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We have talked at length on my forum about how a leaky gut can cause havoc for modern humans. What many people do not realize is that humans having a leaky gut happened by design. Primates, our nearest relatives, do not have leaky guts by design because they do not have zonulin the protein that binds our gut cell membranes where they join. Many people are shocked to find out that this make it impossible for a Primate to get an autoimmune disease. This is also true. Primates also can’t get an infection of H. Pylori in their guts either. This is why Barry Marshall had to drink a vat of H. Pylori to prove it caused human ulcer disease in the last part of the 20th century. He had no animal models that would prove his hypothesis. Check out this detailed history of precisely what the establishment did to Dr. Marshall and his ideas for close to 20 years. LINK

Choosing the correct animal to study at the right time of the year makes a huge difference in science. This is a fact that few people even consider when reading many of today’s pub med articles. If you do not believe it is true consider that small doses of penicillin can kill a guinea pig during the winter time. During other seasons the guinea pig can tolerate massive doses of penicillin with out any problems to their physiology. What if scientists had chosen to use guinea pigs to study penicillin instead of mice back in the 1940’s? Do you think we might have made some bad assumptions? Might antibiotic research taken a massive turn if we were not aware of what we did not know? When you realize that this kind of result can happen in a species, it has to make you consider the limitations of extrapolating any data from one species of mammals to others and then drawing a conclusion. Sadly, this is one of the biggest errors in all nutritional science today, in my opinion. It is also why we see some much bad science being done and regurgitated. Alexander Pope had it right when he said, “The only proper way study of mankind is man.” We must always remember that humans are not animals and what we find in research done upon them rarely parallels the expected results to be found in us. This is why aftermarket data can cause a drug to be pulled from the market. Think of what happened to the diet drugs Phen/Fen or the recent COX2 inhibitor drugs like Vioxx or Bextra.

Evolutionary friend of foe round two?

So why would a human have a leaky gut by design?

Moreover, why don’t we see it in primates?

Like we saw in our last CPC #4 maybe this liability today used to be a huge evolutionary advantage in eons passed? I think that is precisely the case when you think about the co-evolution of the gut and the development of the brain in humans. What happened between Ardi andLucy and Homo Habilis is a story that must be considered by modern humans to get back to Optimal. I believe this transition in speciation within the hominid tree of life is just another way that Factor X helped fueled natural selection because of a rapidly changing environment that Ardi and Lucy found themselves in. You will soon find out in the next monster blog series why the differences in the human gut likely fueled our evolution into a new species.

So today I am going to show you how a leaky gut can cause massive collateral damage to many systems in a modern human. This shows you how a leaky gut can cause other body systems to fail because the gut is just not working as it was designed too.

It is a pleasure to share with you a video today from my clinic on a patient who had a severe leaky gut with dreadful adrenal fatigue. This patient came to me for a pseudoarthrosis in her neck. This means her previous neck operation for a disc herniation causing spinal cord compression never healed. She had this surgery done by another surgeon in Nashville. The cause of her leaky gut was a long standing Hepatitis C infection that she got from a blood transfusion earlier in her life. This viral infection was actually the “real cause” of why she never properly healed the fusion in her neck. When she first came to me for a revision surgery I told her it would never work unless I first treated her leaky gut and her Adrenal Fatigue first. How I did this was by making lifestyle changes. Some of the techniques I used on her I have not discussed on the blog to date. In her I used an Epi-Paleo dietary solution, spot CTing, control of night time light cycles, and a special supplement regimen to help her. I also sent her to a colleague for some special treatments to rapidly heal her leaky gut before and during her surgery to make sure the osteoporosis would not hinder her healing once again. None of these things were done by her original surgeon in 2007 because they just thought these illnesses were ‘bunk’ and would have little impact on her case.

Take a look at this video here before going on and see if the surgeon in 2007 was correct or not.


Leaky gut and adrenal fatigue are two modern diseases that were once evolutionary adaptations that protected us. Both of these processes dramatical alter levee 5 called the brain gut axis. Today because of a modern lifestyle both of these adaptations can cause massive collateral damage in our bodies. This video clearly depicts how it can radically alter a persons life if adrenal fatigue proceeds to wreck havoc. The good news is that once we become aware of just how much we do not know and we try to reverse the process we can also help a person. I am happy to report that that her good fortunes continue using Cold Thermogenesis in helping her reverse her illness. You don’t wear out, you flame out…….limit inflammation and you control the burn rates for all neolithic diseases.

