Cold Thermogenesis 5: Biologic magnetism


Readers Summary

  1. How can cold change human biochemistry, a real world example?
  2. What are the major biochemical change induced by cold in mammals?
  3. If humans have this adaptation in their blind spot, do other species use it?
  4. Is there a ketosis training fallacy?
  5. What is the ketogenic diet advantage in mammals?

My first encounter with thermoplasticity in human biology

I first became aware of this seeming paradox as a neurosurgical resident in my first year of training.  We were doing a real “gnarly” brain surgery case.  It was a young mother who had a massive basilar tip aneurysm. Back in the mid 90’s before endovascular coiling procedures we use today, this was the most risky operation that existed in all of medicine.  I spent a month prepping for this case.  We had to enlist the cardiovascular surgeons to come in and surgically open the patients chest wide open to stop her heart on purpose temporarily and place her on complete cardiopulmonary bypass to stop all the blood flow to her brain.  We had less than 20 minutes to then place a clip across the aneurysm to save her life.  To complete this herculean surgical task, we had to fill her entire chest cavity with ice to preserve her heart muscle and cool her core temperature so that we could have 20 minutes to complete the brain surgery.  Simultaneously, we would open her skull and split the Sylvian fissure in the brain and approach her basilar artery in the geographic center of her head and attempt to put a clip on it without disturbing any of her surrounding anatomy.  The best mental image I can give you for this is the ultimate game of “Operation” you used to play as a kid. You must avoid hitting the sides or the nose lights up!!!! One problem in this case, in this game there was live bullets. This maneuver was deadly if not performed correctly the first time. This is one of the most delicate surgeries one can do on a human. Moreover, even if we were successful with the clip obliteration of the aneurysm, we had to restart her frozen heart, get her off cardio pulmonary bypass without an air embolus and awake.  In this case everything went well until the last part and this taught me a lesson I would never forget.  She died after the operation was a complete success.  Her head was already closed up surgically and dressed, the intraoperative angiogram looked awesome, and we restarted her heart and got her off cardio pulmonary bypass without any evidence of a stroke and then she died suddenly.

She received two units of cooled banked blood because our surgical team felt she lost some ability to carry oxygen in her blood because several of the monitors showed she had a low oxygen carrying capacity of her hemoglobin.  This concerned us because we were worried about her risk of having a stroke because of low oxygenation due to her loss of blood flow for 20 minutes when she was on full bypass.

So we did what any surgeon would do. We gave her blood to restore her oxygen carrying capacity and the oxygen monitors showed her oxygenation had totally returned to normal.  We were all happy until I noticed her pupils were fixed and dilated when I was putting on her dressings.  She also had blue fingers.  And then all of a sudden she got a fatal heart rhythm, and she died right there in my arms.  I was devastated.  I will never forget talking to her family later that day.

What I found out 2 weeks later about why this happened was more shocking.  She died because of the combination of her cooled blood with her cooled heart allowed for a biologic change in how oxygen was released in her capillaries.  In cold environments, oxygen is not released in the same fashion as it is normally in a warmed surgical environment.  In capillary beds that feed cells for respiration, the oxygen is tightly bound and it is returned to the heart still oxygenated.  This is why cold can make life survive in hypoxic environments for long periods of time.  This highly oxygenated blood was sensed as normal by our oxygen monitors giving us the false belief that everything was fine.  Her blood was fully oxygenated but the cold provided us with a major issue we were unaware of.  If a anesthetized patients core temp is too cold red blood cells do not release the oxygen at the right time or in the right place in a capillary bed to allow for respiration.  It does not matter if your blood is well oxygenated at all.  She basically suffocated because the cold starved her tissues of oxygen.  The cold cause increases the binding affinity of oxygen. It also causes protein transformations of the Hemoglobin molecule due to alterations in the cell’s ability to sense magnetic fields. In fact, cold environments can have some rather shocking effects on human biochemistry due to magnetic effects, I learned after this case.  One factor can change everything you think is true.  I never forgot this lesson.   If we had used slightly warmer blood,  as we warmed up her core temperature she likely would have never died after this epic operative feat.  We did all the crazy hard surgical things correctly but the physical and chemical effects of cold on the oxygen disassociation curve took our surgical victory to utter defeat in the matter of 5 minutes.

The reason this happened was from the paramagnetic effects of blood during a temperature cold while the patient was under a general anesthetic.  When you are anesthetized you lose you magnetic sense. Super-paramagnetism is a form of magnetism, which appears in small ferromagnetic or ferrimagnetic nanoparticles. The hemoglobin molecule is one such particle.  In sufficiently small nanoparticles, magnetization can randomly flip direction under the influence of temperature alone! The typical time between two flips is called the Néel relaxation time. In the absence of an external magnetic field, when the time used to measure the magnetization of the nanoparticles is much longer than the Néel relaxation time, their magnetization appears to be in average zero: they are said to be in the superparamagnetic state. In this state, an external magnetic field is able to magnetize the nanoparticles, similarly to a paramagnet. However, their magnetic susceptibility is much larger than the one of paramagnets.  Cold is directly linked to magnetic effects.

The moral of this story is that biochemistry acts differently at extremes.  Most things published in a biochemistry book are about normothermic reactions.  Do not forget this because everything you hear from a scientists mouth is based upon those conventions.  Modern humans have two pathays they can operate on metabolically.  One is just OK (mesophilic), and the other on is optimal (Psychrophilic)  99% of the world does not know about the Ancient psychrophilic (cold) pathway in mammals.  That is changing rapidly today.  We are going to discuss this over the next few blogs as I slowly break down the biochemistry for you to digest.

The biochemistry of cold: Be prepared… It’s going to hurt your head

Non scientist: Cold adapted mammals can do things warm adapted ones can’t because at extremes chemistry, physics, and biology change when the temperature is colder.

Geek Alert: Our anthropocentric point of view has resulted in the classification of cold-adapted organisms as extremophiles, even though environments of permanently cold temperatures (around 0°C) abound on Earth, especially when one considers that these include not only the polar and alpine regions but also deep-sea waters.  90% of life on this planet is cold adapated as we speak.  Psychrophiles, both prokaryotic and eukaryotic, have successfully colonized these cold environments and are able to grow efficiently at sub-zero temperatures. This adaptation requires a vast array of structural and physiological adjustments in order to counteract the reduction in chemical reaction rates due to the low temperature of the habitat. Most scientists study human physiology in mesophilic environmental conditions. This is a big problem. The reason is that humans have completely different abilities in cold and the resultant physiologic changes are often 180 degrees opposite that one would expect. This fact has blinded many scientists and physicians to some deep realities about human biology.

Temperature is one of the most important environmental factors for life as it influences most biochemical reactions. Low temperatures slow down and strongly inhibit chemical reaction rates catalyzed by enzymes, the ‘work- horses’ of cell metabolism. The effect of temperature on chemical reactions is basically described by the Arrhenius equation: k = Ae -Ea/RT , where k is the rate constant, A is Ea is the so-called activation energy, R is the gas constant (8.31 kJ mol ~1) and T is the temperature in kelvins. Accordingly, any decrease in temperature will induce an exponential decrease of the reaction rate, the extent of which depends on the value of the activation energy. The thermodependence of the activity can be approximately expressed by the Q10 value that is normally close to 2- 3. This is the main factor preventing the growth, at low temperatures, of non-adapted organisms.  So biochemistry of cold says we should have slow growth patterns based upon the biochemistry. I told you earlier that evolution has sped up tremendously as time has gone on. So the question remains is, how did evolution overcome slower growth? Since the cell cycle was slowed by cold it sped up epigenetics to compensate for the slower growth.  That is the basis of Factor X.  It is the most important part of my theory because it is why the human brain was naturally selected for in a mismatched environment.

The low temperature challenge to life

For the non scientists: enzymes adapt at extremes to allow for ideal function and ideal signaling to improve metabolic efficiency

For the geeks: Biochemistry at extremes reveals three basic features…

  1. Psychrophiles synthesize enzymes with higher specific activity (kcat) at low and moderate temperatures
  2. The apparent maximal activity for cold-active enzymes is shifted towards low temperatures, reflecting their weak thermostability.
  3. The adaptation is not apparently complete, as the specific activity displayed by psychrophilic enzymes around 0°C, although high, remains generally lower than that of the mesophilic enzymes at their own environmental temperature.

Kinetic optimization of enzymes:  Biochemistry is thermoplastic too!

For the non scientists: the take home: If evolution faced this problem before it has a plan to adapt already built in. Cold makes proteins and enzymes bend in different ways than occurs in warm states.  Skip ahead to next one to make your head feel better.

Geek view: A possible strategy to counteract the negative effect of cold on the activity of an enzyme could be to synthesize more enzyme, but it should be easily understood that this would be energetically expensive move. Energy sources in cold are scarce because food is not abundant therefore evolution had to come up with a plan B.  Therefore, the common strategy used to maintain sustainable activity at a permanently low temperature is to produce a cold-adapted enzyme with enhanced catalytic efficiency kcat/Km (Feller & Gerday 1997).  A compilation of available data (Smalas et al. 2000) indicates that cold-adapted enzymes optimize their catalytic efficiency by increasing kcat, decreasing Km or by changes in both parameters simultaneously.  Mother Nature is a master of biochemistry at extremes. Too bad our species is not. She uses quantum effects to make this work.

As also expected in cold, all psychrophilic enzymes studied so far display much lower delta H# values, with the consequence that the temperature dependence of kcat is buffered and thus the deleterious effect of low temperatures on enzyme reaction rates is moderate in nature.

This feature leads to an antagonistic effect of the activation entropy so that the activation energy is not as low as would be expected from the decrease in activation enthalpy. It follows that the decrease of the activation enthalpy of a reaction catalyzed by a psychrophilic enzyme can be considered as the main adaptive character to low temperatures.

These interactions initially contribute to the stability of the protein folded conformation and, as a corollary, their alteration presumably gives rise to an increase in the flexibility of the structural domain of the enzyme involved in catalysis. This is a huge change in thermodynamics.  As a consequence of active-site flexibility, the ground-state ES complex occupies a broader distribution of conformational states translated into an increased entropy of this state when compared with that of the mesophilic homologues, leading to a negative value of delta (delta S #)p-m3.

Activity – Stability – Flexibility Relationships of the biochemistry

For the non scientist: cold shrinks proteins and alters their function to meet new demands.  Cold affects the microgravity of enzymes in us to change their physiologic abilities.  Cold requires that we add certain PUFA’s to our cell membranes and alteration of protein folding to accomplish biochemical reactions.

Geek View:Low temperatures tend to improve the compactness of a proteins by limiting the ‘breathing’ of the structure corresponding to micro-unfolding processes. Cold affect local gravities and magnetic fields of small things in our cells.  Therefore, at low temperatures, a mesophilic protein will lose the mobility required for its catalytic activity. What this means is that as it get colder we need to make the molecules more flexible to work in the cold. This means at extremes, physic laws (quantum things) do some strange things to our biochemistry. The current accepted hypothesis (Gerday et al. 1997; Zavodszky et al. 1998) suggests that psychrophilic enzymes have to increase their plasticity in order to perform catalysis at low temperatures. They do this by compliant design changes by the “addition or subtraction of packets of energy” to the protein back bone.  The enhanced plasticity being generated by the generally low stability of the protein structure. This balance between flexibility and stability represents one of the crucial points in the adaptation of a protein to environmental temperature swings. We now know in 2012 that cell membrane signaling is the single most important feature of cold adaptation. The colder it is the more omega 3’s are need for cell membrane signaling. The warmer it is the less omega three we need in cells to signal. This implies that in warm adapted mammals omega 3’s (DHA) might have deleterious effects at excess. They actually do if they are used incorrectly.  

It has been shown that the psychrophilic alpha-amylase from Pseudoalteromonas haloplanktis has reached the lowest possible stability of its native state (Feller et al. 1999). This has been notably demonstrated by DSC, which is a powerful tool to investigate the thermal unfolding of proteins. Differential Scanning Calorimetry (DSC) is unsurpassed for understanding the stability of biological systems.  DSC directly measures heat changes that occur in biomolecules during controlled increase or decrease in temperature, making it possible to study materials in their native state. I  also saw this some remnant effects in my example that opened this blog. Not only was oxygen binding tighter than normal but there had to be changes in the hemoglobin molecules to make this physical chemistry happen. It appears that there are some unusual effects in the chemical bonds and in atoms on a sub atomic level that allow biochemistry to adapt. These adaptations are also present in humans when they are cold adapted. I mentioned earlier in the CT series that mammals have a unique way of altering their own cell membrane structures in anticipation of cold. My theory had predicted that because of the physics of the chemistry at cold I am describing to you here. It is clear certain PUFA additions make the cell membranes more fluid in cold so their signaling can work well with a different environmental signal.  This in effect makes the cell membrane looser or more fluid. This has bigger implications for the optimal fuel for mammals in cold. The more extreme the environment the more flexibility the cell membrane needs. This is why omega three fats would be favored over omega six fats in mammals who live in the coldest environments on Earth. The reason is that omega three fats have more unsaturated bonds that allow for more fluidity in the cell membranes for ideal signaling. There are also electrical reasons for this as well.  DHA can select for certain phospholipids to work in a more optimal electric manner. Take a guess where the omega three sources come from? The deep ocean. It appears evolution is using form for function ideally, once again.  The best natural source is krill and other fish that support huge ecosystems in our polar seas for these mammals. Seafood is always the right choice, but the use of krill oil use makes a lot more sense for warm adapted mammals than fish oil does because of its stability in warm temperatures. DHA is also not optically stable outside of fish.  This is a major down side to fish oils.

Non scientist and geek unite: The best food source then for a cold adapted mammals biochemistry would be a ketogenic Epi-paleo diet that has a high omega 3 content.

For the non scientists: This is similar to all the paleo 1.0 books we have in print today. They have come to the same conclusion however from a different route than I have. I did not come to this life template via paleo 1.0/2.0, as I mentioned in my podcast with Jimmy Moore in May 2011. I came to it by following evolutionary medicine and where it took me. We did, however, meet here. This is no coincidence either. This is precisely why I believe the optimal diet for all eutherian mammals is a ketogenic seafood laden paleolithic diet when they are cold adapted.

I think some will say here , “Doc are you totally forgeting that we have had to time to adapt to a different diet and do well”? I have not forgotten at all. People have forgotten our environment today is radically different too.  I think this is precisely what the evolution of the leptin receptor has allowed for over time in land based mammals and especially in modern primates and hominids.

Radical Rule Number 8: The leptin receptor is primordially a cold based electron counter. I think it evolved the ability to function in warm environments as mammals evolved onto land and took the planet over. They began in the cold seas.

My point is that while we can tolerate other diets and thrive on them, they are not optimal because they are not using the leptin-melanocortin pathway for optimal living. That is the distinction I am making here. I think the modern paleo template is great in comparison to a SAD, but the best design for all mammals is to use this fuel source while one is in this pathway for optimal functioning.

Non scientists pay attention here: Let us use A new Ferrari as an analogy to explain this. If you spend $250,000 on this car, would you put cheap gas in it to drive around or will you put super octane in it? Most car enthusiasts would not think twice about those options After all if you can afford this type of car what is the point of saving 20 cents a gallon on gas? If you buy a new laptop, do you put bad software in it? If you do, what do you get? You get bad performance. For tangible things we get this point implicitly. Where our neolithic thoughts trip us up is in our own “Ferrari engines” from evolutionary design. Modern humans are facing the same choice. What are they putting in their engines? They are choosing cheap gas constantly, and not the best gas at the correct time of the season. And what do they get? Mediocrity as a species is that answer. More biochemistry coming… Geek alert.

Non Scientist take home: there is a lot of life (90%) that is cold adapted on earth. There is plenty of proof that biochemistry at extremes is common and exists.

Geek Alert: Do we have proof of this from real life on our planet now? Yes, in cold adapted Antarctic fishes. The molecular flexibility I mentioned above,  should possibly be accompanied by a weaker substrate binding strength and consequently by an “evolutionary pressure on Km” in order to maximize the overall reaction rate. Psychrophilic enzymes, however, display identical substrate binding site and active site architecture when compared with their mesophilic homologues, as illustrated in the case of A4-LDHs (lactate dehydrogenase) from South American and Antarctic notothenoid fishes (Holland et al. 1997; Fields & Somero 1998) and chloride-dependent alpha  amylases from Antarctic bacteria and pig pancreas (Qian et al. 1994; Aghajari et al. 1998a; D’Amico et al. 2000).  An experimental demon- stration of the relationship between kcat and Km was recently provided using cold-adapted and mesophilic alpha-amylases (D’Amico et al. 2001). Stabilizing weak interactions found in the porcine alpha-amylase, but absent in the cold-active alpha-amylase, were reintroduced by site-directed mutagenesis in the psychrophilic enzyme.

