Leaky Gut / Grain Brain

The Leaky Gut Prescription

Well, we have talked about the gut in three other blogs so far. (1) Could It Be the Gut?: An Introduction to the Brain-Gut Axis, (2) Your VAP = Brain Gut Axis Function, and (3) Why Leaky Guts Lead to MS? Click those links or go to my home page under Brain Gut Axis and find each one for a quick review. We have hinted at the leaky gut as a cause of serious human disease in all those posts. Today we get to focus on the "leaky gut" and how we might offer to treat it. What is a leaky gut syndrome? It is the complex biochemical reactions that occur in the gut appear to be the genesis of where inflammation initially passes in to our body. We need to realize this and avoid eating the things that cause this inflammation. As I have said for close to five years now this means strict avoidance of omega 6's, all grains and especially wheat of any kind and very limited fructose (fruit or synthetic sources) The gut associated lymphatic tract (GALT) is the first place where our immune systems interact with the outside world. This occurs right below the intestinal brush border and is our first line of defense. It seems to me that evolution has dictated that this is precisely where the battle between health and disease begin in humans and why our immune system is set up ready on that battle front.

By Jack Kruse|July 30th, 2011|Adrenals, Anorexia and Bulimia, Autism, EMF, Fibromyalgia, Inflammation, Leaky Gut / Grain Brain, Nutrients and Supplements, Optimal Pillar 3, Optimal Pillar 5, Series: Leaky Gut, The Digestion Connection, The Leptin Prescription, The Optimal Paleo Diet|306 Comments

The Leaky Gut Prescription

Well, we have talked about the gut in three other blogs so far. (1) Could It Be the Gut?: An Introduction to the Brain-Gut Axis, (2) Your VAP = Brain Gut Axis Function, and (3) Why Leaky Guts Lead to MS? Click those links or go to my home page under Brain Gut Axis and find each one for a quick review. We have hinted at the leaky gut as a cause of serious human disease in all those posts. Today we get to focus on the "leaky gut" and how we might offer to treat it. What is a leaky gut syndrome? It is the complex biochemical reactions that occur in the gut appear to be the genesis of where inflammation initially passes in to our body. We need to realize this and avoid eating the things that cause this inflammation. As I have said for close to five years now this means strict avoidance of omega 6's, all grains and especially wheat of any kind and very limited fructose (fruit or synthetic sources) The gut associated lymphatic tract (GALT) is the first place where our immune systems interact with the outside world. This occurs right below the intestinal brush border and is our first line of defense. It seems to me that evolution has dictated that this is precisely where the battle between health and disease begin in humans and why our immune system is set up ready on that battle front.

By Jack Kruse|July 30th, 2011|Adrenals, Anorexia and Bulimia, Autism, EMF, Fibromyalgia, Inflammation, Leaky Gut / Grain Brain, Nutrients and Supplements, Optimal Pillar 3, Optimal Pillar 5, Series: Leaky Gut, The Digestion Connection, The Leptin Prescription, The Optimal Paleo Diet|308 Comments

WHY LEAKY GUTS LEAD TO MS?

READERS SUMMARY: 1. What determines our ultimate health fate? 2. What exactly is epigenetics? 3. How does an autoimmune disease begin? 4. Is multiple sclerosis tied to gut inflammation? 5. What is an inflammasome and why is hypomethylation so critical? My first post on epigenetics seems to have stimulated a lot of talk based upon [...]

By Jack Kruse|July 29th, 2011|Cancer, Diabetes, Epi Paleo, Epigenetics, Hashimotos / Grave's Disease, Inflammation, Leaky Gut / Grain Brain, Longevity Principles, Mitochondria, MS - Multiple Sclerosis, Optimal Pillar 5, Series: Leaky Gut, The Leptin Prescription, Thyroid|Comments Off

WHAT MIGHT CASEY ANTHONY AND OJ HAVE IN COMMON?

Do you have dark circles under eyes? Are your eyes sunken to some degree? Do you sleep poorly? Have you lost your energy? Sex drive gone? Do you bloat and start getting unusual bowel movements? Do you live in a plateau phase constantly? Has your weight remained the same too long? Tired for no reason? Need to drink a ton of coffee and salty carb snacks to get by? Do you still crave sweets? Do you feel generally rundown? Do you exercise a lot but still have belly fat that is resistant to loss? Are you forgetful often? Hair loss or brittle? Diagnosed with GERD (dysbiosis) and feel nervous often? Often depressed? If this sounds like you welcome to the diagnosis of adrenal fatigue. Many conventional docs don't buy this diagnosis but that is because they can't see what they are not looking for. This syndrome is most often seen in middle age women and can present with multiple endocrine changes that are often confused with thyroid issues or perimenopausal changes. Men do get this syndrome and most often it is seen with dietary issues and fatigue from working out or from chronic stress.

By Jack Kruse|July 8th, 2011|Adrenals, Depression, Endometriosis and PCOS, Estrogen Dominance, Heart Disease, Hormones & Methylation, Hypothyroidism, Leaky Gut / Grain Brain, Nutrients and Supplements, Optimal Pillar 2, Optimal Pillar 5, Series: Leaky Gut, The Importance of Sleep, Thyroid|Comments Off

CANCER HITS, WHATS NEXT?