This is case illustrates that cold is not just hormetic and many times in a detailed clinical treatment plan can be curative for those who have it. We must always question our preconceived notions of what we believe. Sometimes when we do we can go to a place we did not think was possible. These neolithic diseases are complex presentations with numerous causes and solutions. Our job as clinicians is to continue to look for solutions when patients show up in our clinics with puzzling questions we can’t answer for them. There are many ways to treat them but you first must consider them as possibilities in order to help a person with it.

Healing her non healed neck fusion was a very complex situation that required and outside the box approach using multiple modalities………the moral of her story is that we should not settle when you do not feel well regardless of what an expert may tell you.

The joy is in creating your health……not maintaining it.

Do not believe for one minute that you can not change your life when you take back control of how you think about things. Sometimes we can’t help people because we remain blind to what we don’t know.


1. http://users.path.ox.ac.uk/~svhunt/PopeVerse.htm
2. /the-leaky-gut-prescription/
3. /why-leaky-guts-lead-to-ms/
4. /what-might-casey-anthony-and-oj-have-in-common/
5. /primal-cortisol-response/

6. F. A. J. L. Scheer and R. M. Buijs, “Light affects morning salivary cortisol in humans,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 9, pp. 3395-3398, 1999.

7. http://jbr.sagepub.com/content/25/3/208.abstract (effect of bright light on human cortisol levels)

8. R. Leproult, E. F. Colecchia, M. L’Hermite-Balériaux, and E. Van Cauter, “Transition from dim to bright light in the morning induces an immediate elevation of cortisol levels,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 1, pp. 151-157, 2001.

9. Thorn L, Hucklebridge F, Evans P, Clow A. (2006). Suspected non-adherence and weekend versus week day differences in the awakening cortisol response. Psychoneuroendocrinology. 31(8):1009-18. PMID 16876958

10. A b Schlotz W, Hellhammer J, Schulz P, Stone AA. (2004). Perceived work overload and chronic worrying predict weekend-weekday differences in the cortisol awakening response. Psychosom Med. 66(2):207-14. PMID15039505

11. Steptoe A, Cropley M, Griffith J, Kirschbaum C. (2000). Job strain and anger expression predict early morning elevations in salivary cortisol. Psychosom Med. 62(2):286-92. PMID 10772410

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  1. coldbren June 10, 2012 at 7:18 pm - Reply

    I know you probably can’t answer this, but I don’t know how to determine the root of my main health concern – nocturnal panic. I have taken all my labs and have that info, but can only assume these attacks come from:

    Adrenal fatigue
    Leaky gut,
    Blood sugar probs
    Thyroid dysfunction

    I have dealt with these attacks that come on only after I fall asleep for 20 years and I am only 38. They are getting much less frequent since following your protocols, but when they hit and I am up all night, I become a complete wreck. I had an episode last night and am so discouraged. If I knew the source of these dreadful full blown panic attack that last all night, I feel I could better deal with them. Any thoughts would be appreciated, you are the best!

    • Jack June 10, 2012 at 8:17 pm - Reply

      @Cold Bren Night terrors are similar to nocturnal panic an often is tied to cortisol/DHEA/melatonin axis issues with abnormal blood glucose swings that cause dramatic energy shifts in the brain during sleep. I’d suggest a hormone work up and a sleep study with a doctor who is an expert in this area.

  2. shilohman June 10, 2012 at 7:42 pm - Reply

    If someone has adrenal fatigue does that imply that their adrenal fatigue is caused by leaky gut or could someone not have a leaky gut and have adrenal fatigue?

    • Jack June 10, 2012 at 8:19 pm - Reply

      @Shilohman Adrenal fatigue and leaky gut have multiple complex causes……and yes you can have one without the other.

  3. JedEye June 10, 2012 at 8:08 pm - Reply

    What can you do to more rapidly heal a leaky gut? I thought it is a 6 months to 2 year GAPS style diet that could fix it.