Normal mammalian biochemistry

Non scientist and geeks unite: Mammals have special cold adaptors on their skin that wire to the gut and to the central nervous system. This system is not well studied but it is clear that they are involved in readying the animal for cold adaptation quickly and eventually hibernation. Mammals add PUFA’s from their tissue stores directly to their cell membranes by a process that we know exists because chemistry says it has to for life to live at the ocean floor.  I discussed them in Cold Thermogenesis two blog. We do not know the precise molecular mechanisms yet, but we do know that it is not dietary dependent. It appears construction the cell is the key to life’s success.  This is how mammalian biology is designed to work normally. It is actually initially signaled for by excessive dietary carbohydrate loads in the diet during summer and fall that occur prior to hibernation. Since This is why diabetes, AD, and most other neolithic diseases of aging seem to be associated with high omega 6 tissue content. When humans never face a winter to rid themselves of the omega 6 levels in their tissues they concentrate slowly over time. When this occurs we see higher tissue omega six levels and our 06/3 ratios become unfavorable for health. Diabetics have the highest levels. People with chronic neuropathy and chronic pain have higher levels. The work of Chris Ramsden has been very helpful to me as a neurosurgeon in treating these people.

It is not that the omega six content itself is pathologic, because we need to use them for life daily in the proper ratios. Where it becomes a problem is when we do not rid our cell membranes of excessive PUFA content once winter ends. The reason is because we never face winters any longer because of our brain has created warm clothing and housing for us to use. This is a mismatch. this allows us to concentrate omega sixes slowly over time. We see this in excessive 06/3 ratios in younger people and it eventually increases their HS CRP. It will further cause other hormonal decay with time. I am no longer surprised that I rarely see normal hormone panels in my patients. Modern human behavior is built upon these mismatches because our neolithic thoughts are not congruent to any circadian cycle. Normal mammalian biochemistry is based upon timing from circadian cycles and food signals. As I said in the Leptin Rx and the FAQ’s blog timing is as important to us as what we eat. This is why. to regain control you first have to know how fast your chemical clocks are running in you. This gives you insight to how much your modern life is hurting your cellular biology.

When dietary carbs show up in our diet normally, we begin to normally upload our PUFA’s to our cell membranes because our cell membrane need to be more flexible in the cold of winter.  For modern humans winter never comes because we cover our bodies in modern life.  The other mismatch is our diet.  We eat a 24/7 diet of carbohydrates and PUFA’s while winter never comes. We eat this because we “feel” better doing this. That “feeling” might be slowly killing you. Wild mammals might have feelings, but they can not act upon them because their are no supermarkets in the middle of Yellowstone park catering to their needs and wants year round. Our brain created all of modern life. This creates huge problems for our cells. Our cells get over run with omega 6’s and become pro inflammatory over time as our cells are recycled in sleep with autophagy.  This is where the cytokine storms and leptin resistance comes from that shorten our telomeres and age us faster.  These cytokines are the fuels that speed our chemical clocks up and shorten our telomeres.  We remain unaware of this when we are young and have a large supply of stem cells to replace the ones we are destroying, but it catches up to us eventually. It is clear that there is a mechanism to replenish stem cells but it appears it does not work optimally when our chemical clocks are working too fast. We deplete more than we make. It is also clear that organ have their own individual chemical clocks so we see differential aging in organs because of this.

The only known way to reverse this process is cold thermogenesis while eating a diet that optimizes our Ferrari engines given to us by Mother Nature.  What else do we do to keep ourselves in the dark about mismatches?  Humans protect themselves from the cold by clothing and heating. We no longer hibernate because our brain extinguished that need. We do not have a lot of surface hair either to warm ourselves because we no longer needed it when we evolved into a warm environment and began able to control it with clothing. Mammals became able to compensate for a slowed growth rate in cold, by speeding up epigenetic expression of our genome to eventually create our species whose brain power far outstrips its somatic genes. We are still prisoners to many parts of our mammalian biochemistry and we seem blind to this as well. The brain is so advanced that it puts our genes constantly at risk, while we remain blind to it as we deplete our life force within us slowly.  We, as a species have not realized this until we found out about telomere biology and what it means.

We can now see if this theory is correct for ourselves by checking our cellular age against our real age.  So far, not one person I have checked has a lower biologic age then a chronologic age on telomere assays.  This implies that much of modern life is a mismatch.  It also implies we need to question every aspect of our behavior to understand the mismatch and how it might harms us.  This is how an optimal human thinks. This is also how thoughts can change our DNA. This is why I gave you the banana analogy in the Paleo Summit talk.  It is an easy way to show you how blind you really are to this situation.  Most people found it fascinating because they never thought about it before I said it.  I can not stop thinking about this since I realized it was true for our species 6.5 years ago. When I saw my own mismatch for the first time it was sobering. Much like the video I showed you in the Holy Trinity blog. I have been studying human mismatches, and the inflammation cascades they cause for the last 6.5 years. I spend many days and nights thinking about ways to use this evolutionary medicine to help treat and often reversing disease in my family and in my patients.  It is critical to a healthy lifespan.

Mammalian life uses this evolutionary blueprint.  We are mammals. Mammalian biochemistry is thermoplastic in vivo. NASA andAthletes have found it first. Their application and the applications by NASA have opened my eyes. We need to apply this information to modern healthcare. Sleep and longevity researchers are “waking” up to this new reality today. Sadly, the human researchers do not understand that all their current studies are not controlling for this mammalian ability.  This throws many of their results up in the air. That is a tough reality to swallow. I had to eat my own dogma 6.5 years ago and adapt my own practice. It was difficult. I sat down with a some friends who are biochemist in academia in Nashville and this news was sobering to them too. This reality has made them think differently as well about many aspects of science.

So what other things might cold do to us?

Studies done on the Sherpa’s and NASA astronauts clearly show a major metabolic benefit that has not  been well explored by modern science and medicine.  These ancient programs can allow humans to not only survive on low calorie diets, but they can actually make us superhuman in some respects.  Sherpa’s and astronauts can sustain themselves well on a lowered caloric intake yet with superior ability to handle their climates when they are cold adapted.  The same has been found true of the native Inuit on their native diet as well. This ability is no longer found in the modern Inuit because most now eat a Western diet.  We also found out since the Cold War ended that the Russians have also stumbled onto this science in their research.  Their athletes and cosmonauts have been using this data for years to dominate at alpine sports in Olympic games.  It appears the U.S. Olympic swim team and Lance Armstrong got the message too before any of their competition here in the US or in Europe.  It completely explains why they were able to do things some humans previously could not accomplish.  It maybe why people still accuse them of cheating.  We all heard about Michael Phelps eating escapades by being able to eat larger amounts of calories daily routinely in his training for the Olympics!  Most scientists at the time said the NBC report of Phelps feat was not possible.  Ray Cronise was one of those scientists.  Well, by conventional calorimetry studies it is impossible.  This is why many scientists were lost.  They forgot to look under the right rock for the reason it might be true.  I can assure you Phelps and Lance Armstrong learned what I learned about leptin and about cold.  They used this knowledge to become world class athletes, and I used it to reverse my obesity.

The reason modern science believe this to be impossible is because their studies fail to account for the thermal coefficient of the environments that they trained in.  Phelps works out in a pool at 50 to 60 degrees for an extended amount in a day.  His training regimen is closely guarded.  His competitors have publicly commented that they know what is published in his books are smoke screens because he wont even train with his own teammates.  Armstrong still has never said precisely what he did but there are many leaks that he worked out in freezers installed in his house with stationary bikes built in to them.  He also guards his training regimen.  This regimen shredded their body fat to the small single digits, and it allowed them to gorge on calories that they became able to just burn off as free heat, while increasing their ability to perform work at superhuman levels.  This was possible because they found out that in cold, the leptin receptor allows for unbelievable adaptability in resting RER. In Phelps and Armstrong’s case,  they were both able to expand their native VO2 max ranges north of 70 according to their former trainers!  This is truly super human ability territory and explains their fabulous athletic feats.  There are other humans who can induce this biochemistry too.

The Sherpa’s have the ability naturally because of where they live.  In the cold and high altitude of the Himalaya’s.  They cold adapt in a few days when they take a climber to the summit of Everest.  They lose an  unreal amount of weight when they climb,  so they eat pure butter and lard the last 2000 ft of the ascent.  NASA studied them closely and used this information to help maintain the weight of the astronauts who also lost tremendous weight during space walks in the 1960’s and 1970’s.

Many believe that humans are best adapted to use carbohydrates to burn for fuel using endurance exercise.  Take a look at the following link from 1994 about the use of fat burning  on its effects on VO2 max testing that is of prime importance in any high performance athletes.  The Buffalo Bills of the NFL are the first team to institute this change because they were made aware of this study done in 1994 in runners.  It is one of the few studies that give a “glimpse” of what a cold adapted runners can do eating fat.  Ironically, these runners were all from Buffalo, NY where it happens to be cold.  This is the only reason this VO2 max expansion was found.  When the NASA data came out over the last ten years the NFL took notice finally when it was brought to their attention by a the agent of a hockey player.  The Bills have been the NFL team most ready to adapt because of what happened to Kevin Everett their TE in 2007. That story is for a later blog on Factor X.

Conventional wisdom and Paleo dogma state that you can increase your carb load as you exercise. When you use carbs to fuel your Vo2 max flattens. When you are fat adapted your V02max expands. No one seems to correlate it with their performance VO2 max to see how dietary fat helps or hurts their exercise in a thermoplastic environment.  We have all seen and heard that those thoughts all over many blogs about how performance suffers on ketosis.  The real problem is they have no idea that it soars when your biochemistry is cold adapted.  Well this article shows that assumption may not be true at all. In fact, the opposite might be true.  Both used cold training techniques to raise their level of performance. Can fat loading be a better choice than carb loading for performance?  Could this be true?  Why might be this be the case?  Question everything is my response.

Training Fiction: Ketosis is most efficient mammalian fuel in the cold not carb loading.

Modern hominids think this is reversed because all the research is done on warm adapted humans eating the wrong diet.  The elite athletes are now finding out that is not true thanks to NASA.

Burning fat (FFA) actually increases our VO2max when the ancient pathway is induced. I test VO2 max routinely in some of my patients, and I will tell you those people who are interested in long term performance and longevity use a  ketogenic version of the paleolithic diet show huge gains in their VO2 max over 24-36 months of adaptation.  Being adapted to fat is better for performance too.  It increases strength and power because the cold increases the steroid receptor affinity for steroid binding. This means your Growth Hormone and testosterone levels surge as you cold adapt over 2-3 years. No one studies it that long but it does occur. Modern elite athletes are now using it routinely. It just does not happen as quick as most athletes want in modern training, therefore they mistakenly believe that carbs are better for their performance in the short term.  The reason is that they only measure their performance over a few months at most.  Few cold adapt.  The elite athletes are all beginning to cold adapt these days.  The NASA data and Russian data is no longer a secret.  Believing that carbs are better for performance might be also be a big mistake that might subjugate your paleolithic genes.

When humans are warm adapted carb provide great fuel but they also increase our ROS as we do this and we deplete our stem cells.  Ironically, this methodology shows no measurable loss in performance to the person in the short term, it actually improves it in the short run.  This falsely gives the person a false sense of security that they are improving their body.  The look at their facade as proof.  The real problem presents but it does when the get past their 45th birthday.  These athletes are depleting their stem cells.  It can be measured in their telomere lengths.  Why does this happen?  Carb training increases ROS at the first cytochrome of mitochondria when we make ATP from glucose.

So what happens to athletes who are cold adapted who use fat to train?  Why is ketogenic diet more energy efficient at a Krebs cycle level?  The reason is that mammals  generate very little ROS comparatively to the warm adapted carb burners mammals at their mitochondria.  Why?

Non scientict read here: when you eat fat your mitochondria are less leaky so you age slower. When you eat carbs you leak more and shorten your telomeres.

Geek alert: During oxidative phosphorylation, almost all of the reducing equivalents produced by glucose metabolism in the Krebs cycle are in the form of NADH (cytochrome 1/where carbs enter) with the exception of the succinate dehydrogenase step, which takes place in mitochondrial complex II and makes FADH2. Metabolism of one molecule of glucose produces an NADH:FADH2 ratio of 5:1 whereas fatty acid metabolism in beta oxidation and the Krebs cycle will produce a ratio of ≤3:1 depending on the length of the fatty acid.  This implies that fat burning is reducing to the interior of the cell compared to glucose burning.  Carbohydrates create more oxidation inside the cell.  If you do this over a life time you are just throwing gasoline on your stem cell population as you age.  The toll is seen in your telomere length.

This effect is more pronounced in organs that use tremendous energy like the brain.  Over a life time this can results in serious disease of aging that occur sooner than expected.  This is what we see in our modern world.  Our species is mediocre because this has remained in our blind spot.  This is commonly seen in retired NFL football players who have substantially reduced life spans.  The NFL is the best example of my theory in practice today.  They train hard and carb load while building amazing bodies that just wither away quickly as they hit their 5th decades.  If you train and eat like this, you burn out fast instead of fading away slowly.  When you look at the NFL data on longevity it is eye opening.  In modern humans, aging is a biologic novelty.

NADH is oxidized only in mitochondrial complex I whereas FADH2 is oxidized only in complex II. Complex I produces more reactive oxygen species than complex II.  This means that carbohydrate metabolism increases “mitochondrial leakiness” compared to fat burning  does.  The more leakiness a cell metabolism exhibits the shorter are its telomere lengths.  Short telomere lengths correlate with disease and shortened lifespan.  Fats metabolism by contrast is a less leaky process.  Moreover, oxidation of fats reduces mitochondrial leakiness and decreases intracellular oxidation that depletes stem cells and shortens our telomeres over a life time.  This is why telomere lengths are a great way to see what your lifestyle choice are doing to you as a gross measure of effectiveness.

The production of a specific number of ATP molecules from glucose/carbs has the potential to generate more reactive oxygen species compared to the generation of the same number of ATP molecules from fatty acids.

The trainer blind spot

They key question then should be why are these benefits not perceived by athletes or trainers today?  The reason is quite simple.  Modern life is fast and we want results yesterday.  This is another example of how our neolithic beliefs subjugate our paleolithic genes.  Once again, time is relative for most performance athletes and trainers.  This fact is axiomatic in physics, chemistry and biology.  This is a neolithic thought that can hurt you over a lifetime without you realizing it if you do not look for the evidence in your cells.  None of them have realized that the thermal coefficient of their environment makes this biochemistry work against their telomere lengths in this fashion. It is all relative to the time of the adaptation.  If they changed the environment to cold and used the same diet things would be dramatically different because ROS would be low and the stem cells protected.  If the diet was adapted to a ketogenic version over 24-36 months they would see amazing expansion of performance.  At extremes, biochemistry changes in nature for our benefit.  Evolution has a plan for this because it tapped it many times before. REALIZE THAT modern trainers are oblivious to this therefore they regurgitate what is best from the literature that is based upon mammals who are warm adapted eating a warm adapted diet! Can you say major mismatch!

Can you prove me wrong or right on this training assertion?  Yes you can.  We can follow this with VO2 max progression in training or with a quantified self platform of testing.  You could also check your telomere lengths over a fat burning and carb burning training periods.  Many professional teams are realizing just how bad warm adapted training on a carb loaded diet is.  Since VASPER was studied in space in the 1980’s and 90’s,  the world of training has been inverted over night. It promises 2 hours of exercise in 20 minutes using cold technology licensed from NASA. You will not find this reflected in the modern day literature yet because its been in exercise physiology’s blind spot.  It takes 15-25 years for bench top research to hit the clinical shores.  You will find that when you fat burn 100% of the time your VO2 max goes higher than at any time when you are training using carbohydrates.  You can do this yourself in your own gym without any Rx.  It is the ultimate challenge to our community.  You owe it to yourself to question your own dogma and find out what I already know to be true.  The ketogenic version of the paleo diet is what mammals are best adapted to because it increases our VO2max, REE and RER.  This is how all mammals are designed to function best. We seem to forget we are mammals too.  NFL teams are now introducing this type of training over the last few years because of NASA technology and findings.  Moreover, they are trying desperately to make their game safer for the players.  This was recently licensed to a company called VASPER in California. It appears humans are awakening that their might be a new way to train to live that they have never pondered before.

Individual difference in humans who cold adapt

Special forces training has been at the fore front of this type of information.  I have a few friends who are former Seals and Rangers.  I spent a lot of time talking to them picking their brains about their training.  Most of what they were taught and trained for is not published for obvious reasons.  Here is what I found.  Cold tolerance is increased by large body size (small surface area – body mass ratio), abundant subcutaneous fat, good physical fitness (good ability for heat production, good circulation), male gender (predominantly due to larger body size), young age (via muscle mass and circulation), cold adaptation and good health. Recently it has been shown that also personality affects thermal responses, especially the levels of extrovertion and neuroticism. Increased level of neuroticism dampens or slows the autonomic thermoregulatory responses whereas increased extrovertion has an opposite effect.

Cold acclimatization and acclimation

Why has this escaped your awareness?  Your brain is far advanced in design than your genes are because of epigenetics.  This is a mismatch you remain blind too for your whole life. This was the basis of my Paleo Summit talk.  I am going to continue to make you aware of how many modern humans face.  They are vast because of our amazing brain.  Each mismatch that does not favor our genes shortens your telomeres right under our nose’s.  That is a reality you better get very comfortable with because it is why our species is now mediocre.  It is why old age happens in the 50’s now and why neolithic disease is accelerating in younger generations.  It is why children now have heart and carotid disease below ten years old. It is why heart failure is the number one reason for admission and death in all humans.  It is why Alzheimers is now common when 100 years ago no one knew what it was.  It is why colon cancer went from 37th to 2nd in death from cancer.  It is why ADD and ADHD are common today and were not in decades past.  It is why the NHANES curves for obesity have shifted.  Yes, fructose is playing a role, but it is not the major cause.  There is not a disease we face that is not accelerating as time marches on.  It is because our modern world is speeding up our biological chemical clocks because our brain is expert at creating biologic mismatches for our genome.

