Colon Cancer

Cold Thermogenesis 8

Radical Theory #1: If our brains can rewire, then Einstein’s theories predict our biochemistry should be able to as well. My Leptin Rx and the modern cochlea implant definitively prove this in modern humans. Radical Theory #2: Considering that 90{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} of the earth’s current biome lives in extreme conditions on our own planet today still, we might need to consider that what we think is “our normal environment” is not so normal for most of life on our planet or our evolutionary history. Life on Earth evolved in an environment much like we see on Titan today; in a deep ocean frozen solid at its surface with the capability of life buried deep with in it. The only escape was due to ejectants of water vapor from super heated water from underwater volcanoes. All these things are present today on Earth’s crust too. There is one major difference now between the two. We are a lot warmer today than when life began. There are others, but when one looks at Titan we see a frozen giant moon with a monstrous ocean beneath it. All life on our planet came from the oceans first. We know this to be true as well. And because of this, studying extremophile forms of life here on earth today might explain the complexities of how biochemistry allows for life to exist at all in a thermoplastic environment. What the bio-astrophysics found on Titan with the Cassini Solstice mission, may be a huge clue that life first adapted to extreme environments and then was naturally selected and adapted to a cyclic warming trend on our planet's crust over time.

By Jack Kruse|April 2nd, 2012|Cancer, Circadian Cycle, Cold Thermogenesis, Colon Cancer, Diabetes, Epi Paleo, Epigenetics, Leaky Gut / Grain Brain, Nutrients and Supplements, Optimal Pillar 1, Optimal Pillar 2, Optimal Pillar 4, Series: Cold Thermogenesis, The Importance of Sleep, The Leptin Prescription, The Optimal Paleo Diet|307 Comments

Cold Thermogenesis 8

Radical Theory #1: If our brains can rewire, then Einstein’s theories predict our biochemistry should be able to as well. My Leptin Rx and the modern cochlea implant definitively prove this in modern humans. Radical Theory #2: Considering that 90{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} of the earth’s current biome lives in extreme conditions on our own planet today still, we might need to consider that what we think is “our normal environment” is not so normal for most of life on our planet or our evolutionary history. Life on Earth evolved in an environment much like we see on Titan today; in a deep ocean frozen solid at its surface with the capability of life buried deep with in it. The only escape was due to ejectants of water vapor from super heated water from underwater volcanoes. All these things are present today on Earth’s crust too. There is one major difference now between the two. We are a lot warmer today than when life began. There are others, but when one looks at Titan we see a frozen giant moon with a monstrous ocean beneath it. All life on our planet came from the oceans first. We know this to be true as well. And because of this, studying extremophile forms of life here on earth today might explain the complexities of how biochemistry allows for life to exist at all in a thermoplastic environment. What the bio-astrophysics found on Titan with the Cassini Solstice mission, may be a huge clue that life first adapted to extreme environments and then was naturally selected and adapted to a cyclic warming trend on our planet's crust over time.

By Jack Kruse|April 2nd, 2012|Cancer, Circadian Cycle, Cold Thermogenesis, Colon Cancer, Diabetes, Epi Paleo, Epigenetics, Leaky Gut / Grain Brain, Nutrients and Supplements, Optimal Pillar 1, Optimal Pillar 2, Optimal Pillar 4, Series: Cold Thermogenesis, The Importance of Sleep, The Leptin Prescription, The Optimal Paleo Diet|Comments Off