    Would you treat one of the two (leaky gut or adrenal fatigue) first or treat them both concurrently?

    • Jack June 10, 2012 at 8:21 pm - Reply

      @Jedeye depends upon the case presentation. Use of IV medication, liposomal meds, banked human colostrum use of special diets like GAPS or the Epi Paleo diet will help. Things like NAC, ultraglutathione, Meyer’s Cocktails are all examples of how to get uber aggressive with treating the leaky gut.

  4. JedEye June 10, 2012 at 8:12 pm - Reply

    Would you alter your prescription for treating leaky gut and adrenal fatigue for a 29 year old hypogonadal male to raise DHEA and T production?

    • Jack June 10, 2012 at 8:24 pm - Reply

      @Jedeye The Rx are meant as beacons or guideposts for patients to have discussions with their doctors. When you engage a doctor a custom game plan is usually constructed baed upon your specific issues……no humans share the exact templates because of how our biology works via epigenetics.

  5. WeAreDevo June 10, 2012 at 8:42 pm - Reply

    This post makes me think of a quote from one of my favorite movies… “The light that burns twice as bright, burns half as long. And you have burned so very, very brightly, Roy.”

  6. Jennifer Johnson June 10, 2012 at 10:27 pm - Reply

    Great testimonial. For those of us working on leaky gut, what are some of the signs to look for that would show healing? Thanks Dr K!

    • Jack June 10, 2012 at 11:51 pm - Reply

      @Jennifer Improving energy, decreasing symptoms, improving bowel function, and improvement of labs. Vickie lived ten yrs in decline and in 4 months her life changed because she was sick and tired of being sick and tired.

  7. JoannH June 11, 2012 at 12:34 am - Reply

    Dr K, Would ibs type symptoms caused by antibiotics be a definite leaky gut? and where it has gotten better but then will relapse upon taking antibiotics again but not as bad as initially?

    • Jack June 11, 2012 at 6:49 am - Reply

      @JoAnnH they would be a source of it. Once it begins due to antibiotics the gut flora can change for ever.

  8. Krusing_to_Optimal_in_CA June 11, 2012 at 12:37 am - Reply

    Do antibiotics ALWAYS cause leaky gut?

    • Jack June 11, 2012 at 6:51 am - Reply

      @Krusing No they do not…….but these days most often they do because of what we are using. There is a time and place to use them……modern humans just use too many of them indiscriminantly

  9. LeonRover June 11, 2012 at 2:58 am - Reply

    “Know then thyself, presume not God to scan
    The proper study of Mankind is Man.”
    A. Pope

    Popes can quote ex-cathedra.

  10. Dali Dula June 11, 2012 at 6:58 am - Reply

    Another great blog. It went back and read Leaky Gut prescription. I don’t believe I have leaky gut issues, but was intrigued by this: “Many people do not realize that exercise can open your gut to inflammation.” Whenever I exert myself like slamming ten pull ups or sprinting I instantly get a acid reflux-like response. This is nothing terrible and passes quickly even with continued exercise. It also doesn’t seem to have to do with how recently I have eaten. It will even happen on a empty stomach. Thanks once again for your efforts.

    • Jack June 11, 2012 at 7:06 am - Reply

      @Dali with a lot of exercise we are increasing the release of cortisol…….cortisol in excess causes destruction of zonulin. Today this is bad news for us because most humans eat things tht destroy brain tissue instead of things that repair it……in eons passed when we were evolving from ape to man say as homo habilis……we would have ate something to repair us and restore us…….so extra exercise to survive the elements to get to high density foods would have required a leaky gut as an adaptation…….today it is killing us. This is another way Factor X is hitting our shores today while we remain unaware of it.

  11. Caroline Cooper June 11, 2012 at 9:47 am - Reply

    Hi Jack,

    What is the Epi Paleo diet?

    • Jack June 11, 2012 at 10:42 am - Reply

      @Caroline That information is coming in the Brain gut series as we develop it…..Stay tuned.

  12. Dennis Walla June 11, 2012 at 1:24 pm - Reply

    I really enjoy the patient videos. I can relate to what this woman has gone through, but really get tired of dealing with docs looking for “Optimal.”

