REALITY #19: THE MITOCHONDRIAC BASICS: THE SUN

REALITY #19: THE MITOCHONDRIAC BASICS: THE SUN

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Every wave connects with everything in nature via resonance and so it is with life.    —- Dr. Jack Kruse
 
THE TAKE HOME:  Is there something special about how the sun creates light that is critical for a mitochondriac in training to understand?  Do you know what it is?  If the blood plasma connected the sun with our mitochondria by way of hemoglobin, what is it about the sun’s light that makes it seem so cozy with our mitochondria?  Could the sun be an object that uses magnetohydrodynamic equations to communicate directly with mitochondria and use our blood plasma as its conduit?  It is a provocative idea for a convention physicist and biologist.  The interesting thing is…………………

Nature provides education for our cells with waves from many sources. The dissemination of her wisdom is buried in the energy and information in them. We’re built for each cell to absorb this information unless our choices interfere with that wireless download. The yield of the download develops a cell’s genius or set a journey of illness. When we are disconnected from nature, our lives become muffled before we’re silenced by debt of nature. This should be an education we are all interested in.

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  1. J. Stanton August 13, 2011 at 2:36 pm - Reply

    Dr. Kruse:

    I'm honored by the plug, and thankful for all the great information on Mg! (As well as the rest, which will take some time for me to digest.)

    Come see me at http://www.gnoll.org!!!!

    It was a pleasure to meet you at AHS, and I'm presently leaning things by burrowing through your archives.

    JS

  2. Chris Tamme August 13, 2011 at 2:04 pm - Reply

    I have tried to supplement Magnesium with Mag Citrate and ended up constipated. It is possible to OD on Mag Citrate and cause this problem or should I try another method? It would be nice if I could determine my Mg levels and supplement accordingly but as you say there is no real good accessible test. I have substantially changed my diet to mostly veggies and grass fed beef so the only supplements I believe I need are D3 and Mg. I have always known Mg was important but this post really puts the mechanisms together for me.

    • Jack August 13, 2011 at 2:08 pm - Reply

      If Citrate binds you up try adding magnesium oil with Mg malate. Malate is my workhorse supplement. Glycinate is really good too if you have gut issue. But use the oil with it.

  3. Stabby August 13, 2011 at 2:25 pm - Reply

    Mind trip! I have read your first cite, great stuff. That's why I always suggest magnesium to people looking to lose weight. A kink in ATP synthesis is kinda like a big deal if you are trying to burn a lot of energy. Apparently some people don't think that mitochondrial dysfunction and deficiencies in the cofactors for metabolic reactions affect the ability to expend energy. Wtf.

  4. Rick August 13, 2011 at 2:29 pm - Reply

    Thanks for your nutrition articles. Good stuff. I'm a big fan of Eenfeldt, Lustig, & Taubes' views on causes of obesity. I've had great success changing up my diet this year by eliminating sugar, which in turn eliminated my need to take allopurinol for gout. Down 32# so far, feeling great, and no medications.

  5. Cameron House August 13, 2011 at 2:35 pm - Reply

    Hey I tried Gnolls.com and it is a godaddy hosting page. I did a little more searching and I am pretty sure you menat Gnolls.org

    Thanks

  6. Jim August 13, 2011 at 3:08 pm - Reply

    Yep gnolls.org. I'm reading the knoll credo right now.

    Anyway how much mg malted do you have your patients taking?

  7. Jack August 13, 2011 at 3:21 pm - Reply

    @stabby the comments at SG page from some of the docs hurt our profession. These guy don't realize the first step in IR is intracellular loss of Mg……then calcium too. Just freaking wow. That is why I had to post this. Dr Eenfeldts comments about not knowing what caused this hurt. And SG did not comment about it either but he gets a pass from me because he is a researcher and not clinician. Not even Kurt mentioned it and he is a sharp cat. But did they both not talk about Mg at some point in the past?

  8. mem August 13, 2011 at 3:37 pm - Reply

    For this who may be unfamiliar with Stephan's excellent Mag post of about 17 months ago…
    http://wholehealthsource.blogspot.com/2010/02/mag

    • Jack August 13, 2011 at 8:57 pm - Reply

      @mem I thought he had a post about this a while ago. But I have to say this does not make me feel any better. This makes it even more concerning considering how the comments read.

  9. Marie August 13, 2011 at 4:08 pm - Reply

    So being morbidly obese and having severe sleep apnea, magnesium malate is the type that would be most beneficial?

  10. Jack August 13, 2011 at 9:17 pm - Reply

    @ Marie……depends upon your current fasting insulin level. If it's real high you need to add Mg oil or gel to the malate because the insulin just makes you urinate it out. This is why giving a diabetic with osteoporosis calcium is a joke

  11. DH August 13, 2011 at 6:51 pm - Reply

    You state that if LR/obesity continues long enough, hypocretin neurons will be permanently destroyed. Ballpark wise, what levels of obesity or how long of a period of being LR are you talking about? Like anyone who has been very obese, or older demographics who have been obese/diabetic for decades?

