BRAIN GUT 12: DARE TO DISAGREE?

READERS SUMMARY:

1.  IS NUTRIENT DENSITY FROM A USDA CHART IMPORTANT IF IT IS OUT OF CONTEXT FOR THE SPECIES IN QUESTION?

2. PALEO SAYS PUFA’S ARE BAD.  ARE THEY REALLY; OR IS OUR UNDERSTANDING OF THEM LACKING?

3. WHY IS IODINE A CRITICAL FOR A HUMAN?

4.  IS GETTING A HASHIMOTO’S DIAGNOSIS LIKE GETTING A CANCER DIAGNOSIS?

5.  DO WE HAVE A GIANT PHARMACY IN OUR HEAD?

We recently heard about nutrient density in the Brain gut 5 blog.  It seems all of a sudden it has become a hot topic in the paleosphere too now.  The one issue however that is not well understood or talked about enough in my opinion is putting this key factor in proper evolutionary and scientific context.  When someone uses the FDA and USDA massive databases to look at foods with the highest nutrient densities to make large assumptions what is best and what is not, you might be smart to begin to question if that is a wise assumption to begin with.  Let me explain.  The tables are measuring nutrient density of foods against other foods and not against the species of animals eating those foods.  What it does not do is taking into consideration is the species of mammals who are eating that food.  Does their physiology have some special requirements that may make nutrient density a false prophet for their nutrition?

Mammals are adapted to what they evolved to eat, not what they think they should eat.  The process continues as their evolution continues.  That means modern humans are adapting even now, to the SAD, as scary as that may seem.  In humans, physiologically what separates us from all land based mammals is how incredibly complex our nervous systems are.  When one considers nutrient density in our species you must look at the organs in us that uses the most energy to really get the appropriate context of what we should be eating.  If you don’t do this you may find out, what we can eat and not what we should eat.

These are different questions with different implications.  Moreover, if one is healthy or if one is ill the nutrient density story may be different yet again.  In humans close to 50% of the energy consumption is used up by the brain, heart and gut during meals.  This implies when we begin to consider nutrient density we need to look at these  organs physiologically to see what they optimally require to function.  I have done that. In Brain gut 5, I made the case, using the massive research efforts of Dr’s Cunnane, Crawford, Tobias, and Kuipers that the human brain can not function well without a diet loaded in brain specific nutrients.

This directly implies from a physiologic standpoint, the  brain specific nutrients are far more important than nutrient density recovered from a database.

Recently in a FB group, Brook Dubose posed this question: “I was reading some random things and came across the definition of an Apex Predator – “Apex predator species occupy the highest trophic level(s) and have a crucial role in maintaining the health of their ecosystems.” <- humans are apex..argument for NEEDING to eat meat for natures sake?”

His answer assumes that humans domain is over the land.  I don’t believe that.  My response was this:  Brooke what is the biggest ecosystem on our planet? You assume it is land by your answer. What if I told you it is not. The earth is 75% ocean.  Scientific facts should nudge you to begin to think differently.

What are brain, gut, and heart works best upon is the best measure of nutrient density in humans? 

We also know from modern physiology books that the brain and heart works well on a template that is steeped in ketosis.  The brain and the heart have this feature in common, contrary to what you have heard your whole life.  Ketosis in particular, for the brain is requirement for post natal brain growth and myelination of the major tracts in the CNS.  This also underlies why mother’s milk is constructed by evolution to support nutritional ketosis for quite sometime after birth.  We will cover that later in this series.  If eating bacon, offal, and skeletal meat was critical to brain development, we should see many mammalian predators with much more advanced neural systems than they currently possess, and yet we do not.  Why hasnt’ paleo addressed that issue?   Maybe they never considered the brain’s evolution in hominids before they reviewed hunter gather data.  Most mammalian predators eat foods with nutrient  density found on the savanna, but they do not possess what humans have in their heads.  This implies the nutrient density of foods in the current paleo template can not foster explosive CNS growth in our species or in any other on this planet.  They merely support its function after the nervous system has formed post natally.   

NON GEEKS:  Shellfish and seafood is critical for our species for a reason.  Begin to ask yourself why that is.

It also implies that if these foods were “so nutrient dense for human brain evolution” then we should see many mammals who have similar neural biological evolutionary progression that humans have taken.  I have seen many comments in the paleosphere that meat eating supported brain growth.  This is completely false belief and unsupported in the literature or research, and it is just a meme  and/or belief.  Dr. Cunnane is a world expert in neural lipid metabolism  and I would suggest you read his work before you believe that current meme.  No one in the paleo leadership has this backround and I believe that is why it has been largely ignored.  Moreover, no land based mammals have complex nervous systems as humans do, eating these ‘so called nutrient dense foods’ with these characteristics mentioned recently at AHS 2012.  That is a big problem from an evolutionary standpoint.  Begin to ask yourself why that may be the case.

Let us take a look at this recent abstract from here:

“An increased iodine requirement as a result of significant changes in human nutrition rather than a decreased environmental iodine supply is suggested to represent the main cause of the iodine deficiency disorders (IDD). The pathomechanism proposed is based on the fact that serum concentrations of thyroid hormones, especially of triiodothyronine (T3), are dependent on the amount of dietary carbohydrate. High-carbohydrate diets are associated with significantly higher serum T3 concentrations, compared with very low-carbohydrate diets. While our Paleolithic ancestors subsisted on a very low carbohydrate/high protein diet, the agricultural revolution about 10,000 years ago brought about a significant increase in dietary carbohydrate. These nutritional changes have increased T3 levels significantly. Higher T3 levels are associated with an enhanced T3 production and an increased iodine requirement. The higher iodine requirement exceeds the availability of iodine from environmental sources in many regions of the world, resulting in the development of IDD.”

Many in the paleosphere have been reporting,  for sometime, about pitfalls and dangers of a low carbohydrate diet with respect to thyroid function.  What they have failed to mention, however, is that paleolithic man ate a very low carb diet too!  Often that history is just ignored and many continue onward with their modern perceptions of what the diet contained.  They never seem to ask themselve how they did our ancestors manage their free T3 on a low carb diet?   When you do ask that question it might bring you to a different conclusion than most believe today,  because it appears from most accounts we did not eat a diet high in carbs when we evolved.  It is hard to contemplate something when you are not aware of; especially something you never even realized might be true.

It appears from the study of the  bones of paleolithic humans they  were able to somehow maintain their own optimal hormone status in spite of their lack of carbs are so critical to a free T3 level and high pregnenolone to support the pro-gestation of our species?  We know hunter gathers looked the part of supreme health from old pictures and accounts of them in the last few hundred years.

Here is what they might have forgot to contemplate:  there might be another way to drive thyroid function in humans without carbs.  What might do that?  Iodine also drives the production of free T3 formation even when you eat a low carb diet!  Iodine has always been the achilles heel in the paleo diet as it is written about in the popular paleo books.  This is why many need supplements to improve their own results.  My blog’s focus has always been to point out that circadian biology is critical with respect to food and to light.   It means in long light cycles we can, and should use carbohydrates to help support free T3 levels. But in low light seasons, we need to go ketototic and use s heavy seafood template because the iodine content in the marine food supports free T3 in fall and winter.

In ketosis, the human cell is the most chemically reduced it will ever be biochemically.  This protects the cell from ROS and oxidation.  Iodine is also a major antioxidant in human cells.  In fact, Iodine protects the most sensitive parts of the human body from oxidation.  Those areas are the human synapses of neurons.  No area of the human body has a higher metabolic rate of oxygen consumption anywhere.  This means it generates tremendous reactive oxygen species or inflammation. We all know our brain is what separates us from other mammals, but few of us have looked into the biochemistry or metabolism of the brain.  My day job is to master those critical facts.  We are designed to eat a marine diet year round to lower the oxidative state in our cells to support the metabolic rate of our nervous system.  Oxidation creates inflammation.  Inflammation causes leptin resistance.  When we do not eat a marine diet, leptin resistance is the result.  Neolithic disease follows.

YOU WANT THE ANTIDOTE FOR LOW CARB PALEO FLU THAT IS FAMOUS REFERRED TO EVERYWHERE ON THE NET?  

EAT SHELL FISH LOADED WITH IODINE, AND EAT A LOT OF IT BECAUSE WHEN YOUR TANK IS EMPTIED OF IODINE BY MODERN LIFE AND A LAND BASED PALEO TEMPLATE YOU FAIL OR HAVE PLATEAUS COMBATING DISEASE!

The thyroid makes 80 mcgs a day of  T4 and 5 mcgs of T3 a day in its normal basal state.  Another 25 mcgs is made by peripheral monoiodination of T4 into T3 in the peripheral tissues.  The conversion of T4 to T3 is stimulated by high iodine levels which in turn lowers the HS CRP.  This is especially effective in the gut where a lot T4 is stored.  Since iodine is found in high concentration in seafood,  which permeates our gut when we eat it, it shows forms meets function once again.   It is often why the paleo diet may fail to meet your expectations based upon the promising stories and testamonials we find in the books and blogs around the internet.  The meme out of AHS 2012 was bacon and offal is best for us based upon USDA tables on nutrient density.

TRUTH BOMB ALERT:  Our brain’s function directly  imposes on our biochemistry, our real dietary needs, and it primarily determines what nutrients contain our best nutrient density.  You wont find that data in any USDA or FDA table.  The tables have no biologic context because they never account for metabolism of the human brain.

Let us consider this proposal more closely.  I don’t believe this to be true or factual, (because the proper physiologic contexts were completely ignored by those who raised them) and as this series goes on, I will painstakingly show you why this might be the case.  I believe, the answer is buried in neural lipid biology.  This is something very few in the blogosphere know much about.  This idea was not what the science has been leading many researchers like Kuipers, Tobias, and Crawford to see in recent times.  It certainly was not what Dr. Remko Kuipers was bringing to the game at AHS 2012.  Too few people even heard what Dr. Kuipers had to say in Boston, by all reports of his talk.  That is sad for those of us who are interested in the science behind keeping us optimal, because he may know something no one else seems too know.  It might be  why the Epi-paleo Rx might give a far better result to patients who suffer from neolithic diseases, eating as we are designed to eat by evolutionary history.  What they dont realize is that even modern humans in decline as a species can increase their free T3 without their famous safe “paleo”  starches.  We are able to optimize our free T3 quickly eating an Epi-paleo Rx consistently year round.  Eating carbohydrates in long light cycles creates more ROS in our mitochondria no matter when we eat them.  The reason is simple.  Carbs drive ROS at cytochrome one in ourt mitochondria.  This is a biologic fact of life on earth.  Fats and proteins are accounted for differently based upon their FADH/NADH ratio’s.  Peter from Hyperlipid has on on going series now talking about the intricacies of this very issue.  Iodine from our diet helps offset that inflammation and oxidation that carbs bring.  In winter, when carbs are not readily available,  you offset that dietary loss of carbs, by eating a diet high in iodine.  Why did they not tell you this?  Why did few show up to Dr. Kuipers lecture at AHS 2012?  Humans need to do this because they have big brains.  No other land based mammal needs to do this because they have small brains!  The context  to decipher this puzzle is about brains not bones!!!

Iodine is loaded in seafood and found in the marine food chain, not the land based one.  That does not sit well with the tribes current stance.  You must know this and change your stance regardless of what they continue to tell you.  Read the works of the researchers I am quoting in this series.  These principles are well studied and well established.  They are just not well known in our paleo tribe.  Humans did not evolve from a land based food chain, as many still believe in blogospshere.  This belief is why they are not aware of how critical iodine is to human biochemistry.  That meme is big in paleo because it fits their idea of what they ‘think’ happened.  There is one problem with this thinking, in my view.  They dont have a clue about how Mother Nature built a human brain from a primate brain to make that assumption.  Moreover,  if they did they would begin to realize why paleo often falls way short for a mammal with a large brain in its head.  The proof of that is found all over famous paleo forums.

Moreover, since the human brain is the key defining feature of humans from transitional apes, maybe,  you need to begin to question the current meme too.  That is precisely why this data remains in their blind spot even today.  They just are not aware of what they do not know or understand.  It is simply impossible to evolve a human brain eating meat/offal alone, when you understand how human brain evolution actually occurred.  Again this is not my conjecture.  The science on how we developed a brain is there for you to look at.  I am just the neurosurgeon with the flashlight shining the light on how a brain is formed.  It is published in many books I have had to read to become a neurosurgeon.  Once again, I am telling people they need to get the complete story for our species before they make a decision on what dietary template is best.

A partial evolutionary story gets you partial clinical results.  Examine this data for yourself, then decide.  This series has many cites still yet to come many studies pointing out this foundational findings.  The truth is often said to set us free, but when we first hear it, it usually pisses us off.  I fully expect that response from the tribe.

NON GEEKS:  You don’t get a big brain and smart eating offal, bacon and meat alone regardless of its quality.  Meat and offal eating does not lead to a human brain in the wild, at anytime in our evolutionary history.

Dolphins and whales are the only two other mammals who actually can boast some of this explosive neural development we share in our central nervous systems.  Both of these mammals, share one common trait with humans.  Their brain growth to body mass ratios were fueled by a seafood template of their diet.  It appears that nutrient density for mammals with complex nervous systems requires high levels of DHA and iodine.  That was not the meme out of AHS this year.  Only Dr. Kuipers had that the lone voice in Boston.  I want to you read his work and decide for yourself.

Neither of these nutrients are found in high density in offal, bacon or in skeletal red meat as most believe.  When one talks about optimal nutrient density of foods in the human context,  one must consider the mammalian central nervous system before one makes any assumptions, in my opinion.  In fact, when one eats a paleo template today, the most common nutrient that is depleted is iodine, followed by DHA.  I talked about this in my top ten paleo supplement blog long ago for a reason.

NON GEEKS:  DHA and Iodine are huge for us. The next few blogs are going to open that discussion for you to explore.

