Cold Thermogenesis 1: Theory To Practice Begins

Cold Thermogenesis 1: Theory To Practice Begins

image_printPrint PDF

Readers Summary

  1. How do we perceive environmental change?
  2. Does evolution use climate as the currency for epigenetics?
  3. Does the functional organization of the brain tie quantum mechanic theory to Biology?
  4. How might astrophysics give us the insight we do not currently consider?
  5. If the brain undergoes neuroplastic change does it follow that Biochemistry uses thermoplastic change?

Today, we are going to bend your mind a bit by explaining to you many of the things you might be believed as biologic truths published in biochemistry books today are in fact truths when certain environmental truths are held within a constant range. Yet, they change tremendously when certain factors are altered.  Often the biophysical changes do not even have to affect the thermal coefficients of the biochemistry in the hypothalamus. Just the perception of the environmental change from the brain is enough to alter the chemistry as is the enzyme and proteins existed on the top of Mount Everest or on the ocean floor in the coldest environments on earth.  When biochemistry was observed in living cells and described, the scientists rarely considered these effects on our biochemistry and how it may alter the cellular terroir.  Our hypothalamus rewires too many stimuli, and it appears that temperature is a major factor in the rewiring protocol of our brain.  Evolution has clearly needed to use this in the past for some reason.  Our job as inquiring bio-hackers, is to figure out why and how this might have happened.

In essence, they looked at the complex biologic machinery from a standard Newtonian platform.  Most scientists know that Newtonian physics explain much of what we observe in the physical sciences here on earth, and that quantum mechanics best describes the physics of subatomic matter of matter in space on a universal scale using mathematics. When QM theory is adapted to many biologic systems we must invoke quantum electrodynamic theory because some puzzling things emerge that are hard to explain.  Complicating matters, we have few ways to measure the quantum effects within biologic systems to test how they may affect living cells but we cannot measure several aspects of things at once because we are dealing with subatomic particles.  This does not imply in any way that quantum mechanics does not apply to biologic systems because it clearly does.  Many believe these effects are often buried in the biochemistry equations that biochemists use to describe how living cells make order from the complete chaos that rules matter.  I do not.  This implies the effects might be difficult to discern or measure with current techniques we have, and this is why we have yet to uncover them in biologic systems.  It means we need to ask better questions in our biohacks and experiments to uncover these effects.  The brain clearly uses QED to operate optically to affect our protein polymers that act as condensed matter.  This is a controversial point at all in the scientific world.

When biochemistry laws and equations were laid down in human history, it occurred in a time where our understanding of the nervous system was rudimentary and felt to be static and unchanging.  The current laws of biochemistry have never been able to explain how the human brain functions totally on a biochemical level or a functional level.  Moreover, we have yet to hear a complete thesis on how it is able to perform all the things it is capable of even today.  Biochemists still cannot explain the biochemical fluxes that control some of the most basic functions in a cell.  We still have no idea how sleep occurs, how ECT transport occurs,  why anesthesia works, or how the brain wakes us up every day.  We understand many parts of it, but we do not understand the biochemical processes of the nano-machinery in our cells, and how the make order of the chaos of the matter in our cells.  The belief that the brain was static remained medical and scientific dogma until the last 15 to 20 years of modern science.  When brain researchers began to unlock new mechanisms of neuroplasticity and brain circuitry, everything changed for us in the neural sciences.

When it dawned on us that the brain could rewire on its own and it was proven in humans, we had no biochemistry to tell us how it all worked.  In fact, we still do not.  Here is where some very smart biochemists and physicists began to collaborate together and share ideas of how biology may be impacted by quantum mechanics to explain “queer reactions” in biologic systems where modern biochemistry theory just stops.  The organisms that sparked these theoretical experiments were extremophile organisms that live deep in the sea in the coldest darkest environments possible, and thermophiles that also live near boiling vents or deep in cenotes in scalding hot sulfuric acid.  How can life exist in these wildly diverse environments is no longer just a biologic question, it is a question for biophysics these days.  It has brought many bio-astrophysicist to the same table to solve the mystery.  Today, most of these bio-astrophysicists think that the best chance for extraterrestrial life may lie on the moon of Titan.  Titan is a moon of Saturn and is a giant frozen ocean that has volcanic jet streams erupting from its surface in radiant displays of light that have been seen by the Hubble telescope and by the Cassini spacecraft. These enigmas maybe solved when we first relook at how the human brain rewires to environmental pressures that climatic change brings to bear upon it.  Neuroscience has taught us over the last 25 years the neuroplasticity in the nervous system is ubiquitous. Explaining the functioning of the human brain comes in to play because it remains the one human organ whose function continually stumps modern science but readily adapts its own biochemistry.  What are the links that here that we might consider important?

How might we experiments reconcile these issues?