    • Jack August 13, 2011 at 8:52 pm - Reply

      @DH This is a loaded question. To give an honest answer Id need to see and examine you and get labs……but I am going to tell you something to is important. In cases where stress is high….IE cortisol……neurons can be damaged. For example, the driver of Princess diana's car to this day still has no recall of the events of that night because the cortisol release was so high it would not allow the hippocampus (memory part of the brain) make any new memories. This is an extreme example but it happens with PTSD and in anorexia too. We learned in the Amgen trials even in the morbidly obese only ten percent of those patients destroyed their hypocretin neurons. Those are the patients who needed synthetic leptin to keep the weight off. Most obese dont have that. One way to tell is to do the leptin reset and see if your cravings go away and yoru sleep improves. If those things happen your hypocretin neurons are likely still OK as are your leptin receptors. You can follow the thread over at Marks Daily Apple on my protocol under his nutrition tab. It has 100K hits and there are many people doing this reset and you can see how it works and how they do.

  12. v August 13, 2011 at 6:54 pm - Reply

    Last year in August I had a "Magnesium, RBC" test done. It was 5.8 mg/dL, which is within the reference range of 4.2 – 6.8 I also had a reverse T3 done at that time and got 252 pg/mL, which is within the reference range of 90 – 350. In April of 2010, my c- reactive protein was 0.18.

    Everything is looking good, right?? I have lots of bone loss in my jaw and my gums have receded a lot- that was even pre-paleo, but it has not seemed to improve post-paleo. I don't have tooth loss yet, but I had to have a graft done as a "plug" since I was having the most recession on my front/bottom teeth.

    I know you were also a dentist. Any insights of gum recession/bone loss? Can I be satisfied my calcium intake in adequate if i am within the serum calcium reference range on a blood panel? I hardly take in any dairy, but was supplementing pretty regularly with viactiv calcium chews.

    PS i just bought a jar of virgin coconut oil. the girl at the register kept flipping the jar around to figure out what it was 🙂

  13. v August 13, 2011 at 6:55 pm - Reply

    PS I got that magnesium number just by eating paleo foods, not by supplementing. and i don't buy grass-fed cuz it's too expensive for me.

  14. Pat Palmese August 13, 2011 at 7:43 pm - Reply

    Since I started taking the magnesium supplement in March I no longer have restless leg syndrome and my sleep is very restfull. Great article Jack!

  15. whakahekeheke August 13, 2011 at 9:52 pm - Reply

    Magnesium (both as dietary magnesium deficiency and related hypomagnesiumia) indeed seems very promising for taking at least a part of the causation story one step back from IR. Just looking around the lit, there are many recent quality studies like this one:

    "Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects – a double-blind, placebo-controlled, randomized trial"
    http://www.ncbi.nlm.nih.gov/pubmed/21205110

    Why haven't we heard more about this?

  16. Fat Nurse August 13, 2011 at 11:19 pm - Reply

    HCG Diet, safe? or Dangerous? What is your advise on this

  17. Daule August 14, 2011 at 4:45 am - Reply

    It really surprises me how many people can't actually connect the dots…The brain is the organ that controls the actions of the organism — it also controls sleep, energy balance, etc. It surprises me how people focus on insulin and not on the interactions of leptin with the hypocretin neurons; at least Stephan Guyenet focuses on the food reward going on in the BRAIN!

    BTW, doc, can you start writing some blog posts about mental disorders? It'd be very interesting to see your take on the subject of mental disorders from a biochemical perspective!

    Also, why don't you devote any of your levees to organs such as the thymus, kidneys, and spleen? I know research about improving thymus function, for example, is hard to come by, but I really wish you could make some blog posts about these topics!

    Thanks for a very informative site 🙂

  18. Adriana G August 14, 2011 at 5:16 am - Reply

    Dr. Eades has been a major promoter of magnesium:

    "In fact, there exists an entire school of thought that posits that the entire Metabolic Syndrome is nothing but a manifestation of a a magnesium deficiency. Which isn't as crazy as it sounds since virtually all the components of the Metabolic Syndrome – diabetes, high blood pressure, obesity and lipid disorders – are associated with low magnesium."
    http://www.proteinpower.com/drmike/uncategorized/

  19. Terry McGinnis August 14, 2011 at 5:54 am - Reply

    I was wondering, given how highly you stress the importance of Mg, do you believe supplementation is beneficial or even necessary for someone who was never obese or anorexic and maintains a diet of whole foods with roughly a 10:50:40% ratio of carbohydrate, protein and fat respectively?

    If you consider the above a loaded question, then please tell me what your stance on the RDA values for Mg is?