Cold Thermogenesis 6: The Ancient Pathway

The best way to describe this pathway to the lay public is to explain this is how evolution allows for ideal form to meet function in a tough environment. This environment is likely the primordial environment for life on our planet. This makes astrophysicists excited, because life might also be evolving in places like Titan. After all 5 extinction events on this planet geologist have told us they were followed by an extended cold climate. In cold mammals live longer. You will find out more about why this happens in Energy and Epigenetics 4 and 5 blog posts. The pathway uses very little energy from ATP and gives a whole lot to the organism who uses it. Fat burning is required and it is tied to a biochemical pathway that paleo forgot to speak about. But it requires cold temperature to be present and used commonly. In the pathway, the less effort you give, the faster and more powerful you will be when this pathway is active. People who live in this pathway can run a marathon with no training. They can lift unreal amounts of weight with little training. Their reserve and recovery are just incredible. You have to see it to believe it. Many will say cold thermogenesis a hormetic process, when in reality it is created using a coherent energy source due to something called the Hall effect. When we have had extinction events on Earth before, the events usually affect the evaporation of water in some fashion from the surface of lakes and oceans. It also affects the transpiration from the forest trees, plants, and flowers and this change cools the air. You must understand how climatology works here; liquid water needs to absorb a lot of latent heat to in order to evaporate, so it sucks energy from the atmosphere to make this energy transfer. This loss of energy from the atmosphere directly cools the planet and this preserves the charge on life's inner mitochondrial membrane and in the nanotubes present in our cells that contain water. This is how life lives long in the cold. Those people don't realize this because they do not live in this pathway for the majority of their life, and few studies have been done to say otherwise. The link above is recently added to this blog post. It seems science is now proving me correct in my theories of extinction events.

Cold Thermogenesis 5: Biologic magnetism

My first encounter with thermoplasticity in human biology I first became aware of this seeming paradox as a neurosurgical resident in my first year of training. We were doing a real "gnarly" brain surgery case. It was a young mother who had a massive basilar tip aneurysm. Back in the mid 90's before endovascular coiling procedures we use today, this was the most risky operation that existed in all of medicine. I spent a month prepping for this case. We had to enlist the cardiovascular surgeons to come in and surgically open the patients chest wide open to stop her heart on purpose temporarily and place her on complete cardiopulmonary bypass to stop all the blood flow to her brain. We had less than 20 minutes to then place a clip across the aneurysm to save her life. To complete this herculean surgical task, we had to fill her entire chest cavity with ice to preserve her heart muscle and cool her core temperature so that we could have 20 minutes to complete the brain surgery. Simultaneously, we would open her skull and split the Sylvian fissure in the brain and approach her basilar artery in the geographic center of her head and attempt to put a clip on it without disturbing any of her surrounding anatomy. The best mental image I can give you for this is the ultimate game of "Operation" you used to play as a kid. You must avoid hitting the sides or the nose lights up!!!! One problem in this case, in this game there was live bullets. This maneuver was deadly if not performed correctly the first time. This is one of the most delicate surgeries one can do on a human. Moreover, even if we were successful with the clip obliteration of the aneurysm, we had to restart her frozen heart, get her off cardio pulmonary bypass without an air embolus and awake. In this case everything went well until the last part and this taught me a lesson I would never forget. She died after the operation was a complete success. Her head was already closed up surgically and dressed, the intraoperative angiogram looked awesome, and we restarted her heart and got her off cardio pulmonary bypass without any evidence of a stroke and then she died suddenly. She received two units of cooled banked blood because our surgical team felt she lost some ability to carry oxygen in her blood because several of the monitors showed she had a low oxygen carrying capacity of her hemoglobin. This concerned us because we were worried about her risk of having a stroke because of low oxygenation due to her loss of blood flow for 20 minutes when she was on full bypass. So we did what any surgeon would do. We gave her blood to restore her oxygen carrying capacity and the oxygen monitors showed her oxygenation had totally returned to normal. We were all happy until I noticed her pupils were fixed and dilated when I was putting on her dressings. She also had blue fingers. And then all of a sudden she got a fatal heart rhythm, and she died right there in my arms. I was devastated. I will never forget talking to her family later that day.