There is a reason these things are happening.  These diseases did not just show up out of the blue.  These mismatches speed up our chemical clocks.  It means the young become older faster so the diseases of aging will show up in us as young people. This has happened in just 8 generations from the Industrial revolution. It is a situation where a “progeria-like state”  has become our modern day primordial condition.

The cold and a ketogenic diet can slow and often reverse that process.  Thermal adaptation, either natural acclimatization or artificially produced acclimation, to cold takes 2 weeks. After the development of adaptation, the physiological responses to cold are usually attenuated and cold environment is subjectively considered less stressful than before adaptation. Cold adaptation of hands diminishes the local vasoconstriction which allows higher circulation and skin temperatures in hands (fisherman’s hands). The classical forms of physiological cold acclimatization are insulative (increased skin vasoconstriction or subcutaneous fat), hypothermic (decreased core temperature), insulative hypothermic (most common type of cold acclimatization) and metabolic (increased energy consumption).

Why have we not seen this in modern humans?

Behavioral adaptation is most important for the survival of human species. It includes e.g., well heated houses, good thermal insulation of clothing, warm vehicles and short exposures to cold. In fact, behavioural adaptation can work so well, that no physiological adaptation is developed in winter, as shown in young urban residents. These neolithic creations are why we do not see the metabolic benefits of this pathway in modern humans often. When modern humans become aware of them and their benefits they may consider building a small part of their current environment for cold thermogenesis.  Modern humans may find that when they cold adapt it will help treat diseases due to mismatches in circadian biology.

Warm clothes and buildings are neolithic creations that kept us in the dark about the ancient pathways benefits.  Wild mammals can’t do what our brain allows us too.  Mismatches are not just not good for humans in our modern world where it constantly seems like it is summer time due to artificial light and 24/7 access to carbohydrates.

Neolithic disease of aging is total chaos. Health is perfect order, in between is mediocrity. We are searching for optimal.

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Cites:

  • ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/19890013690_1989013690.pdfLeBlanc J, Ducharme MB, Thompson M. Study on the correlation of the autonomic nervous system responses to a stressor of high discomfort with personality traits. Physiol Behav 2004;82(4):647-652.
  • www.dtic.mil/cgi-bin/GetTRDoc?AD=ADA213047
  • http://www.mendeley.com/research/human-physiological-responses-to-cold-exposure/
  • http://ntrs.larc.nasa.gov/search.jsp?Ns=Loaded-Date%7C0&N=4294741499&Nn=4294944512%7CSubject+Terms%7CAMBIENT+TEMPERATURE%7C%7C4294956868%7CSubject+Terms%7CCATS
  • http://www.researchgate.net/researcher/38172278_Wouter_D_van_Marken_Lichtenbelt
  • LeBlanc J, Ducharme MB. Influence of personality traits on plasma levels of cortisol and cholesterol. Physiol Behav 2005;84(5):677-680.
  • http://www.unboundmedicine.com/evidence/ub/citation/8133743/
  • Buffalo Bills :  http://www.buffalonews.com/sports/bills-nfl/article222856.ece
  • Mäkinen TM, Pääkkönen T, Palinkas LA, Rintamäki H, Leppäluoto J, Hassi J. Seasonal changes in thermal responses of urban residents to cold exposure. Comp Biochem Physiol A Mol Integr Physiol 2004;139(2):229-238.
  • naca.larc.nasa.gov/search.jsp?R=20010114156&qs=Ns%3DLoaded-Date%7C1%26N%3D4294880621
  • http://www.sciencedirect.com/science/article/pii/S0031938407004738
  • http://www.mendeley.com/research/endocrine-and-signalling-role-of-adipose-tissue-new-perspectives-on-fat/
  • Donaldson GC, Keatinge WR, Näyhä S. Changes in summer temperature and heat-related mortality since 1971 in North Carolina, South Finland, and Southeast England. Environ Res 2003;91(1):1-7.
  • McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 2002;416(6876):52-58.
  • ISO 10551 ISO 10551. Ergonomics of the thermal environment -Assessment of the influence of the thermal environment using subjective judgement scales. Genève: International Organization for Standardization.
  • Stevens JC, Choo KK. Temperature sensitivity of the body surface over the life span. Somatosens Mot Res 1998;15(1):13-28.
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  • Gavhed D, Mäkinen T, Holmér I, Rintamäki H. Face cooling by cold wind in walking subjects. Int J Biometeorol 2003;47(3):148-155.
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Comments

  1. Thanks doc!

  2. Coriander says:

    Thankyou! I love the way you've written this.

  3. Love the style. Your blog is evolving! Keep it up!

  4. Dr. Kruse,

    Thank you for this latest post. I like the non scientific explanations, as I am not a science geek. But I might just become one yet! Each blog post you put up is making more sense to me on each of the connections of diet and environment. The way you explain it, it make good sense.

    Susan M.

  5. Mamagrok says:

    You're cracking me up with the geeks & non-geeks unite. I can't wait to read and find out which one I am. Maybe one day the brain fog will lift and I'll be full-on geek again. ;)

  6. Resurgent says:

    Outstanding..!

    And you say you are not done yet.. ;)

    Must commend that the writing style is far more enjoyable, not that I had any problems earlier.

    Going to re-read it now. My rigid mitochondria takes more time to absorb.. Ha ha!

  7. Glamorama says:

    Loved this! Very helpful and answered many of the things I've been wondering about, seeing I want to get serious about sculpting my body.

  8. I started Paleo *exactly* 6 months ago (it's my anniversary today). I felt better almost immediately, and a lot of my ailments went away within a few months. Because I wanted to lose weight faster, I went Paleo-ketogenic (up to 30gr of carbs daily), on January 20th. On Paleo-keto I feel even better than on plain Paleo. My IBS-D does not trigger at all anymore (on 70-100 gr carbs per day Paleo it would trigger once a week, down from 4-5 times a day on SAD), and I'm care-free all the time, with an exceptional mental clarity, and without attention deficit anymore. I even started exercising recently!

    The reason I write this is because this blog convinced me to go keto. Dr Kruse has his friends and his enemies, but I'm a friend, and I listen when he theorizes or researches stuff.

  9. Daniel Han says:

    I've read that swimming increases the insulative component you mentioned AKA increased subcutaneous fat. Is that not a bad thing? I'm asking since many are trying to decrease body fat.

    • @Dan H that could be true in a warm adapted mammal who is swimming. See my recent response to Owl regarding this. When people say these things they are not even realizing that they are creating potentials for mismatches with their thoughts and beliefs. This is a great example.

  10. I think you will get a lot of confirmation on the statement that "cold adaptation takes 2 weeks". Your first CT blog was 11 Feb, about 3 weeks ago. I know quite a few started that day and are already reporting positive outcomes. The MDA monster thread is full of these stories! http://www.marksdailyapple.com/forum/thread32345….

  11. You say, "The classical forms of physiological cold acclimatization are insulative (increased skin vasoconstriction or subcutaneous fat)", does that mean we may actually GAIN fat with CT?

    • @Owl you can if you are warm adapted in a cold environment……ie you where warm clothes and stay in a heated house all day long and eat carbohydrates and safe starches all day every day for the entire winter……….Ask AKMAN if its possible? HE is living proof that even when you are in Fairbanks Alaska a modern human can gain fat in the ideal environment to lose it…….because of neolithic thoughts and habits. Now, I have akman using biology correctly as his tailwind………..and he is reporting his result here already. His last HT post was rather remarkable in what he has accomplished in 3 weeks of living with the cold directly. People here need to understand we need all the moving parts done at the same time to get the effect. Cold is the primordial way to make this all work. If you do it all correctly togehter results are optimal. If you half ass it you get good but not optimal results. If you do none of it you get mediocre modern man

  12. Dr"s M & M says:

    Dr K,

    This Blog was posted on the clinic screen by our very enthusiastic reception staff today( who stayed behind waiting for you to put it up).We had a full waiting room with lots of discussion and surprise surprise all wanted to read the geek section….. either we have a clinic of highly educated patients or you as one patient said "DR K said don't take his word do your own research… " he had his teenage son's biology book open to the kreb cycle with six on lookers…

    Our Russian doc was on hand to go through the CT and at one stage it looked like we were heading for communal ice baths in our back car park, with another patient offering to bring in the ice ( he is a fish monger and has refrigerated truck) ..

    We finally closed our doors at 4.10pm( we normally close at 12pm)

    CHEERS DR K..

    • @Dr. M & M I'm glad they like it. Down in Oz you are headed for winter. You are quite lucky. We are headed for spring so that means I will be packing ice and driving in air conditioning constantly and setting my thermostat to 55 degrees F

  13. Mama2Groklets says:

    Enjoyed both content and format. Thanks Dr K!

  14. Mama2Groklets says:

    …. And am really looking forward to winter in Oz!

  15. Coriander says:

    Dr's M&M, where is this magical clinic?

  16. Eleanor says:

    Your story of the young woman you lost after surgery hit me hard, it brought along with it a new respect for you and what you have to deal with on a daily basis. And you still come out here and share your knowledge with us, it humbles me to see how special of a person you are. Thank you for changing our world as we now see it.

    • @Eleanor This is one of the secrets of neurosurgical training……..you must learn to think steps ahead to avoid complications and death so that they never happen. but when they do you make sure that you learn from each failure. We had morbidity and mortality conferences each week and it was here that I learned to embrace failure and become stronger because of failure. Most humans run from their fears or failures. I embrace them because they help me improve my former self.

  17. Thank you for the information about how long it takes to adapt to cold – this is helpful. Before I changed my diet (years ago), I always ran hot (body temp)… ditched grains, legumes etc and lost weight, and now find I feel the cold much more than I used to. Been trying to be comfortable at a colder room temp – knowing I've got about 2 weeks will help me stick with it.

  18. I'm really liking the combination of geek and non-geek explanations. I like to be able to tell a novice (myself included) the bullet points of what you are revealing. That makes the more detailed writing more accessible.

    As a biotoxin illness subject, I'm looking ahead at changing my genetic susceptibility to mold exposure. I have particular genetic haplotype that disrupts my ability to clear boitoxins so constant cytokine feedback loop is created. I am thinking that CT, LR, and ketogenic diet will do this.

    Also, I have haplotype for "low alpha MSH" with all it's resulting problems:

    Chronic pain

    Non-restorative sleep

    Gut issues. Nausea, queasy, farts, pain.

    Get sick often and it hangs on.

    Adrenals wear out trying to compensate.

    Lousy sex drive.

    Gotta piss all the time. Incontinence.

    Flu-like, tired, cognitive difficulties, muscle aches, headaches, cramping. etc.

    When I read that CT, et al, increases aMSH tremendously, I saw my future and I am coloring it bright. I believe that I can change my birthright by rewiring. I am no longer a "victim" of my parental download.

    I have a plan:

    In six weeks I have an appointment with a doc who is doing Dr. Shoemakers' biotoxin clearing protocol. I should be done with my mold remediation on my home by then and have done an aMSH test that's due back any day. I will start CT before I go to him to see if my symptoms improve even if it means rescheduling the appointment further out. Go see doc, we will test to see where I am and adjust.

    At last! A pathway that is naturally, primally, HUMAN! I have searched for it all my life! I knew it was there and thank the good Doc for all his work.

    The way out is the way through.

    Martin

  19. On FB Jesse Marandino askes, Dr. Kruse, is it that all biological mismatches lead to increased epigenetic "searching" (for a match) and this is what causes the acceleration in aging (somehow tied to stem cells and telomeres)?

    My response: Jesse the primordial condition of all modern humans was set by Factor X……this by definition means that we come into the world with a very rapid epigenetic program that allows for some amazing responses to our environment. This implies that our chemical clocks are super sensitive to mismatches. When they occur it generates cytokines that speed the clocks up even faster. This shortens telomeres even quicker so that neolithic modern disease show up in earlier generations or ages as time marches on. If you eat a warm adapted diet at the wrong time as most humans today do it is the fastest way to shorten your telomeres and cause your hormone panel to be destroyed. The best single test to check my theory is watch your DHEA level after 25 yrs old. It tells you what is happening to autophagy real time. This is where sleep and metabolism couple. The more efficient you are the higher your DHEA level will be……the worse you are the lower your DHEA will be. It correlates well to telomere lengths too……

    FACTOR X hint: http://www.sciencedaily.com/releases/2012/02/1202http://www.sciencedaily.com/releases/2009/01/0901http://www.sciencedaily.com/releases/2009/04/0904http://www.sciencedaily.com/releases/2009/12/0912http://www.sciencedaily.com/releases/2012/02/1202

  20. " These athletes are depleting their stem cells."

    Well you surely answered one of my questions. All this elite-level endurance sport training has left me broken. And that's just one of my issues. Who knew "looking" so healthy and performing at such levels could essentially knock years off your life.

    • @The Kid The paleo 1.0 and 2.0 crew remain blinded to this. Im fine with it. But later down the road when they stop blogging because they are in the doctors office I think I will be older and still dipping in cold pools and not seeing any docs……..I gave them an actionable plan to check it out. Their arrows flew. Time will settle the biologic war of the pens. Insanity is an exercise program that is aptly named. Match that with a standard paleo template and you have modern day cross fit.

  21. So i go to get my semi annual teeth cleaning the other day. 8 months paleo now. Not only do I have significantly reduced plaque on my teeth, but the ultrasonic tool they use , while not exactly painful, was always an unpleasant sensation on my teeth is no longer bothersome at all. The tooth sensitivity must have disappeared with less O6 in the tissues. One more change to add to the list.

  22. CoolingWeb says:

    I had this bookmarked 2 months ago. All this talk about cold water made me remember this: "then he plunges into the freezing water for a swim."

    http://rosstraining.com/blog/2011/07/20/inspiratihttp://www.heraldsun.com.au/news/more-news/footy-

    An 80 years old ex footballer none the less.

    Cooling

  23. Dr Kruse just discovered your blog! I am a 47 year old male. I've been following Paleo for a year. I am also a cyclist with BF in the 13% range and I can't seem to lose my belly fat. Could the cardio from cycling and the lack of cold adaption be hurting my efforts? I eat low carb paleo but HATE the cold. I live in WI and rarely venture outside from September until March doing most of my workouts indoors.I also take lots of hot showers because I feel constantly chilled. Would more time outside coupled with Ice Baths and cold showers help? I also have renouds in my hands and feet that seems to strike when the temps dip below 40 and/or I'm not layered up with lots of warm clothes…Thanks again for the great blog- thanks again.

    Mike

    • @Mike you feel cold because your internal pilot light is off. That is what we see paleo's plateau as you have and it seems to confound them. The internet is littered with them. If you use CT protocol it is designed to re-light your pilot light using the way we were designed. No gimicks just real evolutionary biology at its core. You remain unaware that the reason you hate the cold is why you are sub optimal. When you begin to become aware of how it works you will be shocked at the results in your mirror and in your testing.

  24. Thank you Dr. for the speedy response. I'll start my CT today. I just moved my stationary trainer to the garage where it's 30 degrees. We'll see how long I last. I'll also try some cold showers or ice baths for the next couple of weeks. Thanks again!

  25. scandinavian girl says:

    Jack, I am so very thankful to you sharing all this.

    I have one question. I have a smallish lipoma on my hip. I have it since about 7 years. Do you think it could help to put ice on it for a while every day? I want it to disappear. But without surgery.. is it possible?

  26. @Dr. Kruse – going back to coffee, is it the caffeine that we want to avoid during CT or is it something else? I'm fine with drinking decaf, I just want to make sure that I'm addressing the issue. If it is the caffeine, does it really prevent adaptation or just slow it down? Thanks!

    • @Mark Decaf is terrible Never drink it. The coffee issue is controversial. My personal rules is if the cortisol level is OK then coffee is OK…….problem is most people cortisol, especially the diurnal one is way off.

  27. From a non scientist, thank you for your latest post. This is so motivating!

  28. So our neolithic world has taken winter out of the picture but our paleolithic body is expecting winter. A complete mismatch that causes chaos and breaks our bodies. I think it is really sinking into my mind! I picture the four seasons as a street block with each side representing a season. We walk through spring, summer, and autumn but we cut through our neighbors yard to avoid winter. Dr. Kruse, you are the very best!

    • @Larry you got the main issue at why there are no safe starches for humans……..when we eat them out of the time they should grow they cause major issues for our body. It is what increases cytokines. There are lots of safe starch folks cruising around with elevated HS CRP's low DHEA's and whacked out cortisol's and have no clue why or if it matters………it will eventually when they are in my office.

  29. I've been keto/paleo for 3yrs, VLC for 21 yrs. I live in cold climate with lots of snow. We moved to a new home 5yrs ago. After the move I gained 10# – for no reason I thought. The old house was cold and drafty and the bedroom was freezing at night. The new house stays at 75 degrees all winter. Started CT 2wks, lost 5#, and just feeling great. Not even to the point of ice baths yet, just cool showers and ice packs at night. Taking the dogs out snowshoeing etc. The effects on my mind and body are amazing and already I'm hooked. Listening to your every word. Thanks Dr K.

