So what is the most important signaling pathway in all life forms for longevity and for optimal health? That is the subject of this blog. The short is answer is the redox potential stored in the membranes, organelles and the exclusion zone of water in cells. I will be bold to say that maintenance of intracellular redox homeostasis is the most important thing to get right to get Optimal.Continue Reading
We are all products of our environment. Our genes are the first draft of what we are created to be, but the experience those genes face (epigenetics) is how the novel of our life is really written. This blog is about how this experience begins to unfold in our species.Continue Reading
Today, we begin to examine levee’s 6, 14, and 26 in the Quilt document for the first time. We begin to show examples of these levee’s by examining how the human brain forms and functions in an infant. This example will act as an analogy to help us understand many other processes as the blog series rolls on.
There are many countervailing influences in life that on the surface confuse our intellect. They create the appearance of paradox, enigma, and myths, and mysteries. I find when we look at the world through the hull of a glass-bottom ship, to look through a kaleidoscope at the galaxies that exist on the edge of our mind, we begin to see the sense that nature makes from the chaos of the world. I like the irony that mysteries often create. Today, we are going to use some “other observations” we have all made to show you how the mysteries of our modern world might be solved asking better questions instead of settling for the answers we have been given.
The Human Infant
It is clear in modern medicine now that we can not have optimal human brain development unless we have a secure nutrient rich food supply for both mother and child. This relationship also needs to be maintained postnatally for several years after birth until neuralation is successful. It does appear in modern neurosurgery research that human brain development is programmed genetically to a certain extent, but is more malleable then we thought because of the new science findings of epigenetics. This is also more apparent in humans than other mammals because our brain is so complex that even small changes in functional regions can lead to massive clinical changes that become apparent as the child develops. Autism and spectrum disorders are a good example of this phenomena.Continue Reading
Today, we are going to dive into the gut flora story a bit deeper than we did in our first gut flora post to help you understand how a a change in gut flora might lead to changes in your health by altering your hormone panel. Obesity is an inflammatory brain condition. Where does the infection come from? The gut flora actually is what causes humans to become fat. It has to due with shear numbers and the species of bacteria in our gut. There is a particular flora that produces adiposity and obesity in humans. These bacteria make something called FIAF (Fasting induced adipose factor) that control this process. This factor blocks lipoprotein lipase (LPL) in fat cells. LPL allows us to convert dietary Free Fatty Acids carried in lipoproteins into neutral fats that are stored in adipocytes.
Non Geeks: Our gut bacteria makes humans fat.
Geek Alert: The FIAF is made by our liver, muscles, and our small bowel wall when food sources are in short supply. This is the signal to stop storing fat in our fat cells when food is scarce. What is not well appreciated by many is that the FIAF in our intestinal wall is controlled 100% by our gut flora. When we have a simplified gut flora it favors fat cell creation. When our gut flora is complex and healthy, it has 100 trillion cells with 250 species. We tend not to make fat in this instance either! Moreover, when the bacteria are active metabolically due to the presence of simple sugars, production of FIAF ceases, and fat creation is signaled. This implies that our gut flora is directly tied to fat creation in humans. The gut flora’s action is directly signaled to the brain via the afferent nerve fibers in the vagus nerve. In those newly created fat cells, a protein called leptin is also produced, and acts as a score keeper for the brain of how much fat is stored in the body. This messenger is sent to the brain around midnight when we are sleeping allowing the brain to assess total energy balance in the body.Continue Reading
Buy Teleseminar If you struggle with eating disorders, obesity or diabetes; or if you have a family history of Alzheimer’s or Parkinson’s, this webinar is especially for you. The Epi-Paleo diet is different from the traditional Paleo template – it is rich in iodine and magnesium and gives you complete, optimal brain function. Remember, HEALTH STARTS IN THE BRAIN. The way the brain goes, your health goes. In this teleseminar, we’re going to explore: The epi-paleo diet and how it affects the gut microflora. As you know from the leaky gut series, a healthy gut is imperative to reversing disease and experiencing a great quality of life. Iodine and it’s relationship with thyroid functioning. Iodine is the most important mineral in human optimization. Learn why fish oil and seafood and shellfish are NOT the same (quantum electron tunneling) — it’s the difference that “creates” consciousness (gamma coherence) and reveals why anesthesia works. We’ll also talk about fish oil, its antioxidant properties, and why it’s been conserved by evolution for 600 million years by every nervous system and every animal on this planet, including dinosaurs. The importance of DHA. When its levels fall in the brain, so does cognition, making way for diseases like Alzheimer’s, Parkinsons and Eating Disorders. […]Continue Reading
Do you think you may be deficient in Vitamin D?