Why is DHA and Iodine so important to humans? 

Let us begin with DHA.  DHA Is a PUFA.  If you read the popular blogs and books they have few good words for PUFA’s.  Some praise DHA, but no one has done a good job of telling why DHA is special to our species, in my opinion.

BLIND SPOT ALERT:  The reason for that is because it is a brain chemistry story.

Let’s face it, no one who has wrote a book about paleo has any expertise in brain physiology or evolution.  You may not realize this, but you better for your own well being.  This series is exploring that very issue for you to examine for yourself with any dogma present.  Arachidonic acid (AA) is another PUFA that has been vilified in many paleo writings.  Let us examine this to see if it is correct belief.  I wrote over a year ago that vilifying omega 6 PUFA’s may not be wise in mammals like us before AHS 2011!

NON GEEKS:  Pay attention to the details in the brain because they are big tell what is best for us to eat, over what one thinks we can get away eating.

AA and DHA are PUFA’s that work in magic together in the human brain.  They are essential fatty acids that are critical to cell membrane signaling and structure.  If you follow the work of biochemists and organic chemists they have told us that PUFA’s are very susceptible to oxidation because of the double bonds they have in their chemical structures.  This is true.  But here is what they did not tell you about PUFA’s in the brain.  AA and DHA are critical for the human brain function.  These PUFA double bonds are protected by iodine levels in several special ways.  In Brain gut 5 we spoke about the special quantum effect of the pi electron clouds of DHA.  Now let us look at the most powerful protector of our DHA stores in all of our cells.  Iodine is that protecter.  When iodine is bound to AA and DHA it protects them from free oxygen radicals that oxidize them.  The second mechanism of protection of these PUFA’s uses iodine and hydrogen peroxide in combination.

GEEK ALERT: An iodine peroxide catalyzes the iodolactonization of DHA and AA.  The requirements for DHA and AA for iodolactone formation are the presence of an enzyme called iodo-peroxidase and an elevated concentration of iodine and the presence of hydrogen peroxide.  These conditions can only be met in certain human tissues.  These tissues are the thyroid gland and the choroid plexus of the of the brain.  Most of you know what the thyroid does.  I doubt most of you understand what the choroid plexus does.  The reason for this is because modern science and neurosurgery do not even know what its purpose is today.  This is a tissue in the brain, I deal with every time I open someone’s head for surgery.  The choroid plexus makes CSF fluid that surrounds the entire brain.  We think CSF has a major effect on the chemical stability of the brain but we really do not know for sure at this point.  CSF is an ultrafiltrate of the blood’s plasma and it is made by specialized tissues in the brain’s ventricles called the choroid plexus.

One thing we do know is that AA iodolactones specifically inhibit cellular signal transduction pathways that are induced by local growth factors that are released in many tissues.  They are a critical step in controlling cellular growth and helping regulate cell cycle to metabolic and circadian signals.  For example we know today that delta iodolactones have anti-proliferative effects (tumor growth).  This is especially true in the brain and thyroid gland.  This implies that when iodine levels are low in either of these tissue we might see increases in thyroid or brain tumors.  In the last hundred years, both of these types of cancers have risen dramatically and their incidence and prevalence.  It is particularly startling over the last 50 years in human history.  When this occurs in the thyroid gland these iodolactone block the formation of goiters too.  A goiter is an enlargement of the thyroid due to lack of iodine.  In 1990, we also found out that iodolipids, like iodohexadecanal is critical in the thyroid and brain physiology.  It appears that these iodolipids are a critical player in transport of iodide in the gut and thyroid.  They also direct the formation of T4 formation and secretion in the thyroid.  T4 is the thyroid pro-hormone that is converted to T3 in the liver and gut, which is the bioactive form of thyroid hormone that gives us metabolic control and control over our synthesis of hormones from our LDL cholesterol.  T3 is critical in making every hormone in the human body.  I covered this in detail in the Hormone 101 blog long ago.

We also found out in the 1990’s that reverse T3 and other iodothyronies like T2 and T1 function as iodine transporters in humans.  They also have a dual function in protecting PUFA’s used in the brain from oxidation.  They are the most powerful inhibitors of lipid peroxidation in humans.  Many of you have heard many bloggers talk about lipid peroxidation many times over the last few years,  but no one mentioned the iodine system that prevents lipids from being oxidized in the first place.  They are so powerful, that they exceed the efficacy of vitamin E,  glutathione, and vitamin C in humans.  Most of them however, have talked up these other BACK UP systems in humans.  In fact, it appears the real reason vitamin C may have lost its role in humans, as a powerful antioxidant protector in cells, is because it is not strong enough to protect AA and DHA in human brain tissue, especially at the synapse of neurons.   Yes, the evolution of the human brain may be the reason Vitamin C lost its biologic mojo in our species.

The brain has the highest requirements of requirements of oxidative protection in the synapses between nerve cells.  It appears that iodine is a lot better protector of all lipids in all cells not just the brain.  If that what science says is true in the brain, and the brain separates us from apes, how in the hell did we do this without iodine if the current meme is correct?  

Simple…….we did not, and you may need to consider they maybe mistaken about what they believe.

You want some support for this assertion?  

Kupper found in 2008, for example, that iodine is a supreme scavenger of ROS in RBC’s and dramatically regulates the inflammatory response.  He also mentioned in his 2008 paper, that iodine is essential for all aerobic organisms because of how it protects these organisms from ROS.  This ability is even found in sea based algae’s that forms the base of the food chain in the sea.  To understand how iodine can be used in disease protection that have  associated ROS consider these clinical pearls from Dr. Jonathan Wright:

“Iodine is a basic element, like calcium, zinc, oxygen, etc. The word “iodine” usually refers to two iodine molecules chemically “stuck together,” just as the word “oxygen” usually refers to two oxygen molecules “stuck together.” Since pure iodine is more reactive to other elements, it’s more likely to cause problems, so iodine is usually used as “iodide,” a word that refers to one iodine molecule combined with another molecule — often potassium (KI). So, even though they’re not technically the same, for simplicity’s sake, I’ve used the terms iodine and SSKI (saturated solution of KI) interchangeably in this article (though always meaning SSKI unless noted otherwise).”

“When we’re forced to travel by air, Holly and I drink a few ounces of water with 10 drops of SSKI. The SSKI rapidly accumulates in any and all body secretions, including in the sinuses, where it inhibits or kills bacteria, viruses, and fungi before they can cause an infection.”

SSKI is close to 100 percent effective in eliminating bladder infections, but the amount needed is a relatively high dose, so it’s important to use it with caution.”

“End years of suffering with painful breast and ovarian cysts in as little as three months.” “In minor to moderate cases, 6 to 8 drops of SSKI taken daily in a few ounces of water will frequently reduce fibrocystic breast disease to insignificance within three to six months.”

“Over the past 30 years, I’ve also used SSKI to treat at least 30 women – one of them my own daughter – for ovarian cysts. These cysts usually disappear within two to three months with the same quantity of SSKI mentioned above for breast cysts.”

“But please do not use this treatment for either of these conditions without monitoring your thyroid function.”

“Peyronie’s disease occurs when the tissue along the shaft of the penis thickens, causing erections to become increasingly curved and even painful. Applying SSKI to the thickened tissue twice a day over several months can soften it considerably and eventually allow for more normal functioning.”

“…hemorrhoids will disappear – sometimes literally overnight – when a mixture of 20 drops of SSKI and 1 ounce of flaxseed oil is applied to them at bedtime.”

“Dupuytren’s contracture is a condition sort of along the same lines as Peyronie’s disease, except in this case, the thickened tissue occurs along one of the tendons in the palm of the hand, pulling the connected finger down. If it progresses far enough, sometimes it’s impossible to straighten the finger out at all. Rubbing SSKI into the affected tissue of the palm at least twice a day can “loosen” it and prevent the condition from progressing to the point of causing a deformity or disability.”

“This loosening of thickened tissue also works for scars, especially keloids, which are abnormally thick (sometimes up to an inch) scars. Rubbing SSKI into a keloid at least twice daily will ultimately flatten it down to a normal scar. But patience really is a virtue here: It can take many months to a year for particularly bad ones. You can help the treatment go a bit faster if you mix SSKI “50-50″ with DMSO.”

“Over 30 years ago, two ophthalmologists observed that when they gave patients a combination tablet called “Iodo-niacin” (which contained 120 milligrams of iodide and 15 milligrams of niacin) and instructed them to take it for several months, the supplement actually reversed atherosclerotic clogging of arteries.”

“Cysts and stones melt away with just one dose a day.”

“Sebaceous cysts are another example of SSKI’s ability to dissolve fats and oils. Unlike breast and ovarian cysts, sebaceous cysts contain oily, fatty material and usually appear rather suddenly on the face or in the groin area. But the good news is that you can get rid of them just as quickly as they come on – generally in just a week or two – by rubbing in a mixture of equal parts SSKI and DMSO.”

“Parotid duct stones (which block the ducts that carry your saliva) can be dissolved in four to eight months just by drinking a glass of water containing 3 to 4 drops of SSKI each day.”

“The SSKI and DMSO mixture doesn’t work any faster, but it’s just as effective as antifungal drugs – and definitely safer. Rub it on, around, and under the affected toenails. And make sure to wear old socks, because SSKI and other forms of iodine leave an orange-brown stain.”

“SSKI can also help clear up vaginal infections. Twenty to 30 drops in water, used in a small douche” once daily for five to 10 days will usually do the job.”

In my neurosurgical clinic, I have seen iodine replacement using my Epi-paleo Rx be able to seriously turn around degenerative disc disease in men and women over the last six years. When you have neolithic diseases with inflammation associated with it,  it implies that you might also have an iodine deficiency.  I usually use a free T3 and free T4 level to show me if a patient is iodine deficient.  Iodine is a supreme cellular antioxidant in all human cells.  When pain and depression are present with a spine problem, I know that sleep efficiency is also poor.  This was explored in Brain Gut 11.

NON GEEKS TRUTH BOMB ALERT:  If you carb up,  and increase your cross fit participation to raise your T3 as ‘paleo theory‘ tells you to consider,  you likely will be having surgery sooner than you think.  If you do not believe that go look at internet forums and see how many young people have to have surgery to repair themselves after WOD’s because they are specifically deficient in iodine while simultaneously eating large amounts of “safe carbs” to support their free T3 levels to work out.  You need to question that logic using evolutionary evidence.  That is not the road to optimal in my view,  it is the road to my operating room.    That choice is yours.

WHAT IS THE LINK TO IODINE/IODIDE TO AN OXIDIZING DISEASE LIKE HASHIMOTO’S DISEASE?

Venturi reported in 1985 that iodine was the first inorganic antioxidant to be described in any living system on this planet.  He showed that iodine is is collected in cells by proteins in its iodide form and is bound to amino acids to form iodoproteins.  It was later discovered that in all vertebrate cells iodide acts as electron donors in the presence of hydrogen peroxide and thyroid peroxidase enzyme.  This enzyme is the one that is destroyed in Hashimoto’s thyroiditis by auto antibodies.  This helps explain why Hashimoto’s is often seen as the first step in many neolithic disease’s that oxidize human tissues to alter cellular signaling.  It also helps explain why Hashimoto’s disease  is now so common today. Iodine is blocked by the action of fluorine.

IODINE IS THE MAJOR ANTIOXIDANT IN THE BRAIN SIGNALING SYSTEM:  THE BRAIN MAKES US A SPECIAL SPECIES

When a person is iodine deficient,  a person loses the ability to handle ROS (oxidation) optimally, and other organ systems have to offset those losses to protect the cell from more oxidation. When this happens we see a failure in their adrenal stress index because the cell is placed in a chronic survival mode.  The person must rely on the “alternate biologic systems” built in to cells to handle these problems and they eventually become overwhelmed.  That is the uric acid system, Vitamin E and C systems,  and glutathione systems in humans.  This often leads to a slow progressive decline in function on a physiologic basis of many organ systems in the body over time.  It can occur in any organ system, but Hashimoto’s has particular affinity to those two tissues in which iodine plays a critical role.  The thyroid and the brain, especially the HPA axis in the brain. This loss is potentiated by the dehydration effect on water by fluoride. Loss of iodine degrades sleep and synaptic function as the first step in disease generation.  Iodine is found in high concentrations in the synapse of neurons to optimize signaling.  With more time for further iodine loss,  it affects more epithelial tissues like the breast, ovaries, and testes to cause fibrocystic disease, cancer and infertility.  It even can cause thyroid cancers.  Once iodine goes, Magnesium is not far behind.  This affects our cells ability to make energy from ATP.  Our bodies ATPase is magnesium dependent.  This is why diabetics and fat folks are so magnesium deficient; because they are energy inefficient because they live in the chronic oxidative pathway their entire life.  Eventually this degrades their sleep and their ability to think clearly.

HOW DO CELLS LOSE THEIR ABILITY TO SIGNAL?  

When cells lose iodine chronically and it is not replaced in the diet constantly,  they lose the cellular ability to properly signal. Cells lose the ability to signal correctly and can not “chemically reduce” themselves at night when we sleep.  This causes all organs to age faster with time because sleep is restorative by reducing our cells.  It causes neolithic disease to happen earlier. This is precisely why bad sleep is associated with all diseases.  Sleep is when we are the most chemically reduced in our entire life.  When we do not sleep we are more oxidized or inflamed biochemically.