  30. Ok, I believe that carbs and gut flora put off sugars that tell your body lies, confuse, and disorder things. So is there any reason to take probiotics when you are on the winter diet? Do they work for that? We are still brothing and now I'm wondering if the broth should be reworked?

  31. Jack, am I correct in assuming that the best types of seafood for omega-3 fats would be the fatty, oily varieties that live in the coldest parts of the ocean, AND consume food involving the krill foodchain?

    If so, then any farmed seafood, and white flaky types of fish would be much less beneficial. A quick look reveals fish like wild salmon, mackerel, sardines, and herring are tops, while mussels, oysters, lobster, crabs and shrimp are down the list a little bit (again noting farmed of any of these varieties are not good due to the diets they are fed).

    • @Rodney Fish should load the winter diet…….why? because at our coldest times of the year we need as much flexibility in our cell membranes. As the summer comes we want to stick with Coconut oil because it help balance out the things carbs can do to our systems……This of course is after we have fixed all our underlying issues first. When youre in transition you must know what youre doing to get back to the median. This is where a health coach comes in. That is what doctors should be……instead of what we really are which are body mechanics.

  32. Dr. Kruse, would you agree that some of the main benefits of your protocols are a shift from using carbohydrate to fat as fuel? Which enables one to awaken their pilot light, allowing an exponentially more efficient metabolism?

    • @AG yes……but if it is done with the cold, the paleo diet allows for the very same mismatches we see with CRON or HCG. In fact I worry that the paleo mismatch is the most dangerous because it allows young people to think all is well inside because the outside looks so great…….while they are depleting life force as they cross fit themselves to death.

  33. I'm curious about something. Say we become cold adapted during the winter. Now I know you keep everything cold even in the summer. But, if we are cold adapted is it bad for us to live normally in the summer as well. Isn't it natural to just follow the seasons where you live? Or will it make your not cold adapted again and you would be starting from scratch every fall/winter?

    I'm just wondering what the health implications are since obviously as you say animals have no choice and just follow the seasons. Can we do this as well without negatively affecting our health?

    • @Erica you only need to be cold adapted 365 if you are reversing a disease or a process. I go warm adapted in summer now, but that is the only season

  34. RE: concern about increase in subcutaneous fat.

    Not all fat is created equal?

    I am much more concerned with a decrease in my visceral fat. Visceral fat is the baddie.
    http://scienceblog.com/15764/subcutaneous-vs-visc

    Plus, we want a healthy degree of Brown Fat, in fact, we want to grow Brown Fat so we become better butter burners.

    "If we can find a hormone that does that, it's reasonable to think that it might provide a direct anti-obesity treatment."www.google.com/cse?cx=009119254252368659791:9cuhzwckldq&q=Brown Fat#gsc.tab=0&gsc.q=Brown Fat&gsc.page=1

  35. RE: winter and summer living.

    THERMO PLASTICITY: Perhaps our burners are of the flex fuel variety? Cold & sleep activates fat burning, heat, sunlight & increased movement activates carb burning? but the ideal is to have those in balance (which doesn't happen in our modern world, unless we create it).

    That's where my mind is going.

  36. RE: Carb vs fat fuel. I'm comparing it to shifting from using a wood fire to a natural gas furnace. Wood stoves require a little more effort to keep them stoked and running well. But they have their place in the right environment

  37. Erica- i love your questions.

  38. Dr. Kruse,

    My husband and I are both doing the Leptin Rx (I am not really sure that I need to, but I want to support my husband). So far, so good. I have been trying to move forward with the CT, but my husband is not ready to move on just yet. I am doing the face dunks, and cold packs and also have started with some of the baths. My question is that my husband refuses to low our thermostat even a little. It is always about 72 degrees in our home. Am I correct in my thinking that the efforts on my behalf, regardless of the fixed thermostat, are still doing some me good? Any other suggestions?

    Susan M.

  39. So I live in the middle of the desert and the temps have already hit the 90s on a few days and will climb to 120+ by August. I take it that you consciously try to "live cold" all year round with A/C cranking and continued cold baths. Is that necessary or is that specific to your needs? Do you have "dose" guidelines. In the 4-hour-body, Tim ferris talks about the "minimum effective dose." what would that be for the average person?

  40. Sorry for the typos in my last comment. I forgot to mention that on the nights that I cold pack my stomach that sometime during the night I get very warm and have to remove much of my covers. On the nights that I have not iced, I don't seem to experience the night time warmth. I have not been icing my stomach every night however. Is this going to do me much good unless I progress to the cold baths?

  41. Dr Kruse, why is it that some people can jump into a 50 degree cold bath right off and others have trouble with 75 degrees?

    • @huck we are all in different stages of mediocrity and our clocks are all set based upon our genome, epigenome and what we are doing to both since we were born…….we are on a huge continuum our species is…….but overall we are mediocre specimens.

  42. Terry F says:

    Could someone put the CPT number in for the Omega6/3 ratio test? When I was in the lab the other day the staff was all confused about what it was. I noticed others on this blog have mentioned it.

    It will be interesting to find out the ratio. I've been experimenting with some of this for the last 7-8 years. I eat VLC from October on. (Trying to eat like the ancestors and initially to keep from being tempted by all the crap holiday food.)Before that I would get a cold/flu come January. After that never.

    The other thing I do is spent time in the cold when it first hits and this has helped to keep me from feeling it too bad. However, the applied cold packs and baths are more organized. I'm even thinking of moving back up north, have some family there and Lakes Leelanau and Crystal are very beautiful and safer than lake Michigan for a plunge which now looks intriguing. I have a daughter living in Colorado too. Until I read this blog I never saw those places in this light.

    I'm intrigued about the subcutaneous fat comment. At near 70 I noticed my hands especially show the effects of this loss. I've upped the coconut oil and they aren't as bad as others my age but it bothers me.

    I'm taking some pictures of hands etc. today for my log purpose. Thanks.

  43. One thing I did when starting the face dunks, was use a snorkel. I was able to keep in longer periods than my breath would allow. Being a weenie, I am following the easily measured gradual route. I spent a couple of weeks on face plunging + going out in the cold and not wearing coats (Colorado). I can easily get water temps at 50 without ice, so I've not done that. . but the face dunk really helped me know what to expect to feel with the 1st cold bath. I'm keeping a detailed analysis of the process and what I find. I'm armed with a snorkel, infrared thermometer, regular thermometer and a child I'm teaching the "scientific" process. It even gave him the idea to document a cold adaptation process for science fair. I'm a little nervous about letting him do something like this, @Jack/Anyone – cautions or experiences with different ages?

    • @Cavemam This is an awesome kid project! I may have to mention this to my daughter. My daughter is a meat carnivore and walks around without any clothes on and walks barefoot all the time……

  44. Dr K: Thanks for the wonderful blog post–which I'll have to read numerous times to really absorb. We're so lucky to have someone in our midst who is brave enough to challenge the paradigm and spread the info widely.

    I have a question about my diabetes, which seems to have disappeared. I'm almost afraid to claim that since in the past I've tried so many things that just seem to work a little bit for a while. However, I feel so different on the CT that I'm sure something fundamental is changing. HOWEVER: I'm experiencing very low numbers in the afternoon–my glucose numbers drop into the 60's and if I don't catch it, sometimes into the 50's. I don't feel at all hypo, and I'm thinking that my insulin sensitivity has increased a lot and the old body hasn't caught on and is still pumping out the same amount, driving the numbers down. Or it could be low cortisol? (But I feel fine, plenty of energy.) My question is, should I worry? Can I just leave it alone and let my body figure out the new normal? Would prefer not to go the route of eating something sweet to drive it up, but don't want to get into dangerous territory either. The new normal seems to be glucose numbers mostly in the 70's and 80's.

    Thanks! Maggie

    • @Maggie I have a lot of diabetics in my practice becoming un diabetic while the rest of the world believes it is a disease……its not a disease. it is a metabolic derangement that the cold fixes. Anyone can rid them selves of this disease if they cold adapt at home. Your doc wont believe it…….it took me two years to believe in my office. Regarding the rest of your questions……without testing Im shooting in the dark

  45. @Terry

    I have not seen a PPT code either Quest or Labcorp.

    But I had mine done through http://www.omega3test.com/ Ask for the Slanker's Grass Fed Beef $99 special. Call them direct and you will talk with Doug Bibus, the owner. And tell him Dexter sent you and also point him to CT5.

    @Caveman I am 69 years old and I did the first CT in non heated bathtub water. Just stood there naked in the tub of water and said, "He's crazy". But I just sat down and stayed for 30 min reading "Monk". The process is getting the neolithic mind to embrace the cold.

    Just finished a 1/2 hour CT and as I type this, I have on only running shorts and am warming up quickly. If your O6/O3 ratio is under 5/1, Dr K says it is much easier to cold adapt. Mine is 2.3/1

  46. Dr. K…as a resident of Buffalo, NY..I can tell you that if your theories are proven over time..You will have done what no one to date has ever done..Namely, give a scientific basis to the proposition of re-locating to Buffalo, NY ;) We will give you the key to the city and anything else….Now for a tangential question..for those who suffer from anxiety (genetic component) and use typical meds to combat it..can cold adaptation take place with consistent practice. Furthermore…is there any relation between anxiety and fat accumulation

    • @Vince I think the cold will improve your anxiety and I will go further……you need to eat a super loaded seafood diet to overcome as you do this. That will heal you sooner.

  47. Hey Dr. K and students of CT. CNBC had a video segment yesterday and VASPAR and CT. http://www.bing.com/videos/browse?mkt=en-us&v

    They're focused on exercise benefits and efficiency, however, its definitely validation on NASA and Professional Teams seeing benefits and validity.

    • @Kevin I wonder if some of my fellow Paleo 1.0 or 2.0 can aim arrows at NASA now, too? I guess they are crazy too? Check your telomeres folks. Destroy the thoughts that are killing you without your knowledge. Today we have the ability to do this. We never had it before. We need to thank Dr. Blackburn for this. Now clinicians have to be taught how to employ it for our species benefit.

  48. Completely agree. The last thing anyone needs is to train crossfit style. But a training system accounting for the pathways you've laid out can do incredible things.

    • @AG its already hear……Wil Hof is using it and he does not even know it. Vasper is partially using it……..its the ancient pathway at work in our brain.

  49. How would you define and quantify life force? Telomere length? What are other indicators?

    • @AG no…….current telomere testing is too non specific for this…….I have another part of my theory that is epi-primal……that will come later. I think we have a built in way to expand our stem cells but it requires us to be cold adapted to use it for optimal longevity.

  50. Drs M&M – where's your practice? I live in Sydney and would love to find a clinic that is Paleo/Low carb/CT friendly…

  51. Very true. Maximal stimulation = maximal recovery. What are your experiences in gaining conscious control over the cardiovascular system?

  52. Dr K, just discovered your work a week ago and in the process of digesting all of the info that my brain can handle. 2 big questions for me right now:

    -lance armstrong as endurance athlete is good, but marathoner or 'cross-fitter' is bad. why?

    -i know you explain it, but i don't understand the connection: the sherpa eats very little, but the cold-thermo ketogenetic paleo should eat a shitload. can you come at that from another angle?

    i am a former elite-level carb-laoding cyclist who developed crohn's disease. in search of another route to health and really liking what i'm reading on your blog. thanks very much.

    • @MGH 1. Lance did some things correctly……he trained in the cold and he earths. His diet was not optimal
      2. The connection is simple…….cold allows one to calorie restrict naturally when you are a mammal. The ketogenic version of the diet is ideal for this environment because we need the omega 3's to make our cell membranes flexible as the cold ensues.
      3. You are a perfect example of my theory in practice. Get your telomeres tested and find out how bad things are and you can be fixed. You better start my CT protocol with that history.

  53. Dr. K, Would a circulating ice machine(the kind used for post surgery also do the job of lowering body temp. I live in Fl so a cold lake is out of the question and constantly buying ice can become tedious. I was thinking of buying a used machine on ebay and the largest pad I could find and lying on top of it. I know its not the best solution but would it get the job done?

    Thanks! Thank you for the great info

  54. Something I've noticed is that the more heat I am able to generate, sometimes I feel as if my heart is remodeling. I become very conscious of the area, but there is never any pain. It almost feels as if the muscle is becoming stronger. Is this a normal part of the process?

  55. I went ice fishing today near Fairbanks, Alaska. It was -10F. There were about 20 others on the lake, everyone had a heated ice-shanty and when they got ready to leave, used there remote auto-starts to preheat there truck before they got in. Most released the fish they caught. See any mis-matches yet?

    I sat on the ice for 3 hours wearing a light jacket with a brilliant March sun in my face, caught a 4 pound arctic char and it's cooking now.

    just sayin'

  56. @Dr. K – Your Nashville neighbor, Ray Cronise, just got back from Holland where he spent some time with Wm Hof. You guys really need to drink some wine together and compare notes. You two could be the dream-team of 'cold'. http://hypothermics.com/

  57. Dr. Kruse, great stuff! First time questioner. Does epsom salt work in cold bath? Thanks!

  58. Is there any reason to be concerned if I feel my heart kinda feel like it flutters sometimes? HRV readings show no flutter. I'm in good shape with a vo2 max of over 60 and low levels of inflammation. Becoming conscious of something that was very unconscious for so long can be a bit scary at times.

    • @AG rewiring of the heart happens fast in CT. CT is awesome for cardiac rehab……most cardiologist do not realize it. The reason is how it increases GH and T because of receptor affinity binding. That is the next covered in CT 6…….coming soon…..maybe Friday

  59. Thanks for the answer Dr. Kruse I understand now. I have one more question though. Do you happen to know if CT could possibly help stretch marks? I don't have any loose skin.. but a couple years ago as I was gaining weight I got some stretch marks. I don't know why as they are on my inner thighs and though I def was/am overweight I wasn't huge/obese. I'm guessing a lack of some nutrient as I was vegan at the time. Anyways, I was just wondering if anyone that you know who has done this has had it help their stretch marks. Thanks. :)

  60. Hi Dr. Kruse,

    I'm going to try your leptin reset with the cold therapy. I have been on a strick paleo diet for about 6 months. I only dropped about 5 lbs. I'm dealing with hashimotos and was wondering if it is possible to get results with the leptin reset when dealing with a thyroid that is sluggish. Since going paleo my thyroid levels are back in range but the weight will not BUDGE!!!

    Looking forward to finding out if there is hope for me to reset my brain and my weight set point even while dealing with Hashimoto's. Thanks and really appreciate everything you are doing. Keep up the great work.

  61. Hey Erica-

    A lot of people have faded stretch marks with collagen induction therapy, i.e. microneedling the marks to induce damage that the body then has to repair. Taking vitamin C and MSM during the process is recommended and some use copper peptides topically with the needling. It's not a quick process, but it works.

    Here is an example: http://owndoc.com/dermarolling/stretchmarks-singl

    You would needle the marks once every 4-6 weeks (you don't want to prematurely break down the forming collagen).

  62. ChimpChick says:

    Hey Doc,

    Is there any correlation to CT and the fact that HCG makes you feel like you are freezing all the time? Also, last night I woke up sweating (never happens on HCG) could this be due to my ice pack sessions? Thanks!

  63. Thanks Doc! You're the best! I'll try not to ask so many questions all at once in the future.

  64. That's great news Jack! Yeah at first I was really upset and disappointed in myself for letting myself get to the point to get them. Especially since I haven't had children so I don't have the normal excuses. But, after a little while I decided to think of them just as that… Battle scars. It's funny you mention the same mindset. For the past year I have just enjoyed my new mindset about them and don't notice them much anymore. But, I figured this CT seems to work wonders on so many other ailments and when I do it they get super red.. so I was kind of hopeful that maybe it would minimize them at least. :)

  65. My husband was just told to reduce his synthroid. He has been on the reset for one month. How low could his synthroid medication possibly be reduced to?

    I wish cold and the leptin Rx could bypass "no thyroid"!

    Susan M.

  66. @Caveman, I tried to e-mail you via your website, but I don't know if you got it. Otherwise, your e-mail is not published here.

  67. @CW – I sent an email there, too, about a week or so ago, and I don't think he got it.

  68. Dr. Kruse,

    Thank you soooo much! I wasn't sure you would respond to my last comment. I think my husband might pay even more attention now! Thank You!

    Susan :)

  69. @CAVEMAM and LinD, Ooops I meant Cavemam, not Caveman. She posted yesterday about issues with women and cycles, etc. and was going to share her story with me. I hope we can still connect.

  70. No worries dr Kruse; now that I am on the way to optimal, I can wash dishes non-stop and without ever getting tired until the bill is paid. win-win :P

  71. Resurgent says:

    Dr Kruse,

    You write "Mammals have special cold adaptors on their skin that wire to the gut and to the central nervous system. This system is not well studied but it is clear that they are involved in readying the animal for cold adaptation quickly and eventually hibernation."

    Does this imply that cold adaption should preferentially be done at the onset of winter.. and not at the onset of summer when the mammal should be coming out of hibernation. Will it confuse the hard wiring of our CNS with the circadian cycle?. This is confusing me a little, could you clarify.

  72. Dr"s M & M says:

    Re Ice Vests.