    • Jack August 14, 2011 at 9:32 am - Reply

      @ Terry Since we have 40-60 million T2 DM……the answer to the RDA should be simple on a population basis. Of course its too low. And RDA is based on those type of parameters. Do I think everyone needs it? Nope. But to make sure go get an EXATEST and you'll know. The easiest way to avoid it is to assess sleep and fasting BG or one hour post prandial glucoses with 15 min splits…….Then you can extrapolate.

  20. Evelyn (CarbSane) August 14, 2011 at 6:14 am - Reply

    Jack, are you in the camp that believes insulin resistance causes obesity? Thanks.

    • Jack August 14, 2011 at 9:26 am - Reply

      @ Carb Sane It's a path to obesity. I think the bigger path to obesity is excessive omega 6 contents on the diet as measured by O6/O3 ratios. This is the number one thing I see clinically. In children it's the perfect storm……it's the fructose and PUFA content together and this is why the NHANES data the Lustig et al have found to be so dramatic. Some of my patients hormonal response to carbs clearly shows that their epigenetic switches have made carbs a dirty word for them……but I have found they are easier to treat. Proof of that……go check out the thread on MDA under his nutriton tab called the leptin reset and see what has happened there for people just following my Leptin Rx. It works. It was never about macronutrients……its about epigenetics.

  21. cancerclasses August 14, 2011 at 7:01 am - Reply

    GAWD I love your brain, I want to marry it and have it's babies. Oh, sorry for putting that on a public forum but your biochemical kung-fu is the best! Guess I'll just settle for reading your posts, and reading yours obviates having to read SG & some of the others, great time saver!

    Avoid mag oxide because absorption is minimal to nonexistent.

    Blood testing for MG levels is not so much bad as much as it is the wrong test and is not indicative. From Wikipedia: "The body contains 21-28 grams of magnesium (0.864-1.152 mol). Of this, 53% is located in bone, 19% in non-muscular tissue, and 1% in extracellular fluid. For this reason, blood levels of magnesium are not an adequate means of establishing the total amount of available magnesium."

    "The result is measured in our hormonal response to foods" but the hormonal response to foods depends on the foods themselves since, again, trans fat intake and avoidance of good fats dictate. Patricia Kane PhD., Lorenzo's Oil article: "The ingestion of trans fats literally blocks fatty acid metabolism, hormonal production and the fatty acid metabolism. The synthesis of prostaglandins-local hormones that control ALL cell to cell interactions within the body-are *completely* dependent upon the ingestion of high quality, unaltered fatty acids. The body requires specific fatty acids to create gastrointestinal integrity, bilipid membranes, hormones, neurohormones, prostaglandins and immune modulators all derived from fatty acids and these fats must be supplied and trans fats avoided if modulation of the faulty metabolism is to be achieved." (Emphasis added by me.)

    For my money trans fats are the mother of all metabolic disregulations and mineral deficiencies only a secondary problem. Take trans fats out of the diet "picture" and a whole foods diet including good fats will normalize & even optimize most peoples systems, vitamin & mineral balances with little extra supplementation needed.

    • Jack August 14, 2011 at 9:42 am - Reply

      @ cancer classes Many other bloggers out there approach this from a bottom up research approach. I am a clinician and have a ton of experience fixing people live in vivo. My approach was honed by emperic evidence, sound clinic judgement and marrying it with the best academic and clinic data. This is why medicine is an art and not a strict science and it is what separates me from a SG or a Chris Masterjohn. Their expertise and mine overlap but there is ahuge divergence as well. I use a top down approach that looks at the brain's biochemistry first…….and then I use labs to decipher how the brain is partitioning calories based upon the epigenetic settings for the patients. In my view if you dont understand hormones clinically you dont understand anything period and you are apt to make huge thinking errors and clinical mistakes. This is why I test and test a lot. I do it to myself and my family, Every quarter I want to know what response my brain is giving me and I tweek things. When I first started this out as an obese surgeon I deduced from my labs that Omega 6 fats, fructose, grains were my major problem. Now years later I know that I can eat carbs to a great degree without any problems because I have clearly flipped my own switched over the years due to dietary modifications. I did not fry my own hypocretin neurons. The one thing I have noticed is that most obese people are very sensitive to the omega 6 content of their diet……the O6/O3 ratio with a HS CRP is a great tell of health in my clinical estimation. Most fit people woudl be sick if they drew their O6/O3 ratio as I do. Their dietary advice would certainly adapt. You only get that level of knowledge from feedback testing.

  22. Don August 14, 2011 at 11:33 am - Reply

    Magnesium probably competes for absorption with calcium. That may be an issue for some trying a larger dose. For maintenance of CA/MG that is probably less of a problem. Some of the CA/MG tabs are a good choice for long term. But for someone with true MG deficiency that could be a long haul to "tank up".