    Relative to the book “Wheat Belly” genetic alteration of grains over the decades has got to be throwing a wicked curve ball at our epigenetics if people are still eating them.

    • Jack June 11, 2012 at 1:57 pm - Reply

      @Dennis Eating Wheat speds up epigenetic expression faster…..and not to our benefit either. When you combine it with all the other things that speed up DNA expression it should help you understand why we see the diseases we are seeing to day and why our species is now mediocre.

  13. Susan Carlson June 11, 2012 at 2:05 pm - Reply

    Thanks, very helpful because it is this rodeo I am trying to quit riding in. Where do elite athletes source banked human colostrum? The only sources are in Asia so far in my googling research. Also, using Bulletproof Whey which is grass fed. A serving includes ten grams of protein. Is there a range of suggested servings one should take a day? I also have some grass fed bovine colostrum. I am trying to determine a decent amount per day. Following the ketogenic plan makes this much more like a biochem protocol. But, if that’s what it takes to get to optimum I am all for it.

    • Jack June 11, 2012 at 2:22 pm - Reply

      @Susan Look for a local lactation specialist and ask them where this resource is in your community……then when you find them it gets fun…….you need to find a young mom to be your front to get into the banked system. I doubt bovine colostrum will push you out of ketosis.

  14. Souldanzer June 11, 2012 at 7:30 pm - Reply

    I love the testimonials… it’s nice to see somebody get well amongst all of us who keep trying. Complex… I’ve always known that AN (already collateral damage from whatever caused AN in the first place) was creating a lot of interconnected damage but the last few days have been eye-opening… first the hunger went, then the electrolytes crashed, then the hormones crashed, then the sleep went bye-bye, … one domino after another and still going. And the speed of stuff happening is astounding this time. I feel like I keep running and running from more collateral damage for the past few years but it keeps catching up with me somehow and then I’m back in full damage control mode.

    There really isn’t many docs out there who get this. I’m dealing with them daily now and they just can’t understand the complexity of what is happening to me… and the urgency that creates. They keep looking for isolated causes – which there is few of. They keep telling me to wait for whatever – which I don’t have the time to.

    • Jack June 11, 2012 at 7:44 pm - Reply

      @Souldanzer……..never give up. I am anxious to see your metabolic brain scan…….

  15. Souldanzer June 11, 2012 at 7:44 pm - Reply

    I went and re-read levee 5/brain gut axis.
    You mentioned my vagus nerve is wired differently b/c of my history with AN. How so?

    • Jack June 11, 2012 at 7:54 pm - Reply

      @Souldanzer The vagus nerve sends most of the messages from the gut directly to the floor of the fourth ventricle in the brain……so much of the bad signaling from the gut hormones is not accurately sent and received and this completely changes the processing of food/energy status to the brain. This is why we see the bizarre findings in the brain of people with AN.

  16. Souldanzer June 11, 2012 at 8:33 pm - Reply

    Some things are not an option – giving up is one of them!!

    I’m a bit (a lot) freaked out about the scan but I guess that’s part of this journey. Fear and curiosity are so closely related… they can work together or they can work against each other, they can get you moving or they can keep you stuck… lots of thoughts about this lately. Finding the optimal balance between the two can be challenging.

    • Jack June 12, 2012 at 6:55 am - Reply

      @Souldanzer on the other side of fear is complete freedom……..

  17. JoannH June 11, 2012 at 11:00 pm - Reply

    Dr K Yes I think my gut flora is not what it was prior to 2005 I mean I know the exact day it started. I take probiotics religiously for years. It helps but no flora is growing on its own. Genova test showed small amount then a second genova test showed none. no candida showed.
    tried FOS but couldn’t handle it my gut went nuts.
    seems like something I’ll always deal with….no magic pill!

    • Jack June 12, 2012 at 6:57 am - Reply

      @JoannH I use time and diet to alter mine flora when nothing else worked.

  18. JimG June 12, 2012 at 1:15 am - Reply

    Hello Dr.Kruse,

    you mentioned in the forums that cooked eggs are not advisable on leaky gut, but can you elaborate why that is a problem, being a vegetarian currently, eggs are my main source of protein. Thanks.