CRITICAL BG 12 POINT ALERT:  When this chemical effect is CHRONICALLY present, the decision in the cell always has to be made between survival or reproduction based upon how the cell signals using its nuclear hormones.  When we are oxidized we are using up are hormones.  When we are reduced we are resupplying them in the great pharmacy in our brains.  This means that all the LDL cholesterol that is normally made into pregnenolone will either go into cortisol OR to the progesterone pathway.  If all the pregnenolone shunts to cortisol’s path, it helps you survive life’s oxidation.  The shunting signal that determines that choice is the level of cellular inflammation that oxidizes the cell.  When we measure cortisol in the plasma, saliva, or urine,  it is often low when we are oxidized chronically.  That is a sign the PVN nucelus in our brain is working over time, and this is sign you are oxidizing your cells. You are aging faster than normal.  This is measured clinically  in an adrenal stress index test and really accurate in a low salivary melatonin level.  The result is all the hormones going the “other way” in the hormone synthesis chain are very low……..that is the “reduction path”. Reduction means you are staying younger.   If you re read Brain Gut 11 you will see what a chronic low cortisol buys us. Low cortisol = low melatonin = epithelial cancers = LR.   We tend to get cancer as we age.  It follows then that oxidation = Leptin Resistance and LR = aging.   Low cortisol is not a good thing for  a human long term. When the process first begins……ACUTELY, you will have hyper-cortisolism for a time, until you fatigue the output of your PVN nucleus in the hypothalamus. That PVN nucleus is just one of the major pharmacies that function in your brain.  If you do that long enough,  you oxidize (age) your body,  while simultaneously destroying your sleep, to cause your body to slowly begin to fail while your  body composition declines.  For example, Hashimoto’s disease is a disease of chronic oxidation for human nervous system.  It depletes you of the life giving chemicals in the pharmacy that resides in your brain.  This is why it is associated with so many other neolithic diseases.

CANCER = A LOSS OF CELLULAR SIGNALING

Remember back to the Hormone 101 blog post: The critical equation of life = LDL cholesterol + T3 (and Vit A) = pregnenolone. This implies if free T3 is low for any reason, you can’t make enough pregnenolone. If you live a life in the modern world,  you are constantly in survival mode, (living in the cortisol pathway of oxidation) shunting the already low amount of pregnenolone to the cortisol pathway.   Your cells are designed to always pick survival over reproduction, so they make to cortisol at the sake of making progesterone.  Progesterone is the base hormone in both sexes for the DHEA, testosterone, estrogen, etc (the hormones of fertility).  The more and longer we shunt to survival mode hormones, the less fertility hormones we make.  More survival path activation of cortisol also makes the cell more oxidized, and the faster the cell age.  The faster the cell ages the shorter its telomeres get.  When they get short enough we wind up with another decision.  Cell death or immortality is the choice.  That is what cancer really is;  a decision to become immortal over cell suicide.  Life is looking for a way to survive a massive oxidative effect.  So far, life has not found a way around this situation.  It appears the best current solution to this problem is to never lose your ability to cell signaling by avoiding oxidation to begin with.  This is why we want to limit inflammation at all costs.  It improves our ability to signal well.  It is the result of a loss of cellular signaling that speeds up the shortening of our telomeres that leads to all cancers.

Moreover, the more oxidized the cell becomes, the more Vitamin D has to be used to offset this increased oxidation as a buffer to keep the immune system activated to work.  Our immune system protects us from cancers.  When this process goes on chronically,  Vitamin D levels eventually  falls with oxidation too.  This is why low Vitamin D levels are associated with higher cancer rates, like breast cancer.

LOSS OF CELLULAR SIGNALING  =  INFERTILITY

It is also why infertility plagues modern humans, (1 in 7 couples) because to have a child you must be more chemically reduced than oxidized,  because a state of reduction is the signal that favors a higher level of the pro-GESTATION hormone called progesterone. Most modern humans are starved for progesterone because modern life keeps them in the survival pathway of cortisol.   Brain Gut 11 laid all that foundational science out for you.  Hashimoto’s is a disease that also keeps you in the survival pathway (oxidized).

KEY POINT:    Evolution says, the cell must always chose between “survival or reproduction,”  and the inflammation levels are the “traffic cop”  who helps make that decision for us.

Hence, this is why we see upside down PG/E2 ratios in all modern neolithic diseases. When this happens chronically,  the lab panels we order show increased HS CRP, increased E2, and LR, with LOW free T3 levels. Lowered Vitamin D levels are an epidemic because modern life forces us to live in a constant state of oxidation of the survival pathway (cortisol).

DAYLIGHT AND SUMMER, NIGHT TIME AND WINTER:

In daylight, human physiology is in a state of oxidation because we are burning lots of ATP (energy) because of activity.  When light cycles are longest, in summer, we are also oxidized most.  This is also when carbohydrates grow.  They also cause more ROS than any other macronutrient at the mitochondrial level.  Why you ask?

GEEK ALERT: “During oxidative phosphorylation, almost all of the reducing equivalents produced by glucose metabolism in the Krebs cycle are in the form of NADH with the exception of the succinate dehydrogenase step, which takes place in mitochondrial complex II and makes FADH2. Metabolism of one molecule of glucose produces an NADH:FADH2 ratio of 5:1 whereas fatty acid metabolism in beta oxidation and the Krebs cycle will produce a ratio of 5:3:1 depending on the length of the fatty acid.

NADH is oxidized only in mitochondrial complex I whereas FADH2 is oxidized only in complex II. Complex I produces more reactive oxygen species than complex II.

As such, production of a specific number of ATP molecules from glucose has the potential to generate more reactive oxygen species compared to the generation of the same number of ATP molecules from fatty acids.”

NON GEEKS: At night during sleep, we are in a state of chemical reduction.  It is during sleep that our cells are  repairing the damage we have done to our cells during the light of day.  In winter, when carbohydrates are sparse, we are the most reduced of any season.  This is another reason Cold Thermogenesis is so effective at limiting inflammation.  It fosters a chemically reduced state.  Hashimoto’s disease is a disease of constant chemical oxidation during day or night and all summer or winter.  The reason is simple for this.  Since Hashimoto’s destroys your thyroid’s ability to make free T3, you have chronic low levels of free T3 to convert your LDL to pregenenolone.  This keeps in you in a chronic state of oxidation no matter what time of the year you are in!  Physiologically when you get to the step in the hormone chain that is pregnenolone the cell has two choices to make, survival, the cortisol path, or pro gestation, the reproductive path.

When we chose survival we are in a state of chemical oxidation constantly.  This is why an adrenal stress index is quite helpful clinically in understanding the current pathway your body resides in.  This tells you how healthy or sick you really are.  When you are in a pro-gestation path, you are more chemically reduced as you are in night.  You are able to make the distal hormones, progesterone, DHEA, estrogen, testosterone and Vitamin D easily and in proper physiologic quantities.  The pharmacy in your brain is open for business and well stocked.  This is why your hormone panel tells all about your health.  It tells you whether your house is on fire or whether your ready to make a new generation of humans.  Evolution says the battle for life should be met when there is low stress and low oxidation.  When we are stressed or being chased by a great white shark, our goal is to flee to survive another day.  This is a heavily oxidized state.  When you’re a modern human, you often live in this state your entire life.  This is why we see trashed hormone panels that confuse so many patients and clinicians today.  When you get the blueprint for the battle in the cell, you can reengineer people back to the reduced state………Hashimoto’s, artificial light, chronic cardio,  and chronic WOD’s are all oxidative events that push you down the wrong pathway.  Eating a diet that is highly chemically reduced (think Epi-paleo), help’s mitigate these risks, but not entirely.  You just can’t out supplement or out exercise a bad diet no matter what some people may  tell you to believe.

GEEKS and NON GEEKS: Hashi’s is a gateway disease to many illnesses because we cant fight the inflammtory cascade well any longer.  It depletes the immune system  and the antioxidant system in cells to alter proper signaling.  This cascades when reserves are diminished and causes massive alterations in adrenal stress index testing which signifies an issue in the circadian signaling of cortisol/DHEA/melatonin system of the brain.  DHEA, oxytocin, and melatonin are the three gateway hormones that oversee the antioxidant protection system in the brain.  This implies that adrenal fatigue is not really an adrenal disease……it is a failure of the brain’s ability to defend itself due to altered signaling in the neurohummoral and neuroendocrine system.

Many times women with Hashimoto’s will develop eating disorders and auto antibodies that block nuclear receptors this area (PVN) of the HPA axis and it will give a characteristic abnormal diurnal pattern of cortisol depression in the middle of day.  The antibodies often signal to the astute clinician that an autoimmune disease is lurking in this axis.  These antibodies can alter the ability of the nuclear hormone receptors in  paraventricular nucleus in the brain,  altering the cellar signaling to any stressors and inflammation present.  The PVN is a central area of “stress management” of the human brain.  It is here where oxytocin, CRH, TRH, ACTH, GNRH all act, and are released.  Their synaptic effects then project all over the cerebral cortex to cause their normal physical effects we expect.  This is the seat of control of the neuro-immunological system in all humans.  This is where the pharmacy of our brain is.  The brain is the major drug pusher of hormones to the rest of the body to optimize signaling.  This is an area of the brain that is firmly in NEURAL GEEK TERRITORY  for most readers.  I will be writing about this in the future of this series.  It is the major control center for the real etiology of what people call “adrenal fatigue”.  The source is in the brain, at the hypothalamus, and not the adrenal gland as most believe.  This is why adrenal fatigue is rarely solves with most of the OTC moves everyone seems recite on the net.  You have to fix the circadian signals first,  that destroy the PVN’s control over CRH, TRH, DHEA, and oxytocin to make headway when you are oxidized.

The incidence and prevalence of Hashimoto’s has grown tremendously in the the last 30 years.  When I was writing this blog post several months ago,  I opened my Robbin’s pathology book from medical school (1986) and read a passage on Hashimoto’s.  What it said there was shocking to me today.  It said that this type of  thyroid disease was rather rare and that medicine has several good  surgical and medical ways of dealing with this rare condition.  Today, 80- 90% of people diagnosed hypothyroidism today, have Hashimoto’s today.  This is a dramatic change of events in a small amount of time.  This is why Hashimoto’s is now becoming known as a gateway disease to many chronic neolithic diseases today.  It allows for tremendous damage to cell membrane  signaling that directly affect the physiology of the organ in question.  This opens the door to many disease processes.  As you saw above in Dr. Wright’s newsletter, there now are many reports of the supreme antioxident activities of iodides in many chronic neolithic diseases like cancer, atherosclerosis, cataract formation, CAD, and muscleskeletal diseases like osteoarthritis.  This also have been verified in other mammals now when scientists are beginning to look at how iodine functions in cellular immunity.

It seems to me, this data is not well known in the paleosphere.  The reason maybe because the paleo diet is historically very low in iodine,  no matter how it is constructed in the modern world.  The reason is simple, seafood is not a large part of the diet as it is described in Cordain’s original books or research papers because he did not appreciate how we really evolved in the East African rift zone.  This is further confirmed in the popular books that followed, and in the data reviewed by Cordain in his latest book as well.  He does not look  at seafood carefully, even though the charts on pages 108-113 in The Paleo Answer say we should be carefully examining this data very closely.  When you understand neural chemistry you can not help realize how incredibly important iodine is.  Iodine and thyroid hormone are crucial for brain development and functioning throughout human evolution.  It just seems to have been ignored by paleoanthropologists.

I think we need to look at the data of neural lipid scientists to really gain some insight into this topic.  Moreover, this appears to be why the Mediterranean diet has fared so well in most nutrition studies done over the last 50 years in the medical literature.  While this diet still allows for some harmful foods to humans,  like grains and legumes, it has superior  amounts of iodine to offset some of the harmful effects of the grains and legumes in this nutritional template.  In my view, it would make sense then to remove the harmful nutrients and increase the nutrients whose density favors lower inflammation and higher iodine levels.  This is precisely what the Epi-paleo Rx prescribes.  I found nothing in Cordain’s work to argue with the nutrient density of shellfish and seafood to unseat this hypothesis.  He just seems to have missed the data that is littered all over many scientific disciplines.  He also has not considered the special metabolic effects of the human central nervous system that requires this template to optimally function.  You need to appreciate this and examine it closely.

Let me be clear here, so no one uses my words out of context.  I like what the 99% of what the ‘paleo team’ brings to the table.  I like their leaders, inspite of what they say or do to me, because I buy 100% why they are doing it.  We all must be starfish in our own way!

WHY DO I DARE TO DISAGREE?

If our goal is to really understand our world better, our lack of scientific diversity is what really makes it a more difficult task.  I am no exercise guru, gym owner, or research scientist.  But they are no experts on neural biology.  And humans have big brains, and this is what separates us from all eutherian mammals.  I am a clinician who thinks best outside the box and lets the science guide me.  Paleo can be described as a team or a tribe today.  Team building requires you to limit diversity of thought, and subjugate it for a common goal.  It sounds counterintuitive at first,  but this is what the concept of “group think” is all about.  There is an entire social science built upon this subject and concept.  When people begin to all share values and scientific beliefs, they become a sort of “team”. Moreover, once you engage the “science of team”, it shuts down open minded thinking that goes against what the tribe believes to be true.  Normally this is not a big issue, if things are truly correct scientifically, for those values or beliefs the group holds sacred.

But what if they are not correct?  In my view, that is my role on the team.  Someone has to challenge conventional thought even in an unconventional group of people.  I am that guy.  It makes me a target.  I am OK with it, because I am looking out for our optimal health, and nothing else.  This path got my own health back.  I think it is worth sharing with you too.

What if you are not aware of something you never considered?   What my blog represents, is that guy, who dares to disagree with the current beliefs.  I tell all my members and readers to question everything, including what I tell them, or write about.  I already know I don’t know everything, even though many of my critics will put words in my mouth that suits their agenda best.

One thing I do know about, is how this information help fix me and my family.  It then helped me fix many patients.  We did not get the results found on most paleo sites doing it their way.  We used a different method.  Because we did it differently does that mean they were wrong and we were right?  No.  It means we have more to learn about each method.  When you can not get the results you see from the public testamonials we are all accustomed to seeing weekly, I want you to know why you can’t.  I do not want you to be depressed or shell shocked because the advice given elsewhere just does not work for you.  I do not want you thinking you are broken deeply somehow.  I rather enjoy a collaborative model of scientific exploration, that requires my thinking brothers and sisters, not to become echo chambers of the same beliefs the tribe currently has.