Cold Thermogenesis 3

Evolutionary strategy is based upon finding an environmental niche and exploiting it. Evolution is based upon change and the natural adaptations to it. Today, we are going to explore how some environmental triggers might open a “biochemical trap door.” Why is circadian biology critical? For evolution to work, a cell first must adapt to its environment. So the first thing any living cell would see in an earth day is a period of day and night. It also has to find food to make energy (ATP). In addition, it has to control its own cellular division. The epic battle for the cell is the circadian cycle has to “yoke” the metabolic cycle to its growth cycle. Most people know that the suprachiasmatic nucleus (SCN), is the circadian pacemaker that monitors this dance between darkness and light and the seasonal cold and hot temperatures in our environment. Evolution apparently agreed with this assessment, because we now know it to be true. What most people do not know is how leptin plays a massive role in regulating it. Research has revealed that leptin can induce expression of a neuropeptide gene called vasoactive intestinal peptide (VIP) through the VIP cytokine response element. VIP actually is what sets the circadian pacemaker to light. Leptin yokes metabolism and sleep to the light and dark cycle. When temperature becomes the dominant environmental trigger and not light cycles, leptin induces endothelial nitric oxide synthetase (eNOS), that shuts down the photic effects of VIP on the SCN. This means that leptin forces the SCN not to be able to use light any longer to yoke circadian cycles! Once temperature begins to yoke the circadian rhythms, some very special things happen to our biochemistry that normally does not occur in other environments. These are ancient epigenetic programs that are hardwired into the DNA of every descendant of a eutherian mammal. We are descended from these animals.

By Jack Kruse|February 23rd, 2012|Cancer, Circadian Cycle, Cold Thermogenesis, Colon Cancer, Diabetes, Epi Paleo, Epigenetics, Leaky Gut / Grain Brain, Mitochondria, Optimal Pillar 1, Optimal Pillar 4, Series: Cold Thermogenesis, The Importance of Sleep, The Leptin Prescription, The Optimal Paleo Diet|234 Comments

PRIMAL CPC 1: TOURETTE SYNDROME MEETS EVOLUTIONARY MEDICINE

READERS SUMMARY: 1. WHAT IS TOURETTE'S SYNDROME? 2. HOW MIGHT IT BE LINKED TO A LEAKY GUT, GRAINS, AND TIE TO OTHER DISEASE'S WE KNOW NADA ABOUT? 3. HOW DOES OUR HARDWIRING GIVE US NEW INSIGHTS? 4. HOW MIGHT NEUROSURGERY HELP CHRIS JOHNSON? 5. HOW MIGHT SOME PIONEERING DENTISTS TIED A NICE BOW ON THERAPY FOR CHRONIC TS PATIENTS? Tourette's [...]

By Jack Kruse|January 28th, 2012|ADD / ADHD, Bipolar Disorder, Cancer, Colon Cancer, Epi Paleo, Guillian Barre Syndrome, Inflammation, Leaky Gut / Grain Brain, Optimal Pillar 5, Pancreatic Cancer, Series: CPC, The Digestion Connection, The Importance of Sleep, The Leptin Prescription, Tourette Syndrome|60 Comments

How Does The Leptin Rx Work?

Many people have contacted me about "why" the leptin Rx works and "how" does it work. Many people in the blogosphere have made some claims that much of what is in the leptin Rx is a rehash of the work found in some diet books. Well, today's post is being done to show you the science underneath my recommendations were formulated and made. None of the underlying science I will mention to you about neuroplasticity will be found in any diet book mentioned in any blog post that I know of. Most of you know I am a neurosurgeon, and as such, I was dramatically influenced by two world famous neurosurgeons named Wilder Penfield and David Kline. Dr. Penfield was the first neurosurgeon to use electrodes on the brain to map it prior to surgeries to avoid neurologic damage during tumor removal. Dr. Kline was and still is the pre eminent world expert in peripheral nerve surgery. I happened to train with Dr. Kline in New Orleans, and got turned on to his work, Dr. Penfield's work and the work of Dr. Merzenich in the early 1990's before leptin was even discovered. Dr. Michael Merzenich work on sectioning the median nerve in the hand and seeing how the brain remapped its sensory territory in the cortex via micro-electrodes was brought to my attention by Dr. Kline while I was a resident.

Could It Be the Gut?: An Introduction to the Brain-Gut Axis

READERS SUMMARY: 1. What is the brain gut axis? 2. What diseases likely are tied to its breakdown? 3. Why might medical training force us to miss the importance of this axis? 4. How did I discover the brain gut axis in my own clinical practice? 5. Did evolution dictate where the initial battle of [...]

By Jack Kruse|July 6th, 2011|Autism, Cancer, Colon Cancer, Depression, Inflammation, Leaky Gut / Grain Brain, MS - Multiple Sclerosis, Optimal Pillar 5, Osteoporosis, Series: Leaky Gut, The Digestion Connection, The Leptin Prescription, The Optimal Paleo Diet|15 Comments