    Mg/6:3 omega ratio treatment/Vit D is foundational and gets lost in all the excitement of competing hypotheses of late. MG is the one that probably has to be done by supplement. (Although practically balancing 6:3 will need supplementation at first).

    For memory, the only pill Kurt Harris takes daily is Mg.

  23. Adriana G August 14, 2011 at 12:04 pm - Reply

    Here is an excellent discussion of the bioavailability of magnesium, in particular magnesium glycinate. I will definitely be switching from mg citrate and looking for the Albion chelated ones:

    http://www.afibbers.org/resources/magnesiumabsorp

  24. David H August 14, 2011 at 2:45 pm - Reply

    I've had very good experience with Jigsaw Health (malate) and Solgar (glycinate) with Albion chelated magnesium.

  25. Jack August 14, 2011 at 3:36 pm - Reply

    @ Fat Nurse…..very loaded question. I wrote about this on PaleoHacks.com You can search it over there. I am not a fan of the homeopathic dosing of HCG…..but the IV dosing is a way to get thru a leptin reset quick. But within 6-8 weeks you must transition to a paleolithic diet as outlined in the Paleo 1.0 books. My name over at PH is "The Quilt" for searching purposes.

  26. Jack August 14, 2011 at 3:43 pm - Reply

    @Daule That is why I came up the idea of the QUILT. I think it may help patients and doctors start to realize how this is all tied together. Every time I post we add to the that framework. I hope people go back to The Quilt often. I think its a great place to start to understand this process.

  27. PigeonOrStatue August 14, 2011 at 4:04 pm - Reply

    Maths question:

    Mg sulfate (Epson salts) … 1 teaspoon has 100 times the RDA of Mg at 3.5 grams. It contains only 10 percent magnesium available for absorption.

    Mg RDI is 400mg so at 10% absorption you would need to take 4g. So how can 3.5g by 100x requirement?

    • Jack August 14, 2011 at 4:22 pm - Reply

      The recommmendation changed since Dr Deans book was written……that is all. The experts realized they still had their heads in the sand. Its still too low if you ask me.

  28. PigeonOrStatue August 14, 2011 at 4:14 pm - Reply

    Just went to the bathroom and got my Epson Salts, then to the kitchen for a 5ml spoon, poured the salts, leveled off and weighed the resultant quantity of salts: 4.243g.

    • Jack August 14, 2011 at 4:18 pm - Reply

      Nice…..make my water warm now.

  29. PigeonOrStatue August 14, 2011 at 6:08 pm - Reply

    Have now read your post three times. Fantastic. I don't know enough to comment on it's validity but it certainly sounds plausible to me.

    Sorry to be such a pedant, but, I read "I teaspoon has 100 times the RDA of Mg at 3.5 grams." and thought that the RDA would be 0.035g and so a small box of Epson Salts would last me a lifetime. Why pay for expensive Mg supplements?

    @cancerclasses I thought Mg oxide was a laxative.

  30. […] deficiency, Metabolic syndrome, diabetes, obesity prevention. 1. WHY IS MAGNESIUM SO IMPORTANT? DID THE OBESITY BATTLE OF THE BLOGS MISS IT? 2. HOW SHOULD YOU THI… Bear in mind what Jack says "Supplementation generally takes 30-90 days to replete a minor to […]

  31. deb August 15, 2011 at 10:20 am - Reply

    Question: With all the coffee and cocoa consumption, why is there a magnesium deficiency? Is this form of magnesium poorly absorbed?

    P.S. I started the "Dr. Robert Lustig Fan Club" group on Facebook after hearing Sugar: the bitter truth. Just quoted you on Dr. Lustig at AHS

    • Jack August 15, 2011 at 11:26 am - Reply

      @Deb Simple…..if your eating sugars with those things its spikes your insulin and you urinate the Mg and Ca…….and lose it. You never absorb it.

  32. cancerclasses August 15, 2011 at 12:51 pm - Reply

    @PigeonOrStatue I've never had any health problem other than being a little fluffy around the edges caused by sitting in front of my computer 24/7 reading health & nutrition blogs for the last 2 years while on unemployment, so all I know about mag oxide is what I've seen & read on the web.

    From Wikipedia search of 'Magnesium': "Numerous magnesium dietary supplements are available. Magnesium oxide, one of the most common because it has high magnesium content per weight, has been reported to be the least bioavailable. Magnesium citrate has been reported more bioavailable than oxide or amino-acid chelate (glycinate) forms." Other sites say mg oxide is used in common off the shelf supplements because it's cheap.