    The husband of a patient works in the mines and wears an Arctic ice vest which he changes every hour….. he had full bloods done before he started the job( not great and he really should have been rejected)..and then again 6 months later… he is the only miner to change his vest every hour, he has lost 20kg and reported diminished appetite( his wife was worried).. Full bloods were taken monday last week and the change is considered miraculous…. I will forward copies of comparison bloods..

    As a side note when his family was away skiing in Japan over xmas holidays he was the only member who was able to tolerate the extreme cold conditions and wore no more than a light jumper.

    Not sure how effective the Arctic Cooling vests are in CT but they seem to have had some effect in this patient…in our climate where even the winter does not often get below 17deg Celsius..I think they maybe worth a try?

    • @Dr. M&M go back to this blog and watch the sleep TED video at the beginning. http://jackkruse.com/cold-thermogenesis-two/ Jessa Gamble shows you why……but never explains why they become so productive and why they all wanted to go back in the dark cold hole. I will tell you the main factors of WHY this happens…….all are tied to my CT theory of life.
      1. Cold……we run more efficient autophagy in the cold and the dark life did in its Primordial state. Part of my theory is that life began in this state. So autophagy had to be efficient then because nutrients had to come to us because we could not go to them (levee 15 in the Quilt)
      2. Performance of the central nervous system rise exponentially when autophagy rises because the brain is an energy hog. (levee 15 in the Quilt)
      3. Inside the earth there is no modern EMF screwing with us and we are also not subject to the earth magnetic field either further enhancing cognitive function. (levee 30 in the Quilt)
      4. The earthing or grounding effect of being in the ground 100% of the time has major benefits.

  73. Saw this today about planarian worms and their telomeres. Not sure if this has been linked on the blog before:

    http://en-maktoob.news.yahoo.com/scientists-key-i

  74. CoolingWeb says:

    Comet Kruse-CT2012 is hitting this planet like the comet Shoemaker-Levy that collided with Jupiter.

    I can feel the same childish exuberance and excitement those astronomers felt watching it happen live on their small monitors while the rest of world looked at them wondering what is the big idea?

    The effects of the blast went on to cover Jupiter and I see the same happening here. I think I should buy some stocks of ice maker machines' companies. Oh boy .. We are all gonna be rich.

    I suspect Dr.K has delayed his info release while he builds huge ice makers in underground caves in Tennessee. The global warming thing could be his doing too but I can not prove it thus far.

    http://www.youtube.com/watch?v=CiLNxZbpP20

    Cooling

  75. Dr Kruse..

    Just an update. Finished week 4 of reset and about 2.5 weeks into CT. Cold showers at night (3-4/week), walking around house in shorts t-shirt without heat on, cold walks, occasional icepack. Blood pressure dropped from 120/85 to 115/65 and FBG was originally 94. Two weeks ago it dropped to 86. Last Friday it was 75. Been losing about 3lbs a week too.

  76. http://www.independent.co.uk/news/science/scienti
    I was talking to my kid after I found this article and reminded her to call the doctor about her stomach for a test. She had been throwing up every morning and had bad breath that wouldn't go away before we started reading this blog. She has an HMO. She told the HMO doc she had been throwing up for months. Almost a year ago, I didn't even know it hadn't gone away. When we started on the supplements I told her the b6 would help with the stomach acid. It did. She stopped throwing up, but now. She said she is nauseous at the thought of food, afraid she will throw up. (Not like pre episode stuff). I was convinced she had a pyloric problem, just because of the intensity she went at spicy foods in jags. I learned later, that's a zinc deficiency , making the whole thing a vicious cycle. Do you know of any words that would nail her a gut test? I think we've hit a wall.

  77. Unbelievable, my always cold husband with Crohn's started CT! I did not think this could happen. Dr. Kruse, you certainly can impact people!

  78. @Jack I am still interested to know how this all plays into autoimmunity, which I believe a number of people who comment on this blog face problems with. I understand that maintaining telomere length prevents cellular degradation over time; but that seems to point to disease prevention, not disease reversal in cases where certain types of damage has already been done.

    I think you mentioned somewhere, that once cancer starts, it's hard to reverse that. Or if you've destroyed your pancreas, it's gone.

    With autoimmunity, you may supress the cytokine and other inflammatory responses that come with lupus, Hughes, MS, etc. but you're not reversing the disease. The antibodies aren't going away, if I understand things correctly.

    And there is a big difference between being asymptomatic and being cured. For me, a cure means no more rat poison (Coumadin). Asymptomatic means, I keep medicating, although the likelihood of a clot forming is much lower.

    Your thoughts?

  79. Thanks for sharing your research Doc. I've been eating paleo for many months and just started the LR two weeks ago. (I'm 5'10; 200lbs with a remote hx of being 300+ lbs) I've lost 4lbs since LR and am now VLC — no nuts. I've been taking cold baths daily at @52F and am up to @45mins. Shivering while in the tub has decreased to minimal amount (for me) though still shivering lots for up to 2 hours post bath. I know this means my 6/3 ratio is outta wack so I added fish/krill to my regime though I was eating sardines.

    Questions: 1. How long does it take to improve omega 6/3 ratio to a point where post bath recovery is short? (labs not in the budget atm)

    2. You already said that working out is good post bath but would that be "cheating" if I do it to help warm up? How about a Far Infrared Sauna blanket? I think this would be cheating but I'd like to hear your thoughts on if it has any place in this CT/LR regime?

  80. Dr. Jack, does CT do anything to improve the current O3/O6 ratio in cells? I'm sure my ratios are off so I'm eating cleaner and ordering fish oil, but I want to get into the full CT protocol ASAP.

  81. My husband has been using Cholestyramine -used to prevent diarrhea in Crohn's patients with ileal resection – for the past 25 years. Could CT phase out this supplementation?

    He also takes Claritin-D 24 hrs around the year for alergies. Any thoughts on that?

  82. Is there a possibility of overstimulation when trying to progress very quickly in CT? A year ago, I stimulated my body to create a very large amount of heat. I had an intense sympathetic response for 5 days, with elevated blood pressure and heart rate. And then I hit a period of parasympathetic immobilization for about 7 days, with dizziness and fatigue. I came out of it feeling like my heart had remodeled drastically. Are these intense stress adaptation cycles part of the process, or is CT a more gradual method, thus reducing overstimulation?

    • @AG I think so……if you stimulate the core receptors of cold before the surface ones…..adapt youre going to die. But mammalian biology is not designed for this……to ever happen unless you are warm adapted and fall into the BEaring Sea. Will Hof has shown many times over cold adapted humans do not die when they do this………CT 6 gets into why? Wil Hof does not even know why. He will by weeks end.

  83. CoolingWeb says:

    @Maggie Wonderful news you are reporting here. Could you please elaborate a little about your diabetes and the CT protocol you used please?

    How long? How cold? and stuff. :)

    Congrats on your results.

    Cooling

  84. Dear Jack,

    I have been following your protocol with great success. You are a blessing to all of us out here. My bodyfat was 24% it is now 16.5%. HDL went from 42 to 58. Tri's went from 120 to 60. I am 51 yr old caucasian male.

    This is were it has stalled. I had my testosterone tested via saliva morning test.

    Progesterone 26 (normal range 12-100) testosterone 51 ( normal range 44-148).

    Could my low normal Test be the reason for my stalled progress on bodyfat composition? And do you approve of Test supplements for patients?

    All The Best

  85. @Jack I am wondering if there is a difference between "kinetic thermogenesis" and "non-kinetic thermogenesis." With the former, I mean that which is inducded by exercise or movement.

    If I jump in a swimmnig pool and start swimming, it's not surprising that I start to feel warmer as I do more physical work. But If I sit stationary in cold bath, that's something else.

    In order for CT to work properly, should our therapeutic exposure be motionless soaking, or is kinetic immersion OK?

    • @the kid the more you move in a cold environment the more heat loss you have and the faster you lose fat and shred your body………but here is the down side……you could induce core hypothermia……if you do this……so instead do what mammals do…….they are sleeping (hibernating) as this occurs……no movement at all……..And the implications of this for humans…….well you will love CT 6…….I promise.

  86. Because of my past success with cold thermogenesis to say that I am enthusiastic about your current blog series would be an understatement. For the time being I've decided to revolve my life around CT as much as I can. As you said, it is cumulative.

    I've done the following:

    1. Purchased a 110 gallon insulated tub and put it into my garage. Plumbed the tub to the cold water supply of the house. (ran a hose from the washing machine connection).

    2. Purchased an external water chiller. These are used for aquariums to cool the tank. I can get the water any temperature between 39 to 75 degrees Fahrenheit.

    It is very Spartan but very effective purpose built setup. I know skin temp is the ultimate goal, so I don't think I need any ice. Is this true? Should hands, feet, and head not be submerged? I've heard this is counterproductive.

    Thanks Dr. Kruse, your blog is a lifesaver. When is the book going to be released? :)

  87. For those that have tried to email. I'm so sorry I didn't get your messages! Since most of the comment form stuff on my site was 50+ emails a day of spam, I quit even looking at that. Since that is business anyways, you can email me directly at marketingjeanie@gmail.com

    Please please ladies and bypass folks email so we can group and share.

    Thanks for trying.

  88. So now I'm doing that dangerous thing of thinking. My son had minocycline for acne and had to take it separate from vitamins or milk because of calcium. If the calcium over load is in the brain and needs displaced by lithium…

    Now I'm thinking just go to the family physician and get the minocycline for zits, just cause he works with us. That probably wouldn't raise eyebrows, but it wouldn't get a gut diagnosis. What kind of doctor is gut check happy? and would know about lithium?

  89. This may probably be covered in the next blog…but whaddya think about skin brushing prior to the cold bath?

  90. nuttmegs17 says:

    Great post! Love the format!

    CT is going great for me…i've rarely missed a day and noticed intense sleep, lowered inflammation…some days are easier than others depending on circumstances (ie, when i have missed out on sleep, CT is harder to tolerate and my Cold adaptation will be lower that day).

    The leptin Reset has been amazing – one of the best and earliest changes was my ability to fall asleep and then wake up naturally before 8 w/o an alarm clock…since CT I still sleep VERY well – in fact my sleep is alot deeper, however, I find myself having a harder time waking up….its not unpleasant its just that my sleep is so deep that its hard to get out of….has anyone experienced this? what does it mean? I might post on his blog as well….

  91. What's the mechanism behind skin brushing being bad before a detox bath?

  92. I meant cold bath..

  93. I just read that. The darn minocycline hurts als patients and its mitochondria also. I was just intrigued by the article and hoping to get more folks dunk happy. I think the only thing we can do that is not frightening is try to get all the minerals in balance. I might need a silence of the lamb pit to throw my family and liver into.

  94. Dr. Kruse. You just gave me a helluva hint about hibernating. I'm in Iowa and I'm gonna sleep with the windows open in my bedroom for the rest of the winter and spring.

    Thanks!

    • @Cody………CT is going to blow your mind………I have been dropping major hints for 1.5 years. PH, blogs, etc……none of them got it. Look at the Paleo 1.0 and 2.0 folks now…….I have them just where I want them. Just watch.

  95. Lee: @ your daughter and the zinc deficiency. Do you know about PYROLURIA? i just got diagnosed with this…. it is a blood condition where zinc and B-6 are expelled from the body. There is some info if you google. and great FB page called PYROLURIA. The morning sickness is a definite sign. A urine test can give you answers. she is also likely very high in copper… supplementing with zinc i am reading can make the copper detox a bit unpleasant. I have not started yet, still doing some testing. the high copper also makes for susceptibility of infections and a very leaky gut. Zinc is needed for gut integrity.

  96. Lee: also forgot to add i also tested positive for the H. pylori….. guess goes hand in hand with leaky gut and lack of zinc. its all about testing now.

  97. I laugh when I think back on the 4 or 5 times you have told me in the last year, "If I were you, I'd eat like the Inuits". Did I do it? Nope. I went with 'safe starches' and 'carb loading'. Did that work? Nope.

  98. so this morning, now that we have some snow in upstate NY, after 3 weeks of CT protocol I walk out into a private field near my house take off all my clothes and lay down in the frozen snow. the sun is warm on my belly even though it's 32 deg . I did ten min on my back and ten min on my front. Then I did 40 pushups like it was nothing in the snow. going back tomorrow. sun on the top ice on the bottom.

  99. Dr. Kruse, does CT allow us to strength train more? Could I get away with 4 days per week without the resultant injuries and hormonal issues? More even?

  100. Are you familiar with the book 'Biology of Kundalini'? Do you have an opinion on the science in that book?

  101. Here is a link to; The Dive Reflex: for rapid lowering of anxiety/stress or elevating mood. The Dive Reflex, originally noted in cold water diving, is a first rate vagus nerve stimulation method capable of rapidly chilling down anxiety, panic, stress and body-wide inflammation as well as elevating moods. At first the dive reflex was done by dipping the face from the lips to the scalp line into very cold water for 30 seconds to 1 minute. This would quickly melt away anxiety and stress. Later it was found that a large zip-lock plastic bag filled with ice or ice cubes applied to the face from the scalp line to the lips would perform as well without leaving the user appearing like they just emerged from a river. The Dive Reflex, because of its ability to stimulate the vagus nerve, has proved helpful for:

    http://www.emoclear.com/thedivereflex.htm

  102. I cannot wait to read your epigenetics stuff. Read the Biology of Belief by Bruce Lipton. Interesting theory but i want PRACTICAL application. I have a feeling you are going to be helping us there…

  103. Cody,

    When recovery systems are trained maximally and one is in an adaptive state, you can train daily with no problems. And progress is insanely fast. But it takes time and more importantly strong intention to get to that point.

  104. Dr.

    Sorry this is off topic, but just read your osteoporosis blogs and HAVE A VERY IMPORTANT QUESTION:

    You advocate some hormone replacement for women concerning osteopenia/osteoporosis.

    I have been taking EVISTA, a hormone drug prescribed by my GYN for osteopenia (after bone scan 2 years ago-no wrist module on the scan). DO I CONTINUE THIS? On paleo/primal diet since last Nov/Dec. Age 63. Small boned, not overweight. Kicked up my K2 intake with supplement, fats and protein.

    PLEASE–what do you think of the EVISTA?

    THANK YOU. Found you through the excellent PaleoSummitt.

  105. Thanks so much LEXI.

  106. Maybe a dumb question, but will we roast outside in the summer if we are cold adapted?

  107. @Monte

    Regarding your tub/chiller set up. Want to learn exactly what you did. If you could email me dextery at hughes dot net with subject: CT Chiller.

    Thanks

    Dexter

  108. Lee: you are welcome! this condition is blowing my mind…. looking back, i can see i have had this since i was a kid. i wish docs knew about it b/c it would have saved me some real grief: mental, emotional, physical. having your minerals out of whack is detrimental on so many levels. treatment is coming b/c i researched "orthomolecular" and "functional" medicine. i found help from this site: http://www.walshinstitute.org/WebLinks.asp it is worth contacting them to see if they have similar centers or practitioners near you.

    and why don;t docs know @ it? b/c its treatable with supplements. need i say more?

  109. Dr K: has Mrs. K been doing CT? what have her results been?

  110. Well, we were waiting to find the orthomolecular psychiatrist and then get insurance to match… we have calls out…I think we might have to ask for hook ups. These orthos are very precious and popular. Or maybe try to "bump" into one. lol

    And yes, my daughter was pissed off from about 13 years old on. AND Everything else.

  111. Dr. Kruse –

    This new format makes it much easier for me (a non-geek) to get the message. Once I get the message then I can go back and learn the science.

    Thanks,

    Elin

  112. Just as everything Dr. Kruse has laid out, training must also biologically match. Meaning use the body the way it was designed to be used. Eliminate all compensation patterns, and learn the ability to interact with force efficiently. If the foundations of human movement aren't accounted for, we jump right back into producing needless inflammation.

  113. TheKid: is there an autoimmune condition associated w/ abnormal blood clotting? what is it called? BF has this and docs are "stumped" b/c all his other bloodwork / health markers are stellar. he is on coumadin too. thanks.

  114. @Jack Kruse

    With bypass, should I do reset diet or continue keto-paleo as the same issues with vagus would still apply?

    @Jack and @ BR re: dive reflex. Would this stimulate vagus section attached to brain in right way or would there stll be a disconnect because of, well the disconnect!

    • @cavemam depends upon how far out you are from the bariatric surgery and if your weight has plateau'd yet. If you're fa out and weight loss is stopped CT will light you on fire.

  115. @Jack,

    I'm 10 yrs out, and stopped.

    BUT – What is optimal, doing CT with my current keto-paleo diet or will the CT make the reset RX work better for me? Should I restart the reset?

    THANK YOU THANK YOU!!!

  116. I constantly want my shoes off and my feet seem sweaty. I'm not a really sweaty kind of person, but I think that might be changing. I had like a die off rash last week I thought, but maybe I was getting ready to sweat?

  117. So, my experience so far with CT. I live in Ohio and my water comes out of the tap at 39-40 degrees. When the CT1 came out I started with the ice packs and face submersion. Face was easy right out and so were the packs. Though I had previously done ice packs on upper chest and back of neck from the Tim Ferris book. This time I did the same area and added my stomach to try to lose weight there faster. It was pretty easy as well and I did it about 4-5 times about 2 wks ago.