  19. Robbie Bourke June 12, 2012 at 3:23 am - Reply

    Howya Jack,

    Great post.

    I’m actually just leaving a post here to ask if you received my letter?


    • Jack June 12, 2012 at 6:56 am - Reply

      @Robbie I did get it recently, thanks

  20. Alex June 12, 2012 at 4:30 am - Reply

    Once again, another fascinating read. What evolutionary advantage might the destruction of zonulin have presented to our hominid ancestors? I can speculatively infer that, because the introduction of foreign particles into general circulation would have undoubtedly promoted additional inflammation in the body, the consumption of anti-inflammatory nutrient dense food following extreme muscular exertion to obtain it coupled with inflammation initiated in the gut would effectively serve as a force anabolic multiplier.

    In my mind this makes intuitive sense, but I am just making an uneducated guess as to what the evolutionary advantage conferred by a leaky gut might have been. Is this a correct assumption?

    • Jack June 12, 2012 at 6:54 am - Reply

      @Alex dont ask that………ask why do humans have zonulin and why dont other primates have it…….then realize since we do have it…….how could this great advantage go awry……going awry is celiac disease or anyother AI disease……….think just like I showed you in CPC#4 with the hemachromatosis story.

  21. Alex June 12, 2012 at 7:48 am - Reply

    @Jack I read the blog post again, in addition to the linked article “Human zonulin, a potential modulator of intestinal tight junctions”. The evolutionary advantage of zonulin induced gut permeability conferred to a human would be an accelerated nutritional influx and a subsequent acceleration of tissue growth and repair! Primates and other animals without this inherent advantage would not have been able to adapt to the environment as quickly due to the limitation imposed by an impermeable gut.

    On an unrelated note, I printed off the entire Leptin series and added a number of personal anecdotes to facilitate comprehension. Examples include; how my diabetic grandfather is perpetually freezing due to leptin resistance his cellular furnace is effectively turned out of order, how my mother seemingly cannot participate in aerobic exercise without injuring herself and continues to gain weight insidiously (in some cases severely, having had three reconstructive knee surgeries) and why a dogmatic daily regimen of acetaminophen and ibuprofen in addition to rigorous spin classes is killing her, how he himself was able to spend three years living in the freezing woods of Northern Canada as a surveyor for the Canadian government and emerge from that experience to walk on to the University hockey and soccer teams despite being removed from both sports for five years, and many more. After taking an hour to read it all, he seemed somewhat overwhelmed. I asked him what he thought, and I was met with the longest conversational pause I have I ever experienced. Then he said he’d have to read it again and that he would have to check out the references. My Mom claimed he spent an additional hour reading it again that night.

    The next day while we painted the garage, my Dad said, “If everything in those papers is true, and everybody were living in accordance with that information, I would never have to work again unless somebody hit their head or broke their arm.” Clearly the implications were well understood.

    With all this information in mind, he now understands why and how the current standard practice of care for diabetes is effectively a diabetic holocaust. He said that he cannot, in good conscience, continue to downplay dietary and lifestyle factors in the onset and development of the “disease” as these factors are not merely variables in the equation, they ARE the equation.

    • Jack June 12, 2012 at 11:00 am - Reply

      @Alex I am quite glad to hear your Dad gets the implications. We will see how long it takes for real change to happen.

  22. Jerry Malone June 12, 2012 at 8:37 am - Reply

    @Jack is there anything specific you’d recommend to help get rid of belly fat? Any supplements? What’s the most important thing I should be doing? Thanks.

    • Jack June 12, 2012 at 11:01 am - Reply

      @Jerry Belly fat is related to leptin and cortisol issues. You would need to start with the Leptin Rx and likely get your doc to do a work up on you.

  23. Nonchalant June 12, 2012 at 9:04 am - Reply

    Alex, you have floored me.
    “With all this information in mind, he now understands why and how the current standard practice of care for diabetes is effectively a diabetic holocaust.”

    Thank you for explaining the other side of the equation to me. With all the information I now have, it has been difficult for me to see that doctors truly don’t understand what’s going on.

    I’m glad that you have been able to open your father’s eyes. That was a very interesting anecdote, about his experience in the Canadian woods.


