Cold Thermogenesis 13: The FAQ’s

Cold Thermogenesis 13: The FAQ’s

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Readers Summary

What are the top 25 questions on CT from my forum?

The readers of my forum asked for a FAQ’s on CT and I decided it would be a good idea to make a short blog about this. They picked their top 25 questions and I decided to answer them for this blog. If you have any others, just ask in the comments section. I answer them all when I have time.

1. What in the Heck is Factor X? [LisaAPB]

Because of the last extinction event on our planet, the weather was changed in seconds to a cold earth and all life forms that survived that event had to navigate that environment and this survival was wired into the animals who survived and all their descendants epigenetically. Survival occurred by speeding up the reaction time to the environment. 65 million years ago this was an advantage. Today this is killing humans.

2. Isn’t CT mainly about activating, recruiting, and using brown adipose tissue (BAT)?

No, but it is a large part of it. CT also depletes glycogen like exercise does and this stimulates our IGF 1 and sex steroids to improve endotoxin clearance in the portal circulation, lowers FBG, lowers glycation and lipid peroxidation, and destroys elevated inflammatory cytokine arrays.

3. How do we know if we have an adequate BAT to properly use CT?

An adequate BAT is not needed to begin it. CT will force your sympathetic system to induce BAT from WAT.

4. Does being cold-adapted make one more intolerant of a hot climate in summer? [healthnut] +1 How will the sunny weather effect me biologically now that I’m cold adapted? +1

In my experience being cold-adapted makes you more tolerant to the heat of the summer. This has been the experience of the patients who have implemented this in my practice as well.

5. Since leptin is sexually dimorphic hormone in humans is cold adaptation different for men and women?

Yes, Women take longer to cold adapt than men because they generally have higher leptin levels than men. They can, however, offset this by increasing the amount of seafood they eat doing CT. I would not suggest cheating with fish oils and the closer your 06/3 ratio is to 4:1 the better your response will be to the cold.

6. Where does the 50-55 degree skin temp specification come from? Is this a specific trigger that has been shown or is it a rule of thumb? Is the energy throughput more important or the skin temperature? It would seem that the body would respond to the energy demand of the pathway as well. If 50-55 degrees is a trigger then we should trigger it many times a day, but possibly would not need to be for the 45-60 minute duration of the ice baths, which could provide a strong energy demand of the pathway at lesser temperatures. Please expand.

It is quite simple. This is the temperature that the PNS cold receptors begin firing based upon functional MRI data and from direct recordings. This is set by mother nature in eutherian mammals. For humans, the range is 50-55 degrees.

7. Is CT enhanced if done at temperatures that DON’T result in shivering? ie. Non-shivering Thermogenesis.

It can be depending on the person’s initial condition. Those who are obese usually don’t shiver but those with low BF {a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} shiver quickly and deplete their glycogen stores pretty quick.

8. What are the signs/indications of hypothermia? If someone pushes themselves too far on the protocol, would mild hypothermia have any effect on the progress of cold adaptation?

CT should never induce hypothermia as the protocol is written. It is designed to only use the surface cold receptors at 50-55 degrees and does not utilize the deep cold receptors. This is why the protocol is safe. If one chooses to embark on Deep CT all bets are off and you need a spotter and a doctor to help you implement it. That is just not a safe choice for a beginner.

9. Please talk about how to maximize CT. Is there something to a compression garment or not? would we have to be moving, like in Vasper, to get this lactic acid/HGH benefit?

At NASA Ames Research Park, scientist Peter Wasowski has developed an alternative exercise machine called Vasper. The user wears compression cuffs on the arms and legs and core-cooling panels on the chest and head. During exercise, the machine traps large amounts of lactic acid in the body, stimulating the pituitary gland and producing more HGH or human growth hormone. [Lexi] +1
Vasper is a great tool but it cost some serious cash. I love it and it has been tested in deep space and the data behind it show the result is not just pure hormesis. My CT protocol is designed for the common man to do in their home to get results. A compression vest and ice water work too. It will just take more time than Vasper. If you can get access to Vasper, you’d be a fool not to do it.

10. How should you modify exercise while doing CT (donkjellberg).

Depending upon your issues and goals you might not have to alter anything, .if you’re severely limited by disease or illness CT can often replace exercise until you become more healthy. Checking with your doctor serially is a great idea here if you are not healthy and wondering when exercise can begin and what exercise is best.