Might you also not be able to afford to see a doctor or get testing done? I think you might find this blog helpful until you can get a doctor’s help and blood testing and salivary testing done. There is a pretty easy “home testing” you can do by yourself if you know what to look for. Use an eating utensil like a knife or spoon handle or a screw driver shaft to roll over your tibia bone in your anterior lower leg. This is the part of your leg commonly known as the shin. People who are Vitamin D deficient usually have a lot of pain when it is rolled over their shin using directed compression of the hard instrument over the length of the tibia. If you have that symptom, you might be Vitamin D deficient and you may need to supplement with D3 or go higher in your dosing. You can even figure out how much to stop taking once the tibial pain begins to subside when you recheck yourself, but blood testing is way more accurate for an Optimized life. Pre tibial pain is pretty common these days because the poor qualities of food predispose us to lower Vitamin D levels. These lower levels control over 350 epigenomic signals for gene transcription. So it is really important to make sure your Vitamin D status is optimal.
How do you tell if you are taking too much Vitamin D to get to optimal?
For men or women, you might notice your own free testosterone level is really low on a high Vitamin D3 supplemented level, and your libido is lagging badly or your body comp is not coming around. Or you might try reading in low light conditions and see how you do. Many will notice that they can’t do it well any longer. If you listened to my recent Nov 2011 podcast on JoanneUnleashed.com you might have wondered why I read in low light and red light levels during my own reset. I was checking myself for signs that I was pushing my Vitamin D3 status too high. Affected individuals are unable to distinguish images in low levels of illumination. Vitamin A deficiency affects vision by inhibiting the production of rhodopsin, the eye pigment responsible for sensing low light situations. Rhodopsin is found in the retina and is composed of retinal, which is an active form of vitamin A, and opsin a protein made by the retina. Basically, if you “over do” the use of Vitamin D3, you will not make enough rhodopsin (from a relative Vitamin A deficiency), and you will suffer from night blindness. I pick this up in patients who notice night time visual driving issues. Most people won’t read in low light levels like I do to assess themselves for this issue. However, you can use this simple test too. Their doctors usually send them to the ophthalmologist, but most are cured once they tweak their diets and add back some vitamin A containing foods.Continue Reading
What are some of the medical conditions that are associated with osteopenia or osteoporosis?
1. Excessive alcohol intake- greater than two drinks a day consistently will do it.
2. Tobacco use- This causes a 100 fold increase in bone loss. Oral tobacco is worse than inhaled smoke
3. Stress- any cause be it emotional, physical, mental, psychic all raise cortisol chronically and kill bone
4. Lack of physical activity increases obesity risk, which increases cortisol from leptin resistance
5. Low calcium intake or absorption from gastrectomy or low acid production from any reason
6. Reduced strength and activity due to a chronic illness or a sedentary life (checked with a grip test)
7. Small build or leanness naturally – correlates with BMI below 19 for women and men.
8. Asian women have a particular propensity to osteopenia genetically and from their diet.
9. Drug therapy, for example, long-term use of corticosteroids such as prednisone-used to treat rheumatoid arthritis, asthma, celiac disease, autoimmune diseases, Crohn’s disease, IBD, and ulcerative colitis.
10. Low Magnesium, strontium, boron, Vitamin D3, Vitamin K2, elevated PTH levels, low sex steroid levels, high insulin levels, low progesterone levels, any cause of a leaky gut.
13. Any cause of chronic inflammation (perimenopause can cause severe acute bone loss)
14. Disuse atrophy from any cause (space travel)
16. High carbohydrate diets
17. Veganism or a plant based diet.
18. A diet high in whole grain (carbohydrates) is especially risky due to mineral malabsorption in gut
19. A diet lacking in animal protein and animal fat and cholesterol.
20. Excessive use of statins and thyroid hormone can cause osteoporosis
21. Age and sex: the older one is predisposes to osteopenia. Women lose 1-3% of their bone density ever year after their last period.
22. Chronic endurance athletics of any type cause severe bone loss due to chronic cortisol elevations
23. Gastric bypass patients carry enormous osteopenic risks.
24. Severe liver or kidney disease; Renal insufficiency can lead to osteodystrophy.
26. People with scoliosis of unknown cause (idiopathic scoliosis) also have a higher risk of osteoporosis. I believe this is because most of these children have severe underlying Vitamin D deficiency and a leaky gut, but this has never been studied in the spine literature. Any time I see a scolisosi patient, I always screen for low sex steroid hormones, low Vitamin D levels, and low Carboxylated osteocalcin levels. Bone loss can be a feature of complex regional pain syndromes.as they develop over time. It is also more frequent in people with Parkinson’s disease and chronic obstructive pulmonary disease as well.