  24. Alex June 12, 2012 at 10:07 am - Reply

    @Nonchalant Yeah, it is both sobering and alarming to understand that general practitioners only require a cursory understanding of human biochemistry. My Dad told me that he was only required to take a “course or two” in biochemistry in medical school and this was in the late 1980s. Our understanding of human physiology and human biochemistry has grown exponentially since many current doctors graduated from medical school.

    Modern medicine is myopic in that it is focus is almost entirely at the terminal end of the equation-in other words, it is brilliant at keeping sick people from dying, even when they technically have no business being alive. Coupled with the ludicrous health recommendations that have been tainted by the influence of the food and pharmaceutical industries, this creates a situation in which modern man is more often than not a shell of his ideal prototype.

    As far as living in the woods is concerned, my Dad explained that the only way to survey lines effectively in such a cold environment was to keep moving physically. They primarily ate what they caught, but once a month the company would transport boxed and canned food to the encampment base. So, unwittingly, they were all transforming themselves into ridiculously fit (on a metabolic level, and by extension, physical level) human beings.

    Also, if a medical doctor can overwhelming endorse all of the information available on this blog, yet the online conceptual community that is the Paleosphere is willing to rake Jack Kruse over the coals and discredit his work in its entirety based upon a misplaced vowel or a minor logical inconsistency that is entirely irrelevant to the plot AND openly claim ignorance/inability to understand the technical aspect of the writing, this speaks to an ancient psychological truth-our fundamental fear of the unknown. We seek to control, quantify, and manage-rather than to accept the uncertainy of the unknown unquestionably. These people are all either too impatient to learn, or are too insecure to entertain the idea that they don’t know everything. The kicker is that you will never know everything that there is to know, so you cannot fear the unknown as seemingly everybody within the Paleosphere has.

    Einstein said that the universe was easy to understand, but understanding human beings is a profoundly difficult task. I can’t argue with him there, as it seems there is proper insanity everywhere I look-both on the Internet and in real life. Even if somebody is speaking the truth, it will always fall upon deaf ears if an audience that perceives that truth to be uncomfortable, unless these people have learned to sit with discomfort-which is a difficult habit to acquire, but nonetheless the most important habit anybody can acquire if they have any hope of achieving any success in the world. This is outlined in many of Jack’s previous blogs, but it is a maxim as old as time itself and one of the key foundations of positive psychology.

    • Jack June 12, 2012 at 11:08 am - Reply

      @Alex This comment makes me feel I am doing it right…….It may take a long time to get through but you and your Dad are getting the implications I realized 7 years ago. I really think some in the paleo sphere just want to control the message. My focus is on helping those who want help……helping those who are sick and tired of being sick and tired.

  25. Alex June 12, 2012 at 11:18 am - Reply

    @Jack You are most certainly doing it right. Hopefully the message conveyed can initiate real change. Cheers!

  26. Jonathan Swaringen June 12, 2012 at 11:36 am - Reply

    @Jerry If you don’t have a good doc or someone that may turn into one with work try to find someone interested in functional/integrative medicine. http://paleophysiciansnetwork.com/
    This is a good resource for finding docs. Sadly the list doesn’t have near as many as I’d like. As far as I know there are none in Lewisville, TX I’m seeing a chiropractor not a full doc who can do everything in Dallas, TX because of this. She does the nutrition part and blood tests.

    She did say she could give me referrals for prescriptions but she can’t write them herself.

  27. Alexandra Gatsis June 12, 2012 at 2:47 pm - Reply

    Hi Dr Kruse. I didn’t know where to post this, but I want to recommend checking out THRIVE.COM. Your work seems to me to be about awakening – and this film, as your work, seems to be critical to our survival. The filmmaker, Foster Gamble, does his own quilt and gives the viewer a very powerful perspective on “reality.” I think your work goes hand in hand with his ; he xplains how we’ve gotten off the thrive path and how collectively we can get back on. I hope you can watch the two hour free film.

    Thanks universes for saving so many lives and putting us on a thrive path!!!!

    • Jack June 12, 2012 at 3:14 pm - Reply

      @Alexandra Thanks for that I will look into this.