In order to get different results we need to think differently about things at times.  The science of DHA alone, tells you something is very off in the current belief structure.  I want to be that lone nut, that gets you to look at something the whole tribe believes to be true for yourself.   But do it without having to worry about what the tribe thinks of you or your methods.  That is what the comment section of my blog is for.  It’s for you to exert your ability to think differently than you usually might given the tribe’s beliefs.  I want everyone who is sick and tired of being sick and tired to come here and read.  I want the weary who have failed the Rx found in the medical books we have all read to come find out why.  My blog is not for those of you who have found success easily.  It is for the people who have not found success for a reason.  I want you to know why everyone’s mileage varies in this journey to optimal.  I do not want you thinking there is something wrong with you.  I want to teach how our ‘Ferrari’ really works, and for you to discover that you too can reclaim your health when you understand the owners manual you came with.  I agree with most of what they say, but on brain biochemistry they do not have it all together.  That is their puzzle.  As a clinician my job is to make sense of our present biochemistry puzzle.  Everyone of us is at a different point on the same continuum of human biochemistry.  Deciphering where you are at now is my domain.  There is a scientific epistemologic basis of how the laws of biochemistry apply to our species, and that is universal for our species. I am trying to show you how it works in an evolutionary context, and not how we think it works.

The concept of “team” requires confirmation in the face of adversity.  I want to you embrace that discomfort with this information, and realize that all of what we believe may not be what we all thought.  Will, you allow yourself to examine things for yourself and dare to disagree with your perceptions of your current truth?

Victory is had by opening eyes on both sides. There’s room for many opinions, as long as we all warn the readers that with or without degrees, they have to take their own lives in their own hands. ~A.B. Dada

SUMMARY:

ANOTHER TRUTH BOMB ALERT:     Nutrient density is a function of the mammals physiology eating that nutrient, not a USDA food database taken out of that physiologic context!

The larger the brain the mammal has the more iodine levels in the dietary nutrients becomes critical.  IE:  The brains evolutionary construction is what controls the decision process of what foods we should be determining contains optimal nutrient density, not someone’s belief of such.  Iodine is not conserved in human physiology to any great degree.  This implies that our environment always had a deep supply, from an evolutionary standpoint.  This foundational fact, is in many people’s blind spot today.  It is underscored when you consider that human physiology has no source to concentrate or reserve iodine for future use at all in human physiology.  A constant source is required for proper neurologic and thyroid functioning.  I want you to examine it and realize why iodine is critical when you have a massive brain.

The greatest enemy of knowledge is not ignorance.  It is the “illusion of knowledge”.  When you know better – you do better.  If you are not doing better, ask better questions to get to answers you need, and not the answers Rx by the tribe.  

In 2005, when I began my own study of the literature, I was taken by the fact that Liu showed that ROS and lipid peroxidation increased dramatically in both rodents and human children that were iodine deficient.  It did not matter what the glutathione, Vitamin C or E levels were intracellularly in these cases.  This implied to me that iodine is critical to us humans.  It appeared that iodine has a magical effect on the PUFA’s when they interact. This effect is found in all mammals, no matter how complex or simple their nervous systems were, but it becomes the most critical element when neural complexity increases.  Humans fit that bill to a T.  This blog is not about reading research on rats or mice physiology in getting well.  It is about you getting well.  This data all  implied to me early on that iodine had to be a critical part of getting people healthy from a illness state. As a physician, my goal is to get people well, if I can.  I think this information is critical in that regard, so I am sharing it with you.  Today almost 1/4 of the total human population consumes diets that are completely inadequate in supporting brain development and proper functioning over their lives because their diet lacks the essential brain nutrients I laid out in Brain Gut 5.

The key question for you now is to ask yourself today is what kind of dietary template are you using for yourself today, and why are you really doing it?   Do you dare to disagree with your tribe?

A narrow mind will be your most harmful thing you’ll ever own………….

Today, begin to swim against the tide. Rock the boat. Paddle your own canoe. Decide to be different than average. When you dare to go against the grain, you dare to live life to its absolute fullest.  That is where optimal lies for us all.

CITES:

1.http://onlinelibrary.wiley.com/doi/10.1002/ijc.11578/full

2.http://iddd.de/umtsno/cancertrends.pdf

3.http://www.ons.org/Publications/Books/Excerpts/INPU0597intro

4.http://jcem.endojournals.org/content/early/2012/05/08/jc.2011-2996.abstract

5. New Treatments and Shifting Paradigms in Differentiated Thyroid Cancer Management

W. Bradford Carter, MD, John B.Tourtelot, MD, Jason G. Savell, MD, and Howard Lilienfeld, MD

6.http://www.ncbi.nlm.nih.gov/pubmed/18458346

7.http://www.atmos-chem-phys.net/9/823/2009/acp-9-823-2009.pdf

8.http://books.google.com/books?id=rxe7jPwW65EC&pg=PA149&lpg=PA149&dq=Kupper+2008+iodine&source=bl&ots=ze5Jf5Nx2r&sig=wNLMv-OMIR5GwbFgcXLn6NegxiE&hl=en#v=onepage&q=Kupper%202008%20iodine&f=false

9.Venturi S. Preliminari ad uno studio sui rapporti tra cancro gastrico e carenza alimentare
iodica: prospettive specifiche di prevenzione. Editor U.S.L. n.1, Regione Marche;
Novafeltria (PU). 1985. pp. 203

10.http://www.intechopen.com/books/lipid-peroxidation/trends-in-the-evaluation-of-lipid-peroxidation-processes

11. Lui,Y 2000.  The damage role of free radical in iodine deficient children. 12th International Thyroid Congress, Kyoto, Oct. 22-27, p.560.

12.Excerpts from Jonathan V. Wright, M.D. Nutrition & Healing, 11/1/2002 Newsletter

Comments

  1. @TIM Today begin to lose your arrogance, because arrogance kills curiosity and passion and we need your passion and curiosity to shine.

  2. Krusing_to_Optimal_in_CA says:

    Whoa…that ties together so much of this blog in one place for me. Lightbulbs are flashing!! I’ve never felt better in my life since seafood became a daily thing rather than a weekly thing. I can’t get enough f it now and crave it the way I used to crave cookies and French fries (neither of which you could pay me to eat, now)!

    Here’s the thing- I’m a thinker and NEED to understand how and why things work. That belief fuels my behavior at a very deep level and keeps me on the path to Optimal. I get that belief here and reading the cites you drop in every post. And yeah it’s working for me, big time!! 55 lbs since 2/21/12 and we will see what my next set of labs say very soon.

    But here’s the other thing…. If you just do it, without understanding it, it works too. I couldn’t pay my dh enough to get him to read a magazine, much less this brain bending blog. But he follows along and is down 40 lbs himself(and is at his goal weight, we’ll see from his labs what else needs to happen soon, because its not about weight, its about seeing optimal labs, for us – a true measure of how healthy you are on the outside, apart from just looking good naked!!) He did it with Epi-paleo, and beginners CT (not even a consistent habit for either of us yet).

    Still struggling with lights out after sunset..but for me that will just take a deep dive back into this blog on all the light related posts…where I know my conviction will grow, the blue blocking glasses will get a workout and my candle budget will be increased….

    I feel like this blog post was just for me to tie it all up in a bow to explain to my doc what’s happened to me and why Im doing it… But then I’ve been reading this blog obsessively for months. If you’re new here and feeling challenged by the sheer amount of information, take heart. Just start DOING it…changing where you are ready to, and keep reading. The more you read the more belief and motivation you will have to change, if you’re like me at all. There are so many broken people getting fixed here and the support in the forums is enormous for every kind of metabolic broken I ever thought of (and many I never knew about).

    We’re here because Dr K is filling our big brains with hope… Telling us why what seemed to work great for other people didn’t work so swell for us….and pointing us toward what WILL get us there, to that Optimal place. Little by little he lays it out for us and yep it’s a he’ll of a lot to digest. Persevere….read…ask questions (he does answer them!!)… And don’t be afraid to think for yourself. That kind of behavior is welcomed !

    (sorry Jack, I got all swept up there for a few… What I meant to say was: Thank you for yet another awesome blog post!)

  3. ok, now I’m a little panicky about the iodine iodine iodine message

    perhaps I bump up my daily half pound of raw scallops to 1 lb?

  4. Once again, you outline the story of my life. Mismatched circadian cycles, poor diet, pregnancies that depleted my minimal resources… and then thyroid function crashing, inflammation, hormonal imbalance, poor gut health and, voila, cancer. I am definitely paddling my own canoe and while still a part of the tribe, I embrace ‘lone nut’ status. Each step of the quilt you unveil and each bit of depth you give us to understand helps me understand myself. That is how I know it’s true. Paddling a lone canoe back to optimal isn’t an easy journey (and I’ve still got a crashed T3 to figure out), but I’m getting there. My boat is loaded with raw fish, shellfish, ice and candles. You are a true doctor and a lighthouse in the storm.

    • @Lauren It is why I laid this out piece by piece. If 18 months ago I would have put this piece out on MDA you think anyone would get the context? Nope……….the biochemistry of optimal is critical. I am teaching you the epistemologic foundation of how to rebuild yourself using that pharmacy in your brain that is out of drugs. This is where paleo ends…….and I begin. I want all the broken……..I love broken because I think I might have found the owner’s manual to the Ferrari…….It begins with that thing in our head……..I know something about that thing.

  5. Elizabeth Kamm says:

    Dr. Jack,
    I have Hashi’s and PCOS, so I hear you on everything you are saying…except Dairy. More so cheese, butter, and yogurt.
    I can give up wheat, grains, and most fruits but…..sell me on the no dairy.
    I cannot seem to find anything concrete online about Hashi’s and dairy free.

    • @Elizabeth If you have PCOS and Hashi’s and you are eating that……..well you need an education consult. Wear a helmet because you wont like the lesson I am going to give you. Just ask some of the people on my site who have done a consult……..you got work to do, knowledge to gain and wisdom to attain.

  6. A masterpiece. So much is coming together in my brain, thanks to your writing and my 2/day seafood meals. Lots to ponder. Now I’m wondering about the big-brained sea mammals and their light cycles. We know they thrive in cold water and a diet filled with seafood. What other clues can we take from their lives to improve our own?

  7. Elizabeth Kamm says:

    Dr. Jack, how do i do a consult? I would love one. I am a nurse, and a tough cookie (lost four pregnancies between my two daughters) and I am only 31! i did the standard low carb diet to be able to have daughter number two successfully.
    I am ready for any education, wisdom, and knowledge you got. Just tell me how to consult and I will lock it down.

  8. I was just telling my mom today: time to become a pescaterian. It is interesting on a search on pescaterian paleo I see inquiries from trainers who are at their wit’s end trying to get their pescaterian clients to eat red meat, offal, and bacon. Some of my ancestral line includes Swedish coal miners who lived near the sea. Gives me more hope. Thanks for the light and tying it together for us.

    • @Glamazon I try……using what I have learned. The miracle of our mind isn’t that you can see the world as it is. It’s that we can see the world as it isn’t.

  9. wally courie says:

    Good article by the doctor and good comments. i guess it took me three hours to read it intermittently while attending to chores. One of the chores was eating a can of boiled oyster w/ a can of crabmeat sauteed in olive oil. And taking a couple of grams of pharma grade fish oil. This is in addition to all the D3, magnesium malate, and krill i had this morning. I just like to get in the spirit of what i’m reading.

    At the same time, i am picking thru Dr. Barry Sears, Toxic Fat, which i picked up at Tuesday Morning for $5. His theory seems to be that starchy carbs and grains coupled with seed oils cause an accumulation of too much Arachanoid Acid (PUFA 6) in the fat cells which sequester it b/c above a certain amount it’s toxic. the fat cells have stem cells that proliferate b/ eventually u run out of omega 6 and the stuff leaks out all over the place getting into internal organs- hence the term toxic fat. He suggests that fish oil works by diluting the PUFA 6, but he says nothing about iodine, and the importance of eating seafood.

    I think Kruse has the deeper approach and I thank him for this and all his other “deep nutrition” articles. I am a fan of deep and detail, if u couldn’t tell.

  10. Zorica Vuletic says:

    Stay chemically reduced, my friend!

  11. John Sorrentino says:

    Nice job Jack. For me the money quote is:

    “When they get short enough we wind up with another decision. Cell death or immortality is the choice. That is what cancer really is; a decision to become immortal over cell suicide. Life is looking for a way to survive a massive oxidative effect. So far, life has not found a way around this situation. It appears the best current solution to this problem is to never lose your ability to cell signaling by avoiding oxidation to begin with. This is why we want to limit inflammation at all costs. It improves our ability to signal well. It is the result of a loss of cellular signaling that speeds up the shortening of our telomeres that leads to all cancers.”

    You know I am a fan of iodine. Follow the infusion of iodine into the hominin brain and you follow in the footsteps of human evolution. This is no surprise to me. We need to talk about the East African Rift Zone and the Out of Africa theory. Finally medicine needs to embrace this paradigm but I am not sure that big pharma will allow that to happen. Keep fighting the good fight.

  12. John Sorrentino says:

    Munching on dried wakame as I am re-reading this.

  13. John Sorrentino says:

    That’s what made it so powerful.

  14. Audrey MacLean says:

    Thanks Dr. kruse for this blog and all the time you spend to educate us. I am actually understanding it first time around – or are you writing more for us non-geeks??? my motto to live by – when you know better you do better.

  15. John Sorrentino says:

    You know I never liked the name epi-paleo. I think evolutionary paleo or evo-palio is a more accurate description. Just sayin’

    • @JS I know…….but sometimes what you call it does not matter……because it is what it is…….and how we evolved pre dates and is more important than hunter gathers data…….