The key to understanding these perplexing questions and paradoxical reactions requires us to rule out the impossible first.  This implication is not meant to mean that the laws of biochemistry or organic chemistry are wrong.  Quite the contrary, it means that humans today remain in the dark of how biochemistry reacts at extremes of our environment occur because we have not faced them in the past.  Because they are rare from an evolutionary context, we rarely study them in current human studies. This includes super hot, super cold, and nonnative electromagnetic energies in our environment.  With extremes, what we believe to be true today in printed textbooks may just be mere folly, because all of the pathways were studied in climates that we consider normal.  Moreover, the way in which we studied the cells might affect the outcome of our studies.  The research on evolutionary biochemistry today is in its infancy, but few people seem to realize this.  Most people believe that basic metabolic pathways are well known and well understood by humans.  I do not believe that is true.  Hyperlink.

With that all being said, if the brain is capable of rewiring, this implies that the cells it is made from, the nano quantum-machines within those cells, the proteins and enzymes they are made from, the space-time windows they exist in, and the atomic and subatomic particles they are all made from must also have the inherent capabilities to be “plastic” as well.  Einstein hypothesized this early in the 20th century and so far to date, no theory that has been mathematically proven by quantum mechanics has been experimentally proven to be false.  Does it also have issues?  Yes, it does.  But so far on an experimental basis, the results imply the theory is pretty solid.  Science is never true or false.  It is a culture of doubt that is designed to be metastable as our knowledge advances.   Assuming Einstein was correct, we must conceptualize what it may mean for biologic nano-machines in our cells.

It appears biology is beginning to find out why these new founded ideas and realities may hold for us a new world of possibilities and realities with regard to the biochemistry of life in general.

1. Radical new truth number one: If our brain can rewire, then Einstein’s theories predict our biochemistry might too using biophysics under the power of cold.  It may work via compliant design mechanisms by the movement of subatomic particles like electrons.  The movement of electrons or the activation by photons would not be reflected in a biochemical equation.  But the effect is real.  Consider how rhodopsin bonds are rotated by light in our eye.  It does not change stoichiometry, therefore, anything in classic biochemistry experiments will find it unless we are looking for it.  This implies we need to redesign experiments looking for these possible effects.  Many of the things believed to be anchored and already well accepted may not be correct.

Mind you, when I use the word rewire I am not saying this in the literal sense.  I am saying it is thermoplastic and subject to the energies in our modern environment. I am telling you that even today the laws of chemistry exhibit some unusual properties at extremes and that the laws of evolution seem to have used this in our past for adaptation for and natural selection to allow all life a chance to thrive in the natural extreme conditions on earth.  For example, Kirchhoff’s law of thermal emissions from our sun has come under fire.  Sunlight powers all kingdoms of life so any change to how we view its light and emissions has massive implications for biology.  Physics and chemistry now have to grapple with the ideas that the gravitational constant and radioactive decay rates are also variable.  These all have huge implications for our current beliefs.  We have a model for this today in our own solar system that has transfixed modern bio-astrophysicists for the last few years because of the possibilities it holds for us and for the universe.

2. Radical new truth number two: Considering that 90{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} of the earth’s current biome lives in extreme conditions on our own planet still, we might need to consider that what we think is “our normal environment” is not so normal for most of life on our planet or our evolutionary history.  Life on Earth evolved in an environment much like we see on Titan today; in a deep ocean frozen solid at its surface with the capability of life buried deep within it.  The only escape was due to ejectants of water vapor from superheated water from underwater volcanos.  Does water acts the same when it is cold and hot?  We know that water is a repository for electromagnetic energies from the sun.  How might this change our experiments?  All these things are present today in Earth’s crust too.  There is one major difference now between the two.  We believe we exist in a warmer environment today than life began 3.8 billion years ago.  There are others, but when one looks at Titan, we see a frozen giant moon with a monstrous ocean beneath it.

All life on our planet came from the oceans first.  This does not seem controversial.  It points out that water-protein interactions would be quite important to understand in these extreme environments.  What happened then might be radically different than we see today.  Our current models have not controlled for these changes.  Protein and water chemistry has been a constant so one would assume that they would also be highly adaptable and compliant with changes.  If you read a biochemistry book that is rarely mentioned.  Gilbert Ling found in frogs that insulin does not work the same below 62 degrees as it does above 62 degrees.  And because of this, maybe we should consider studying extremophile forms of life here on earth.  We seem to believe that how pathways work in a biochemistry book is how life uses it in all environments.  I think this is deeply faulty thinking.   This might explain the complexities of how biochemistry allows for life to exist at all in a thermoplastic environment.  Based on what is in our textbooks today, understanding how life lives in 25,000 feet of freezing water is unknown.  Moreover, on those geothermal vents, we have bacteria that live in 750-degree water that cannot boil because of the pressure and cold of the water, causing us to wonder how life manages this perplexing set of circumstances.  What the bio-astrophysics found on Titan with the Cassini Solstice mission, maybe a huge clue that life first adapted to extreme environments, and then was naturally selected and adapted to a cyclic warming trend on our planet’s crust over time.