    A year or so ago I stumbled across a short article by Anthony Colpo titled The Most Important Supplement You Will Ever Take, where he also says to avoid the oxide form because of it's poor absorbtion. Then after reading about electrolytes and the biochemistry of muscle cramps & cardiac health over at Ed & Patricia Kane's bodybio website I started supplementing with a half ounce of Aaron Brands liquid mag citrate (with Pleasing Lemony Flavor!) that I get at the 99 cent store. It's sold as a laxative, but for that you have to drink 1/2 or the entire 10 ounce bottle either in divided doses or all at once along with at least 8 ounces of water.

    Since I'm not plugged up or have any bowel problems either I just put around a half ounce or less of the mag citrate in the bottle I use to mix up my first thing in the AM Emergen-C vitamin drink pack, which already has 60 mg of mag hydroxide & carbonate. The Aaron mag cit has 1745 mg of mag per ounce, so I only take it every other day or so. Seems ok, but then not having any health problems it's hard for me to notice any difference, but I do seem to be dropping body fat fairly fast, but that may also be from not eating so I stay in ketosis & maximize the fat burning. I was close to 240lbs in January this year, but at 205 lbs this AM with little to no exercise I'm real close to getting under 200lbs for the first time in over 10 years.

  33. PigeonOrStatue August 15, 2011 at 3:57 pm - Reply

    @cancerclass Thanks for the Anthony Colpo article "The Most Important Supplement You Will Ever Take".

  34. cancerclasses August 15, 2011 at 8:59 pm - Reply

    @PigeonOrStatue No problem. If that's the only thing I do for you in this life I'm a sorry son of a biscuit eater.

  35. Adriana G August 16, 2011 at 6:11 am - Reply

    I have been testing my Fasting Blood Glucse over the past two weeks and it has been consistently running between 104 to 106. You made it clear this should be below 89 and my GP considers this a sign of pre diabetes. Over the 2 weeks I have been experimenting with different things to see if I could drop the FBG: zero carbs all day, carbs below 30, Exercise after dinner, protein snack, carb snack – nada, zip, FBG >89 day after day.

    Then I read your magnesium blog. I was aware of the importance of mg because I strted my journey in the Eades camp, so I have been supplementing with 400 mg magnesium citrate inconsistently, using it primarily for sleep, with so-so results. Ditto Natural Calm.

    The last two nights, before bedtime, I have taken 400 mg. Magnesium citrate capsules washed down with a half dose (1 rounded tsp.) of Natural Calm diluted in 6 oz water, which adds another 175 mg citrate for a total of 575, much higher than the recommended doses. I have seen an immediate and amazing improvement on FBG:

    Day 1 – 92

    Day 2 – 84

    This is an N=1 experiment over just 2 nights, but I'm pretty confident mg in the right dose is driving the numbers down as this s the only significant change I have made. I will continue to test to see if it the dose , the source or the combination. I'll be testing my husband as well, since his FBG has been running 106-110.

    Stay tuned! Dr. K would it make sense to get an Exatest? Once you get mg levels up will they stay up with a paleo diet or will ongoing supplementation be required?

  36. Jack kruse August 16, 2011 at 7:13 am - Reply

    It would but since you responded that fast I would dose escalate to 1000 to 1200 mgs a day for two weeks and see what happens

  37. Adriana G August 16, 2011 at 7:24 am - Reply

    1000 to 1200 at bedtime or can I add the additional 400-500 mg throughout the day?

    I know lots of people can't handle 400 mg without getting the runs, so far so good for me on bumping to 600.

    • Jack August 16, 2011 at 10:09 am - Reply

      titrating it up will answer that for you. Just go slowly and see what happens

  38. majkinetor August 16, 2011 at 8:01 am - Reply

    Hello Jack and thanks for great info.

    I hope you don't mind few questions.

    – What do you think about hair test for magnesium and X/MG ratios.

    – What is your opinion on supplementing Mg via carbonated water, for instance the one like this: http://goo.gl/k5GIW
    It contains over 1g/L Mg++. Is this better or worse then chelated forms. I drink water containing Mg++ entire day, does this frequency makes things different then single a day pill.

    – How do I recognize difference between Mg deficiency cramps and Ca deficiency cramps, since extra Mg might lead to lower Ca levels.

    Thx in advance

    • Jack August 16, 2011 at 10:10 am - Reply

      @maj….1. It is not as accurate as the Exatest.

      2. Not a fan of it at all

      3. Without testing youre flying blind.

  39. Hilary August 16, 2011 at 9:05 am - Reply

    For J. Stanton: you'll want to fix the link in your comment above. Comment #6. It points to gnoll.org rather than gnolls.org. Gnoll.org is unrelated. It's some kind of open source SDK.

  40. Evelyn (CarbSane) August 16, 2011 at 3:40 pm - Reply

    Thanks for the clarification Jack. I'll check out that thread.

  41. cancerclasses August 16, 2011 at 4:41 pm - Reply

    @majkinetor Cramps are caused by potassium deficiency, not just mg deficiency, you need both. Calcium is the signaling molecule for sodium that causes muscle to contract, mg signals potassium to enter the cells and causes muscles to extend & release the contraction.

