Thyroid Cancer

Rewiring The Leptin Rx Reset

Evolutionary strategy is based upon finding an environmental niche and exploiting it. Evolution is based upon change and the natural adaptations to it. Today, we are going to explore how some environmental triggers might open a “biochemical trap door” that will allow me to add a new recommendation for you to consider adding to the Leptin Rx reset protocol for those who are LR. I am beginning a series on circadian biology to show you how this all ties in together. Today, I will give you a very cursory review of why circadian biology, leptin, and environment are critical to using the Quilt to obtain your Optimal life. Why is circadian biology critical to humans? For evolution to work Optimally, a cell first must adapt to its environment. The first situation any living cell would be subjected to in an earth day is a period of day and night. Over time it would also be subject to the seasons in our environment because of the earth’s revolution, tilt, and angulations of the sun. As time continued on, further life would have been subjected to solar variations and would have had to account for it. It also has to find food to make energy (ATP) to survive, and it also has to control its own cellular division. The epic battle for the cell is to have the regularly expected circadian cycles found in our environment and ”yoke” those signals to its metabolic cycle and to its growth cycle. Most people know that the suprachiasmatic nucleus (SCN) in the brain is where the circadian pacemaker lies in humans. It monitors this dance between darkness and light, and the seasonal cold and hot temperatures in our environment to help control and monitor our own growth and development. Evolution apparently agreed to use these signals in all living things because this is what it uses for all life on earth today. What most people do not know is how leptin plays a massive role in regulating it. Many people and physicians think it plays a small role. Recent research has revealed that leptin can induce expression of a neuropeptide called vasoactive intestinal peptide (VIP) through the VIP cytokine response element. This is an epigenetic modification from our environment directly signaling the master hormone in our body. So what does VIP actually do?

Osteoporosis 3: Related Drugs and Diseases

What are some of the medical conditions that are associated with osteopenia or osteoporosis? 1. Excessive alcohol intake- greater than two drinks a day consistently will do it. 2. Tobacco use- This causes a 100 fold increase in bone loss. Oral tobacco is worse than inhaled smoke 3. Stress- any cause be it emotional, physical, mental, psychic all raise cortisol chronically and kill bone 4. Lack of physical activity increases obesity risk, which increases cortisol from leptin resistance 5. Low calcium intake or absorption from gastrectomy or low acid production from any reason 6. Reduced strength and activity due to a chronic illness or a sedentary life (checked with a grip test) 7. Small build or leanness naturally – correlates with BMI below 19 for women and men. 8. Asian women have a particular propensity to osteopenia genetically and from their diet. 9. Drug therapy, for example, long-term use of corticosteroids such as prednisone-used to treat rheumatoid arthritis, asthma, celiac disease, autoimmune diseases, Crohn’s disease, IBD, and ulcerative colitis. 10. Low Magnesium, strontium, boron, Vitamin D3, Vitamin K2, elevated PTH levels, low sex steroid levels, high insulin levels, low progesterone levels, any cause of a leaky gut. 11. Menopause 12. Andropause 13. Any cause of chronic inflammation (perimenopause can cause severe acute bone loss) 14. Disuse atrophy from any cause (space travel) 15. Paralysis 16. High carbohydrate diets 17. Veganism or a plant based diet. 18. A diet high in whole grain (carbohydrates) is especially risky due to mineral malabsorption in gut 19. A diet lacking in animal protein and animal fat and cholesterol. 20. Excessive use of statins and thyroid hormone can cause osteoporosis 21. Age and sex: the older one is predisposes to osteopenia. Women lose 1-3{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} of their bone density ever year after their last period. 22. Chronic endurance athletics of any type cause severe bone loss due to chronic cortisol elevations 23. Gastric bypass patients carry enormous osteopenic risks. 24. Severe liver or kidney disease; Renal insufficiency can lead to osteodystrophy. 25. Diabetes 26. People with scoliosis of unknown cause (idiopathic scoliosis) also have a higher risk of osteoporosis. I believe this is because most of these children have severe underlying Vitamin D deficiency and a leaky gut, but this has never been studied in the spine literature. Any time I see a scolisosi patient, I always screen for low sex steroid hormones, low Vitamin D levels, and low Carboxylated osteocalcin levels. Bone loss can be a feature of complex regional pain syndromes.as they develop over time. It is also more frequent in people with Parkinson’s disease and chronic obstructive pulmonary disease as well.

How Does The Leptin Rx Work?

Many people have contacted me about "why" the leptin Rx works and "how" does it work. Many people in the blogosphere have made some claims that much of what is in the leptin Rx is a rehash of the work found in some diet books. Well, today's post is being done to show you the science underneath my recommendations were formulated and made. None of the underlying science I will mention to you about neuroplasticity will be found in any diet book mentioned in any blog post that I know of. Most of you know I am a neurosurgeon, and as such, I was dramatically influenced by two world famous neurosurgeons named Wilder Penfield and David Kline. Dr. Penfield was the first neurosurgeon to use electrodes on the brain to map it prior to surgeries to avoid neurologic damage during tumor removal. Dr. Kline was and still is the pre eminent world expert in peripheral nerve surgery. I happened to train with Dr. Kline in New Orleans, and got turned on to his work, Dr. Penfield's work and the work of Dr. Merzenich in the early 1990's before leptin was even discovered. Dr. Michael Merzenich work on sectioning the median nerve in the hand and seeing how the brain remapped its sensory territory in the cortex via micro-electrodes was brought to my attention by Dr. Kline while I was a resident.