Our species may have adapted during this warming trend, but the DNA we inherited came from animals that were predominantly cold adapted.  Evolution uses epigenetics to determine adaptation to environments.  Epigenetics is changed by the environment we live in.  Today, epigenetic research since 2003, have discarded the strict definition of genetic determinism in evolution.  We know today that the power of epigenetics dictates a lot more about newer generation’s adaptations than we even knew ten years ago.  The implications of this information now have to make us look at some of our own long-standing assumptions about how living cells work in cold and warm environments to see how our cells react to a thermoplastic environment.

It may be that Titan represents today where the Earth was 3-4 billion years ago and offers us an opportunity to gain some insights on how life starts in extreme environments and how it slowly changes as the environment changes.  Evolutionary pressures are selected for by the environments of our ancestors were exposed to, and not for what we face today.  We remain unsure what the power of those epigenetic pressures can exert on our genome. They may not have even made a big impact when hominids evolved 2.5 million years ago because of all geologic accounts, it was still warm.  But it remains possible that the impact could be a lot larger than we expect as well.  We may not fathom this possibility, but it is clearly in the realm of possibility.  The modern science of epigenetics shows that who we came from, and what they faced has a direct biologic effect upon subsequent generations DNA and phenotypes.  It is crystal clear today, but the biologic implications remain unexplored in all modern day literature.  What is happening on Titan maybe like opening up a black hole back to a reality that used to be our own.  The ability to see Earth at life’s evolutionary beginning.

Sounds pretty radical, doesn’t it?  As Dr. Spock said in Star Trek movie, “When you have eliminated the impossible, whatever remains, however improbable, must be the truth,  correct?”

This is where the story of Factor X begins.

Leave a Comment

More Support: Webinars by Dr. Kruse

Your Shopping List for this Post

About the Author:


  1. cgk February 21, 2012 at 8:02 am - Reply

    something tells me the trap door you found is related to cognition…

    • Jack February 21, 2012 at 8:21 am - Reply

      @cgk No its not. Strap your seatbelt. It's time to challenge modern dogma.

  2. James Duffy February 21, 2012 at 8:46 am - Reply

    Really enjoying this info, but it's a big tease as well. Can't wait to find out more! I wish those cold showers would hurry up and not feel so cold anymore though….

    • Jack February 21, 2012 at 12:02 pm - Reply

      @james…….not a tease. You learn better by making connections……and we are making lots of them now.

  3. Brenda February 21, 2012 at 9:06 am - Reply

    My guess is sleep. I am thankful you let us in on the secret about your brilliant writing technique….knowing I am not necessarily supposed to grasp it all makes me hang on and enjoy it all more 🙂

    • Jack February 21, 2012 at 12:11 pm - Reply

      @Brenda…….this will be one of those times were the the truth is likely stranger than any fiction you might imagine. Because I am viewing the problem differently than the rest of the blogosphere…….I am nuts. They have never considered that maybe there is another possibilty that they failed to think about or account for. Will this challenge everything they believe to be true…… absolutely will. It may erase much of their dogma, unless they begin to act like some professions who choose to by the party line regardless of where the science takes us. QUESTION EVERYTHING.

  4. Jonathan Goins February 21, 2012 at 9:10 am - Reply

    it is my intention to create an ice sauna or an ice tub in my garage. the ice sauna is probably cheapest.

    Dibs on the concept!!!!! 🙂

  5. Stevenson February 21, 2012 at 9:33 am - Reply

    This mammalian dive reflex is really cool. Two quick questions – is there a reason this won't work well on stubborn belly fat? And is it normal for the fat to feel sore the next day?

    • Jack February 21, 2012 at 12:01 pm - Reply

      @Stevenson It works if you apply it and understand how it works.

  6. Shijin13 February 21, 2012 at 10:16 am - Reply

    Ready for the ride!!! I'm going to have to re-read this tonight to ensure I grasp where we're going!

  7. Chris Bjork February 21, 2012 at 10:35 am - Reply

    Maybe Spock used the quote "When you have eliminated the impossible . . " in a movie, but it is originally from Sherlock Holmes, "The Sign of the Four" (ch. 6).

    • Jack February 21, 2012 at 12:00 pm - Reply

      @Chris…….I have never seen any Sherlock Holmes……but I am a science guy. My bad.

  8. Jonathan Goins February 21, 2012 at 10:35 am - Reply

    Extruded Polystyrene + 6500 BTU window unit + 6'x4'x6' space = <50F , thoughts?