  42. Adriana G August 17, 2011 at 2:53 pm - Reply

    Update – day 3 of super sizing Mg supplements before bed was out of line with previous 2 nights with FBG jumping to 113, the highest of the past 2 weeks. Go figure!

  43. LSSeeker August 19, 2011 at 8:04 am - Reply

    Dr. Kruse,

    You said "In children its the perfect storm……its the fructose and PUFA content together and this is why the NHANES data the Lustig et al have found to be so dramatic." If your child if at 150 carbs/day or under and on a paleolithic diet, should fruit be limited to a number of carbs/day or should it be eliminated to avoid problemss?

    Thanks.

    • Jack August 19, 2011 at 6:31 pm - Reply

      Depends upon other variables. Everything must be done in context. Carbs are not everyone's enemy. Carbs and PUFA to excess however are very problematic for anyone who is HUMAN.

  44. […] ATP and of Magnesium (Mg) because they are coupled together by our ATPase enzyme as we saw in this post. This is classically seen in diabetes development as we mentioned there. Another interesting thing […]

  45. Evelyn (CarbSane) August 21, 2011 at 10:02 am - Reply

    Jack, can you provide the support for this statement:

    depletion of Magnesium always predates insulin resistance

    Thanks.

    • Jack August 21, 2011 at 10:29 am - Reply

      Sure Evelyn……any biochemistry or endocrine book that has been printed. Here is a a quick link off my hard drive. There are thousands of such articles. Check out http://www.sciencedirect.com/science/article/pii/S089570.... Just ask your endocrinologist or diabetes specialists for the books at their office. If they gave them away (likely) go to the nearest medical library and pull them out. Enjoy.

  46. Adrienne August 22, 2011 at 8:39 am - Reply

    I am at goal weight and generally eat no more than arouBoth my parents and brother are type 2s and this is why I've lowcarbed for over a decade — paleo lowcarbed for the last few years. I take small amount of thyroid medication (armour and cytomel) and generally eat 30 carbs per day. I've gotten into the bad of eating late suppers — 9:30PM or later — largest meal of the day. My fasting glucose is normally around 85 but lately it's occassionally gone as high as 107 — this happens after very large late evening meal. Can having to digest large meals at night during sleep impact magnesium levels by raising cortisol and insulin?

  47. Evelyn (CarbSane) August 22, 2011 at 9:45 am - Reply

    From your own linked abstract we have: We further suggest that a reduced intracellular magnesium concentration might be the missing link helping to explain the epidemiological association between NIDDM and hypertension. This seems like a far cry from your definitive statement that (bolded in this post of yours) depletion of Magnesium always predates insulin resistance.

    Would Guyton & Hall's textbook of Medical Physiology qualify as one of those "any biochem or endocrine book that has ever been printed"?

    So I ask again for specific references (full text preferably but I'm usually able to get those from abstracts) to support your assertion. Not that Mg is involved in cellular function. That is a given. But that the deficiency always predates — e.g. in effect causes — insulin resistance.

    • Jack August 22, 2011 at 10:17 am - Reply

      Again I will answer this for you. Any recent textbook used in medical schools will clearly talk about this issue. In fact any endocrinologist who treats diabetes knows this information. It is a clinical axiom that is taught in medicine. Its a cornerstone of diabetic pathophysiology.

  48. Jim August 22, 2011 at 1:12 pm - Reply

    Eveyln – these may or may not be bulletproof support you are looking for but it was easily found in google search and looks like there are more articles to be assimilated if need be. Also, I do not believe the phrasing "MG deficiency predates IR" is necessarily tantamount to [i]causing[/i] it, although maybe that is true too.

    http://www.mgwater.com/diabetes.shtml

    http://www.drmortonwalker.com/2011/04/magnesium-d

    MG, IR, and Children http://care.diabetesjournals.org/content/28/5/117

    http://www.ncbi.nlm.nih.gov/pubmed/19629403

    http://www.ncbi.nlm.nih.gov/pubmed/2253826

    There seem to be plenty of related articles.

  49. majkinetor August 31, 2011 at 5:00 am - Reply

    Doc, how come that loss of hypocretin neurons doesn't always induce anorexia ? If orexins are major food promoters, how loss can induce obesity ?

    Thx.