    Then last wk I thought I might as well jump in an do the baths. I did my first one and stayed in for about 12 min. I covered my feet and head and didn't submerge either of them or my hands. It was cold, but not as bad as I thought. I only shivered one time which I thought strange, but when I was younger I loved the cold and would always take cold showers. I did the second bath two days later. This time I noticed either pronounced goose bumps or the Uticaria that Dr. Kruse warned of. I couldn't tell the difference so I erred on the side of caution and got out… I was in about 15 min. Jack said not to do the baths unless I had skin temp things. WHich I don't. So, I've decided to do showers instead as the water isn't constant and I can move it around and pay closer attention to my skin. Tonight was my second one.

    This time I started with the water at a warmer temp of 50 degrees. I figure maybe i just had it too cold before. Funny enough it felt warm! It was like I was swimming in a heated pool LOL. I did it for about 15 min then changed to a lower temp of 40 degrees for about 5 min. It was cold, but still no shivering. My skin gets numb and tingly almost instantly. Is this good or bad? Also, is it bad that I don't shiver at all? I feel like I should be colder than this, but I'm not. I don't shiver much normally even when it's dead winter, but I figured it's because of my clothing. I'm concerned that most people seem to be shivering and I'm just instantly numb without feeling very cold at all.

  118. LisaAPB says:

    I had a rash last week too. I also had a fluttery feeling in my heart so I decreased my T3. And I had 3 episodes where I felt nearly hypoglycemic, but I didn't get to the fuzzy stage… I just knew I'd gone too long without food.

    The biggest thing I am noticing now, is that I can work out for longer periods without feeling much muscle fatigue. And the recovery time seems to be very fast. I generally take 2 cold showers a day, work out 2-3 times a week for about 20 minutes. Three weeks ago I was doing 4 sets of 12 squats, today I did 6 sets of 20 and felt like I could keep going!

    Also, and this sounds crazy, but I seemed to heal very quickly. I had a burn on my forearm, and a crunched finger and they only took a few days to heal.

  119. @Erica, I'm sure Dr. K will respond but aren't you supposed to keep the cold water temp to 50-55 degrees? Why are you doing 40, especially with possible Uticaria the other time? I am still just dunking my face and my tap water is 53 degrees so I don't have to do a thing to it. I still didn't get a compression shirt or ice packs and not sure which ones to get. Also, a skin thermometer seems like a good idea but not sure where to get that either.

  120. @CW: When you do ice it would be colder than 50.. so I didn't think it mattered. I can make the water 50 if I need to. I think it was just like constant goose bumps, but if you look at the pic on wikipedia it does look like that unless you get the big welts. No welts so it was just hard to tell ya know. Nothing hurts though and my skin stays red and warms up pretty quickly. If I should keep it at 50 that's not a problem… hopefully Dr. K will comment. No problems in the showers though with any persistent goose bumps. Just normal red skin.. and tingling/numbness.

  121. Julie Mccarthy says:

    Dr Kruse, I was wondering if using flexeral would mess up the leptin reset. I am having muscle spasms at night and thought about taking one. If it does mess it up, is it permissible to use my electric blanket on my legs instead? That also seems to help but I didn't want to get too warm since I am cold adapting.

  122. @Lexi – The blood clotting condition is called antiphospholipid syndrome (APS). It is also referred to as Hughes Syndrome, named for the doctor who discovered the condition.

    It is an autoimmune disease in which 2 different antibodies impact the clotting cascade. This results in the creation of clots that can be life threatening. There is a test for both antibodies. Just ask your hemotologist. Hope this helps.

  123. Dr. Kruse. Once again I have to thank you. I hibernated last night. Best night of sleep I've had in a long, long time. It is 4:15 AM and my apartment is 60 degrees. I resisted the urge to turn the heat up and instead chose to eat a big breakfast of roast beef and cabbage (which I had in the crock pot overnight). The leptin reset did not work for me. My appetite has been uncontrollable. I was born that way. My mom shared stories of how I was constantly hungry as a baby, and I've ALWAYS inhaled my food and eaten to the point of pain. Even though my stomach is full, something in me has a ravenous desire to eat, eat, eat. Only ephedrine has been successful in reversing this (along with African Mango). Yesterday I switched from PSMF to keto, and about double the calories, and for the first time in ever, I am full from about 3/4 of a lb of roast beef and 1/4 head of cabbage. I am shivering as I write this, but I know that winter is almost over, and I don't have much time to enjoy free cold here in Iowa. So now it is. I am excited to by the lowered appetite and amazing sleep. I was actually sleepy when the sun went down yesterday. I can't remember the last time that happened. It certainly didn't happen the first time I tried the leptin reset. This CT thing is going to be my Godsend and I have to thank you for having a strong back bone and giant icy balls. Because you have withstood some ridicule my friend, and I appreciate everything you are doing!!!

  124. Also, I love that you reminded me of the book The Monk Who Sold his Ferrari by Robin Sharma.

    Everyone should read that book.

  125. @Jack – Is it a problem if I can't fully submerge myself? We have a horribly small bath tub and I have to bend my knees to fit, resulting in my legs being exposed to the air from mid-thigh to mid-shin. My chest also is just above the surface of the water.

    Currently, I let the tub fill with water from the tap, which is probably 75 degrees (we can't control this). Then once it's as full as I can get it, I start adding ice by the scoop full from a bucket I have next to the tub. I slowly add-in about 3 bags worth of ice.

    Because the tub is small, the ice seems to melt pretty quickly. In order to get an all-ver cooling, I end up sitting up and continuously pouring water over my head and shoulders while letting my legs submerge.

    I have no idea how cold the water is (don't have a thermometer at present), but I do get pretty numb. And last night I ended up shivering VERY uncomfortably under my covers for about an hour and half. My body seemed to remain very cold. I also had goosebumps and itched like crazy.

    Am I doing this right?

  126. @Jack:

    Thanks for the word on Evista–and also for all the great information and science.

  127. Are there any women out there who are post-menopausal and having success with this? I would like to have an email conversation with you about the particular issues we face. My e-ddress is elinduke@hotmail.com.

    Thanks,

    Elin

  128. What happens if you have been diagnosed with Cold urticaria?

  129. Dr. Kruse, have you seen improvement in spinal stenosis with any patients following the CT protocol? My father has the disease and I am working on him to begin the adaptation. Thank you as always!

  130. @TheKid: thanks for the info… i think they tested that and a bunch of genetic markers too and came up with nothing…. will ask

  131. Jack,

    First of all. A huge thank you for all you're doing. As a classically trained practicing ER doc I can attest to the fact that modern medicine teaches all the wrong stuff (USDA food pyramid) or nothing at all about nutrition, and I think your pioneering work with CT is a tremendous benefit to mankind — and particularly to me as I jump in our pond today and feel the weight continue to melt off on a ketogenic paleo diet.

    My question though, if you'll answer I'll be thrilled. My beautiful athletic wife, once a competitive swimmer (and raised a carb-aholic, to a lesser extent now) and still maintains her college weight seemingly without effort (thus I suspect she is leptin sensitive) has had Raynaud's Syndrome since I met her (late 20s) and it seems to be getting much worse is in recent years (even months) to the extent that she got it in multiple fingers while cracking eggs from the fridge the other day). It worries me. I've seen several blog replies here and there relating to Raynaud's syndrome, but haven't quite tied it all together. Would you be willing to do a quick post on the pathophysiology (increased O-6 fatty acids in the periphery?) and the best way to deal with it / reverse it.

    I've been working on my CT since reading your posts (by jumping into our pond here in there northern CA winter x 2 days now) but she is tremendously cold averse. I might be able to get her to do the face dunks as a starter… take fish oil and go more Paleo (she believes a lot of it but still persists in eating a lot of wheat carbs etc as she always has.)

    Am I on the right track? Thanks in advance if you have time to answer.

    Respectfully,

    Rob

    • @Rob her Raynauds is caused by the mismatch in her diet…..she is concentrating omega 6's in her tissues. After CT 6 comes out you'll get it. If not you can call me and we'll talk. I'll make sure you get it. As an ER doc you can help thousands of people with this information. That is my ultimate goal. Changing our species.

  132. And one other point / question: I have noticed several times you posting that "I eat anything I want now" or something to that effect. I have noticed in myself that what I want to eat (and particularly how much) has really changed in the last few weeks of an imperfect start to your Leptin Rx. Satiety comes much more quickly now than it did just weeks ago (didn't *want* to finish the food I took to work a couple nights ago — when before I would have quickly polished it off and been tempted by the pizza the night nurses ordered). I've apparently overstocked the fridge with fresh veggies and such because I just don't *want/need* to eat as much as I used to.

    So, I'm guessing that "anything you want" is a whole lot less (maybe less than 500 kcal / day?) than it used to be, and you've retrained your mind in terms of what you want to eat — so perhaps not interested in cream pies and pizza and Cinnabons… 8^) And you're not left wanting?

    Just wondering.

    Thanks again,

    Rob

    • @Rob This is also covered in CT 6…..its part of the ancient pathway. Cold destroys appetite. And when you find out why…….well you will be on the road to optimal

  133. Clabbergirl says:

    Dr. Kruse must be an amazingly busy man! My not-yet-optimal brain overheats at the thought.

    That being said, anyone doing CT having worse-than-usual sinus drainage issues? I don't know if it's part of the CT process or seasonal (trees beginning to bloom in my locale), but even if seasonal, this is worse than I've experienced in previous years, and really picked up when I started icing my thyroid with cold packs.

    Curious if anyone else has experienced this.

  134. I was reading up on Pyroluria. We will have a solution today. There is no doubt about it. My husbands highly achieved loner family members and the hit and miss make me think its a mismatch like anything else. If you ate sea urchins, you need this. But who knows what time of year it is you're supposed to eat sea urchins. We don't know if its a virus or we just don't know what to feed a mermaid. I sure wouldn't want to kill my mermaid with sea urchins. I guess we'll go vites and try to kill the virus or switch off the gene in the cold.

  135. @Clabbergirl Yes! I've been experiencing the same..my sinuses are going nuts and I've never been one to have seasonal allergies or allergies of any sort. Mine started with the face dunks.

  136. Wires crossed.. thanks Dr.

  137. @Caveman; The dive reflex link came from the "Cooling Inflammation" blog. Here is a link to the vagal search of this blog. http://coolinginflammation.blogspot.com/search?q=… Also take a look at the Anti-Inflammatory Diet and Lifestyle, http://coolinginflammation.blogspot.com/search/la

  138. Jonathan Goins says:

    when will CT-6 come out?

  139. Nuttmegs17 says:

    not that calories matter- but due to CT, how many calories do you estimate you taking in…"reduced calorie diets" mean something different to everyone so I'm curious about a range…

    • @Nuttmegs I do not answer questions on calories because like macronutrient ratios they are worthless. CT renders them completely null and void.

  140. @Jack – don't have a cold shower either. Is what I described early ok and effective or should I be doing something else in my little tub??

  141. Someone somewhere (here or on MDA) posted a reasonable place to get your serum 06/03 ratio tested. Can you please repost? Thanks!

  142. How long is too long for the head in the sink treatment? With a snorkel, I can go for awhile, so I don't want to overdo it.

    Thanks.

  143. Fine motor control (typing) seems port when cold (after my wonderful long daily plunge in cold lake today). Returns slowly. Also 2 numb toes on left foot, slowly coming back. Is this something that adapts / changes / gets better? Due to O-6 in the periphery or something else?

    Have now dipped in my cold (need to get a thermometer to know how cold lake) 3 times with a remarkable improvement in tolerance to it each day. That and working in my office with all windows open and trying to be chilly every where I go…

    Thanks again.

    Rob

    • @Rob the colder you go the more omega three's you need in the diet to add fluidity to your nervous system and all your cell membranes in your body to improve signaling.

  144. golooraam says:

    my word there are so many comments to read through!

    I wanted to get clarification as to if the ice vests mentioned in some comments would be useful for cold adapation – if so I want to order one and use it to do pullups outside, go for walks, and wear to work with the AC on

    by the way (before my disastrous weekend in Vegas this weekend), last Friday morning I was able to bust through my weight plateau of 190 lbs, dropping to 188.8lbs

    I have been consistently driving to and fro work with the AC on full blast, sometimes having ice packs on me. If I get time at night I have my missus pile ice packs on my chest and stomach and I take a 30 minute ice nap. So far soo good – still regretting the crap I ingested in Sin City though

  145. @Carolyn I would try CT first…..you might be shocked.

  146. Jonathan Goins says:

    So if i read you correctly CT may require an increase in O3 intake to fuel the process. is that correct?

    • @Jon depends upon your CT time…..if you use it a ton you need to up your dietary o3/o6 intake. I like nut encrusted fish to solve both issues.

  147. @jack – when it comes to cancer, I assume from what you're saying that it, like diabetes, doesn't happen all at once. So just as metabolic syndrome is a warning of diabetes down the road, are there cancer warning signs?

    I ask because I'm in my early 40s when new mole development should cease. Yet, I've for new ones popping up all of a sudden and old ones changing shape. I've had at least 7 removed. None were cancerous. But it got me thinking as to why this is happening and why it's happening now. Any thoughts?

    • @Thekid……the cancer warning signs are coming in organ specific telomere tests……right now the older you are on the rough estimates the closer you are to cancer…..I also look at HS CRP as a big indication especially if DHEA is crashed……..low DHEA and high serum insulin's are a huge issue for CA.

  148. Jonathan Goins says:

    twice daily 32 minutes each. my hungry has gone through the roof this is the second day i have crashed totally crashed at 2 pm.

    • @Jon if that is the case it is the estrogens from you fat. Good sign. Try not to eat crazy but if you do make sure its a ghee/bacon grease loaded meal.

  149. @Jack – I had my HS CRP done 2 weeks ago and it was .76 mg/L. What does that say to you?

    • @The Kid tells me your better than the mediocre humans but way too high for optimal…..i want my patients as close to zero as possible, So you have some fat on the bone.

  150. Good to know about the nut crusted fish. I have been concerned about not getting enough fats as my hunger decreased so did my food intake.

    • @Kami people who do CT will be asked to up their natural 06 content in late summer and autumn. This will be reflected in my e cookbook too. It is supposed ot go live tomorrow or Wednesday. So you all can see how to eat by circadian cycles.

  151. Dr Jack: You mentioned low DHEA and high insulin as CA warnings. Is the insulin to be tested as a fasting or as a postprandial level? Or both? I think you mentioned less than 2 for fasting. What would be a safe after-meal number? thanks!

    Maggie

  152. Michael says:

    @Jack What kind of nuts do you like to encrust your fish in? (Or do we have to wait for the Cook eBook?)

    • @Michael I use Macademia nuts 95% of the time and then go to pistachio's, brazil nuts, almonds. That is big for me in autumn. This yr I did it in a bit differently because of bio hacks I was running on myself.

  153. Christy says:

    hi all —

    playing catch up here & I'm sure someone asked this, though I don't see the answer — where is the Cold Thermo 4 blog or is it titled something else? or is this actually 4&5 together?

    thanks!

    Chris

  154. Michael says:

    @Christy It is titled differently: THE HOLY TRINITY: CT-4

    http://jackkruse.com/the-holy-trinity-ct-4/

  155. Christy says:

    ok great! thanks Dr. Kruse and Michael for those links — I'm printing it all to read and reread …also will likely be buying stock in paper now, too :)

    thanks again!

  156. Coriander says:

    How long Jack, how long?

  157. Christy says:

    @Dr. Kruse…well I have no doubt there because it's happening with each and every blog you post — just such amazing breakthrough science with the proof, in the hacking!

  158. Coriander says:

    CT 6 of course. You've built it up so much.

  159. Will a temporal digital thermometer work on the skin after drying off, not on the forehead as it's intended? I already own this. I saw some skin thermo. that cost $600.00, not in out budget. Thanks so much. I want to do this right.

    http://www.exergen.com/medical/TAT/tatconsumerpag

  160. Grottenolm says:

    Hi doc, just letting you know that since starting CT I did my first spontaneous 24 hour fast EVER – was simply not hungry or interested in food. Was absolutely fine the whole time – energy stable and got a lot of work done without the food distraction ;)

  161. Coriander says:

    Very cool.

  162. Just dunked face a couple of time until needed to take a breath and then into a cold shower with the window opened in the bathroom (in New York, temps are in the mid 30s here). I lasted 7 minutes and got the goose bumpy thing. I feel warmer now. I thought I would be cold for hours. Would it be a good idea to wear a compression shirt while in the cold shower?

    • @CW yes it would. When your cold adapted you can head over to Central Park Row boat lake and take a dip. Yes, I have done that about 1000 times too.

  163. Thanks Dr. Kruse. So, it's yes on the compression shirt in the shower or is it yes, on the temporal digital thermometer in lieu of the skin thermometer? Or yes, to both???

  164. A dip in the lake at Central Park would be awesome!

  165. Dr. K – Thanks to a previous reference of yours, I've read "Ageless" by Suzanne Somers and know the importance of balancing hormones, eating good diet, avoiding stressetc. I have a 18 year history of being on synthetic hormones after a hysterectomy/loss of ovaries. Worrying about their effects, I quit entirely for 9 months but restarted when the lack of sleep was killing me. I did testing late last year and found my hormones are all in the tank, cortisol is high, and hsCRP is 4.4. I am avoiding n-6 like the plague, taking fish oil & krill oil, dousing my food with turmeric, eating 100% chocolate and limiting carbs. I started bioidenticals plus DHEA, pregnenolone, iodine, & DIM 7 weeks ago but sleep is still poor. Is CT likely to improve my situation? I am betting you will say emphatically yes.

