I have seen it many times. I am currently treating an Asian patient with horrible back problems and her Cyrex testing found it. I was not surprised but she was. Since we eliminated all rise her pain meds have been stopped and she is now using the Leptin Rx reset to strengthen her paraspinal muscles. I would suggest calling Cyrex labs for the references and to speak with one of the GI immunologist about this. I believe this will be covered in one of the talks at the Paleo Summit on safe starches. So register for it. The sign up box is on the top right of my blog. Cyrex, metametrix, and Genova labs has quite a few to cite for you. I do not have any on this computer.

  45. christy February 20, 2012 at 8:48 pm - Reply

    Oh great, looking forward to seeing that!

    thanks Dr. Kruse


  46. Lee February 20, 2012 at 9:50 pm - Reply

    I have a question about converting protein to carbs. If there is too much protein and it gets converted to carbs, does it go directly to fat or does it go around glycating?

  47. Terry F February 20, 2012 at 10:20 pm - Reply

    just found the Hormones 101 post, very helpful for my next round of lab requests. I am planning on doing the thyroid panel, a salivary Cortisol Assay, along with redo of DHEA, plus HSCRP and serum ferritin level (because of issues with HCL. I'm reading through your posts and gathering a bit here and there. This way I can learn as I go along. I gave my new Dr your website as well as gave it to my brother who is also an MD.

    I remember as a little girl when we visited my Ottawa Grandmother in June, we would go into the meadow for the wild strawberries. As I recall they were small and very sweet and you had to go searching for them. They weren't all together like in a garden. So you got a handful then had to find the next handful and if you were supposed to bring back enough for the family supper you got a bit of a workout for the berries.

    • Jack February 20, 2012 at 10:47 pm - Reply

      @terry F In the wild evolution made the demand for berries high and the supply tight. In our modern world it is reversed. Many on our community are blind to this evolutionary fact. More are blind to the implications it holds for our biochemistry.

  48. Marijke February 21, 2012 at 7:04 am - Reply

    Funny, I looked back in my diary. Last year in the beginning of January I stopped all carbs because they gave me gas. I put them slowly back in in the spring. This year the same thing happened. My paleolithic wisdom surfacing?

    • Jack February 21, 2012 at 7:09 am - Reply

      @Marijke I believe your primal sense it learning to read your Primal Rx buried into your DNA because your mind is beginning to open to new possibilities………you are becoming consciously aware of what previously was unknown to you. This makes me happy. This is how transformation occurs.

  49. rick hammond February 21, 2012 at 7:51 am - Reply

    Morning Dr. K., can u tell us plz what time you will talk on Feb 27th? Sean's site lists all the contributors etc. but no kickoff times (assuming these lectures are live events). Thanks very much, I do NOT want to miss your segment!


  50. Dave Dixon February 21, 2012 at 11:22 am - Reply


    I only show up for the quantum stuff mainly because that's where I feel I can contribute (I find most of your other material dead on, to the extent I'm even qualified to assess it). Quantum physics is also poorly understood even by most professional physicists, and what leaks out to the "lay public" tends be exponentially greater confusion. It can be hard to distinguish "quantum mysticism" from those aspects which, while strange to our classically-oriented minds, actually have some basis in theory and experiment.

    I have a very strong feeling (and it is just a feeling, without any theoretical rigor) that the recent work of Zurek and others around how the classical world emerges from the quantum will have strong relevance to your Quilt. Amongst other things, I'm guessing the brain is a sort of "quantum amplifier", where the microphysics internal to neurons becomes entangled with the rest of the universe to ultimately manifest what we see as "behavior", the macroscopic response of an organism to the environment.

    • Jack February 21, 2012 at 11:38 am - Reply

      @Dave you are reading my mind. I hope you participate more. After speaking to you about my electron post I went o speak with two physicists. One classical and another bio-astrophysicist about my ideas. I told both that I had an idea of how to test my theory clinically and they both perked up because they both understood implicitly that what I was proposing is the biggest weakness in QM theory. Experimental proof and measurements. So after telling them a lot but not the end game…….and telling them what I planned to do with my bio hack……..both became intrigued. The results for one hack is complete. The results we shocking. The second one will be totally completed in April. At the 3/4 pole the results have been even more remarkable. So I am pretty intrigued with what I am finding in my N-1. I have begun to test this on others as well and so far the results are consistent. I get into it in my book. In fact I just updated that chapter with the 3/4 pole data. Science is nothing short of remarkable in where it takes us when we allow it to and not put our biases on it.