    • Jack August 31, 2011 at 4:50 pm - Reply

      @majkinetor This has to do with the specific hypocretin neurons that are lost….because the brain is different than all other organs. Every neuron is specialized in the hypothalamus. This part of the brain is only the size of a small grape and humans have but 50,000 hypocretin neurons in the entire brain. Each neuron and receptor codes for multiple responses and are also impacted by the surrounding cells synapses and the pre and post synaptic changes. This is why leptin can cause obesity and anorexia. Certain hypocretin neurons get knocked off by apoptosis die to long term inflammation or by dramatic increases in cortisol that induce these changes. Once the cells are lost they can be replaced because whne one is LR you have a pregnenolone steal syndrome and repair of neurons requires BDNF which is stimulated by progesterone. Well, in Pregnenolone steal your progesterone levels are low…….so you can induce stem cells to replace the hypocretin neurons and if you knock out the parts that control certain parts you wind up with a different phenotype. This is how leptin can make you obese or Karen Carpenter thin. You must read my central leptin series that was completed in late August 2011. I think you will find it informative.

  50. Kaleein September 8, 2011 at 4:26 pm - Reply

    Dr. Kruse, have you seen this blog?
    http://carbsanity.blogspot.com/2011/08/why-insuli

    She's trying to help people in their fight for health, too. Uses a lot of scientific info to back up her stuff. This particular blog disses Taubes and his theories.

    • Jack September 8, 2011 at 4:49 pm - Reply

      Carb Sane is well known. SGuyenet and Kurt Harris got into it with her over fatty acids and diabetes in the past. After that series of blog comments and seeing her response I decided I would just remain out of it. I dont subscribe to her mechanisms of how diabetes occurs. And I really have nothing more to say on it.

  51. Kaleein September 8, 2011 at 7:12 pm - Reply

    Thanks for commenting. I just saw her today and wasn't really impressed by anything but her "good intentions" … your mind blowing science is much easier to understand than hers. Probably because you do connect thoughts from one "lesson" to the next, and back around to fill the spaces in the Quilt.

    Thanks for what you do.

  52. Grammasmitty September 10, 2011 at 9:19 am - Reply

    How does all this relate to Type I DM? Whan they do for weight loss?

    • Jack September 10, 2011 at 2:29 pm - Reply

      @Grammmasmitty First I would make sure you really are a type one Diabetic. More and more are finding out that they really have type one 1.5 diabetes or what many refer to as the autoimmune type. You can have no insulin at all…..but the cause maybe autoimmune. The diet I would suggest then would be pretty different than for one who was a regular type one DM. Ask your doctor.

  53. Grammasmitty September 12, 2011 at 11:34 am - Reply

    OK, need a little education here. This is my daughter-in-law. Type 1 for at least 15 years. How do you know if it is autoimmune? What symptoms, what's the difference? What tests? What help to overcome?

  54. susanjacob September 14, 2011 at 1:20 pm - Reply

    From what I understand after finding out about coconut oil as a possible help for dementia, coconut oil helps reverse dementia because it is an excellent source of ketone bodies – brain cells are able to use the ketone whereas they have been having problems utilizing glucose, which is why the brain cells die – Alzheimer's might even be called Type 3 diabetes. So,

    This story is about using insulin so the brain can utilize glucose. If you use coconut oil, you go around the need to use insulin to process the glucose.

    Dr. Mary Newport (a neonatologist in Florida) had been desperately looking for a way to help her husband, Steve, who had the symptoms of early onset Alzheimer's. Dr. Newport found out about medium chain triglycerides and that coconut oil is a good source. She began by stirring two tablespoons of non-hydrogenated coconut oil into her husband's oatmeal and he began to demonstrate improvement within about three hours. An MRI in 2009 indicated that the brain atrophy had been arrested. A scientist at NIH, Dr. Richard Veech, has been researching MCT oil and how it can help the brain and is now working on developing a synthetic form.

    Regarding Steve and Mary Newport, you can go to their website at http://www.coconutketones.blogspot.com for more information.

    Also check out youtube.com for stories of other people who have been taking coconut oil for dementia and brain fog.

    "Ian Blair Hamilton"

    "Bruce Flett" (a minister in Canada who was afflicted with dementia as a result of endocarditis).

    You can find the Spectrum brand of coconut oil at Wal-Mart and other stores (whatever brand you buy, make sure it says non-hydrogenated or "contains no hydrogenated fat").

    Also check out Dr. Jack Kruse's website – he is a neurosurgeon who also talks about the benefits of coconut oil:

    jackkruse.com

    When we heard this morning they were going to talk about a new discovery for Alzheimer's, that could possibly even reverse it, I thought they were going to talk about coconut oil.

  55. susanjacob September 16, 2011 at 2:12 am - Reply

    My sincere apologies for my post appearing 3 times!

  56. Jack October 16, 2011 at 10:12 pm - Reply

    @Jody I agree with you about Guyenet. He wrote some great articles about Magnesium but he seems to have completely forgot about that link. In clinical medicine it's common knowledge that magnesium deficiency leads to sugar craving behavior. Moreover, intracellular magnesium loss also decreases brain dopamine in the reward tracts and makes you gain weight. I am at a loss to explain his theory based upon what he already wrote. I really think this is more about proving Taubes wrong than being right for the lay public in some warped sense.