  16. Hi Dr. Kruse

    So in terms of shellfish, especially raw, basically the more the better it sounds like, as more shellfish/seafood, means more bioavailable iodine?

    • Well Golooram iodine is not as plentiful today in all seafoods compared to yester-year but it still blows away grass fed or pastured meats……so that needs to be kept in mind. Eating paleo is still fine but you must keep iodine flowing into your biology constantly.

  17. wally courie says:

    epi-paleo conveys the notion that diet can alter gene expression. it puts an emphasis on epigenetics. i”m not sure about the paleo part. paleo conveys pre-neolithic or pre-agriculture. but the theory presented here goes back alway to our ancestress “Lucy.” i don’t know enough geology to place her in the proper epoch.

    • @ Wally……when you read my book Wally you maybe shocked at how far it really goes back. It is a lot further back than paleo ever dreamed. If you want to learn about Lucy’s geology read Brain Gut 4. And then google her…….the details are all there for you.

  18. This article is so great. I think it will help so many people.

  19. thanks Dr. Kruse – will do! I am going to live on bacon and even more scallops for the next week

  20. Dr. Kruse,

    B/C sumo wrestlers eat a lot of sushi/seafood, they seem to have low visceral fat (and relatively healthier metabolic profile)? Is the Iodine + DHA the reason for it?

    What’s your position on eating kelp for iodine as well?

  21. Philippe Chouinard says:

    Very interesting in the context that my wife has a Hashimoto since she’s 17 ( now 42) and she had a hemithyroidecty because of benign nodes.
    Her mother has Lewy Dementia and all the the stigmatia of to mich oxidation during her life (high blood pressure, high lipids, TCI…) My wife is on synthroid and does not yet have other problems.
    My question is what steps she can takes to help her. Hashi is a chronic disease so leaky gut needs to be adressed and iodine/ t3 must be in adequate amount for her (reducing oxidation an hormonal health) with the right circadian living( right food right light) and CT?
    More on the hypothyroidism case: when I was a resident in the 90’s hypoT was way less frequent than now. I have many patients with obesity, diabetes, high blood pressure, dyslipidemia, hypothyroidism and cancer, and some of them are in their 40’s…
    One last about Hashi: it is a leaky gut acquired disease?
    Thanks for your thinking!

    • @Phillippe It depends upon her biologic context with testing. Since you are a physician I would suggest having her write up a full history and then submitting it for an email consult……once done then I can send you a list of things to test on her to get to the core issues……If she has been Hashi’s since 17 she is likely having issues with grains, rice, corn and BCM-7. All these AB’s then destroy the HPA axis and push her to an earlier menopause because of oxidation of all her tissues and age her even faster. This also shows major changes in the ASI Cortisol/DHEA/melatonin as I laid out in BG 11 and BG 9. Hashi’s is a big deal clinically and few MD’s seem to be aware of how it really destroys our biology slowly but steadily

  22. I just reread this and hit the links. It is such important information for anyone with blood pressure, memory issues, electrolyte issues, etc. Now its morphing into another one that has to be read and reread. One crazy puzzle got answered for me when I read the pvn link and wiki’d it. The vasopression is controlled in the hypothalmus and memories require vasopression to form. (And erections, if you are into that sort of thing.) I definitely have even more rethinking to do. How to get the hypothalmus to behave…. hmmh… leptin reset …I guess I was too hasty.

    • @Lee ADH and BDNF are critical for new memory/synapse creation. They require a great ASI and high progesterone……(reduction pathway) and tons of iodine and DHA to make the new synapse strong and wired so it fires over and over again via Hebbian learning. If it is not fired over again it gets remodeled and taken out.

  23. I have been incorporating sea veg into my diet, I make broth from the veggies. Is the iodine water soluble or is it bound in the plant matter?

  24. carol Carlson says:

    “The proof of the pudding is in the eating”

    You could have never convinced me a year ago I would be eating a seafood diet. But the truth is, I can hardly bare the thought of eating meat, offal or fowl ever again. For two days I have included one meal of my two seafood meals with eating salmon and tuna sashimi. Both times, my brain vibrated….literally. I am almost positive it was the tuna because that has just been added this week to my diet. Am I just imagining this? On the other hand, since I have been eliminating foods in my diet, I have found butter not so good for me. I always thought butter was my friend. Never has there been anything that changed my life, so drastically, then opening my mind to this seafood diet.

    • @Carol When you eat the way we are designed…….amazing things begin to happen for your brain. That organ is the Ferrari in our body. The more you know about it the better you get. It is that simple. It is where I begin and where paleo ends.

  25. Dr. Kruse,

    I know you prefer to get nutrients from real food–but–if you had to use supplements for Iodine instead, how many mcg a day do you recommend?

  26. I think this is your best post yet Jack. Everything is laid out so clearly (either that or my brain is finally coming around thanks to my twice daily seafood meals!) I honestly don’t know how anyone couldn’t grab onto this wealth of info and run full force with it.

    Love this quote: “The greatest enemy of knowledge is not ignorance. It is the “illusion of knowledge”. When you know better – you do better.”

    I was just talking to my 12-year old yesterday about how we are the lucky ones to have this knowledge even though sometimes at her age it doesn’t feel that way. It’s tough to be different especially as a pre-teen already struggling to fit in, but in the long run it’s going to be even tougher to accept your fate when you go against what you know is best. We’re blessed to have this knowledge and we’d be committing a crime to just toss it all away. Once you’ve been given a gift like this, you just don’t turn it down. You embrace it and pay it forward.

    She told me she’s learning what she needs to ‘know’ to pass her health test on nutrition and then will forget it all. She’s beginning to understand how important it is to question everything and not accept everything as fact that’s spouted off by her teachers.

    • @BJK77 That quote came from my son……..he said it to me after he became optimal. I wrote it down in my notebook, because it was so profound. Your daughter is gaining wisdom from her experiences. That is big! Another starfish is created.

      It is funny you mention paying it forward…..you should listen to my open remarks sometime from Paleofx 2012. You might be surprised at what I said there. It fits your replay post here to a T.

  27. Stephen Ross says:

    Great job connecting the dots between carbs, season, t3 and iodine/seafood. I definitely don’t feel optimal low carb paleo but that was with very very little seafood. I now have a solid source of fresh wild sardines and I’m excited about the DHA and iodine content and the effects they’ll quite possibly have on my body. It’s probably placebo because of the timeframe, but already since yesterday I feel sharper and like I slept better after having a rich in seafood dinner. You’ve revived my hope that I can feel optimal on a paleo diet by introducing me to the Epi paleo diet, lol. I wonder, do you call it epi paleo because it’s above paleo or do you call it epi paleo because it’s a form of paleo that works via Epigenetics to literally reprogram our bodies?

    • @Stephan Thanks…….for too long I have been quiet listening to utter nonsense (quackery) about carbs and T3. And those who promulgate this crap just show their ignorance of the science. I have had to bite my tongue for a long time. They are not clinicians and they just are not aware of what they do not know. People need to get the real low down for their own well being. Read A. B. Dada’s quote in the post. He said it best.
      Low carb by itself or with paleo fails because they dont eat Epi-paleo and paleo fails for the same damn reason but destroys the body slowly doing it by the time they get to middle age. I call it epi paleo because it pre dates paleo in time and it also works 100% on epigenetics……..and that is where the EPI comes from. It has never been about our genome……….it is how our genome is expressed. These details were gone over meticulously in BG 4. What sculpted our genome is what selected for the Epi-paleo diet. It is the fuel that our brains work best upon. It is not offal and bacon alone.

  28. NON GEEKS TRUTH BOMB ALERT: If you carb up, and increase your cross fit participation to raise your T3 as ‘paleo theory‘ tells you to consider, you likely will be having surgery sooner than you think. If you do not believe that go look at internet forums and see how many young people have to have surgery to repair themselves after WOD’s because they are specifically deficient in iodine while simultaneously eating large amounts of “safe carbs” to support their free T3 levels to work out. You need to question that logic using evolutionary evidence. That is not the road to optimal in my view, it is the road to my operating room. That choice is yours.

    I’ve been trying to navigate that pathway for eight years, but with this information in mind, I think the evidence is overwhelmingly clear: it is paramount to my health that I turn around now, and never go back to WOD/Crossfit haven. My ambition is to keto-adapt at warp speed eating copious amounts of Nova Scotian dulse and shock a few onlookers with a sort of fitness nobody has ever seen before.

    I believe I am entitled to not one, but two things now. Physical health, and the freedom to dream. Thank you Dr. Kruse.

    • Alex I thought this part of the blog would hit you because of what you posted about your soccer and fasciotomies. I wish you would have known this back then. There are so many crossfit injuries that are unecessary if they would just look at why? Most of the physical culture folks will blame technique. I wont……..when you eat wrong and do wrong two wrongs never make a right. When you learn why you do better. Simple. It is not hard. All the science boils down to simple things we all should have known……..but were socialized to believe otherwise.

  29. Dr. Kruse –Great way to clarify so many things you have been saying. When you wrote –Once iodine goes, Magnesium is not far behind. This affects our cells ability to make energy from ATP. Our bodies ATPase is magnesium dependent

    Does that mean that in order to make ATP we need magnesium and in order to keep magnesium levels up, we need iodine?

    • @Kami you need both in high quantities and that is what BG 5 was trying to get you to understand. The brain’s metabolic demands are direct imperitives of what we need to eat. The Ferrari engine in our head requires special considerations that paleo diet fails to realize.

  30. Since pure iodine is more reactive to other elements, it’s more likely to cause problems, so iodine is usually used as “iodide,” a word that refers to one iodine molecule combined with another molecule — often potassium (KI). So, even though they’re not technically the same, for simplicity’s sake, I’ve used the terms iodine and SSKI (saturated solution of KI) interchangeably in this article (though always meaning SSKI unless noted otherwise).”
    ——————

    Lugol’s solution= Potassium iodide plus iodine.
    The one I use have 4%KI + 2% I

    Should I change to SSKI?

    Should it be (12-50)mg/day or 100mg/day is better?
    —–
    Yes, I eat scallops, crab meat, shrimps.
    Can’t locate good source for oysters.

    ……

    Thank you, this blog tied up iodine and Fatty Acids for me.

    Looking forward to more info on Fatty Acids.

    .

  31. Great Blog! ….”Protect the giant pharmacy in our heads” Words to live by.
    Seeing how the iodine fits in to everything is fantastic because it all makes sense in terms of evolution, biology and culture/history.

    I’m starting to understand how the our labs pinpoint where we are in our individual timeline of aging and oxidation. Now I can see why you can know the past and the future from lab results…it’s not rocket science …it’s having such a great knowledge of that pharmacy…I feel like I’m starting to be able to negotiate the territory with more clarity.

    • @SeaHorse if that is true then I am doing my job. That is the point of the Quilt. Piece by piece lay it out and you decide if what you been told to believe matches what you have learned.

  32. Caroline Cooper says:

    Hi Friends,

    As I have been reading this post, it has got me thinking about two books I have been reading by Jared Diamond this summer: “Guns, Germs and Steel” and “Collapse”. I would highly recommend both books especially for people wanting to understand more about the history of domestication of plants and animals and how that made some groups of people able to dominant others. Bewared, they are sad stories of oppression.

    But this post made me think about Greenland and why the Norses and Dorset died out while the Inuit prevailed. You will have to read “Collapse” to find out why. Just a hint though. The Norses were agriculturists and pastoralists. The Dorest were land based hunter-gathers. The Inuit were the masters of land and sea.

    It appears to me, your latitude will depend on what diet is suitable. At the equator lots of carbohydrates seem to give a Darwinian advantage while as you go towards the poles the game changes towards fat.

    I have been thinking about sea based foods for some time now. Iodine has been a common topic with the Weston A Price Foundation too. It has been a long term practice for WAPF gardeners and pastoralists to add kelp and sea minerals to their feed for healthy animals and to their soils to produce better quality produce. I will contemplate your reductive thoughts about iodine.

  33. A few years ago, I worked as a weight loss consultant for that chain that sells pre-packaged meals. I worked there for two years before quitting. My conscious just wouldn’t let keep pushing that “plastic” food, when all the knowledge I had told me it was bad stuff.

    Now and then I talk to one woman who still works there and told how I was eating wild sockeye salmon fried in bacon fat!! Hhahah! She thinks I’m nuts!! That’s okay though!! I’m the one laughing because so many people ask how my skin is so beautiful and how is it that I looks years younger!!

  34. I have been drinking Kevita for 1 month—eating seafood 2-3 times a day and shellfish when I can get it. My brain is starting to feel better. More clarity and more energy. I will be adding in sea veggies little by little. I am afraid due to taking iodine in the past and not being able to sleep for 3 days in a row. I am hoping that the whole food source would be better tollerated. Would you have any thoughts on why iodine would cause lack of sleep for someone and if the whole food source would be a better option?

  35. Hey Dr. Kruse. I’ve not posted before, but wanted to comment that I really enjoy reading your blogs. I am a final year med student, I find there is always plenty for me to research after you ‘shine the torch’ on science we already know, but has not yet disseminated to common knowledge. I’ve learnt heaps.
    Wondering, do surgeons prefer to retain their ‘Dr’ title in America, or do they return ‘Mr’?

  36. Dr K, if “The critical equation of life = LDL cholesterol + T3 (and Vit A) = pregnenolone. This implies if free T3 is low for any reason, you can’t make enough pregnenolone.” and “High-carbohydrate diets are associated with significantly higher serum T3 concentrations, compared with very low-carbohydrate diets.” does that mean that if one is iodine deficient and goes ketogenic that you could see a DROP in free T3? Assuming that one is epi-paleo, too, could you further assume that the diet (along with other inflammation-lowering protocols) will see the T3 rise again?

  37. Dr. Kruse, I should have clarified. It was in the past that Iodine caused insomnia for 3 days. I am doing good on the Kevita. That was the only thing I did at the time so it seemed to be the iodine. I even tried Iodoral too and it caused insomnia. Major stimulation.

