The Leptin Prescription

The Leaky Gut Prescription

Well, we have talked about the gut in three other blogs so far. (1) Could It Be the Gut?: An Introduction to the Brain-Gut Axis, (2) Your VAP = Brain Gut Axis Function, and (3) Why Leaky Guts Lead to MS? Click those links or go to my home page under Brain Gut Axis and find each one for a quick review. We have hinted at the leaky gut as a cause of serious human disease in all those posts. Today we get to focus on the "leaky gut" and how we might offer to treat it. What is a leaky gut syndrome? It is the complex biochemical reactions that occur in the gut appear to be the genesis of where inflammation initially passes in to our body. We need to realize this and avoid eating the things that cause this inflammation. As I have said for close to five years now this means strict avoidance of omega 6's, all grains and especially wheat of any kind and very limited fructose (fruit or synthetic sources) The gut associated lymphatic tract (GALT) is the first place where our immune systems interact with the outside world. This occurs right below the intestinal brush border and is our first line of defense. It seems to me that evolution has dictated that this is precisely where the battle between health and disease begin in humans and why our immune system is set up ready on that battle front.

By Jack Kruse|July 30th, 2011|Adrenals, Anorexia and Bulimia, Autism, EMF, Fibromyalgia, Inflammation, Leaky Gut / Grain Brain, Nutrients and Supplements, Optimal Pillar 3, Optimal Pillar 5, Series: Leaky Gut, The Digestion Connection, The Leptin Prescription, The Optimal Paleo Diet|308 Comments

WHY LEAKY GUTS LEAD TO MS?

READERS SUMMARY: 1. What determines our ultimate health fate? 2. What exactly is epigenetics? 3. How does an autoimmune disease begin? 4. Is multiple sclerosis tied to gut inflammation? 5. What is an inflammasome and why is hypomethylation so critical? My first post on epigenetics seems to have stimulated a lot of talk based upon [...]

By Jack Kruse|July 29th, 2011|Cancer, Diabetes, Epi Paleo, Epigenetics, Hashimotos / Grave's Disease, Inflammation, Leaky Gut / Grain Brain, Longevity Principles, Mitochondria, MS - Multiple Sclerosis, Optimal Pillar 5, Series: Leaky Gut, The Leptin Prescription, Thyroid|Comments Off

Can’t Remember? Is Your Protein Bent?

READERS SUMMARY: 1. Alzheimer's disease is due to lack of electrons which causes compliant design changes in protein phosphatase! 2. Why are the incidence and prevalence growing for AD? 3. What is a proteopathy? 4. Why is protein folding so critical to so many diseases? 5. What kind of nutrition guidelines do I follow to [...]

By Jack Kruse|July 26th, 2011|Epi Paleo, Heart Disease, Live your Optimal Weight, Series: Leptin, The Leptin Prescription, The Optimal Paleo Diet|56 Comments

AVOIDING FATES OF RONALD REAGAN OR MICHAEL J FOX.

READERS SUMMARY: 1. Why the presence of genes means nothing to disease risk. 2. What do people over 100 years old teach us about genetics? 3. What six pieces of evidence found in 2011 tell us about AD or PD etiology? 4. How will industry try to solve the mystery? 5. What you can do [...]

By Jack Kruse|July 20th, 2011|Adrenals, Breast Cancer, Cancer, Diabetes, Epi Paleo, Epigenetics, Hormones & Methylation, Inflammation, Series: Leaky Gut, The Leptin Prescription|41 Comments

DEVELOPMENTAL ORIGINS OF DISEASE

The basis of epigenetics is founded in fetal development and is heavily influenced by grand maternal and maternal behaviors that influence in utero life of the fetus. This influence seems to be multigenerational as well because of the inheritance of meiotic stem cells in females. It has been known for years that the mother's behavior [...]

By Jack Kruse|July 14th, 2011|Anorexia and Bulimia, Epigenetics, Series: Leaky Gut, The Leptin Prescription|Comments Off

CANCER HITS, WHATS NEXT?

READERS SUMMARY: 1. What to do when you get a new cancer diagnosis? 2. Is the main cancer battle field oncologic treatment or in your own body? 3. How does diet play a role? 4. How to deal with your new doc the oncologist? 5. Do not be afraid of exploring every possibility to win [...]

By Jack Kruse|July 7th, 2011|Breast Cancer, Cancer, Epi Paleo, Leaky Gut / Grain Brain, Longevity Principles, Nutrients and Supplements, Series: Leaky Gut, The Leptin Prescription|Comments Off

CANCER HITS, WHATS NEXT?

READERS SUMMARY: 1. What to do when you get a new cancer diagnosis? 2. Is the main cancer battle field oncologic treatment or in your own body? 3. How does diet play a role? 4. How to deal with your new doc the oncologist? 5. Do not be afraid of exploring every possibility to win [...]

By Jack Kruse|July 7th, 2011|Breast Cancer, Cancer, Epi Paleo, Leaky Gut / Grain Brain, Longevity Principles, Nutrients and Supplements, Series: Leaky Gut, The Leptin Prescription|72 Comments

Could It Be the Gut?: An Introduction to the Brain-Gut Axis

READERS SUMMARY: 1. What is the brain gut axis? 2. What diseases likely are tied to its breakdown? 3. Why might medical training force us to miss the importance of this axis? 4. How did I discover the brain gut axis in my own clinical practice? 5. Did evolution dictate where the initial battle of [...]

By Jack Kruse|July 6th, 2011|Autism, Cancer, Colon Cancer, Depression, Inflammation, Leaky Gut / Grain Brain, MS - Multiple Sclerosis, Optimal Pillar 5, Osteoporosis, Series: Leaky Gut, The Digestion Connection, The Leptin Prescription, The Optimal Paleo Diet|15 Comments

My Leptin Prescription

I have been asked by many to put a short post out about how I reverse Leptin resistance in my own clinic for my patients. After reading all of the comments left here, at MDA, and on Jimmy Moore's forum, I decided that it was a good idea. 1. First make sure you really are Leptin resistant (LR) to begin with. The easiest way to do this if you are heavy is to look in the mirror. If you're overweight you definitely are Leptin resistant. If you still have a large appetite and crave carbohydrates, especially at night, these are also signs that you are likely Leptin resistant. If you are fit or in decent shape and not sure based upon the above symptoms, I would tell you to go get a blood test and check your reverse T3. It will be elevated. I also recommend simultaneously checking a salivary cortisol level. With LR, you will always see higher cortisol levels later in the day. 2. To regain Leptin Sensitivity (LS) follow a strict Epi-Paleolithic diet. To see an outline of a strict Epi-Paleolithic diet, read Brain Gut 6: Epi-Paleo Rx. The type of fuel you eat is important initially in eliminating the foods that cause Leptin receptors to become nonfunctional.

By Jack Kruse|June 29th, 2011|Circadian Cycle, Epi Paleo, HIIT - Heavy Weights, Leaky Gut / Grain Brain, Live your Optimal Weight, Longevity Principles, Mitochondria, Optimal Pillar 3, Series: Leptin, The Importance of Sleep, The Leptin Prescription, The Optimal Paleo Diet|1,162 Comments

WHY DO WE SLEEP?

READERS SUMMARY: 1. Why do we sleep? 2. Does sleep control metabolism and cell growth? 3. Do all living things sleep? How long is too long or too little? 4. What are the stages of sleep? 5. Can sleep help prevent degenerative aging diseases and cancer? 6. Is sleep the primordial condition or did it evolve as we did? Why do [...]