11. Are saunas, hot tubs and sunbathing unhealthy? +1

Sauna is fine, Hot tubs without halides are great, and sunbathing for some people is fine, depending on their light diet, inflammation, Vitamin D levels, and Vitamin D binding protein status.

12. After some point does the law of diminishing returns set in? How much CT would one need a week to maintain what they got if they are happy with it? Will I have to do CT daily for the rest of my life to maintain the pathway? Or once I’m adapted is there a different protocol?[Kpcst/Lexi] +1 CT & Age

Truthfully, I do not know the answer to this one. I have gone 4 months without CT and jumped back in and got immediate results. I will say that the younger one is the better the results of CT are because the younger one is the more BAT they have to activate CT.

13. How does CT reduce/reverse inflammation? [Shijin13] +1

It does this by demolishing the inflammatory cytokine array or storm from disease or from obesity. This is why it is not just a hormetic effect because it has direct and long-lasting effects on IL-6 and leptin.

14. How does CT reverse telomeres that are shortened? {Shijin13] +1

No one knows for sure as yet but based upon Dr. Elizabeth’s Blackburn’s cutting-edge work (Nobel Prize in 2009) we believe that anything that decreases ROS at the mitochondrial level also improves telomere length and is better for health and longevity in cells and organs with a normal cellular terroir.

15. The big HCG connection… I feel like 3 of us get it and the rest are trapped by their fear of fat plus HCG… If CT plus HCG will light the world on fire -And CT needs fat -Wouldn’t HCG + CT require fat in the absence of the “protocol apples”(ChimpChick)

Not necessarily true. We do not know what CT and HCG will do long term because it has not been studied……but several people are in the process of testing it and we will see what they all report back. I personally have zero experience with this.

16. What are the ranges you look for in the basic lab tests? (Please include differences for gender/age/menopause differences.) If we are tracking progress what other metrics would be useful? [Nonchalant/Garfield] +1

I am assuming here you are talking about hormones. The answer is simple. I want most people in the top quartile of their reference range.  This should be done first without drugs/pills/supplements if possible

17. Dr. Kruse. Related to this, you have mentioned in your blogs that additional benefits accrue from ” steepening the gradient.” could you describe some of these benefits along with the specifics of what you mean by “steepening”? Longer? Colder? More often? Your CT protocol mentioned that it was focused mainly on weight loss. What are the other protocols for other benefits (please describe them)? Thanks! [randychaps]

Randy, I can and have talked about it at length on the Webinar on Deep CT, but I can not talk about it on the website because some of those things are on the edge……they are things that one needs to be very careful with to get cutting-edge results. What is posted about the CT protocol on 2/11/2012 is safe for people to try at home? Deep CT is another animal completely and requires a spotter and access to a healthcare professional for guidance in real time.  Changing your water use is key to this.

18. Immediate perceived side effects of CT for both men and women (donkjellberg).

The first one most report is better to sleep and better recovery from exercise.

19. How should diet and CT be adjusted to adapt to seasonal changes? At one extreme, I understand winter should be dark, COLD, and hardcore keto. What about summer and diet, icy tubbing, etc? Can/should we ease up on the keto and cold? THANKS [Meyoolia] +1

If you’re healthy and fit without disease have a good light environment or issue eat a seasonal ancestral diet. If your sick, obese, or not feeling well use CT and a ketogenic template to reverse your chemical clocks until your hormone panel approaches normal. Then get to a seasonal ancestral diet.

20. Why is it important to take Bitter Melon before CT and what is the recommended dose? [Marsha] +1

It helps stimulate BAT from WAT.  It is an adjuvant only.

21. What are good methods of speeding detox? [Glamorama} +1

I went over this in my first webinar on the site, but the best way is to observe your reactions and your skin for estrogen dumping……and as soon as you see it use foods first that help lower estrogens and then you can use supplements if you chose to that I have outlined on the forum for you all.

22. Should Vit D supplementation level track the CT season.(localad)

Great question. I think it should. I take no Vitamin D supplements during March 15-Sept 15 and I rely on the sun to get mine. I came up with these dates based upon by location on the planet and serial testing. It won’t be accurate for everyone. In winter, at high latitudes one can use supplements.  I chose to move from Nashville.

23. How important is calorie restriction in CT?

Long term, it happens naturally. Short term, it is not important but as you go and use CT CRON becomes natural. It is the easiest form of IFing I know of and requires no training. It happens naturally to most people.