  57. Jack October 16, 2011 at 10:24 pm - Reply

    @Jody I just saw this at Peter's site and posted it here for you to read. "BTW, that bland liquid diet (Renutryl) that Stephan told us causes weight loss despite being full of refined carbs, including sugar, also contains magnesium."

    Its just kinda nuts really

  58. Jack October 16, 2011 at 11:09 pm - Reply

    @Carb Sane

    Insulin Resistance Is a Natural Defense Against Energy Excess

    Superoxide sensing and insulin resistance protect cells against too much energy input and oxidative stress, but without the ability to reduce blood sugar, hyperglycemia leads to the suite of degenerative reactions that provide the symptoms of type 2 diabetes.

    reference

    Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE.Insulin resistance is a cellular antioxidant defense mechanism.Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. Epub 2009 Sep 30.

  59. Owl October 26, 2011 at 3:07 pm - Reply

    I have had a problem with leg and foot cramps for years. Some nights I would wake up 3 or 4 times with excruciating cramps. I took magnesium, but it was the oxide or citrate forms, and they didn't help much. After reading this blog, I started taking 600mg of magnesium malate at night. Within 2 weeks, I had no more cramps. Even after an epic mountain hike, where my legs were sore and I was sure I would have cramps that night, I didn't. It's been a miracle for me. Thank you!

    • Jack October 27, 2011 at 12:08 am - Reply

      @ Owl…….your welcome. Loss of Intracellular magnesium is a huge problem for most people who energy efficient. This was one of the first things I learned about in biochemistry and it seems everyone else forgot it.

  60. Jean Sullins November 6, 2011 at 10:26 pm - Reply

    Heya i am for the first time here. I found this board and I find It really useful; it helped me out much. I hope to present something again and help others like you aided me.

  61. […] and why evolution seems to have coupled sleep and energy metabolism.  If you remember from the Gnolls post I spoke about how magnesium is a co-factor in ATP production at the mitochondria.  In people who […]

  62. antabuse dosage November 18, 2011 at 2:58 pm - Reply

    […] the systemic role of trace elements in glucose metabolism (Magnesium and Zinc). Remember, from the Gnolls blog post we spoke about how the loss of intracellular magnesium was the first biochemical step in developing […]

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  64. Mart December 20, 2011 at 8:30 am - Reply

    Dr.K, Could you recommend a good multivitamin? There is a dizzying number of them on the market.

  65. ssegura January 5, 2012 at 1:59 pm - Reply

    I work an early morning (3am), very physical job. I have been doing the LR for 10 days. My question is, is the physicalness of my job going to make my body think i am exercising after my BAB? Is treating my lunch as the big ass meal an option?

  66. Kathrin Falcione January 10, 2012 at 8:35 am - Reply

    This may not be the best place to ask this, but, I'm looking for a good fresno dentist and I don't know where to look has anyone heard of this fresno dentist? They're located in Fresno, 20 min from my home I can't find reviews on them — Fresno Dentist, 411 North First Street, Fresno, CA 93701 – (559) 472-9613

  67. Jack January 13, 2012 at 11:21 am - Reply

    @Jane here are the Magnesium links you emailed me about.

    1. http://www.ncbi.nlm.nih.gov/pubmed/8505087
    2. http://www.ncbi.nlm.nih.gov/pubmed/14684759

  68. Gladina January 27, 2012 at 3:06 pm - Reply

    I am just curious, if one keeps their insulin levels nice and steady (and not too particularly high), does this change the dynamic of magnesium requirement?

    • Jack January 27, 2012 at 4:32 pm - Reply

      @Gladina………it depends upon case and what you call low and I call low or nice and steady. Generally I want insulin levels below 3 and I want the person very insulin sensitive so they can maximally use insulin for body comp building when their liver and muscles are in Optimal shape.

  69. Lee February 27, 2012 at 12:00 am - Reply

    Thanks Jack, your dedication and clear science are invaluable. I have been reading about Magnesium L-Threonate – any thoughts on its role please? (from lef.org)

    • Jack February 27, 2012 at 6:07 am - Reply

      @Lee its good stuff if you need it!

  70. […] blog readers I talked about the Magnesium link in disease months ago after controversy developed at AHS 2011 here between Taubes and […]

  71. […] injury can be from metabolic damage, trauma, or from dietary toxins. We also showed how devastating magnesium depletion is in the development of insulin resistance and diabetes in this blog. Nutrient depletions can play […]

  72. […] Remember from the mitochondrial series or the Gnoll’s post that Magnesium is a co factor in making every last bit of ATP in the mitochondria. So if you […]

  73. amoxil 500 August 20, 2012 at 10:37 pm - Reply

    […] chronically.  Acutely,  it changes it at the intestinal brush border.  I mentioned here in this blog that is precisely how diabetes actually  begins.  This lowers the magnesium available to make […]

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