READERS SUMMARY: 1. What to do when you get a new cancer diagnosis? 2. Is the main cancer battle field oncologic treatment or in your own body? 3. How does diet play a role? 4. How to deal with your new doc the oncologist? 5. Do not be afraid of exploring every possibility to win [...]

By Jack Kruse|July 7th, 2011|Breast Cancer, Cancer, Epi Paleo, Leaky Gut / Grain Brain, Longevity Principles, Nutrients and Supplements, Series: Leaky Gut, The Leptin Prescription|Comments Off

CANCER HITS, WHATS NEXT?

READERS SUMMARY: 1. What to do when you get a new cancer diagnosis? 2. Is the main cancer battle field oncologic treatment or in your own body? 3. How does diet play a role? 4. How to deal with your new doc the oncologist? 5. Do not be afraid of exploring every possibility to win [...]

By Jack Kruse|July 7th, 2011|Breast Cancer, Cancer, Epi Paleo, Leaky Gut / Grain Brain, Longevity Principles, Nutrients and Supplements, Series: Leaky Gut, The Leptin Prescription|72 Comments

Could It Be the Gut?: An Introduction to the Brain-Gut Axis

READERS SUMMARY: 1. What is the brain gut axis? 2. What diseases likely are tied to its breakdown? 3. Why might medical training force us to miss the importance of this axis? 4. How did I discover the brain gut axis in my own clinical practice? 5. Did evolution dictate where the initial battle of [...]

By Jack Kruse|July 6th, 2011|Autism, Cancer, Colon Cancer, Depression, Inflammation, Leaky Gut / Grain Brain, MS - Multiple Sclerosis, Optimal Pillar 5, Osteoporosis, Series: Leaky Gut, The Digestion Connection, The Leptin Prescription, The Optimal Paleo Diet|15 Comments

My Leptin Prescription

I have been asked by many to put a short post out about how I reverse Leptin resistance in my own clinic for my patients. After reading all of the comments left here, at MDA, and on Jimmy Moore's forum, I decided that it was a good idea. 1. First make sure you really are Leptin resistant (LR) to begin with. The easiest way to do this if you are heavy is to look in the mirror. If you're overweight you definitely are Leptin resistant. If you still have a large appetite and crave carbohydrates, especially at night, these are also signs that you are likely Leptin resistant. If you are fit or in decent shape and not sure based upon the above symptoms, I would tell you to go get a blood test and check your reverse T3. It will be elevated. I also recommend simultaneously checking a salivary cortisol level. With LR, you will always see higher cortisol levels later in the day. 2. To regain Leptin Sensitivity (LS) follow a strict Epi-Paleolithic diet. To see an outline of a strict Epi-Paleolithic diet, read Brain Gut 6: Epi-Paleo Rx. The type of fuel you eat is important initially in eliminating the foods that cause Leptin receptors to become nonfunctional.

By Jack Kruse|June 29th, 2011|Circadian Cycle, Epi Paleo, HIIT - Heavy Weights, Leaky Gut / Grain Brain, Live your Optimal Weight, Longevity Principles, Mitochondria, Optimal Pillar 3, Series: Leptin, The Importance of Sleep, The Leptin Prescription, The Optimal Paleo Diet|1,162 Comments

WHY DO WE SLEEP?

READERS SUMMARY: 1. Why do we sleep? 2. Does sleep control metabolism and cell growth? 3. Do all living things sleep? How long is too long or too little? 4. What are the stages of sleep? 5. Can sleep help prevent degenerative aging diseases and cancer? 6. Is sleep the primordial condition or did it evolve as we did? Why do [...]

Dancing Between Purity and Pollution

Mitochondria can allow life or kill us. Mitochondrial DNA has only 37 genes. From those 37 genes comes just 13 proteins. Those 13 proteins code for the electron chain transport complexes. The remainder of the genes code for tRNA. Mitochondria also cant grow outside the cell. They require the 30,000 genes in the nucleus to make up another 1500 proteins for them to function. Mitochondrial DNA and nuclear DNA have to have precise lock and key fit to generate energy production. If not, the cell eliminates itself by apoptosis (levee 19) fast. If It works well, this combination is naturally selected for future cell division to generate energy. Aging is quantified by how "leaky" our mitochondria are to free radicals at complex ones in electron chain transport. Their own DNA is adjacent to the first complex in electron chain transport. So the more leakage, the more damage is done to its DNA and energy production will fall. Moreover, that is the signal to make more mitochondria or undergo cell suicide! This first complex (NADH) is by far the most leaky to free radicals of all the complexes. This paradox of fate caused evolution to select for 10-20 copies of mitochondrial DNA in each cell to sustain energy production of an organ in question. So mitochondria can breathe life into us and end it based upon how many good mitochondria we have in a tissue.

By Jack Kruse|June 15th, 2011|Epi Paleo, Fibromyalgia, HIIT - Heavy Weights, Hormones & Methylation, Leaky Gut / Grain Brain, Live your Optimal Weight, Mitochondria, Optimal Pillar 4, Series: Leptin, The Leptin Prescription, The Optimal Paleo Diet, Thyroid|350 Comments