    • Jack February 21, 2012 at 11:59 am - Reply

      @jon…….you can do the Second evolutionary directed experiment seeing if I am nuts or not. I think its a solid plan. Keep me informed……cause I am more than interested.

  9. Sally February 21, 2012 at 11:08 am - Reply

    I'm surprised at my reaction to submerging my face in ice cold water. Shocking at the moment, but the feeling later is quite … refreshing? Bracing? Invigorating might be the word. It makes me want to do it again in the afternoon, but you said "gradually". Tease indeed!

    I'm hoping this reaction might mean that after a year of avoiding omega6, perhaps my tissues aren't in too bad of shape after all. Getting better, anyway.

    Oh, and thanks for helping me get rid of the nightime munchies. When I started my leptin reset, it was extremely difficult to resist a 9pm snack. Now it is quite easy. And I know to expect about 15 minutes of hunger two hours after eating, my ghrelin moment. Who knew my body was capable of such predictability?

    • Jack February 21, 2012 at 11:59 am - Reply

      @Sally you will be more shocked at what it my do for you by May 13.

  10. Rodney February 21, 2012 at 11:08 am - Reply

    @James Duffy, you might try soaking in the tub just to see if you like it. I found the shower was tougher since only a small part of me was under the stream at any given time, so various body parts were always adjusting to the cold. The bath allows me to keep my torso under water while keeping arms and legs out in the air, so I get used to the cold temps and it doesn't feel cold after a minute or so. I do sometimes shiver a bit, but I also get a redder cooler skin and an odd sensation about five minutes after I exit the tub that feels like I rubbed a mentholated rub on my skin…cool and warm at the same time.

    For people wondering how to keep ice on your torso, would a second compression shirt maybe a size larger allow you to sandwich the ice bags between the two shirts?

  11. Resurgent February 21, 2012 at 11:18 am - Reply


    Fascinating read..

    Sometimes I wonder why did 'intelligent life' evolve on land versus in the water where it all began millions of years ago. Even today water covers more surface area of the planet than land and marine life is more abundant..

    Any thoughts..

    • Jack February 21, 2012 at 11:58 am - Reply

      @Resurg…….The reason to me now makes perfect sense. The crust was molten for billion (or billions) of years and the oceans were not the same. The deeper in the ocean you went the "more hospitable" conditions were for life to evolve. Electron exchange is what makes the world go round, as quelson said this AM. He implicit gets why my thoughts on this 20 years ago ar enow coming to life. It was my primal sense telling me something that was true but could not explain. I feel like I can now. . I suspect this is why life is abundant in the ocean heat evolution has no answer how to conquer biochemistry…….but in cold…….their is an ancient way. Biochemistry is thermoplastic to life. And that ancient way is in all of us. We just need to consider the possibility. It seems many in this community are challenged by their own biases to even consider what I am proposing. Moreover, I have a way to prove that what I think actually maybe the Primal Rx. When people do not see your vision and talk down to you it because they do not understand the framework of your thoughts and considerations. I am planning to slowly let it all out. When it is all out then people can criticize it. These thoughts I have had are all original and all foundational to my Leptin Rx and other things I now belief to be true. The clinical results of what I have uncovered are nothing short of remarkable. And the best part is that when this is all out there anyone can apply what I have found and see the results for themselves. It's hard to lie to yourself unless your a ………..well I'll just save that thought. I am glad you like this Resurg.

  12. Dexter February 21, 2012 at 12:03 pm - Reply

    @Rodney I use one long tailed T-Shirt and then I tie an Ace bandage stretchy around my torso and the tails of the T-shirt. I then insert three 1 gallon bags of ice from the top and position them on my stomach. The Ace keeps them in position and they are submurged in the cold water when I sit down and thus the ice bags make excellent contact with my skin. Stomach skin gets pink but never white. I do have numbness all the time now as I am doing the cold thermogenesis every evening. Makes going to sleep easy. I also wrap a 4" Ace around my neck and insert a frozen blue pack onto my throid gland…hoping to rewire my thyroid to my hypothalamus to get it functioning better.

  13. Lee February 21, 2012 at 12:18 pm - Reply

    Is there a cold weather breeding season for humans? Like maybe a not optimal time to get pregnant? I can't reason this through. I would hate to chase a toddler in an igloo, or then again, it might be easier. I don't know if they stayed on the breast till they had teeth or what? Or was it mix and match for a long time? Were there periods of no ovulation in the dark, or light? the nine months makes it tricky. Gestational switches are diet and circadian? I'm sure the eating is the same regardless. Baby or no right?

    • Jack February 21, 2012 at 12:25 pm - Reply

      @Lee yes there is and the switch happens in the eye. Im getting there……..just not there yet.

