Breast Cancer

Brain Gut 9: What Really Killed Michael Jackson

Today, we are going to dive into the gut flora story a bit deeper than we did in our first gut flora post to help you understand how a a change in gut flora might lead to changes in your health by altering your hormone panel. Obesity is an inflammatory brain condition. Where does the infection come from? The gut flora actually is what causes humans to become fat. It has to due with shear numbers and the species of bacteria in our gut. There is a particular flora that produces adiposity and obesity in humans. These bacteria make something called FIAF (Fasting induced adipose factor) that control this process. This factor blocks lipoprotein lipase (LPL) in fat cells. LPL allows us to convert dietary Free Fatty Acids carried in lipoproteins into neutral fats that are stored in adipocytes. Non Geeks: Our gut bacteria makes humans fat. Geek Alert: The FIAF is made by our liver, muscles, and our small bowel wall when food sources are in short supply. This is the signal to stop storing fat in our fat cells when food is scarce. What is not well appreciated by many is that the FIAF in our intestinal wall is controlled 100{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} by our gut flora. When we have a simplified gut flora it favors fat cell creation. When our gut flora is complex and healthy, it has 100 trillion cells with 250 species. We tend not to make fat in this instance either! Moreover, when the bacteria are active metabolically due to the presence of simple sugars, production of FIAF ceases, and fat creation is signaled. This implies that our gut flora is directly tied to fat creation in humans. The gut flora’s action is directly signaled to the brain via the afferent nerve fibers in the vagus nerve. In those newly created fat cells, a protein called leptin is also produced, and acts as a score keeper for the brain of how much fat is stored in the body. This messenger is sent to the brain around midnight when we are sleeping allowing the brain to assess total energy balance in the body.

Brain Gut 8: Their Trip Down the Rabbit Hole

READERS SUMMARY: 1. What is a day in the life of a vacationing doctor like? 2. Accept that your epigenome is a loaded gun, and your lifestyle is the trigger. Your lifestyle can't change you. It reveals who you really are. 3. Is there an important difference between giving up on somethings and letting go to [...]

BRAIN GUT 7: INTRO TO YOUR GUT MICROBIOME

Many of you know I believe obesity if an inflammatory disease of the brain. Where this disease begins may surprise some of you. It begins in our gut flora. How does this happen? Read this link! Sub optimal bacteria which contain bacterial toxins called lipopolysaccharides (LPS) which are found in bacterial cell membranes. As gut LPS rises, it has been shown to cause a rise in serum leptin levels. Once leptin levels are raised high enough it stimulates SOCS 3 signaling in the hypothalamus to cause LR.

Brain Gut 6: Epi-Paleo Rx

This blog followed a very popular July 2012 Webinar that I put on for my members a few days ago. The webinar was over two hours long and had a lot of Q & A done after it as well. I promised my members I would get a quick blog post up for them on some of the core materials we covered. Today's blog is delivering on that promise. How to consider eating the Epi-Paleo Rx: Always Respect circadian cycles and eat according to seasonality, Lots of good quality proteins (see below), Lots of good quality fats (grass-fed/pastured animal fats - lard, tallow), Liberal uses of seafood broths and bone broth made from ocean and grass-fed animals (to heal the gut), and fermented vegetables and/or probiotics (to repopulate the gut with an Optimal Human flora)

Brain Gut #5: Paradigm Drifts Paradigm Shifts–Epi-Paleo Rx

Geeks: The implications of Brain Gut 4 mean that to develop a brain seafood is required part of the program to maintain it. Nutrients and many other environmental factors have also been found to influence epigenetic programing of our DNA either directly or indirectly via metabolic sensors. Peroxisomal proliferator-activated receptors (PPAR's), the vitamin D receptors, and the retinoid X receptors (RXR), and the retinoic acid receptors (RAR) are all examples of the nuclear receptors that interact with the brain cell membranes to control inflammation and metabolism all over our bodies. It turns out that PPAR's are the receptors that are at the crossroads of where inflammation and metabolism actually cross. These are specialized lipid sensors that pay attention to our balance of omega 6 and 3 levels. 3{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} of the human genome is directly or indirectly controlled by the endocrine functions of the Vitamin D system. This shows you how environmental signals are intertwined into the expression of DNA in humans. The Epi-Paleo Rx controls inflammation at a hormonal level in the brain better than the more famous paleo diet. Non Geeks: What we eat is really damn important when you have 3 lbs of lipid in your head called a brain. If you eat outside our design you get sick.

Brain Gut 3: Look In The Past To See Your Prologue

READERS SUMMARY: 1. WHAT ARE THE EVOLUTIONARY IMPLICATIONS OF A LEAKY GUT AS A POSITIVE ADAPTATION AT OUR SPECIES ORIGIN? 2. WHY DID BIPEDALISM ARISE BEFORE BRAINS IN HUMANS? 3. DID THE CLIMATE AND TECTONIC PLATES DICTATE THE EPIGENETIC CHANGES IN THOSE TRANSITIONAL PRIMATES? 4. DID RAPID CHANGES IN INNATE AND CELL MEDIATED IMMUNITY [...]