    • @Linda once you use CT and get your 06/3 to 4/1 you cant eat foods with 06's without fear. 06's are not the devil paleo makes them to be especially when your cold adapted.

  166. Dr. K – Hope you have lots of peppers in your recipe book! Have you seen this study?

    http://www.ncbi.nlm.nih.gov/pubmed/22378725

    "BACKGROUND: Capsinoids-nonpungent capsaicin analogs-are known to activate brown adipose tissue (BAT) thermogenesis and whole-body energy expenditure

    CONCLUSION: Capsinoid ingestion increases EE through the activation of BAT in humans. This trial was registered at clinicaltrial.gov as UMIN 000006073."

  167. Dr. K, after listening to you at the paleo summit, I began the leptin reset. I'm noticing lots of body heat through the morning after eating breakfast. Is this the usual response?

    Thanks for your amazing discoveries, sharing and feedback.

  168. Dr Kruse, I don't have the words to thank you for all the questions you have answered. I have used the scd diet (modified now) to control uc for 6 years. In the first two years I used too many vegetable oils and after a few months had a single episode of iritis (and was assured this would become a regular occurance. I then had Raynauds symptoms for a whole winter. Thanks to Peter at Hyperlipid I changed the fat in my diet and the Raynauds disappeared without trace but it was not until I read your blog that I knew why.

    Over the years I have felt many of the changes you have explained, my weight is stable and much better distributed, I have stamina and rarely eat between meals,

    I (and the rest of the family) don't often need sun protection and I am frequently asked how I have managed to lose 10 years.

    Recently summonsed for my UK – now you are getting older lets see if we can give you a statin – test with absolutely no questions asked about family cancer history. I was delighted to find my HDL was high and TC/HDL ratio is good but I'm going back to read your VAP post again before I have to explain the figures in the doctor's surgery.

    I'm not very brave, just 6 inches of cold water in my bath so far, but once again I'm over the moon to find no obvious pufa problems, 25 mins is surprisingly easy and half my blankets have gone. Hopefully this will make a difference to the final uc symptoms of slight but persistent bleeding bleeding and some urgency. I would love to know your thoughts on these last piece/s of the puzzle. Wolfgang Lutz said the bleeding could persist for as long as 8 years on his diet and so far he has been right all the way. My best guess is vagal nerve damage and the cold does seem to be reducing the bleeding.

    – a final thought. Many years ago my sickness, nausea and fatigue during pregnancy disappeared as if by magic on a week's skiing holiday. Now I know.

  169. Hi Dr. Jack, looks like others are awakening to the benefits of your CT theory: http://www.drmercola.com/weight-loss-2/benefits-of-brown-fat-for-weight-management/

  170. Gladina says:

    Yes, that's AFTER you're cold adapted that you can eat 06 w/o 'fear'. Even that you indicate that that should be loaded in late summer/Fall. I really quite like the eating to circadian cycles and CT. It makes so much sense evolutionary (as you've explained so well). Not only that though, people are not stuck eating the same thing all year. It has variety. I really feel like this blog/style of eating hits on all the holes in ANY previous eating pattern.

    Loading up on seafood for the next couple of months + CT until the warm weather hits is what I'm all about. Even then, I do plan to keep my seafood intake a bit higher this summer + CT, but will add a bit more fruits of the season, and towards the end, maybe more nuts (06).

    • @Gladina CT-6 is Epi paleo……and you will see why. Evolutionary biology says it, not me. I am just the messenger who found this gorgeous Ancient Pathway in our marvelous brain.

  171. " I have decided tonight at sunset…….CT 6 takes flight."

    WOOHOO!!!! I'm so excited about your work. It's like being a kid again. Can't wait for the blog. CT in the meantime.

  172. Gladina says:

    Casey, that makes sense…I know a lot of places like that don't get too 'cold' in the winter, but then these people generally don't use heat in their house. Maybe a small fire place…but not central air. Makes sense.

  173. PaleoNana says:

    I've been doing the reset for 4 weeks. The following improvements I've found: I'm more in sync with my circadian cycle. I go to bed earlier (which brings some amusement to my kids who think I'm old for doing this) and getting up earlier, with energy. I can rid myself of migraines with CT-instantly. I'm feeling stronger–I carried my 40lb granddaughter up a flight of stairs when she was sick last week-normally this would have fatigued me. (Negative from this, is I caught her cold. Wonder if I should continue with CT when I have a cold? My intuition says yes) I'm no longer losing hair. I was having huge issues with this prior to reset and CT. Weight loss has been slow, but seem to be losing fat–gaining muscle. I have no cravings whatsoever. An observation: my body heats up so often now. I'm a furnace! Crazy.. worried about the desert heat and being unable to be outside in it–thankfully heading north in a couple months. Looking forward to CT-6!!!

    • @PaleoNana I am glad you are finding this helpful. CT 6 may really open your mind to a new reality. If you want to see what it can research this name. Wil Hof. He and I are probably the only two people on the planet that can do the same things. He think its his mindfulness that allow it……..I know the real reason. And tonight you will too.

  174. I am looking forward to tonight at sunset!

  175. This is a question for all of the chocolate eaters. I love chocolate and have always loved dark chocolate. But, I now know what is often promoted as dark isn't very dark. A little while ago I tried a 85% dark bar. It was so gross I couldn't eat it. I have always been a sugar/candy person. I have been paleo for awhile now tho and have cut it out except for chocolate.

    I'm wondering what is the best way you guys have found to start liking the taste of very dark chocolate like 99-100%?

  176. @BenG – thanks for the response. Actual experience trumps thought experiments every time!

  177. My question is this – does the CT work if the diet isn't paleo? I am trying to get there, but it is a process. I have started the cold showers and am feeling my body adapt while at the same time working to change my eating habits. Am I wasting my time if my diet isn't yet clean paleo?

  178. I've been "washing" my face with snow since starting the LR Rx last week; (may as well make use of the snow we will still have for the next 4-6 weeks) and added cold showers a few days ago. I have a question regarding the CT: will cortisol levels raise unfavourably, as my body (brain, really) anticipate the cold?

  179. ChimpChick says:

    @ Erica… I am not a chocolate person at all, especially dark chocolate.. I got these the other day and I have to say.. Not too shabby..

    http://www.amazon.com/gp/product/B003EMQGVI/ref=o

    But expensive…

    So I decided to make my own sweetened with stevia.. Just ordered 5.5 lbs of this…

    http://www.bulknaturaloils.com/Products/15910-bul

    I plan on melting it, adding vanilla extract, stevia, maybe some coconut flakes-oil-manna and macadamia nuts.

    A much cheaper way to go!

  180. @Erica. Tastes change and you get used to the darker chocolate. I make my own now and use stevia so it has no sugar. I make it will coconut oil, raw cacao, and a few drops of stevia, mix up and put it in the freezer and in 10 minutes you have dark chocolate. I used to eat Lindt 90% and loved it and my kids love it, too. They have never had candy before though so their tastes are different. They like the Lindt or my chocolate, nothing to compare it to.

  181. I started the CT 6 days ago and am using cold showers because i dont have access to a tub. The first 2-3 days were amazing and my energy levels were through the roof. But today and yesterday i feel super tired, lack any motivation to do stuff and just cold throughout the day. Is this normal and to be expected? I guess you can call me an endurance athlete and i was doing the safe starches thing with coffee and probably had a little adrenal issues before starting this. I didteched the coffee thoug and lowered my carbs a lot. Should I expect my energy to bounce back soon and do I just have to tough this out?

    • @James yes it comes back…..your cleaning out your fat cells of estrogen. Increase your B12, B6, and betaine to improve the detox…….tonight when I unleash CT 6 you will see why.

  182. @Souldanzer – Like you, I just want to know WHAT to do (exactly), but also learn the science (geek part). ;-)

  183. Thanks for giving me hope lol. ANd about the ripped part. As an endurance guy I've always lacked upper body so I tried a couple months ago to hit 40 pushups for the first i time in forever, it didnt work. After doing CT, last night i randomly felt like it and hit 35 without doing them for a while. I think i tried last week and was under 20. Im pumped for your next post.

  184. I am having an awesome day! I saw a buddy I have not seen in 4 months and he asked me what I was doing to reshape my body. It led to a 30 minute talk about Paleo, Dr. Kruse, & how I am adding CT adaptation to my daily life. I am trying to help open one mind at a time.

  185. @Jack – speaking of ripped, I had a lady give me a high-five for my arm muscles as she watched me pick up a case of water. I didn't realize I had these muscles! Cool! (I haven't been working out–yet–since I started the hCG protocol last June.) Time to get after it some?

  186. James Duffy says:

    Good to hear what you told the other James. I have been increasing the cold baths, and after todays 55 minute session, I am still cold, even 2 hours after getting out of the tub. I just took my temperature and it's 95.6. Still shivering, but hopefully this means I'm making progress. It's estrogen clearing out, huh? Hope this boosts my testosterone eventually then!

  187. If EST, then I get to read this at 5pm CST! Woo-Hoo!

  188. I gave blood yesterday and their initial diagnostics showed my hemoglobin at only 15; temp was 99 (and normally my temp is lower than 98.6).

    I'm sure CT has nothing to do with my hemoglobin (or does it?) and if their temp guage is correct, is a higher than 'normal' temp par for the course with CT?

    Or am I just messed up… or their diagnostics?

  189. @Mark, just to give you a rough idea of what I have found. I have an infrared thermometer that measures my water temp and I THINK does a fair job with skin temps too. With some ice I can get my tap water to about 47 degrees. After a 30 minute soak my water is usually about 4-5 degrees warmer, so 51-52 degrees. Skin temp at my fattest areas meaning abdomen mostly, is usually around 56 degrees, and a few degrees warmer in leaner body parts. Of course your mileage may vary, but hopefully that helps a little! Good luck!

  190. Hi Dr. Kruse,

    Your blog rocks! A few questions:

    1) Around the time I started CT, I came down with a cold, which started to get better but now seems to be getting worse, going on 2.5 weeks now — will continuing CT while sick help or hurt?

    2)I've been getting Raynaud-like symptoms after CT — white fingers/toes, for upwards to an hour — and very itchy skin, does this mean too much CT too fast, or am I on track?

    3) Are there any gender differences to the speed with which one adapts and notices fat loss on CT? I haven't lost an inch/ounce so far (two 60 degree showers/baths per day, working up to ice) and my cold tolerance so far seems about the same.

    Thank you!

    • @jenn Ladies take longer because they have higher leptin levels…..but with CT it happens so fast it does not matter in the grand scale of life.

  191. @Rodney – that does help, thanks! Yesterday when I got in it was about 47/48F, then after 45 minutes, it was about 55F. I think adding some ice on my abdomen (main area where I want to lose fat) will do the trick, as I think I've already trimmed up my hips and lower back.

  192. Dr. Kruse,

    How long did you practice CT before you hit the tipping point?

    • @AG I did it big time the year I lost my weight. Then I began tinkering to disprove my theory…..as I developed the Quilt. The more I learned the more I tinkered. I have done a ton of bio hacks the last 6.5 years to bring me to today. I have not shared any of this with my own family until January 9, 2012. Not even my wife new what I was up to. Now my family is getting the full impact. And they are a lot more shocked than any of you could imagine. I did things that went completely against my core beliefs as I challenged all my own personal dogma. It was very hard to do…….the hardest thing in my life actually. So I get why many in our community have chapped ass now. Destroying a lifetime of beliefs in a few minutes is a hard thing to swallow for anyone. And when they really do not like you to begin with because youre outside the cool kid click…….well its tougher. But guess what, What I know can help everyone, including the skeptics. My job as a MD is to do no harm. When I see harm I have a duty to shoot it down. Tonight I am going to be doing just that……..for all of your benefits. The choice what to do after I give it to you is yours to make.

  193. Dr. Jack, thank you for the response and CT certainly beats going under the knife. I hope this response will help push my dad to initiate the CT adaptation.

  194. I just had a silly thought…. reading the blog and anxiously awaiting the next tidbit of needed info kinda reminds me of reading the book while pregnant, 'What to Expect When You're Expecting.' Can anyone relate?

  195. I’ve been thinking about how the Mediterranean diet can be confounded by CT and your diet recommendations, and that the vast majority of its positive effects would not be due to what most people think they are. During lent, there are severe restrictions in diet for Orthodox Christians. While it may seem like it would be negative as much of the restrictions are for meat, there are very few seafood restrictions. So seafood intake would dramatically increase during this time period (end of winter). This would be coupled with long fasting periods, stimulating autophagy. I’m also assuming that these people are more exposed to the elements as they have less variation in temperature than other parts of the world. They may not get really cold, but they would at least get cold!

    So overall, due to religious and geographic reasons, during winter the Mediterranean’s would be exposed to more variation in diet and temperature than the rest of the world. Diet would favor O3 protein sources, and temperature exposure would be colder.

  196. @ CT tryers – I am now using an infrared thermom – they are not that expensive ($30-$75) for the basic ones on amazon. It's great for CT and we are having a ton of fun with it for cooking. Example oil, poached salmon super easy and it's become our fav way. Must try – silky and delish.

    Speaking of cooking, Ordered the Ebook! Love all the crockpot stuff. Way to go Jack and Mrs Jack.

    @Jack, so if adapting is slow/painful due to excessive omega six – can one just power through and the CT will help work that out fast?

    Please get the published and edited book out soon! I would love to hand out copies to all those that ask me "what have you been doing, you look so awesome" heh.

  197. Completely agree. As a coach/bodyworker of 'athletes' (really just humans trained to function at higher levels), I encounter the same problems you have experienced. The majority of the world is ass backwards. When people begin to realize they're missing an entire part of their 'being', they start to see that they're on the outside looking in. Once 'it' is awakened everything in life makes perfect sense, and living and athletic performance both become effortless.

  198. Trust me Dr. Kruse, you are far and away the "coolest" kid on the block, it just so happens to be in more way than one! I cannot wait for tonight and I am downloading the cookbook as soon as I get home. Keep on rockin'!

  199. Jonathan Goins says:

    UHM, Krap. i have been starving apparantly

    last night we made chuck roast, between the co and the roasts own fat there was a ton of oil left. for come reason i felt compelled to drink most of it. so lets say i drank a cup or about 2000 kcals.

    slept like a baby and woke this morning with ketone breath…..

    either i have been out of ketosis or MORE LIKELY out of fuel

    no wonder i have not been feeling good

    but who in gods green earth eats that much fat… I felt i was doing really well with my bulletproof coffee etc.

    lesson learned

  200. PaleoNana says:

    @Larry wish there was a 'like' button on this blog.. I'd agree with you on the "coolest" kid comment :) and with so many others on here.

  201. Thanks for the cookbook. I've just gotta try that first recipe. Wow! And the broth too.

  202. @Casey–I’ve been in the Mediterranean area, and I’ve noticed you see lots of people there have skin tags caused by excessive O6. One woman I know fries everything in oil…there is so much O6 there. This woman, I know has heart disease, skin tags, and all sorts of Fatty generation, but tons of vegetable oil is the rule there. The seafood eaten there is mostly warm water fish low in O3. You need the cold variety for decent O3..Herring, Salmon, sardines, etc.

  203. Dr. K – you include high carb items like dates, citrus fruits and even cheese and honey in your cookbook. Care to explain? This contradicts keto-paleo, in my book, especially when these foods are geared to a low-carb approach for winter. Confused…

  204. @Jack — During my CT session shivering isn't so bad. But after it can persist for sometimes more than a couple of hours. I took my sublingual temp afterwards today and it read 93.8. Am I doing something wrong?

  205. hope this is not too off-topic Dr K… but you used to be a dentist: is there a way to reverse a receding gum line and very sensitive teeth?

    • @Lexi get rid of the inflammation. Once gone then where your periodontal ligament remain is usually where you are at. I never had perio disease so I cant tell you if CT reverse its. It would not shock me in the least if it did. That maybe a great bio-hack after CT 6 is unleashed. MAybe I can get Dr. Sorrentino the first Paleo dentist to study it?

  206. @Jack – that's encouraging that veggies are ok in winter, but why did I get the idea of nearly zero carbs right now?? Anyway, what is NPY?

    • @LinD I am gonna be honest……I usually stick to the meat and Fish…..the wife likes the veggies. LOL (secret out) She would not let me do a meat only book for winter because she said no one would like it. But that is how I roll!

  207. Suzanne says:

    My brother-in-law is a Type 1 diabetic who is addicted to endurance running. Do you think the cold therapy protocol used by the Buffalo Bills and other NFL teams would help his post race recovery? I've told him he should not run such long distances but he won't listen. Would the cold help or hurt his glucose levels?

  208. Coriander says:

    I think I have your youngest contender. My daughter's friend, 13 year old basketball player, is very lean and strong. She wants to be better, faster, stronger, so in addition to her VLC paleo diet, she has now added ice baths. She rang me after the first one: "OMG, I wasn't even cold. Dad thought I was crazy, but I wasn't even shivering!" Her motivation is that her knees are getting sore with being on two teams, plus two dance classes each week. Let's hope she keeps it up.