  14. Sherry February 21, 2012 at 1:25 pm - Reply

    I have considered myself an open container for information from a very young age. At my core I am a rebel and from my early 20's have never gone to a traditional Western MD once they tried to kill me from a cancer diagnosis. I'm not overweight but have had some hormonal issues that I believe is directly related to the radiation "cancer treatments" from 30 years ago. Thank goodness I refused the chemotherapy. The only thing that has really helped in all those years has been my meditation practice and now I am really appreciating the biochemical understanding of our bodies. I'm experiencing greater health since starting the leptin Rx. The science is sometimes over my head but once I sit with it and it sinks in I find myself sounding like a broken record as I preach this stuff to all of my friends. It isn't for everyone but I am thankful that there is finally someone out there that isn't afraid to be on the fringe. I appreciate each and every bit of information that I find on this site. This cold thermogenesis is the best yet. Thank you Dr. Kruse.

  15. akman February 21, 2012 at 1:57 pm - Reply

    In normal cold response, the blood is shunted from the skin/extremities to preserve the temp of the core and brain. Does this process change in cold adaptation, as brought on by cold therapy such as ice baths or other cold exposure?

    • Jack February 21, 2012 at 11:23 pm - Reply

      @akman it has in me and other who have been doing this long term. I am now at 23 months.

  16. Paul February 21, 2012 at 2:11 pm - Reply

    Dr. Kruse,

    I am enjoying this direction. Are you familiar with the work of Johnjoe McFadden?

    • Jack February 21, 2012 at 11:22 pm - Reply

      @Paul I am.

  17. Susan. February 21, 2012 at 5:15 pm - Reply

    Dr. Kruse,

    Due to our family moving so often, I never was able to take any science classes while I was in High School. Here I am, at almost 59, having a blast reading your posts. What amazes me, is that I am getting it. BTW I your grammar is improving. 🙂 I am looking forward to the next installment. What a fun way to exercise a sluggish middle-aged brain. Cannot wait for the next installment!


  18. Erin February 21, 2012 at 5:34 pm - Reply

    @Lee- I found an abstract on the Inuit natality cycle in the Arctic. Most babies are born in the first half of the year, which means they were conceived in in the brighter months.

    • Jack February 21, 2012 at 11:20 pm - Reply

      @erin conception in long light cycles make sense….especially in a warmer polar climate……….but it can happen anytime in a true polar environment.

  19. Eric February 21, 2012 at 6:04 pm - Reply


    Fascinating topic. You have my complete attention.Yesterday it was a sunny 36F day with a brisk wind outside. As I sat in the cold breeze I thought about how if I had done this 2 weeks ago before you started this subject, I would have been uncomfortable an not have lasted long. Yesterday however my perspective was changed. I was hoping to cool down and rather enjoyed the feeling of the heat being stripped from my skin. I stay out 30 minutes shirtless and wasn't particularly cold when I came in. So much of perception is influenced by expectation I think.

    17 years ago I had an egg size Meningioma removed from between the lobes. It was resting on the motor nerve and I lost most muscle function in my left leg below the knee after surgery. So, I'm ready to give some thermal rewiring experiments a try.

    • Jack February 21, 2012 at 11:18 pm - Reply

      @ eric this is just the beginning. I think you will like where we go.

  20. The Paleo Rag | Cold Thermogenesis 1: Theory to Practice Begins February 21, 2012 at 12:19 pm - Reply

    […] Read More» […]

  21. Lee February 21, 2012 at 6:31 pm - Reply

    @ Erin…Well, cold feet make some women not want to. And the the thyroid goes down in the winter. Cold hands timed and applied perfectly make some men not want to. There is a reason men should chop wood and keep the fires burning or kill a polar bear and bring home its liver.

  22. john February 21, 2012 at 9:24 pm - Reply

    @ Jack, I am so enthused by your Hypothalamus-Nasa lit axis that i just purchased this article HORMONAL CHANGES IN HUMANS DURING SPACEFLIGHT

    From this, the next experiment we could do is to sleep on a slope of 6 degrees and do some more observations!

    just wonderful stuff, thank you so much

    • Jack February 21, 2012 at 11:11 pm - Reply

      @john……we can all do our own evolutionary directed medical experiment together once I lay it all out. I have no issues with people being a skeptic. But when it is all out there digest and dissect it. Then decide what to do. I think what I have stumbled upon in my N-1 x3 is pretty important.

  23. Maren February 22, 2012 at 3:44 am - Reply


    What should I do if I have been doing the leptin re-set and find out I am pregnant? What is a safe amount of carbs to consume when pregnant?

    Thanks for your help!!!