24. Are there any dietary changes that everyone should make while using CT?

Yes, avoid all alcohol at all times and eat 3-5 meals per week with seafood as you apply it.

25. Did you use your protocol to lose your weight or did you do more with CT?

I began with my protocol and as it worked I steepened the curve and monitored my responses. The steeper you go the more danger you incur.

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  1. Resurgent June 2, 2012 at 10:47 pm - Reply

    +100.. and thanks for clarifying Factor X for the one’s who could not attend the webinar

  2. dan han June 2, 2012 at 10:48 pm - Reply

    I feel an additional point is to keep omega-6 intake as low as possible during CT. When I started CT, i still ate some nuts and ate most paleo meats. But for the last two weeks, I’ve stuck strictly to seafood and ruminants (low in n-6) and I’ve felt much more tolerant of the ice bath. Interestingly, I was never a big seafood fan but after doing CT my body suddenly made me want to eat clams/shrimp/mussels like crazy. I used to hate those foods

    • Jack June 3, 2012 at 9:53 am - Reply

      @Dan Han most do but believe it or not as time as gone on I actually have to eat nuts to get my tissue O6 levels higher……because my 03 levels were too low……if your 03 levels go too low you can increase your subcutaneous fat. This is precisely how water based mammals add on their blubber layer.

  3. JimG June 3, 2012 at 3:13 am - Reply

    Hi Dr.Kruse,

    so you don’t recommend fish oils at all to improve the ratio’s or just that it is a less effective approach or there are side effects ?

    • Jack June 3, 2012 at 10:10 am - Reply

      @JimG I only use fish oils to get the EFA cell membrane ratios to 4:1 (06/3) which is ideal for signaling for land based mammals who respond to cold.

  4. Dali Dula June 3, 2012 at 7:28 am - Reply

    Thank you again for continuing this blog as we all work the path to optimal. What constitutes deep CT? What should our doctors who have no understanding of this process be looking for?

  5. The Paleo Rag | Cold Thermogenesis 13: The FAQ June 3, 2012 at 1:44 pm - Reply

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  6. Caroline Cooper June 3, 2012 at 6:08 pm - Reply

    Hi Dr Kruse,

    Can you recommend a brand of “liquid” krill oil? (I don’t do well with the additives in softgel capsules.)

  7. Damion Roop June 3, 2012 at 11:04 pm - Reply

    Jack, thank you for all that you are doing and posting. Is there any way for someone to pay now after the fact to view the recorded version of the webinar? We have several people here doing CT and a few of us have had sufficient experiences to cause us to push to what I suspect would be termed Deep CT and it would be wonderful to build on your foundation rather than poking around in the cold dark so to speak.

    • Jack June 4, 2012 at 6:46 am - Reply

      @Damion I am working on that.

  8. Carlos June 4, 2012 at 12:47 am - Reply

    Hi Dr Kruse,

    What test can be done or how can one measure inflammation? How can I tell if I need CT to reduce inflammation or if I am fine just following the diet you recommend? My weight is in the appropriate range.

    • Jack June 4, 2012 at 6:46 am - Reply

      @Carlos A HS-CRP is a good one with your Vitamin D level

  9. TheKid June 4, 2012 at 2:07 am - Reply

    @Jack – Question on autoimmunity. I wonder where you stand on the autoimmune link to cancer. I seem to remember you writing that once autoimmunity sets in, a person is only steps away from being susceptible to cancer. I am assuming that this would be because of the increased stress that inflammatory state places upon cells, causing them to repair more frequently and replace more frequently as well, which means you drive them towards the choice of “immortality” in the form of cancer a lot faster.

    Would this be an accurate description of the process?

    To the contrary, I also seem to remember reading that being autoimmune protects you from cancer because your heightened immune state means that you are better positioned to kill off mutatated cells before they can mulitply and become a problem.

    Which is it?

    And if the latter is true, can we say that autoimmunity is possibly an evolutionary adaptation that will allow humans to survive longer in a truly cancerous environment (toxins, cellular stress, radiation, etc.)? I can’t remember if you’ve made such an explanation before. But in light of Factor X, I thought this might be a logical measure the body would take to give it more reproductive years when faced with cancer, which can kill you quickly.

    Your thoughts? Thanks.