  38. @Kami, on the iodine thread on the forum Grizz and others have said that supplemental iodine can cause detoxing of other halides stored in the body, which can have a long list of symptoms. You could search for that thread and info, in case it helps clarify your symptoms.

  39. Thank you Lauren, I will check it out. I am hoping that by doing a food source of iodine and not a supplement that my body will respond better.

  40. Dr Kruse, I’ve been eating salmon for lunch everyday for quite some time but also supplementing with a dropperful/day of Lugol’s. I recently had a saliva & urine test for iodine. My test result showed 650ppm in saliva but <1ppm in urine. Doc said that my body wasn't using the iodine. Was this a poor way to test?

  41. To Lauren, Jack wrote:
    @Lauren that is the most common thing that I see on a low carb paleo template without iodine…….and constipation is the result with lots of muscle cramping.

    This highlights my situation exactly after going paleo.

  42. Thinking about oxidation and reduction. When I am being active I am oxidizing. When I CT I am reducing. Both of these will result in a lowering of my BG when it is elevated.I assume in the oxidative state the BG is lowered due to energy demands. By what mechanism is BG lowered in CT?

  43. DR K, What did you mean in BG6 when you say ,,,probiotic and prebiotics being a “double edged sword”? in what way?

    Thanks
    Joann

  44. Jonathan Swaringen says:

    @Jack I think Dali was talking about the reduction in BG because of exercise…and was wondering why if exercise is an oxidized state than why does exercise lower BG.

    Also was the reduction in BG during exercise due to energy demands?

    I guess Dali is referring to the fact that exercise is oxidizing which should increase BG but doesn’t….what explains this?

    If I understand correctly at least….:P

    Hope that was understandable…

  45. Jonathan Swaringen says:

    So basically since exercise is part of an oxidized state rather than a reduction state why does BG fall after exercise? To put it another way.

  46. In my experience both exercise and CT lower BG. When i have elevated BG i will go for a brisk walk.I envision this as burning up glucose due to increased energy demand. This lowers my BG. Before and after CT I check BG and it is lower after. If I do a longer more intense activity like a workout this will sometimes result in a rise in BG. Is mild activity not oxidizing? How does CT reduce BG?

  47. wally courie says:

    @ Grace ” I was eating wild sockeye salmon fried in bacon fat!! ” I don’t know the percentage of blockage or the cite, but i have read one of Kruse’s comments that it is better to use olive oil instead of saturated fats w/ seafood. The reason is that saturated fat blocks DHA absorption.

  48. Wally…bacon fat is mostly unsaturated fat.

  49. Zorica Vuletic says:

    @ Wally, Jack’s take on bacon fat is that it’s a MUFA. It is only 50 % sat. fat.

    The sat. fat and not mixing it with seafood is in regards to the assimilation of DHA in the brain and sat. fat can inhibit this assimilation. This is something for people that are very broken and need as much DHA as possible. I believe that in a healthier individual it is OK to sometimes use sat. fat with seafood as in the case of shrimp in butter/ghee sauce (or coconut oil). So keep in mind that it is prescriptive to not use sat. fat with seafood. As Jack says, everything is in context—so for some people ‘all is not lost’ if you decide to mix once in a while. For example…I can think of a shore based diet in which coconut trees, seafood and whatever available fruits are available…so you would sort of be mixing sat fat and seafood if you decided to have some coconut with your fish etc. See the difference?

    • @Zorica Sat fat is not bad for us…..it just blocks absorption of DHA and brain specific nutrients in the diet when they are eaten simultaneously. The advice it to eat yoru saturated fat at a different meal. Its not rocket science.

  50. wally courie says:

    thanx NittDann. Bacon is not as saturated as i would have thought. Always good to be surprised. from the wikipedia bacon article: “Bacon fat is roughly 40% saturated. ….
    Four 14-gram (0.5 oz) slices of bacon together contain 7.45 grams (0.26 oz) of fat, of which about half is monounsaturated, a third is saturated and a sixth is polyunsaturated, and 7.72 grams (0.27 oz) of protein.”

    their numbers don’t add up, do they. first 40% saturated- then 333%, but the important surprising thing, that it’s not all saturated fat. Kind of a surprise like japanese Wagu beef which has omega fats.

  51. wally courie says:

    for a broken soul as i am: sky hi cortisol, crp, homocysteine, lo free t3, low free T, lo IGF1, i”m only using olive oil w/ my seafood. And i am doing a double rinse w/ those cottonseed soaked cheap-xss smoked oysters to get rid of the PUFA6. i”m taking a ton of Mg Malate and about 5gm of krill and fish oil a day. I would take more,if i could resource it.

    My first omega blood test came back null for insufficient sample. I hope i bled enuff in their little tube the second time around.
    Let’s see what the next test shows? that one, as well as the cortisol, homocysteine, et al.

  52. wally courie says:

    i”m not buying another gallon of raw wild harvested Gulf oysters. I went thru the whole gallon in two days! :) Come to think of it- that was cheaper than two good quality restaurant meals.

    On second thought, I think i will order again, but this time thru a buddy that is a U.S. Foods salesman instead of the restaurant. He could get me a substantial discount. I”ll get five gallons this time, package them into servings & freeze them. After all, we are coming up into all these months with an ‘R’ in them :)

  53. Jack, another great blog entry.

    There are high profile figures in the paleosphere who tell us that energy problems which come from low T3 levels are endemic …..that they come from naturally poor thyroid function, and must be treated with medical intervention.

    Please allow some mechanical minutia.

    As you said low thyroid production of T3 is termed Hashimoto’s disease. Hashimoto’s disease is an autoimmune condition, often an autoimmune disease, characterized by an opioid attack against transduction nerves in the hypothalamus-pituitary-thyroid (HPT) axis. The opioids come from ingested carbohydrates. Stop the attack, and provide the building blocks for production of T3. Simple.

    But low T3 levels don’t entirely point at poor thyroid function. The body uses T3 to regulate cellular metabolism. Adenosine triphosphate (ATP) is the cell’s energy currency. Mitochondria manufacture ATP from ingested sugars and fats. ATP has three phosphate ions. T3 has three iodine ions. Cells make energy by extracting and burning a phosphate ion from the ATP molecule. Extracting the phosphate ion is a dual operation. It also strips an iodine ion from T3. Adenosine triphosphate (ATP) becomes adenosine diphosphate (ADP) as T3 becomes T2.

    Ideally healthy oxidative cellular metabolism immediately reduces ADP back into ATP, and spins T2 back into T3. However, oxidatively stressed cells continue to degrade both molecules. ADP becomes adenosine monophosphate (AMP), and T2 becomes T1. Further reduction entirely destroys these molecules. If cells are healthy, and the cellular stress comes from oxidative exertion, this is great. The cell rapidly reconstructs both ATP and T3 from their respective residues. If the oxidative stress comes from poor oxygen transport or from sugar and opioid degradation of the cellular metabolic engine, this is bad. Reactive oxygen species (ROS’s) prevent reassembly of the molecules.

    As cells gain health they expel these residues. They import more food and make new ATP, and they import new T3. So poor cellular metabolism plays a large roll in causing low T3 levels.

    Now it’s time to point out that the paleo gurus who narrowly blame low T3 levels on low endemic thyroid output are the same people who narrowly focus on a few bad aspects of opioid and sugar ingestion. Humans are not naturally selected for eating many of the opioids which these paleo gurus ignore.

    Elimination of a small number of harmful opioids fails to cure the problem. That doesn’t mean the problem is beyond the reach of opioid elimination and metabolism repair ……avoidance and remediation. It means to keep searching.

    @Jack A final note. The adrenal cortex cortisol fatigue and associated DHEA and testosterone shortages you refer to are accompanied by shortages of aldosterone. Aldosterone shortages cause improper regulation of potassium and other halides. So that’s a pathway to the halide imbalances you referred to.

    Look out parathyroid, kidneys and all organs via nerve transduction insufficiency.
    ..

    • @Bob you are spot on. The quackery that has persisted in the paleo sphere is permeated by a lot of incomplete science. They got part of the biochemistry right. They do not understand how energy coupling between ATP and hormone generation is a human adaptation because of the metabolic demands a huge nervous system has placed upon basic biochemistry. This is why when I hear a rat/mice study make the rounds in blogs I just cringe. Because these are nice folks, who are not out to hurt anyone, people buy it all. The problem is people don’t get 100% better on that and we need to ask why? The answer is buried in a partial answer to complex energy problem.
      You must understand the details around the human brain to understand what is critical at the ATPase……and then you can infer how to keep an optimal energy supply. The brain’s energy needs dictate our optimal dietary needs and it is not the other way around. Paleo is good…..not optimal. That is why so much of this has been, missed by some really smart folks. It happened because their perspective was too narrow and not broad enough for our species. Because I am the guy who is pointing it out…….it has made me their target. Shoot all you want, but when you don’t get the results of the solution they are selling……..come here and read for a while and see if what I am saying is so radical. We all must be aware of what we do not know. It happens to all of us sooner or later if we think we have all the answers at some point.

  54. This link discusses the various iodine levels in different foods. The levels vary greatly in seafood, as mentioned before.

    “In summary the results of the review show the following order of geometric mean iodine content
    for the main food groups (Table 3.4):
    Marine fish (1455.9 μg/kg) > Freshwater fish (102.8 μg/kg) > Leafy vegetables (88.8 μg/kg) > Dairy
    (83.9 μg/kg) > Other vegetables (80.1 μg/kg) > Meat (68.4 μg/kg) > Cereals (56.0 μg/kg) > Fresh
    fruit (30.6 μg/kg) > Bread (17.0 μg/kg) > Water (6.4 μg/l)”

    I was surprised to see that nuts are listed as a decent source of iodine. Guess it depends on where the trees are planted, of course.

    In table 3.3, however, it lists seaweed at the top, with a minimum of 400 and a maximum of 4.5 million μg/kg.

    I need to step up my game with sea veggies!

    • @Nonchalant: “Of the natural food products, highest iodine contents are reported in seaweed, up to 4500000 μg/kg, fish oils and marine fish (geometric means 4066.4 and 1294.6 μg/kg respectively), which contain 10 times (namely 0.45 %) the amount in freshwater fish (geometric mean 102.8 μg/kg) and are an excellent dietary source of iodine (Table 3.3).”

      “Marine fish (1455.9 μg/kg) > Freshwater fish (102.8 μg/kg) > Leafy vegetables (88.8 μg/kg) > Dairy (83.9 μg/kg) > Other vegetables (80.1 μg/kg) > Meat (68.4 μg/kg) > Cereals (56.0 μg/kg) > Fresh fruit (30.6 μg/kg) > Bread (17.0 μg/kg) > Water (6.4 μg/l)”

  55. wally courie says:

    @nonchalant. thanx for the link. interesting about cherries. some sources say b/c or Red Dye No. 2. i just ordered some Life Extension “Life Extension Vitamin D with Sea Iodine and Vitamin K2, Vegetarian Capsules, 60-Count” Pretty good specs: Supplement Facts
    Serving Size: 1 vegetarian capsule
    Servings Per Container: 60
    Amount Per Serving
    Vitamin D (as cholecalciferol) – 5000 IU
    Vitamin K activity from: – 1100mcg
    Vitamin K2 (as menaquinone-4) – 1000mcg
    Vitamin K2 (as menaquinone-7) – 100mcg
    Natural Iodine from: – 1 mg
    Sea-Iodine(tm) Complex Blend
    Nova Scotian Kelp (Ascophyllum nodosum), Icelandic Kelp (Laminaria digitata), Coastal Bladderwrack (Fucus vesiculosus), Nova Scotian Dulse (Palmaria palmata)

  56. Joe Brancaleone says:

    and the chips continue to fall for me. Thank you for bringing emphasis to these things that I could not put together from the existing resources out there. I’ve always been intrigued by your input coming from another angle from the earliest comments you made on PH.
    I’m hopeful the ancestral “movement” if it remains a movement will be all the better for it, despite the tension and drama that seems to attach to these things as persona and branding always emerges in worthwhile movements.

    Looking at my own journey and also the state of so many in my life, what I once saw as the fragility of fate now looks more like ‘encrypted resilience’ buried in there somewhere. People just need the correct ‘deciphering key’ for themselves. I’ll just try to stay focused on decrypting my own resilient self. More work to be done than I once believed!

    • @Joe B I have been dropping hints for a long time. No one really wanted to listen. They choose rather to shoot the messenger. Well, now people can examine things for themselves and decide.

  57. Dear Dr. Jack,

    I appreciate the research that you share on your blog and I follow your recommendations and see some progress. I have one question and maybe you’ve already answered it elsewhere. You talk about creating a Ferrari, a physical machine with magnificent powers, but a machine is only as useful as the purpose to which it is put. One could create a perfect physical specimen, but to what use should it exist? Certainly we do not want to simply drive the Ferrari around cornfields.

    Do you write about what would be a good purpose to put one’s body once it is humming like a Ferrari? Otherwise it would be like collecting a huge workshop of wonderful tools and then not creating anything with them.

    Jack

  58. Jack says “@Jansz Fatty acids are coming…….I am just cooling down.”

    HAHahahaa!

  59. DR K, What did you mean in BG6 when you say ,,,probiotic and prebiotics being a “double edged sword”? in what way?

    Thanks
    Joann

  60. Wow…. this just set off a dozen questions for me —
    @ Dr Kruse re “80-90% of hypothroid now is Hashi’s”
    Is this diagnosed any other way than elevated TPO or reverse T3? Thx!

    PS I can’t believe what a difference the glasses make! From the very first night! Between this and 1 week epi-paleo, and i have so much less chronic pain – unbelievable! Thank you, Dr. Kruse! Thank you!

  61. “something big” would be a colossally egregious understatement… & you’ve helped me do more in one short week than dozens of doctors (costing tens of thousand of dollars) managed over the years! And i’m just getting started! :) again, thank you!