  209. Interesting observation and hopeful at the same time….

    I was scheduled for a root canal last month, but with DH's back surgery (L4/L5 decompression–fun, fun), I postponed the root canal since I am not in any pain. There's just been this bump thing on my palate (since December 2011, actually), that woud get bigger and then a bit smaller, but always there.

    Besides starting CT, I also started liquid iodine, so not sure which MIGHT be reducing this 'bump.' Today it is nearly flat, but it's felt that way before, so we'll see if it stays down—better yet, if it goes away! Crossing my fingers!!!

    Interesint that in 1990 I was diagnosed with M.S., and had a root canal about four years prior, so not looking to aggravate anything more as far as the M.S., ya know.

    • @LinD that bump is an apical abscess of the tooth. If you get and Xray you will see it. I have seen many resolve with diet and lifestyle changes. But they must be dramatic and chronically implemented.

  210. Dr K: thanks for responding to my question about afternoon blood sugar crashes. You said without testing, no way to know. What should I be testing for? I doubt my doctor will have a clue, nor do I. Dropped 20 points in a few minutes this afternoon, down to 60, and would have kept going I think but I ate a whole lot of dark chocolate just to get it up to 90-ish. Scares me to be so brittle. Can you tell me what to test for? Thanks.

    Maggie

  211. Souldanzer says:

    Dr. K would you give your perspective on the place of veggies when (getting) Optimal. There’s been a lot of confusion around this on the MDA…

    1. Do we need veggies at all to be healthy?
    2. Does endless winter for 24-36 months mean no veggies, all meat diet?
    3. Might there be any advantage to always stay in winter (diet+CT) or do our bodies need to cycle according to the seasons to be optimal?

    Thx.

  212. Souldanzer says:

    there's a rumor on MDA that you and your daughter are pure carnivores… incorrect?

  213. Dr. Jack, Yesterday I had a follow up appointment with my PCP. I hadn't seen him in 6 Months. I'm on week 6 of the Leptin Rx and have been burning fat for some time. My pre Paleo and Rx BP was 164/80 and now it's 122/62. Fasting BS is 101 this morning. I have done a few IF sessions and wasn't at all hungry after two missed meals. Oh and I'm down 25 lbs from my last visit. Needless to say I'm thrilled at the results so far as was my PCP. I'm waiting for my blood work to come back and doc is willing to work with me in the future concerning unusual tests. I have been slowly working my way into CT. Face plant followed by large ice water then a light workout (shirtless) in the cold outside. I'm tolerating it very well now. I just thought you might enjoy my success story. Thanks for your help and support here. I have a totally new outlook on life and my future now. Looking forward to CT6.

  214. Sunset Nashville 5:47pm… Oh, hey, it's in the Central time zone!

    • @ Sally when my F. lux come on……it goes live. I will be in front of my fire in the dark…….waiting for you all to get up off the floor.

  215. Sorry I posted before I finished up.

    I just purchased the online cookbook. It looks fantastic! I love the way the meals are displayed and are simple recipes. Good luck with it.

  216. @Dr. Kruse – I’m hoping that you can help me with three things.

    1. Expanding upon your earlier response to @The Kid “You can use cold showers. I spoke with someone yesterday from NASA who uses the cold showers routine to adapt people.” Can you explain the cold shower routine? Is this simply just taking showers with cold water? My tap is about 47F at it’s coldest, so I’d guess that that is cold enough for adaptation. Only it’d probably just take longer to fully adapt than using your official protocol? If this is true, I might opt for this to save some time here and there.

    2. I’ve been doing the cold tubs the last couple of mornings (47F for 35-45 minutes with socks, gloves, and a knit hat on) and they have been pretty easy. Today I did not have much of any shivering while in the tub, actually around the 15 minute mark, I felt quite good and was kind of warm, but once I got out, I was shivering for a bit. This is different from yesterday where around the 30-minute mark, I put my uncovered feet in for like 15 seconds. Despite the short exposure, I started shivering a ton while still in the tub. Does the feet being cold really have that much of an effect on the body or is this just something that will go away as I adapt? Should I wait until I can submerge my feet easily before adding ice to my torso?

    3. Does taking a quick (2-3 minutes) moderate-temp shower (say 60-70F) after a cold tub impede the adaptation process?

    On a separate note, my waist measurement was down again this morning, so that’s good!

    Thanks

    • @Mark 1. No because I dont like settling. My protocol adapts you faster. The water only needs to get your skin temps to 50-55 degrees that is it.
      2. With time your entire body adapts.
      3. No it does not

      After tonight, I bet your goals might increase a bit more.

  217. @Dr. Kruse – so following your response to @TheKid, is there a temp range or change pre/post CT that we should shoot for? Thanks. Sorry if this is covered in CT6

  218. @Dr. Kruse – so following your response to @TheKid, is there a temp range or change pre/post CT that we should shoot for? Thanks. Sorry if this is covered in CT6

    Also, I hope CT6 will explain why we don't need at least 600 calories per day from carbs and/or protein as the PHD preaches. That never made full sense to me but I don't have the background to refute it.

  219. Mama2Groklets says:

    I'm all iced up waiting for CT 6. Will be late morning here in oz :)

  220. Christy says:

    Yay! The cookbook! — can't figure out why I can't get it to print though, thoughts?

    thanks!

  221. And i forgot to say I am all ready as lean as I can get and tend to over eat when I feel like this.

  222. Doc,

    I've been thinking that CT, et al, can reverse the genetic predisposition for low aMSH. And perhaps the same with the mold exposure haplotypes. What do you see around our genetic susceptibilities changing back to normal?

    I found this on a biotoxin study group headed by the doc I'm going to see for my mold illness.

    "I've been out of the loop for a few weeks, but I wanted to mention Dr.

    Shoemaker's comment on Low MSH. I spoke with Dr. Shoemaker at Physician's Round

    Table in Tampa end of January.

    I asked him about a case with biotoxin multisusceptible haplotype AND low MSH haplotype. This patient has an MSH of 20, and I asked if it was likely the MSH would ever go up. He said,"Probably not..but it doesn't matter because now we have VIP!"

    Dr. Shoemaker's point was that the haplotype for low MSH would likely dictate a lifetime of low MSH, but that the anti-inflammatory benefits of VIP could compensate for that.

    Of course, he did stress repeatedly that the drug VIP can't/shouldn't be used

    until: CSM has been used to mop up biotoxins, mold exposure has been eliminated,

    the MMP9 markers, etc., etc., have been normalized, or else VIP administration

    is ineffective."

    Martin

  223. Gladina says:

    @ Amanda: It is probably b/c of the ratio. If fat intake is high enough/predominant, then out of a total caloric intake, the body will still be using fat as fuel. Even if you reduce caloric intake, but the ratios are more on the protein and carbs then you won't necessarily go into ketosis (unless if it's first time reducing calories from previous higher carb diet, in which case ANYTHING is lower). I know that with CT, caloric restriction is something that naturally occurs w/o trying. You don't feel hungry.

    I think Dr. K makes perfect sense, b/c he is simply restating evolutionary/bio-chem science behind these mechanisms. He wasn't the first to discover these things either…BUT he's just excited that he used this for himself and he just wants to share his good experience.

    For me personally it's a much richer experience to gather information regarding this recent CT protocol from many sources. Eg. Tim Ferris, Cronise…etc. It's so cool and that way you can read it from different angles/languages that might 'speak' to the reader in a fashion that suits them best.

    I can see for some in the beginning where reading Dr. K is a bit 'confusing' or seems to be 'contradictory', but if you can see things as a bigger picture, then you realize that it's b/c he makes distinctions about tiny details etc. which are appropriate for certain contexts. It's important to realize this.

    Anyways, I'm quite glad I came across this blog. I like the Leptin protocol + CT, b/c this combination ties in so many gaps and holes previously seen in ANY eating pattern.

  224. Gladina says:

    *Not previously seen in ANY eating pattern.

  225. linda keeper rn says:

    the surgical patient you describe, was boyle's law considered? and the dissociation curve ia also pH dependent. also you (they ) address the cold effect on the enzymes, but pH is even more important.

    when you have time check out Patricia Kane's work on fatty acids , http://patriciakane.net/ she is the queen of this in our lifetime as well as dr. david horribin's work on identifying the correct ratio of O6 to O3. the diet is very important in correcting these maladies in humans. Also John Hopkins does a specialized rbc biopsy to change the ratio. Ray Peat has well annotated research regarding fatty acid synthesis and these folks i mentioned have been on this long before paleo became theme.

    • @Linda I have been talking to Dr. Patricia Kane a lot lately. She has been emailing me a lot lately. My theory could make her research explode into prominence. What she is working on will revolutionize modern treatments of neurodegenerative diseases. Take a look at CT 6 tonight……she got a call out in there.

  226. James Duffy says:

    Jack- I am looking forward to it. Feel like my world has already changed so much since going primal. Now been looking to be optimal. Feels closer every single day, but the change has slowed compared to how fast it was in the beginning. Thanks for all you do!

  227. Anyone else notice extremely dry hands after a few days of CT? After about 4 or 5 days of consistent CT, my hands have become ridiculously dry. Assuming its hormonal balancing? Thyroid related (I have hashimoto’s)?

  228. 6PM EST or CST?

  229. @Dr. Kruse – thanks for the replies

    1) I’ll keep with the morning tubs. I have no idea what my skin temp is, but I might start adding the ice to my stomach and chest after a couple of more days (chest usually isn’t submerged and stomach doesn’t get as red or numb as my back does, probably because it’s only covered by about an inch of water).
    -Would you say that 47F water is cold enough to get the skin temp to 50-55F if fully submerged?

    2) Looking forward to that, for now I’ll just keep them out of the water.

    3) Excellent

    For right now I have to admit that I still get the most satisfaction out of the vanity-related stuff, but I’d love to not care as much about getting below 10%. Though I’m only about 5-7% from there, so it’s hard not to shoot for that lifelong goal. It’s a constant battle, but the additional knowledge helps. Thanks

  230. I have the ebook now, too, “Optimized Cooking.” :-) Yay.

    So little to no carbs with CT? The cookbook shows me otherwise. Please advise. Thanks!

  231. Sorry! Found it.

    NPY = neuropeptide Y

    (discussed here: http://jackkruse.com/how-does-the-leptin-rx-work/

  232. I have been tested as a positive preliminzry match to be a stem cell donor for someone with cancer. I am looking at donating stem cells via blood after four days of Filgrastim injections.

    What effect do you think this could have on my short, medium and long term health? Aside from CT and paleo, what can I do to regrow those as quickly as possible?

    Any drugs or supplements you could recommend I look into to help me in the short run?

    • @Jedeye. Awesome thing for you do. The best advice once you donate is to use alot of CT, resveratrol in 99% chocolate, turmeric, and seafood……that is all I would do.

  233. Does it matter if it is plain cheap tumeric pills or more expensive circumin supplements?

    • @Jedeye nope…..just buy the cheap turmeric from an Indian grocery and put it on every meal. I get a pound from my grocery for 4.99 I eat a ton of turmeric……

  234. Awesome. If you don’t get turmeric in food, how many grams or mg per day would you recommend in supplement form?

  235. I feel so much gratitude for the care you show. Beyond personally wanting to glean the literal and figurative nuggets in your cookbook; I want to buy it as a way to say thank you.

  236. Any thoughts on sublingual vs capsule supplements?

  237. Superior Source has a whole line of sublingual supplements:

    That include: B complex, D3, K2, multivitamins, multi minerals and even hormones like DHEA and pregnenalone. My gut reaction is not to put metals and minerals sublingually.

    Here is their full line of their sublinguals:
    http://www.superiorsource1.com/microlingual.html

    I have more curiousity regarding sublingual supplements after listening to your interview where your friend gargled with green tea, MCT’s and had vitamin D sublingually to overcome his tannin/auto-immune issue after the root canal.

    So I would love your thoughts on the following:

    1) What are your thoughts on the above listed categories of sublinguals? Better than pills? Does this put less stress on the liver?
    2) What do you recommend gargling with? Is the green tea/MCT combo better than Listerine antiseptics?

  238. A small amount of Hematopoietic stem cells (HSCs) normally circulate in the blood. So giving blood means you lose a few stem cells.

  239. FYI, I am not affiliated with the supplement company. I was just curious if you thought one type of micro nutrient supplement would be better via sublingual vs others in pill form. I imagine vitamin D and K2 would be high on your list to take sub-lingualy.

  240. Dr Kruse. For Neolithic disease you recommend staying cold adapted & ignoring seasons untill your healthy. Does this mean limiting sun exposure during spring/summer when reversing disease?

    Im using CT to reverse psoriasis and spring/summer sun has amazing effects on clearing my skin. Nothing comes close to matching the benefits, I can get 75% clearance in a few weeks under the right conditions.

    But is combining significant sun exposure with CT a bad idea? Will the two theraputic approaches cancel each other out & I just get mediocre benefits from both?

    Keep up the sterling work.

    • @Ben no……if your cold entrained the light during the day does not seem to matter……but light after sun set does……and in summer CT is very effective at night…….at least for me it is.

  241. Thanks for the clarification Jack. I’ll try this approach out.

    Also I am little confused as to whether the cold will directly benefit the psoriasis patches or if it works on a deeper level?

    I ask this because with my bath tub I can either have my whole torso submerged and my knees out… or my legs submerged but my pecs and shoulders out.

    Considering I have psoriasis all down my legs but little on the upper half of my torso I thought it more beneficial to keep me legs submerged. Is this correct or am I fussing over minor details?

    Thanks for your time, it is greatly appreciated,

    • @Ben it help the psoriasis patches too Ben. I have several people tell me that their patches improve as time goes on. i still push their D levels with supplements……more cold the better. more coverage of the areas the better.

  242. Hi Doc,
    Firstly-from the bottom of my heart thank you for your work and for paying it forward. I am trying to change my dna with my thoughts everyday because of you- and your enthusiasm is catching!
    My question is in regards to your personal story in the beginning of this post. My uncle, whom I was very attached to, passed away when I was 11 years old from a brain aneurysm. A year after getting married and having a child he complained about a big headache, went to take a nap and never woke up. Poor guy was in his mid thirties-nicest man you could ever meet. I never understood why that happened. To me there is no biological or any evolutionary explanation-particularly regarding aneurysms in the brain of all organs. It doesn’t seem like a neolithic disease…
    Do you have any theories in regards to this in light of your discoveries? I was told this is in genes so ‘passed on’ in the family-any advice on how to avoid or prevent this from happening?
    Kind Regards,
    Expat

  243. Julian Court says:

    Hi Jack

    You state above
    ‘If the diet was adapted to a ketogenic version over 24-36 months they would see amazing expansion of performance. At extremes, biochemistry changes in nature for our benefit. Evolution has a plan for this because it tapped it many times before. REALIZE THAT modern trainers are oblivious to this therefore they regurgitate what is best from the literature that is based upon mammals who are warm adapted eating a warm adapted diet! Can you say major mismatch!

    so am I right in thinking that you should only really be doing CT (along with cold adaptive diet) in the ‘summer’ if you are a.) treating/reversing a health issue or b.) using it along with correct diet/light periods to improve physical performance for whatever reason? I also assume that this is not something that you should prolong throughout the summer when ideally, once the sporting event has passed or the illness has been treated we shoukld return to a more seasonal diet with accompanying temperature and light cycles.

    regards as always
    julian

  244. Julian Court says:

    carrying on from my last question Dr Kruse…I guess what I’m basically asking; is it ok to do CT in the summer with a ‘summer’ eating regime or if doing CT should you revert to a COLD/WINTER diet?..is doing CT with summer carbs problematic?
    thanks

  245. Julian Court says:

    …yeah Jack I get that..but what about doing CT in the summer without changing the diet to COLD adapted? ..i understand that ideally they should be done together but don’t we need to prepare for the ‘real’ winter during the summer and saturate our cells with omega 6 ready for the winter?..sorry if I’m waffling..just trying to underdstand the pros and cons of what I’m doing.
    thanks

    • @Julian…….I cant be any clearer. If you dont get what “NO MATTER WHAT SEASON” means……….it means ANYTIME IS GREAT. And yes, you are waffling. If it does not suit you do not do it. Many people are doing it all times of the yr and it helps recovery and avoidance of illness.

  246. Julian Court says:

    Jack..I think that’s a bit unfair..I do want to do it but I want to do it properly or not at all..I know CT is fine in the summer, i totally get that.. but what about diet whilst doing it???..must it be KetoP (to fit in with the CT I am doing) or seasonal (to fit in with the current long light cycle)??..what is optimal?

    • @Julian I think you can eat the carbs in the season you are in……if you are in summer eat the fruits that are growing in your part of the world at that time.

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  1. [...] posts: First, why you shouldn’t eat a banana if you find yourself in Calgary, Canada on Dec 31st. Second, why the death of a patient from cold taught him that we should expose ourselves to cold. Melissa [...]

  2. [...] a ton of heat and prevents/reverses all neolithic disease.  He explains his reasoning and the biology behind it, and a lot of people are trying it (as evidenced in the comment sections of the blog).  Dr. K. [...]

  3. Paleo Diet says:

    [...] with in the confines of this pathway at all times. This process is a life saver for a diabetic. Cold adaptation pt. I Cold adaptation pt [...]

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