    • Jack February 22, 2012 at 8:08 am - Reply

      @Maren I think you can do the reset. I do not think carbohydrates are obligatory during mammalian pregnancy. I think where they play a role in mammalian pregnancy is they are often used as triggers for growth and reproduction because their appearance on our planet is cyclic from equator to pole. And their presence is a stimulus to the animals so that they can use it as a North Star for knowing when they might consider mating. In most mammals except for humans this ability is tied to the estrus cycle. In humans we have slowly extinguished this need because our neolithic brains have become adept at controlling our environment. We are the first species who can do this because of of our our neocortex or newly evolved brain.

  24. Jack February 22, 2012 at 8:11 am - Reply

    @BenG she is correct…….but she also was quick to point out that this ability has been lost in modern humans in her estimation because of artificial light has been a huge game changer. Since Paris France became the first city in our world that used fake light in 1924. I think most humans are not really ambiently aware of how how circadian mismatches destroy our biology. Moreover, when one looks at the biology and biochemistry of sleep and truly understands the power of autophagy for longevity it becomes apparent to me that we may want to consider that maybe sleep is our primordial conditon and not wakefulness. Maybe we evolve consciousness over time. This theory I have follows the thoughts i have developed in cold thermogenesis because in extreme cold environments the process of autophagy becomes super sensitized to save energy. In fact in cold sleep is heavily selected for in terms of how mammalian nervous systems respond to the stimulus. This is why mammals sleep so long underground in sub zero conditions and survive. You are beginning to ask great questions and I think you might begin to see where there is a convergence of scientific findings that occur in this biology to explain many effects we observe in humans and all mammals. Radical Rule #3: Sleep and cold environments were our ancestors primordial condtion and as such, this was evolutions starting point for life on our planet. I think this thought maybe why epigenetics has become to be found as the major player in genetics too. Because anything that promotes survival and reproductive fitness has to be passed to the next generations. I think evolution found this to be true and it became a backbone law of genomics functioning. Life was likely static at this time and to get the nutrients it needed it had to evolve wakefulness to obtain them. To do this it yoked metabolism to sleep early on so it could account for things. I believe the timing became an easy solution because of the ryhthmicity of the sun and the freezing cold could control these cycles for the cells.

    I believe this fractal organization of sleep and metabolism remains in every organism studied. Because of this I believe that sleep, autophagy are extremely highly conserved across all species on our planet. We still have yet to find a species who does not sleep some. I think as life evolved wakefulness it had to account for it environments and as such evolution then moved from a static model to a dynamic one and then a whole new set of environmental problems had to be navigated to make life persist. This is where movement was first coupled to memory or actions. Even today all learning in higher order animals is directly coupled to movement in their environment. The more one moves the more intelligent one becomes. We can prove this today because if we just get an Alzheimer's patient with a demolished brain, when we introduce exercise we can increase their cognitive function in a completely broken organ. That tells me a lot of how evolutionary design is constructed. I hope this helps you understand how I think about life and how it all began. It is a foundational concept behind my QUILT document. When you see my point of reference you begin to see a new reality that you might have not anticipated before you thought about what I just explained to you.

  25. Dexter February 22, 2012 at 8:42 am - Reply

    @Maren, Read this account of a paleo baby raised in untero on a paleo diet. Although this family was not per say on the Leptin Reset Protocol, it would probably qualify on the Leptin Reset…without the meal timing aspect.

    • Jack February 22, 2012 at 8:57 am - Reply

      @Dexter This is a great add for Maren. Thank you.

  26. Dr. John February 22, 2012 at 9:37 am - Reply

    The humans we see today, are a result of the genetic reaction to the current environment encountered. Every phenotype is the result of every genotype and environmental influences and how they interact to produce the human organism.

    This is known as "reaction norms". It's how your genes react to the environment. This reaction is commonly known as epigenetics. You can plot this reaction norm and get a graph. It will plot a trait vs. an environment…and thus get an amount of trait expression vs. an environmental change….some traits flourish, some diminish.

    The large scale structure of the human, is determined by permanent genetic determinants, but with a deep evolutionary history. So some parts of the human are (in an evolutionary sense) very old, and very well-preserved. Some are very new…from birth to 7 yo. billions of synapses are pruned. Humans are a mosaic of evolutionary patterns. This is the problem I see when we try to either test for a response, or try to say "do this caloric restriction, you will live longer"…or cold…or low carb….or eat like an Inuit…

    Our ancient genes establish a very rigid framework that allows some plasticity to be expressed, however. There are genes that control the genotypes, also involved in determining the slopes/shapes of reaction norms. They are genetically entangled, and this is part of the problem I see with our "experts" and health recommendations.

    For one organism, in one particular generation, the plastic reaction to the environment evolved relatively recently and implements specific contingency plans. That is, "How to survive". I'd like to say, "How to learn"…that's more of a plastic response to the environment.