By Jack Kruse|July 4th, 2012|Breast Cancer, Cancer, Diabetes, Epi Paleo, Epigenetics, Leaky Gut / Grain Brain, Mitochondria, Optimal Pillar 2, Optimal Pillar 4, Optimal Pillar 5, Series: Brain Gut, The Optimal Paleo Diet|Comments Off

Hormone CPC #1: DHEA

This blog post was created for my members who just heard my webinar on bioidentical and synthetic hormone replacement. It is specifically designed to further our discussions in that talk. DHEA has been an enigma to the public and to most physicians. I never once heard about this hormone in four years of medical school, seven years of residency or in any endocrinology lecture from my training. The general public did not learn about DHEA until 1996, when its benefits were mentioned in the media and several popular books that showed up on daytime TV shows. Most in mainstream medicine continued to ignore the science these books contained because they were not found in the usual ways via journals and continuing education classes. You actually had to be on the lookout for this information. With a busy medical practice, this is no easy task. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book called DHEA and Aging. That book provided scientific validation for the many life-extending effects of DHEA.

Breast Cancer Webinar and Q&A

Access the live Q&A Call on: Title: October Webinar/ Q&A – Cancer and Breast Cancer- Healing & Prevention Date: October 31, 2012 Time: 7:00pm CDT You will be emailed the details. Please check your junk folder and whitelist the [email protected] email address to avoid missing important emails. Buy Webinar

By Jack Kruse|May 11th, 2012|Breast Cancer, Cancer, Webinars and Q&A Calls|Comments Off

CPC #3: Do You Need a Gallbladder?

You must become aware of the high cost of low living by cheap thinking. In biology, we often get what we deserve when we forget this. Today’s CPC will illustrate that point for you. Wasting your time doing things that do not get you to Optimal is losing opportunity to improve yourself. Today.......and every day from here become very aware of time. Be wise in the use of time. The question for living an Optimal life is never how much time do I really have...it is in how you use the time you have. And when you realize that…….you can begin to reverse the errors you made in that time. There is a great lesson here for those willing to think. I hope the sharpness of this message strikes you in the correct fashion. When you think average you get average. Reject mediocre...demand optimal from me, your loved ones, and most importantly yourself. When you get this lesson.........you will understand why there is much harm in wasting your most valuable asset. TIME The more sand that has escaped from the hourglass of your life, the clearer we should see through it. If you continue to think the way you do your life's hour glass will remain opaque. Think, adapt, learn, become what you can only envision now through the actions those thoughts bring to you.

Osteoporosis 3: Related Drugs and Diseases

What are some of the medical conditions that are associated with osteopenia or osteoporosis? 1. Excessive alcohol intake- greater than two drinks a day consistently will do it. 2. Tobacco use- This causes a 100 fold increase in bone loss. Oral tobacco is worse than inhaled smoke 3. Stress- any cause be it emotional, physical, mental, psychic all raise cortisol chronically and kill bone 4. Lack of physical activity increases obesity risk, which increases cortisol from leptin resistance 5. Low calcium intake or absorption from gastrectomy or low acid production from any reason 6. Reduced strength and activity due to a chronic illness or a sedentary life (checked with a grip test) 7. Small build or leanness naturally – correlates with BMI below 19 for women and men. 8. Asian women have a particular propensity to osteopenia genetically and from their diet. 9. Drug therapy, for example, long-term use of corticosteroids such as prednisone-used to treat rheumatoid arthritis, asthma, celiac disease, autoimmune diseases, Crohn’s disease, IBD, and ulcerative colitis. 10. Low Magnesium, strontium, boron, Vitamin D3, Vitamin K2, elevated PTH levels, low sex steroid levels, high insulin levels, low progesterone levels, any cause of a leaky gut. 11. Menopause 12. Andropause 13. Any cause of chronic inflammation (perimenopause can cause severe acute bone loss) 14. Disuse atrophy from any cause (space travel) 15. Paralysis 16. High carbohydrate diets 17. Veganism or a plant based diet. 18. A diet high in whole grain (carbohydrates) is especially risky due to mineral malabsorption in gut 19. A diet lacking in animal protein and animal fat and cholesterol. 20. Excessive use of statins and thyroid hormone can cause osteoporosis 21. Age and sex: the older one is predisposes to osteopenia. Women lose 1-3{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} of their bone density ever year after their last period. 22. Chronic endurance athletics of any type cause severe bone loss due to chronic cortisol elevations 23. Gastric bypass patients carry enormous osteopenic risks. 24. Severe liver or kidney disease; Renal insufficiency can lead to osteodystrophy. 25. Diabetes 26. People with scoliosis of unknown cause (idiopathic scoliosis) also have a higher risk of osteoporosis. I believe this is because most of these children have severe underlying Vitamin D deficiency and a leaky gut, but this has never been studied in the spine literature. Any time I see a scolisosi patient, I always screen for low sex steroid hormones, low Vitamin D levels, and low Carboxylated osteocalcin levels. Bone loss can be a feature of complex regional pain syndromes.as they develop over time. It is also more frequent in people with Parkinson’s disease and chronic obstructive pulmonary disease as well.