  28. Nonchalant June 12, 2012 at 3:42 pm - Reply

    Jonathan, you might also try Jimmy Moore’s list, lowcarbdoctors.blogspot.com for other options. There is a good doctor in Allen.

  29. Melchior Meijer June 13, 2012 at 2:17 am - Reply

    Alex, you absolutely nailed it. Thanks. Jack offers magnificent opportunities to learn and to discover new lines of thinking, he is getting some really remarkable results in his patients and readers, yet he is being burned at the stake for having posted a picture of a pair of shoulders. Pathetic. I have long ago learned that you never make friends by being curious. Please keep reflecting on the blog posts, it really helps me to better understand them. The concept of intestinal permeability as an evolutionary advantage becoming potentially lethal in neolithic conditions is just stunning.

    • Jack June 13, 2012 at 10:46 am - Reply

      @Melchior Just wait til the Brain Gut series starts…….

  30. Alex June 13, 2012 at 4:32 am - Reply

    @Melchior I will happily continue to reflect on Jack’s writing and I appreciate the kind words. I am very familiar with the severe provocation proper inquisitiveness and curiosity can provoke, especially when it involves individuals or groups of individuals (i.e., institutions) that are rarely challenged in such a manner. The most common response is panic and subsequent dismisiveness that speaks to both insecurity and a desperation to retain authority at any cost-even a baseless crucifixion of the challenging individual. “Why” appears to be a distinctively dirty word when it is issued to existing structures of power, and especially so in relatively immature societies such as the United States. I have never understood this, as older more established societies have long ago understood that challenge is a necessary precursor to progress. Every sector of society should be held to the same standard that Jack is holding the medical system accountable to. My Dad comes from Holland, and in Holland and Dutch culture in general, this standard of accountability is the rule rather than the exception. Without this societal openness and accountability, Holland would have long ago been swept under the North Sea and their society would cease to function. Could you imagine if the people operating the hydroelectric dams in Zeeland, Zuid-Holland (South Holland) decided to privatize and effectively tried to “control the message” like those in the Paleosphere are trying to monopolize information that should be available to as many people as possible? Everybody would be dead in a hurry. I am more certain than not that somebody like Jack Kruse would be more than welcome in Holland. Cooperation, openness, and accountability are some of the crucial foundations of social behavior and healthy societies.

    I was always referred to as the kid who “won’t shut up” and generally labelled as “annoying” by others or “disruptive” and “learning disabled” by educators growing up. At the time, this engendered a lot of insecurity but hindsight has given me remarkable clarity and peace of mind. I was born twelve weeks premature and initially given a lot of oxygen, that ultimately resulted in near blindness in my left eye and impaired vision in my right eye. This, however, forced me to develop my ability to communicate verbally at an advanced level, an ability that initially pissed a lot of people off (everything needing to be verbally elucidated) but has ultimately served me very well over the course of my life. What many people fail to recognize is that our limitations are our greatest assets! So rather than moan about health issues and resign yourself to pessimism, actively pursue a way forward and forage beyond hardship and adversity. The view from the vantage point beyond fear is breathtaking. This is something that very few people understand, but it seems to me as if Jack and this small but growing community of like-minded people understands it more than anywhere else on the Internet.

  31. Melchior Meijer June 13, 2012 at 8:11 am - Reply

    Alex, man, what a writer you are! Team up with Jack and co-write a book, I would say…

    Interesting that you mention Holland and our ‘Poldermodel’ (the social model that was born ot of the neccessity to coopereate and always embrace the best solutions in order to survive and keep dry feet). I’m a Dutchy living in Holland. You are right with regard to water management and some key aspects of our social structure, but I’m afraid we are as close minded and tied to convention and corporate manipulation as the rest of the world when it comes to medicine. I’ve had my fare share of shit from high profile medical opinion leaders after writing about the less wellknown but horrible adverse effects of HMG Co A reductase inhibition, just to name something. But Jack is welcome anyway ;-)!

    I’m sorry to hear about your eye problems. It seems like you really have made the best out of an unfortunate situation. Thanks for your kind reply!

  32. Robbie Bourke June 14, 2012 at 5:50 am - Reply

    Great stuff.

    Let me know what you think, whenever you get a chance. I know you are very busy.