  51. golooraam February 21, 2012 at 1:27 pm - Reply

    thanks Dr. Kruse for all your work. last few days have not been the best dietwise – but I have stayed consistent with placing blue ice pack (while i watch basketball) for 30 minutes a day. In addition, I drive to work with the windows open, a lot more tolerable.

    Surprisingly enough, looking at wedding venues yesterday i indulged into too much beer and junk food, usually a 5-7 lb weight gain for me overnight – suprisingly only 2.6 – very strange as any beer in my system jacks me up totally.

    I am back to my ketogenic food today. By the way – can you share your thoughts on eating protein and fats 'raw'? Do you see any benefit to this? I usually will cook up some organic grassfed fatty ground beef and take a bit or two raw before eating the rest medium rare. Would be curious to hear your thoughts on this.

  52. COLD THERMOGENESIS TWO - Jack Kruse February 22, 2012 at 11:25 am - Reply

    […] This also signals where movement was first coupled to memory or actions in life. Even today all learning in higher order animals is directly coupled to movement in their environment. The more one moves the more intelligent one becomes. I just explained that to you in a recent blog on here. […]

  53. Marijke February 23, 2012 at 5:48 am - Reply

    In Waldorf schools the children learn knitting because it is good for the development of their brains.

  54. Daniel Han February 23, 2012 at 9:48 pm - Reply

    Thanks for responding to my comment, Dr. Kruse. However, I wanna respond based on what I think, and of course I'm not that advanced yet in my studies but I've learned to rely on my own scientific intuition and experiences from obesity.

    Firstly, I actually understand what you're talking about with regards to chances and the brain's understanding of reality. However, it's not only about nurture (your experiences, the environment) its also about nature (genes). We evolved certain attributes that helped our own ancestors (mine are not same as someone else's etc) survive. One of which is imo storing fat based on how rewarding food is in order to survive harsh climates as hunter gatherers. I traced my ancestry and I have a ton of Mongolian blood, many of whom are not from an agricultural society and primarily eat lamb and some raw dairy. In that sense I am not fit to consume alot of carbs. However, given that I was 290lbs at age 20 at a height of 5'7, I actually feel I'm a more extreme case of dysregulated metabolism across the spectrum than you were. I was much younger and am a smaller guy (granted I have a large build but regardless) than you are yet I was more overweight in total poundage. However, I feel I'm in a position because of being extreme to have a perspective on what works. I'm the guy who can still be 20-30lbs overweight while eating a FULL Paleo diet. In fact, I realized that when i eat sausages/bacon (even organic) or flavored 100% natural broth/stews or various Paleo recipes, I tend to overeat in total calories. Given my history of obesity, I know I'm eating too much if I'm normally eating in the 3000 cals on a typical day. Now I eat literally the same diet but reduced reward by boiling meat/eggs/seafood (no salt/spices), steamed plain vegs and never mixing any ingredients together. it is incredibly plain. absolutely no other flavorings. I'm able to reduce my appetite over time and I'm down to basically my last 5-10lbs. In fact, to further support this anecdote, I found I have literally HALF the appetite I had before if I add a nose clip when I eat (no smell -> no taste…by SG's theory appetite will be further reduced)

    If you believe a low-carb Paleo approach automatically leads to a lean physique, it's just not true. go take a look at traditional Mongolian wrestlers on the Eurasian plains. They're all big, heavy, strong but fat guys (high subcutaneous fat) and the way my father described their diet was basically nothing but: boiling whole lamb (offals, everything) + salt, and milk tea. They rarely eat lots of vegs or grains. however, that body fat helped them survive long distance traveling in the cold/arid land and enabled Genghis Khan's armies to conquer damn near the entire world. maybe for them that's optimal…but it's not the same thing as being thinner.