    • Jack February 22, 2012 at 11:08 am - Reply

      @Dr. john I used to think like you too………now I think differently. Read 2/22 post for my new perspective on how your thought might allow you to make some false assumptions too……….

  27. Lee February 22, 2012 at 10:16 am - Reply

    I know mania likes to occur in the summer time especially the fourth of July, Memorial Day, weddings, and vacations when you get lots of sun, chaos, and adrenaline. I don't understand the sunglasses thing. Light is light… it can't just be uv. My kid was conceived in California and gestated for 6 months, then went to East three hours time zones, was cut out c-section two weeks early…Back to CA at 6 weeks of age and drove north to the World's Fair/family in Vancouver for a few weeks. Everything was stressful. She was having hot flashes at birth and had a chronic incurable yeast infection diaper rash/jaundice. The doctor told me it would go away with solid food. Big mistake, I now learn. Anyway, she likes the climate of cloudy gray skies and always has. The vitamin d/k2 deficiency wouldn't exist without the proper intestinal flora if she were eating only meats/fats/guts. I learned the flora is evolutionary and is need to produce the vitamin k2… so maybe being born with the wrong intestinal garden isn't wrong, it's the food. So if you can't control the fats inside…I am wondering if the palmitic acid where there is supposed to be fish oil needs something to turn it into fish oil, if oil goes where it is supposed to, what is causing it not to… is it a switch or deficiency. This a link to a US study, an Australian non profit that keeps current on things

  28. Paul February 22, 2012 at 10:55 am - Reply

    Dr. Kruse,

    I hope you don't mind, but I took the liberty of introducing Johnjoe to your blog.

  29. Lee February 22, 2012 at 11:36 am - Reply

    So my husband had psoriasis terribly and the very old dermatologist told him that it would go away about the time he needed reading glasses and it did. Was that circadian, or hormonal?

    • Jack February 22, 2012 at 11:40 am - Reply

      @Lee both………and make sure he does not smoke. Smoking increase its severity, even being around it does.

  30. Lee February 22, 2012 at 2:45 pm - Reply

    circadian thermogenesis converts white fat to what ever kind of fat you need? as long as you've got the fat? I'm confused about fat.

    • Jack February 22, 2012 at 5:03 pm - Reply

      @Lee you wont be when I done with this series.

  31. curious February 23, 2012 at 4:54 pm - Reply

    So about the light being let in the eyes… I have some horses and have had goats. When they are trying to avoid a herd while their tails are flagging and they are ready to breed, they look wild eyed for days. Then calm right down. When they have the babies, they are wild eyed for a day or two with the pupil wide open looking for predators. Even the hens are. With the horses, there is a dirty trick pulled. they bring round a teasing stud until the mare starts chattering with him and lead her in to a device and pull the real stud up behind. She looks wild eyed when that happens. There seems to be some sense of danger involved. If she's trying to talk one into it, there is none of that. What hormone triggers those wide open pupils? and what hormone would stop it?

  32. alex March 1, 2012 at 7:18 pm - Reply

    The instructors at my son’s Waldorf school are constantly telling me to put his hat and jacket back on because he’s growing, and “he’ll lose heat needed for growing.” Are they off base? Maybe I should be trusting his instincts?

    • Jack March 1, 2012 at 7:47 pm - Reply

      @alex No one knows this answer because it has never been studied in cold adapted people. My belief is they will be shorter in cold adapted states because elevated sex hormones close growth plates on bone early. the issue for me is this is true in warm adapted humans so we do not know if its true in cold adapted ones. But the Inuit and Sherpa’s are both smaller humans in height. Tall height also correlates with lower longevity too. This also supports my theory.

  33. Gwen A Black March 2, 2012 at 2:32 pm - Reply


    I had thyroid cancer and my thyroid was removed. I take 135 mgs of armour. Have glaucoma, diabetes, rsd fibromyalgia, disc touching nerve in my neck, obese, hot flashes so bad water pours from everywhere. I feel like I could combust. Have mild c.o.d, I beg for help from my doctor and he tells me my blood work falls in the guidelines,then he wants to dope me up. I am 55. About a month and a half ago I started a low carb diet. Around a 20 grams a day. My sister got me reading your blogs, I have a problem with my blood sugar level bottoming out. Shakes and all, then sick. I have migranes realy bad!!! Sometimes three to four times a week. All this has been going on long before I stared low carb. Guess you get the picture, I am a mess. As you might guess my thought process is marginal, I can't get my mouth to say what my brain can't find. I,ve never blogged so If I get it wrong can you still help me? It will help me if you respond in really really lay terms. Thanks, Gwen

    • Jack March 2, 2012 at 8:13 pm - Reply

      @Gwen you need to read here and come over to the monster thread at MDA and introduce yourself to the crew. 2000 pages of the first ever evolutionary medical textbook for humans to apply the tricks of the trade…..….