    I have been into Linda too to try and get you on my podcast for an interview.

    As I said I know you are busy out so hopefully I can get you for an hour for the show.

    • Jack June 14, 2012 at 7:16 am - Reply

      @Robbie Your better off dealing with me about a podcast right now.

  33. Robbie Bourke June 14, 2012 at 5:51 am - Reply

    Sorry Julie, not Linda 🙂

  34. Robbie Bourke June 15, 2012 at 2:39 am - Reply

    How can I contact you to set it up?

  35. […] readers, Alex , got the huge implication of this coming monster series when he made a comment on the last blog that said this, ” The evolutionary advantage of zonulin induced gut permeability conferred to […]

  36. Bob Smith June 17, 2012 at 1:17 pm - Reply

    @Jack – This is just my assessment. There’s no need to reply. As you said, you’re about to tie this all together.

    The advice to “eat more healthy whole grains” has got to be the crime of the century. The second biggest crime of the century is the advice to cut down on “cholesterol” (fat) intake.

    “Healthy” whole grains are responsible for initiating all of the diseases of modern man. Every organ in the body, including the hypothalamus, is controlled by nerve transduction boundaries. Zonulin makes transduction boundaries permeable to gluten and casein opioids. These boundaries are normally protected by the blood brain barrier (BBB).

    The blood brain barrier is not really a barrier at all. It is mostly controlled by the fact that nerves operate in a hydrophobic environment …..a fat amalgam which controls phospholipid-rich nerve membranes. Control and restoration of these transduction boundaries requires replenishment by ingested fats, and proper cholesterol manufacture by the liver. Protection of these transduction boundaries requires ……adenosine. And adenosine is an essential protein. It is mostly a product of complete digestion of proteins in the gut. Eating grassy grains arrests digestion of plant proteins, and dumps them into the blood before digestion can produce adequate adenosine. The zonulin and opioid assault on cholesterol-starved nerve transduction boundaries is aided by a shortage of adenosine and cholesterol.

    Destruction of circadian rhythm is a two-prong assault. Deterioration of hypothalamus transduction boundaries allows compromise of the orexin/hypocretin system. That’s a BIG problem. The body has three states …..exert, rest and eat. The orexin system has tendrils directly into the transduction control nerves of every organ. Orexin control impulses toggle organs like a symphony conductor toggles instrument sections. Once the hypothalamus orexin center has been compromised, organs lose the capability to sleep and wake on demand.

    The wheat-compromised immune system gets confused. It begins, as you said, different patterns of cytokine release. One of the immune system targets becomes ingested polyphenol dyes like lutein. Lutein has an affinity for retinal nerves. Like vitamin A, lutein coats the retina, blocking out blue light. Blue light in the retina is responsible for setting the circadian clocks which control our pineal glands. Our wheat-compromised immune systems attack lutein, and attack the retina. The attack destroys eyesight, and destroys the pineal gland control nerve’s ability to tell day from night.

    • Jack June 17, 2012 at 1:23 pm - Reply

      @Bob I had to reply…….you’re my kinda of reader. We think a lot alike

  37. Bob Smith June 17, 2012 at 1:22 pm - Reply

    Oops, my above post belongs on another thread. Delete at will.

  38. Karen Moore June 20, 2012 at 11:30 am - Reply

    Great article. I was told I was bi-polar and put on many different brain meds for years and I got tired of it because none worked and when I went off I discovered wheat/gluten was causing my emotional outburts/suicidal thoughts/depression. I then had a food allergy test and it came back with casein plus many other foods. I’m not sure I have leaky gut but could you tell me what supplements I should be on? I take probiotics, garden of life vitamins cq10, and fish oil. Thanks. Karen

    • Jack June 20, 2012 at 3:30 pm - Reply

      @Karen I would tell you that cant be done here but it can be done on my forum or via an educational consult if you sign up for one on the members page.

  39. […] healthcare offers and deep insight to the many flaws our current dogma holds on nutrition. 1. CPC #5 THE LEAKY GUT/ADRENAL FATIGUE CASE | Living an Optimized Life 2. THE LEAKY GUT PRESCRIPTION……… | Living an Optimized Life Reply With […]

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