  62. wally courie says:

    revisiting bacon specifically and animal fat generally. it it is pastured, organic, then probably good. But isn’t fat where the fat soluble toxins are stored: PCB’s, pesticides, excess Arachanoid Acid. I would hope that most people patronizing this blog stay away from the meat of poor tortured factory animals, but there’s Engle’s law. Some have no choice. those w/ lower disposable incomes spend more proportionately on food and probably shop at Wal-Mart. (not known for its Organic correctness).

    Bacon is incredibly addictive, a domino food, i have to admit. I once worked at a restaurant where the owner chewed out the cook for cooking it perfect and crisp for the buffet line. He said people would eat too much of it, to cook it limp instead. The idiot- he should do it right or take it off the menu.

    • @Wally…….I am going to blow your mind further……I dont care what kind of bacon you eat….pastured or not and I could care less if they have nitrates in them too. Why? Future blogs.

      Every so often, mainline medical advice reverses itself about something important. For example, what was bad becomes good or what was good becomes bad. That happened with Vitamin D in recent years when stern warnings never to exceed 400 IU a day gave way to recommendations that it is good for older people to take anywhere up to 4,000IU per day (still too low for some). A reversal may now be taking place having to do with whether nitrates and nitrites lead to cancers and Alzheimer’s Disease and are therefore bad for you, or whether they have great cardiovascular effects and are therefore good for you. There is controversy about this, clashing and clanging of gears as contradictory health advice is commonly given even today. It is the pendulum of advice that confuses patients who cant decipher the medical literature.

      The issue at hand is whether it is good or bad for your health to consume foods containing high amount of nitrates and nitrites, foods like processed meats and certain supplements like beet root juice. The controversy extends to whether the large quantities of nitrates used in mass-scale agriculture constitutes a public health hazard because of contamination of public water supplies with nitrates. Is this good or bad for public health?

      The arguments against consumption of substantial amounts of nitrates and nitrites are both old and new and are fairly convincing:

      · Nitrites are converted into nitrosamines under a number of conditions, and nitrosamines are known to be toxic or carcinogenic.

      · Exposure to nitrates, nitrites and nitrosamines is correlated with higher incidences of Alzheimer’s Disease, Parkinson’s disease and diabetes.

      · Consumption of foods containing large amounts of nitrates or nitrites lead to higher incidences of several cancers.

      · Shorter telomere lengths, biomarkers of aging, are associated with consumption of processed meats containing nitrates/nitrites/nitrosamines, but not with consumption of unprocessed meats.

      Nitrates/nitrites/nitrosamines and Alzheimer’s Disease, Parkinson’s disease and diabetes

      Consumption of excess nitrates/nitrites/nitrosamines seems to play a role in creating or worsening these disease processes.

      Then in 1999 this Gem shows up: http://www.ncbi.nlm.nih.gov/pubmed/10615207

      Inquiring minds begin to question CW advice in avoiding nitrites. Not the paleo world…….guys like me look why it is OK. The answer is no USDA or FDA database.

      Until very recently nitrate was perceived as a purely harmful dietary component which causes infantile methaemoglobinaemia, carcinogenesis and possibly even teratogenesis. Epidemiological studies have failed to substantiate this. These type of studies are worthless for causation but if nitrites etc were bad we should see some blip in epidemiologic studies at some point.

      Guess what Wally? It has been shown that dietary nitrate undergoes enterosalivary circulation. Remember what I taught you about in the blog called the teeth in disease? That there is a pump in our teeth controlled by our brain by a hormone! Enterosalivary circulation is unknown in paleo land. These dietary chemicals are recirculated in the blood, concentrated by the salivary glands, secreted in the saliva and reduced to nitrite by facultative Gram-positive anaerobes (Staphylococcus sciuri and S. intermedius) on the tongue in the oral cavity. Salivary nitrite is swallowed into the acidic stomach where it is reduced to large quantities of NO and other oxides of N and, conceivably, also contributes to the formation of systemic S-nitrosothiols. NO (nitric oxide) and solutions of acidified nitrite, mimicking the gastric conditions (pH), have been shown to have antimicrobial activity against a wide range of organisms. In particular, acidified nitrite is bactericidal for a variety of gastrointestinal pathogens such as Yersinia (plague) and Salmonella (food poisoning). NO is known to have vasodilator properties and to modulate platelet function, as are S-nitrosothiols (better than Plavix or aspirin). Thus, nitrate in the diet, which determines reactive nitrogen oxide species production in the stomach (McKnight et al. 1997), is emerging as an effective host defense against gastrointestinal pathogens, as a modulator of platelet activity and possibly even of gastrointestinal motility and microcirculation.

      Become acutely aware Wally there is a lot we all don’t know that we think we know. Question everything my friend and rest on no answers.

  63. Hot damn!

  64. @ JJacks…

    Why would JK write about what “good purpose” a “perfect physical speciman” would apply themselves too? That would be for moralizers and politicians.

    What is wrong with driving around in a cornfield, digging ditch’s or providing for your family in an “optimal” way?

    JK is more interested in elevating this species via epi-genitics rather than watching its decline.

  65. JJack, it’s not just the body that becomes a Ferrari. It’s also the mind. So you get all the tools (switching to your analogy) and also the creativity to use them. A win-win!

  66. @ Wally Courie…

    Crisp and crunchy bacon is not the way to serve bacon. On Conan O’Brien’s TV show he had this guy on a while ago who is like this bacon expert and it was his opinion that cruncy bacon is taboo. I agree.

  67. You have talked about thinking of food as information. I have been rolling that around in my mind for a few weeks.I think activity like HIIT is also information. I have been doing less exercise and continue to have improved body comp. I’m beginning to think that the body only needs to be reminded what it needs to do and doesn’t have to do it chronically. All I need to do is remind my body that it needs to run really fast sometimes and it takes care of the rest if all the pieces are in place. This is fascinating and starting to be fun.

    • @Dali Many of the gym onwers and Phd’s in paleo have this belief that exercise is critical. What other species lift weights in a gym or does WOD? I think Erwan LeCorre is so far ahead of the rest of the paleo krewe on this topic it is not funny…….he moves naturally like a human should.

  68. David Porter says:

    Is canned salmon ok to eat every day? The only fresh salmon we have where I live is farmed, and I’d rather not eat that.

  69. Exercise involves compromise. Too many people think they can be optimal without exercise. They can’t. Too many people exert for the purpose of exertion. They harm themselves.

    One of the biggest benefits of exercise is the clearing of toxins and waste products, both inside of cells and in the extracellular matrix (ECM). Example: You decide to eat kelp as an iodine supplement. Kelp contains monosodium glutamate. No mater how selective we get, we get permeated with harmful proteins like glutamate and aspartate.

    Exertion elevates metabolic rates. Exerting cells can use glutamate and aspartate for energy. The elevated metabolic rate supports a high chemical throughput. Exertion depletes glutamate and aspartate in the ECM with relatively little harm.

    Consistently low metabolic rates allow glutamate and aspartate to concentrate in the ECM. Cells are forced to import and burn glutamate and aspartate in low exertion mode. Cells cannot burn flavonoids for energy in low exertion mode. They can only burn flavonoids for tissue creation. But flavonoids corrupt tissue creation pathways, causing cells to create mutated tissue.

    So flavonoids can only be safely disposed of during aerobic exertion.

    I’ve always been a runner. I like the simple rush of placing one foot in front of the other while watching the scenery pass. It makes me healthier. Like most people my endurance waned as I aged. My waning endurance was well below my capability. Something was wrong, but I was like the frog in a pan of water. The heat was rising so slowly that I didn’t notice.

    I got a tip, and stopped eating grassy grains. Overnight my running endurance doubled. Subsequent testing showed similar results with elimination of potatoes and beans. My research shows that the harm to endurance in these carbohydrates comes from their lectins. Lectins clump red blood cells together. Clumped red blood cells can’t transport oxygen. If I had not been testing the extent of my endurance I might not have recognized the benefit of lectin elimination.

  70. Thanks for the replies, D_Ray & Nonchalant

    I did not say that Dr. K should moralize. I respect that his focus is on physical chemistry. I simply asked if he had written on other facets of this topic that also interest me. Perhaps not.

    Since going Kruse-style epipaleo and CT, I have noticed mental and emotional changes that are superior to both pharmaceutical and herbal remedies for depression, so I can see how chemistry has multi-layered benefits on more than the physical level.

    I also have found that the reverse is true, that thoughts and feelings can influence the physical in both beneficial and harmful ways. Just as there is a discipline in having the best diet, there is also a discipline in having an open heart, positive thoughts and being engaged in meaningful work. I do not think that this is an area of moralizing, but is just as scientific as the chemical sciences, even if the nomenclature of the field is still primitive. Just as our chemical selves are very complex and interactive, so too our emotional and mental states contribute to the mix. This complex is certainly influenced by how we spend our time, what we do with our days, and how we present ourselves in relationship with other humans. These are the facets that my question was addressing.

    If we are “evolving” into some optimal state, then there might be some kind of way to ascertain whether one can improve upon how one is improving toward this optimal state in ways other than lab results, even if it is simply comparing anecdotal stories about what I have done and what has worked for others.

    Jack

  71. Mitch Moore says:

    @Jack…..during our skype you said the coming BG-12 would address my issues and Oh Boy does it ever!
    so I wonder if while beginning to consume MUCH more iodine containing foods, might it be beneficial to supplement with iodine to more quickly reach optimal physiologic levels (possibly to raise T3 in a situation of only moderate levels of cortisol, elevated LDL, elevated TSH, and low T4 and T3)? If so which form of iodine might be most effective – KKSI, KI, other?

    • Mitch I am a fan of iodine the way evolution delivers it…..in food. But if you use iodine you can use SSKI. Lugol’s over 2.2% cant be bought in USA any longer but you can buy it from Canada and Mexico.

  72. “I also have found that the reverse is true, that thoughts and feelings can influence the physical in both beneficial and harmful ways. Just as there is a discipline in having the best diet, there is also a discipline in having an open heart, positive thoughts and being engaged in meaningful work.” “Just as our chemical selves are very complex and interactive, so too our emotional and mental states contribute to the mix.”

    JJack that is so true.
    I hope you will join us in the forum. We share lots of those anecdotal stories. :)

  73. Patty Cakes says:

    Dr. K it is an amazing personally relevant blog! Thank you. It has taken me three days to get through it because I read so slow as to comprehend each piece. I printed it out so DH will read it as well. I need to read it again and again to get it all to sink in. It connects more dots for me. This is the info I would love to see in lecture format with pictorials. I’m a visual learner and reading is usually good but with this one I want charts, graphs, etc. Maybe your book has some of that….can’t wait for it’s release.

  74. Does the SSKI drops put on skin or toe nails raise the Iodine level in your body? If so is this a concern. Also, can Nascent Iodine be used in place of SSKI? Here is a link to Iodine Supplementation with Nascent Iodine; http://www.naturodoc.com/nascent_iodine.htm

    I took SSKI drops for sporotrichosis that had spread to the lymph system in my left are. This was 15 years ago. I took it for several months. After reading about SSKI on the Internet, I am amazed that I did not damage my thyroid.

  75. John Downey says:

    Wow. I must have some good brain fog. I do know that I have been reading since Sunday off and on, and going slow to comprehend all the information and medical terms. It is very interesting. I read in the comment section that fresh water fish are fourth on the list above oysters, crustaceans, and regular ocean fish. Since I have always lived along the shores of Lake Erie, it is apparent that I should finally get a fishing license. I also noticed your mention of my suspected osteoarthritis. I was surprised when I was told my diagnosis of cervical stenosis. Are you implying here that it may be reversible with diet? How long could that take? Besides grains, what other foods should I be careful of?

    • @John Downey It depends upon how bad the stenosis is……sometime we can help it immensely without surgery and other times it is too far gone. That is what educational consults are for.

  76. @ JJack…

    Sorry for misconstruing your earlier comment.

    I too think a lot about our “emotional and mental” states. And I keep coming back to the conclusion that we are merely a product of our bio-chemistry. (Where does that leave free will?)

    I have a very young cousin who has a “brain disorder” and he has no innate fear of anything…people, places, things, animals, height, water, etc. Don’t remember the name of this condition. But if he had “normal” brain chemistry, he’d be a different person.

    Anyway, once “optimal” or not, no telling where one could ultimately go. Hopefully “mindful” as JK writes about but could go the other way, i.e., “Baby face” George Nelson.

  77. Dr. K,

    What if someone is allergic to oysters and shellfish? What do you recommend then? Still go ahead and eat it or just settle for crustaceans, fish, seaweed, etc. Thanks.

    • @PeteHall After I found out the real cause of the problem I would get desensitivity treatments so I could eat them……and I bet that person has a serious leaky gut as the real cause and is not allergic at all.

  78. wally courie says:

    @DRAY: “I too think a lot about our “emotional and mental” states. And I keep coming back to the conclusion that we are merely a product of our bio-chemistry. (Where does that leave free will?)”

    biochem is ultimately based on quantum mechanics, the theory which underlies small scale planck length phenom, which is rich in UNCERTAINITY and is not determined by classical mechanics.

  79. I have measured with Ketostix strips for ketones in my urine, while eating less than 50 grams of carbs daily for 2 months and did not register any ketones. I assume this is because of the high protein vs fat in my diet. Can one be eating a ketototic diet and not be in ketosis? This is confusing to me. I have upped my fat content and still did not show any ketones. Should I keep increasing my fat content until I am in ketosis?

  80. Jonathan Swaringen says:

    @John Downey I don’t think there would be any harm in trying.

    http://jackkruse.com/brain-gut-6-epi-paleo-rx/

    This post pretty much has everything regarding nutrition you could want.

    http://jackkruse.com/easy-start-guide/

    Leptin RX/CT might be a good idea as well.