  10. villjamur_stevenson June 4, 2012 at 7:50 am - Reply

    Thanks Dr. Kruse for this great Q&A!

    In regards to #24 (ie no alcohol) – when is it safe to consume Malbecs?

    • Jack June 4, 2012 at 8:22 am - Reply

      @Villjamur Not when your doing CT……CT and EtOH is not safe.

  11. Krusing_to_Optimal_in_CA June 4, 2012 at 8:27 am - Reply

    Why “avoid all alcohol at all times” with CT? And by all times do you mean, that day, that week, that month or ….? (knowing WHY helps compliance, with me at least…)

  12. villjamur_stevenson June 4, 2012 at 8:45 am - Reply

    I guess that is what I want to know. If I do a CT immersion in the morning, can I have a Malbec that afternoon? Or do I need to wait until I eat seasonally and stop doing the CT during the summer months.

    • Jack June 4, 2012 at 9:11 am - Reply

      @Villjamur You could do that but you must realize that EtOH really can lower your tolerance to cold……you need to be aware of it. Everyone’s ability to clear alcohol is different and it is based upon the activity of their alcohol dehydrogenase enzyme……so there is no way to know where you fall. So you need to be aware of this before you do CT. As long as your informed of the risks ultimately you make your own choices. You are your own boss.

  13. Lyndra June 4, 2012 at 11:12 am - Reply

    From personal experience jumping into an ice-covered lake on New Year’s day, a shot of alcohol before the plunge reduces anxiety but induces cold. One year I had a few sips of champagne afterwards and thought I was going to freeze to death. Never again.

  14. James Collins June 4, 2012 at 12:44 pm - Reply

    Hi Jack, how does the Toba catastrophe theory of a super volcano induced volcanic winter/1,000 year glaciation period 69,000-100,000 years ago affect your KT theory?

    The Toba theory, if true, is linked genetically with a drastic human population drop to a theorized 3,000 to 10,000 individuals, which are the ancestors of all the people that have been involved with genetic testing today.

    So substantially newer than the KT impact, and a direct impact on modern man. A period of cooling, low food, glaciation, etc. for humans to survive through. Potentially wiping out competitors/human variants that couldn’t adapt fast enough.

    • Jack June 4, 2012 at 5:26 pm - Reply

      @James it strengthens it. The reason is that at K-T the animals that survived it had to navigate the environmental cataclysm and did. So if a similar environmental event occurred again this epigenetic program would be re expressed and selected for. I believe this is precisely what occurred because even today in modern humans we see a radical change in DNA expression to a cold environment even thought humans never evolved into a cold environment 2.5 million years ago. It tells you that the program remains in us from our ancestors and it is still capable of expression when we face those situations. I do not think they are ‘hormetic only’ as some do because of the changes we see in our DNA expression suggest this is a long term adaptive action based upon an epigenetic change it induces.

  15. Rob Hamilton June 4, 2012 at 2:05 pm - Reply

    I’m in for the CME course! Please keep us posted.

  16. Tom Field June 4, 2012 at 2:28 pm - Reply

    I’m in for the CME course as well. Fascinating blog. Any role on leaky gut and patients with contact dermatitis?

    • Jack June 4, 2012 at 6:50 pm - Reply

      @Tom if you use the search feature on the blog you will see blog I have written about those issues already.

  17. TheKid June 5, 2012 at 11:34 am - Reply

    @Jack- is there a way that a leaky gut can epigenetically jump from father to daughter?

    • Jack June 5, 2012 at 11:40 am - Reply

      @The Kid My response is yes…..but this is where the research is looking now because we just do not have that answer yet. But it does appear that gut microbiota is seriously affected by epigenetic alterations.

  18. TheKid June 5, 2012 at 12:14 pm - Reply

    @Jack- my daughter has patches of rough skin. We thought it started as a reaction to her last vaccination, as the injection sites got really rough in a bumpy kinda way. But since, she’s got recurrent rough patchiness and it gets red sometimes. Her cheeks get rosy for no reason (she doesn’t CT yet).

    So I am wondering if the skin is an early tell of leaky gut and autoimmunity in a baby? Oh, she also broke out in urticaria all over her body twice. We think it had to do with some almond flour product she ate.

    Any thoughts?

    • Jack June 5, 2012 at 12:59 pm - Reply

      @The Kid I would definitely talk to the pediatrician about this….not sure what to make of it honestly.

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