    I also firmly believe ppl with an addictive personality can get addicted to the taste of foods that are rewarding. Over time your addictive nature makes you seek those foods out that have a strong, pleasurable taste. It's best sometimes to simply keep life simple and your senses sensitized. I don't see a downside to a low "reward" version of a fully Paleo approach. Evolution also plays a role here. I love meat so I tend to seek out artificially enhanced umami tastes like gravies/fried chicken/msg-laden foods. I however could care less for pastries and sweets that others get obese on. so i think taco bell artificially TRICKS my body into thinking I'm eating quality meat. conversely I don't overeat sweets and don't care much for desserts. This is quite opposite to ppl I talk to who would kill for some sweets but care less about the heavy kfc stuff. if u asked me, I'd say their taste buds are evolved to seek out natural sugars like fruits/starches/leaves etc. Take this as you will but I think it's an interesting point. I get fat based on foods that imitate what I need, but take the taste to a more stimulating level.

    Lastly, I reiterate that I don't think I need much starch myself given my ancestry and the climate of where I'm from. But didn't human beings evolve from fruit/leaves/insect eating primates? I would avoid getting tunnel-visioned and only emphasizing low-carb-way or the highway. I understand you're a neurosurgeon but are you going to say that African tribes living off fruits/nuts/leaves and honey aren't optimal? Also, anytime you reintroduce a major macro back to your diet, you're gonna feel weird. The first time I went low-carb I almost fainted. I don't think thats sufficient evidence against the safe starch group lol.

    Sorry if this seems rambling but I too think a bit eccentrically.

    • Jack February 23, 2012 at 10:21 pm - Reply

      @Dan H read CT 1-3. Your missing big parts……..Your behind the quilt as we are evolving faster than you can read! LOL

  55. Daniel Han February 23, 2012 at 10:01 pm - Reply

    But I will say that following your thinking, and the rest of the Paleo blogging community has just opened my horizon and took my passion for medicine to new heights. I never worked that hard in college and I went into medicine because I thought surgery was cool (I was fascinated by the Da Vinci system lol) and I wanted to "help" ppl. But the past year of learning non-CW and changing my own health has really motivated me to work hard to new heights. I want to pursue orthopedic surgery and outside of the clinic, talk/work with the urban community to better their health/rid Neolithic diseases. I know I can match but I've been working insanely hard to try to match into a top program. Doctors like you who dare to think differently are my inspiration. You'll hear more from me maybe down the line. Thanks Dr. K

  56. Daniel Han February 24, 2012 at 5:31 pm - Reply

    sure I'll get around to them. But the reward theory has its merits in daily experience. Sometimes you're on your "diet" and you eat enough to be satisfied, but as soon as you eat say pizza or some other trigger food, you're appetite revs up again and you wolf down 1500 cals. It's happened to all of us before who've been very obese.

    I've also been reading a cool book on Testosterone called Heroes, Rogues and Lovers. It makes a great distinction between low testosterone men/women who are naturally so vs those due to hypercortisolism (by Quilt, this is caused by LR/obesity and this drives down free T). The former are simply happy/friendly ppl who aren't aggressive while the latter tend to be both less confident and anxious/cranky. So one is simply a normal person with low evolutionary T level while the other is under pathophysiology. good point

    • Jack February 24, 2012 at 7:47 pm - Reply

      @Dan H it does. Reward plays a role but it is no where near a dominant role as it has been rolled out. It is an efferent pathway in the neural circuitry. The hypothalamus sends info to it and it is then modulated in the frontal lobes. If it was an obesity cause I would be seeing tons of brain tumors in this area and I dont. In fact no one does. It is not in the neurosurgery literature in humans.

  57. Bonnie Temple March 1, 2012 at 11:45 am - Reply

    Hi Dr Kruse

    I am new to the blog as of this week due to Paleo Summit. I can't stop reading and am staying up way too late… Your message is profound and needs to be shared. I feel like an evangelist question; raw eggs I have been putting 3 raw eggs in my whey protein shake along with MCT oil each day. Paul Jaminet says throw away the whites, they are not safe raw, use the yolks only. What do you say? I am also waiting for the ebook recipe of Optimal Coffee very curious about that. Thank you for responding.

    • Jack March 1, 2012 at 12:04 pm - Reply

      @bonnie egg white raw can rob you of biotin……but if your paleo you will get enough. In 15 years of clinical medicine I have yet to see a biotin deficiency so I given that I think you can make an informed decision.

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