  34. Earlybird April 6, 2012 at 10:24 am - Reply

    +3 in Ontario.Walking by the lake wearing shirts and tank top.Glad I came across your website Dr.Kruse.Good health and good luck.

  35. ROB BREWER May 23, 2012 at 7:49 pm - Reply

    Jack, is there a way your theories still hold if only natural selection is considered, but not evolution? Could not we have been created with the plasticity of biochemistry?

    • Jack May 23, 2012 at 9:32 pm - Reply

      @Rob Im not sure what youre asking or implying? Can you be more clear? Natural selection and evolution are joined at the hip.

  36. ROB May 24, 2012 at 6:37 pm - Reply

    Thanks for replying.
    First let me say, I do not disagree with, or disbelieve the methods of your Leptin Reset Rx or the CT, as I have seen big changes in myself since I followed JanSz to that MDA monster thread in Dec 2011. As a 6 ft 58 y/o man, I went from 182 to 154 lbs, losing 28 lbs. I sleep much better in total darkness, eat tons of CO and mostly VLC. I awake refreshed without a clock. I LHT and sprint. I am very happy with the results I have seen following your revelations and cannot disagree with your methods.
    But in reading your CT blogs, I have trouble embracing your explanation using evolution. Now, I don’t doubt CT reduces body fat. I fully intend to start dunking my face in ice water this weekend to eventually become cold-adapted because I know your methods bring results.
    It is just that, as a Christian, I do not hold an evolutionary viewpoint on the creation of man. I do see the natural selection of variability within species, e.g, the white arctic fox with small ears and the brown desert fox with large ears, each fox having adapted to their environment, but each fox being created by God after its own kind.
    My vague question was trying to avoid an evol/creationism debate, and ask if your theories could hold if evolution was not the starting point, if life did not develop in the ocean, but if God created man with plastic biology in the beginning having the ability to adapt to extremes all over the earth. Granted, I am not a scientist, researcher, or professional clinician; I have no background in biology.
    Again, I plan to follow your ways no matter how you explain them. Time was when an explanation starting with, “hundreds of millions of years ago, we evolved to….”, would simply cause me to stop reading and discount the statements. I no longer do that.
    Again, I was just wondering if you could see your theoretical explanations from a POV of man was created with, not evolved into the characteristics he possesses today.

    • Jack May 24, 2012 at 6:43 pm - Reply

      @Rob I am a christian and no problem with evolution…….they are not mutually exclusive.

  37. […] Cold Thermogenesis Part I @ Dr. Kruse’s Blog […]

  38. Mary December 28, 2015 at 8:09 pm - Reply

    Hi Jack!

    I started trying c/t in addition to the leptin reset but im having trouble with it. I wanted to start slow so i just spent some time outdoors in the cold with a light jacket and the next day i felt horrible 🙁 it lasted several days, too. I then just spent a little extra time oudoors with regular warm clothing on and was still really sluggish the next day. Im afraid to try face dunks because of how negatively the cold air effects me. Is there a reason the cold would hurt someone? I was really excited to add a new tool in.
    Btw i have lyme, adrenal fatigue and my light cycles are very good.
    Thanks, Dr

  39. Tatjana May 9, 2016 at 8:16 am - Reply

    I find the topic of CT quite interesting.

    However, I was wondering if face dunking in cold water could cause facial paralysis (that the facial area above cheeks is particularly sensitive)? Could this happen with CT? Is the key for it to be safe maintaining the temperature above certain level (the range you recommended)?

    I would love to get your opinion on this, Dr Kruse. I apologize if the topic has already been discussed.

    Thank you!

    • Jack Kruse May 9, 2016 at 10:58 am - Reply

      Tatiana I have not seen this with facial dunks when they are done as the protocol tells you to apply them.

  40. Sydney April 2, 2018 at 4:39 pm - Reply

    HI Jack,

    I’m just about to start the cold treatments. Just curious about the metal warning and how it affects the process. I wear metal ear posts all the time – do I need to remove them or just make sure they don’t touch the cold water?

    Thank you, Sydney

  41. Jackie B November 29, 2018 at 10:01 pm - Reply

    Hi , Newbie here, does CT have to be done in cold water specifically ? is just being cold enough or does the whole body need to be submerged in icy water?e.g. I have eczema and place ice on the area to stop it itching, the histamine is driving me nuts and I’m scratching myself to a bleeding mess—any suggestions?. ….on a side note…. does being freezing cold in an office all day help at all lol

    • Jack Kruse January 11, 2019 at 1:20 am - Reply

      No it does not but it won’t be helpful long term if you do not know how to do it. We cover that at Kruse Longevity Center.

Leave A Comment