  81. Jonathan Swaringen says:

    @BobWayne Check out Jimmy Moore’s blog if you haven’t yet.

    http://livinlavidalowcarb.com/blog/jimmy-moores-n1-experiments-nutritional-ketosis-day-1-30/14409

    Hes up to 120 days on a nutritional ketosis experiment. Protein from what I’ve read can stop ketosis because of it getting converted to glucose.

    I’ve read things that go against that issue…I think but if there are other reasons for ketosis stopping that don’t involve glucose production I don’t know what it is?…

    I think the 75 gram protein breakfast would keep you out of Ketosis for at least the first part of the day…though after the Leptin RX I don’t know if the recommendation is to keep eating tons of protein….Jack? Too much information out there I’m overloaded.

  82. Zorica Vuletic says:

    @BobWayne and @Jonathon I know Jack recommends going to more fat once Leptin Rx is completed. The high protein BAB has to do with signalling and re-wiring of hypothalamus etc. (His explanations of course being better than mine, lol). Yes, so after that…the reliance on higher fat and moderate/medium protein is ideal.

    Hope this helps. :)

  83. Dr. Kruse, this post is FASCINATING!!! Thank you! If a person tests deficient in vitamin D, is it an indicator that it might be a precursor to cancer or other disease?

  84. To all: in the States, your right to access natural health options such as vitamin and mineral supplements is under attack by the FDA. The FDA stunned supplement manufacturers with its proposed Guidance that would require all dietary ingredients introduced into the marketplace since 1994 to undergo drug-like safety testing prior to marketing. The tests could cost millions of dollars per each new ingredient, and that includes each variation on that ingredient too. And each supplement manufacturer would have to test each ingredient, even if another manufacturer had already done so. This is the first step in their attempt to make supplements available by prescription only.

    You can make a difference. You can contact your local Congressman/woman and demand they support HR. 3380. Below is a link to locate and contact your local representative.

    Imagine if all the great supplement recommendations Jack has made for optimal health weren’t available in the States. Just ask the Kruisers in Europe about supplement availability.

    http://act.thenhf.com/5602/hr3380-dietary-supplement-protection-act-dspa/

  85. Oops–forgot to ask one other question–why won’t more doctors test for iodine deficiencies? I’ve heard doctors use whether or not patients have a goiter as their measure on whether to test or not.

  86. Lisa Hudson says:

    I have Hashi’s and have heard/read several things that say iodine is contraindicated with Hashimoto’s. Is this more misinformation?

    I am a big fan of this blog and your teachings- I have been incorporating more seafood into my diet per your Epi Paleo Rx. I have signed up and paid for an educational consult, but have not scheduled it yet.

    Thank you for the work you do!

    • @Lisa it is a myth…..but there is some truth to the fact most people with Hashi’s have severe gut issues that cause them to react to many foods in an altered fashion……when you slowly repair it using the correct dietary tools and follow their hormones and use the EPCOTx protocol things get better. Sept Webinar is on the EPCOTx protocol……so if your interested, if there are any tickets left after our members sign up you could listen.

  87. True or False: Thyroid cancer is the fastest growing form of cancer in the United States.

    TRUE: In fact, thyroid cancer is more common in women than in men, but rates are rising in both men and women.

    http://www.huffingtonpost.com/donna-gates/thyroid-cancer_b_1553141.html

  88. Yvonne@ In the ‘old” days they used to use PBI (protein bound iodine) blood test and cholesterol to dx thyroid. I think it was replaced with their “darling” TSH (thyroid stimulating hormone)

  89. Lisa Hudson says:

    Thank you so much for the quick response- I’m really looking forward to the consult and will check into the Webinar too!

  90. BobWayne, I think someone mentioned that ketosis is iodine dependent. Perhaps that is an issue?

  91. Epic Post Jack. Its taken me 5 days to truly absorb the importance of it.

    This epic has driven me to ask the following questions to you and my PCP (they can be rhetorical for you if they’re too specific).

    Is my Low T3 really low if I’m eating an optimal Epi-Paleo RX? before this blog I would have thought having Low T3 is problematic – but I think not. I think my body was doing what its designed to – however, I wasn’t feeding my brain what it needed (which is why I’m in the health state I’m in).

    So eating Epi-Paleo and the increase in natural iodine consumption explains why I feel like my thyroid has turned on w/in the past 8 wks of really pushing the Epi-Paleo Rx.

    Additionally is that Low T3 suboptimal b/c its impacting hormone production because of circadian mismatches and lack of iodine, with the end result being pregnenolone steal?
    so, Theoretically, If this is my only problem, the Epi-Paleo Rx will fix this due to sufficient iodine, correct?

    The next statement that’s rolling around my brain is: When you have Low T3, you produce rT3 as a workaround to prevent ROS, I think in certain situations (short term not stressed neolithic life) this could be a good thing b/c rT3 protects us from ROS in times of stress.

    Additionally if rT3 is an oxidative protection mechanism it is also a good indicator of pregnenolone steal?

    The final takeaway I get from this blog is that If I have Low T3, adoption of the Epi-Paleo Rx will allow my body to recover its Iodine state – which will begin to push changes in the T4-> rT3 conversion, back to T4->T3, which the body can use to convert LDL w/Vit A -> pregnenolone
    and from the pregnenolone -> progesterone -> all other steriod hormones.

    All I can say is WOW.

  92. Jack,has the email about signing up for the Sept webinar on Tuesday been sent to the Klub and Karnivore members yet?

  93. @Rob Regarding your email on the best platform for the brain and heart: Read this:http://www.foodnavigator-usa.com/Science/High-fat-diet-may-boost-functioning-of-damaged-hearts-Study

    Sometimes what you been told is just what you been told.

  94. @ Gretchen- Nice! You get the big WOW. I hope my brain functions this well someday.

  95. Andrei Yakovenko says:

    Hi, first of all Dr. Kruse I am a huge fan of yours. Thanks!

    I have a question regarding LR and CT. Has anyone experienced loss of sleep due to either procedures, if CT is done after 9PM, roughly within an hour of sleep time? Just started LR and CT a few days ago. Very low carbs, high proteins and fats (grassfed stuff), eating on the prescribed schedule. Then around 9-10PM I do CT with face dunking to cold water with ice. Normally I wake up at around 6-6:30AM (no alarm clock). On my first morning after CT I woke up at 5AM, second morning 4AM, this morning 3AM…Looks to me that my cortisol is spiking a bit too soon… Should I eat high protein breakfast right there at 3AM or wait until 6ish? Has anyone else experienced the same effect? I could probably try doing CT in the morning and see what happens, but was curious if what I am experiencing is a known effect.

    About me: male, 38, ~185lbs, 5.9ft, ~19%BF, do High Intensity Training (HIT) 1-2/wk. On Paleao Diet since January 2012 (mostly 80/20 rule). Had Hep C (did the treatment and now it seems to be cured), I find if I eat lots of fat I may wake up in the middle of the night feeling a bit nauseated (does not happen very often, but have this once in a while seem childhood). Otherwise consider myself do be healthy.

    Many thanks for answering my question,
    Andrei

    • @Andrei yes……those who are quite oxidized can have very unusual reactions especially to CT. This is due to detox of fat liberation and toxins. With Hep C your liver is likely not metabolically able to handle large loads of fats…….adaptation for you will be slower……but CT would help.

  96. @ Andrei How long before sleep are your last calories? Should be 3-4 hrs.

  97. Andrei Yakovenko says:

    I eat by 7PM my last meal.

  98. Andrei, yes I experienced sleep disruption with CT for about a month. The LR greatly helped my sleep, but when I started CT a couple months later, my sleep became disordered again, like you are now experiencing. I had to just force myself to stay in bed. I think you should wait until 6am to eat. Be patient and you should regain proper sleep patterns.

    I was doing CT in the mornings, back when I started and was experiencing problems. I kept doing CT in the mornings and my sleep settled down nicely. Currently I now CT in the evenings, and I also sleep very well.

  99. Andrei Yakovenko says:

    @Nonchalant Many thanks, this helps a lot.

  100. Andrei Yakovenko says:

    Thank you Dr. Kruse, I will keep that in mind.

  101. It looks like EPA plays an important role in prevention of cognitive decline. I thought this is more the role of DHA. Have taken extra DHA because I am using Krill oil and that has little DHA.
    Here is a link of a study:
    http://www.vitasearch.com/get-clp-summary/40404

  102. Another link from Barry Sears (Zone) which illuminates the role of EPA/DHA in the brain. Does anybody know what the optimal ratio of the two is?

    http://www.zonediet.com/blog/2011/05/the-fallacy-of-using-dha-alone-for-brain-trauma/

  103. Thanks for another great learning curve. To follow up on what Gretchen said earlier
    “The final takeaway I get from this blog is that If I have Low T3, adoption of the Epi-Paleo Rx will allow my body to recover its Iodine state – which will begin to push changes in the T4-> rT3 conversion, back to T4->T3, which the body can use to convert LDL w/Vit A -> pregnenolone
    and from the pregnenolone -> progesterone -> all other steriod hormones”
    I like this reverse chart- makes sense to me and no doubt with application will fix all of us. This still depends upon addressing and managing cortisol and leaky gut issues-right?.

    • @Jude you my dear are closing in optimal……..because you are getting the larger message of what each blog does to the Quilt………piece by piece all the stuff I been telling you all is beginning to make sense from nonsense. That is my ultimate goal. I am just the dude holding the flashlight while you examine the evidence of what makes us tick.

  104. @Jack, thanks for the hint on Omega3 metabolism. Looking forward to it.

    @Jude, there is evidence that the “most healthy foods” (like broccoli, brussel sprouts, kale and cauliflower) are contributing to thyroid disease because they are goitrogenic.
    I have been happily eating those in large quantitites in the past (because of their strong anti-cancer properties) and was surprised that I have to pay for this with reduced thyroid function and low T3 and T4.
    Wonder if I cut back on those foods the thyroid function may normalize again?

  105. @ Werner,have noticed a big difference in energy=thyroid function, since going fish x2daily(3weeks). Hubby doesn’t want to go there yet and he hasn’t had the energy change….We have super optimal Vit D. Haven’t been big on the vegs you quote mainly because of our very high rT3’s.
    Good explanation here http://www.hairlossclinic.com.au/blog/2012/03/14/reverse-t3-when-the-body-shoots-blanks/

  106. Jerry Malone says:

    @Jack, this is off topic, but here’s an interesting article:

    http://www.sciencenews.org/view/feature/id/345277/title/Tricks_Foods_Play

    You’ve covered some things in this article, but what really caught my eye was they claim that that linoleic acid causes inflammation and periodic cell death in the arcuate nucleus (around paragraph 17 or so).

    For what it’s worth…

    • @Jerry when BG 13 goes live…….you will really sit up and pay attn to this. I said in my TEDx talk that obesity is an inflammatory brain condition…….now I am going to show you why obesity is organ failure in parts of the brain called the hypothalamus.

  107. The September webinar rocked. Looking forward to the Q&A session on Tuesday. There is a lot for me to absorb particularly with my own leaky gut issues. I appreciated learning how to schedule the resveratrol and the curcumin. Good practical stuff. Thanks! I appreciate the webinar format because it helps this brain put things together better than just reading online. It was fascinating to learn about the microfilm and how to reset with the magnesium and coconut oil. I am almost always a four with the Bristol chart. Sometimes I get to a three when I am taking the iron glycinate. Knowing that I do have gut issues why would it still be a 4 and not either end of the chart?

    • @Glamazon I am glad you enjoyed it. I am trying to give you all something you cant find anywhere else. I look under all the stones everyone else steps on to look for new questions to ask.

  108. I did want to add that Misty’s microphone wasn’t muted and it was difficult to hear the last 7 minutes of your talk. It showed muted but her conversations were still coming through.

  109. Inger Larsen says:

    “Sebaceous cysts are another example of SSKI’s ability to dissolve fats and oils. Unlike breast and ovarian cysts, sebaceous cysts contain oily, fatty material and usually appear rather suddenly on the face or in the groin area. But the good news is that you can get rid of them just as quickly as they come on – generally in just a week or two – by rubbing in a mixture of equal parts SSKI and DMSO”

    Now I am going to smear my small lipoma I have (since my “vegetarian-and vege-oils-period” many years ago) with Iodine.. I am curious if it will disappear? CT has not really worked to shrink my lipoma much so far even if a lots of other benefits. I have not iced it that very much, though. I could do a “seaweed-plaster” too I guess. Hmmm.. very intresting..

    I am wondering about rancid PUFAs in seafood. If it matters much. I eat some not so fresh fish and time. And do PUFAs go rancid with heating? I only cook my seafood very shortly, if. I wonder how big an issue is this, ore is it an issue at all? Maybe the high Iodine protects the body enough?

    • @Inger PUFA’s do go bad with heat because of their double bonds. Light can do it too. Iodine is what protects the PUFA double bonds in the cell membranes of humans.

  110. Inger Larsen says:

    Jack, that tells me to enjoy especially the fattier seafood raw if possible, and eat it as fresh as possible.. That is how my body feels best too.

    I cannot believe how velvet-like my skin have gotten the last weeks. It took months and months, it was so dry at many places after I stared CT, like snake skin, huh. Now.. my skin is just so very smooth on my body, without using anything! I eat seafood minimum 2 times / day. I aim for 3 times. Seafood only.
    Wow.. it feels just great! I am addicted to cold, dark and boring too now.. so strange. I never could imagine in my wildest dreams I would ever like that? Something strange is happening. It is like my body and mind crave it.. finally realizing that is what have missed so badly all these last 35 years.

    • @Inger When Brain Gut 13 goes live you will see why seafood has that effect on you. I think it is wonderful that you have shared your story with the members of our forum.

  111. But in some people, iodine makes Hashimoto’s much worse. Not just iodine supplementation, but dietary iodine, too. Of course, In some people, it makes it better. What’s going on with that?

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