The Leptin Rx: FAQs

What should I do before I start The Leptin Reset? Before you start, take a picture of yourself from all angles. Don't be bashful or you'll be sorry in 18-24 months. Next, weigh yourself naked. Let your significant other or a family member take this picture. Go to the store and buy a piece of clothing that does not fit you now, but will when you have met your goal. Remember, calories are important when you're LR (leptin resistant) and mean nothing once you are LS (leptin sensitive). Macronutirents count when you're LR and mean nothing when you're LS. How do I determine if I am leptin resistant? Remember, you can be LR (leptin resistant) if you're fat or skinny. If you're overweight by more than 30lbs, it is a lock you have some degree of LR. If you're underweight by 20 lbs, you are likely LR, too. If you had an eating disorder, you're likely suffering from a serious leptin issue. The easiest test is to look in the mirror. The mirror does not lie and it is really cheap. For those people who still can't be sure after peeking in the mirror, you can order some blood tests. My favorite is the HS CRP (highly sensitive C-Reactive protein) and the reverse T3 tests (but there are others). They are accurate in over 90{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} of cases.

Vitamin D: The Sunshine of Your Life?

I was in a lounge watching the news last week and began to over hear a group of dermatologists talk about the new FDA rules set down for sunblocks that will go into effect in January of 2012. There was unanimous agreement among them all that sunlight was the source of everything that was bad in their world. One of the doctors said to another that, "no human should be out in the sun and they should just take vitamin D3 from the drug store instead of getting it from the sun." It was at that point I knew this was going to make a blog post about this. Apparently no one realizes that photosynthesis supports most of the food chain on this planet? And we are the mammal who has an energy hog in our head that needs energy. Since our skin is derived from neuro-ectoderm and we too use photosynthesis to make Vitamin D for our protection from poor electron dense foods in summer maybe we better re think this position. It is beyond me why the sun is so vilified. We could not have evolved past single cells organisms without it. We all learned that simple fact in school. But now with advanced degrees and plaques on our wall, are we going to blame all skin diseases all on the sun now? I definitely don't buy this conventional wisdom. So I decided to begin to add pieces to the immunity levee in the QUILT because of this conversation. And before we start let me be clear. It is better to get Vitamin D3 from the natural sources before a supplement in my opinion. But there is a catch to this pearl of wisdom. First, review this link on natural Vitamin D production.

CELLULAR DEPLETIONS….WHY SHOULD YOU CARE?

READERS SUMMARY: 1. How do we tie the squabble at AHS to Neolithic disease generation? 2. How does a cell react to acute stress and what results? 3. How does this stress get measured by labs and my doctor? 4. What happens when this stress lasts too long? 5. Why cholesterol is always good for [...]

By Jack Kruse|August 20th, 2011|Adrenals, Cancer, Diabetes, Heart Disease, Hormones & Methylation, Hypothyroidism, Leaky Gut / Grain Brain, Mitochondria, Nutrients and Supplements, Optimal Pillar 5, Series: Miscellaneous, The Importance of Sleep, The Leptin Prescription, Thyroid, Thyroid Cancer|Comments Off

WHAT IS BIOLOGIC CONCRETE?

READERS SUMMARY: 1. What is glycation? Why should I care about it? 2. What are the signs I can see if I am doing this to myself without my doctor? 3. What are the steps in glycation and where will it lead me? 4. What are the consequences if I ignore this biologic process? We [...]

By Jack Kruse|July 24th, 2011|Cancer, Circadian Cycle, Diabetes, Fibromyalgia, Gallbladder, Heart Disease, Optimal Pillar 2, Osteoporosis, Series: Leaky Gut, The Importance of Sleep, Thyroid, Thyroid Cancer|46 Comments

WHY DO WE SLEEP?

READERS SUMMARY: 1. Why do we sleep? 2. Does sleep control metabolism and cell growth? 3. Do all living things sleep? How long is too long or too little? 4. What are the stages of sleep? 5. Can sleep help prevent degenerative aging diseases and cancer? 6. Is sleep the primordial condition or did it evolve as we did? Why do [...]

Hormones 101: Clinical thoughts revealed

Readers Summary Why I use highly sensitive C-reactive protein (CRP) and Vitamin D as biomarker proxies. After Leptin, Cortisol is the next most important domino to fall. Hormone Cascade explained in a paragraph. Unintended consequences of hypercortisolism destroy health. Initial HS-CRP signals the genesis of underlying hormonal disruption (First sign Leptin is toast). Now [...]

Leptin: Chapter One

Okay, so you have heard me talk a lot about leptin. Why is it so important? It is a hormone that controls all of energy metabolism in the body. Not only that it controls all the other hormones in the body as well. So if it is not working well you can bet that the rest of your hormones are going to show clinical problems as well. I can't tell you how many people think they have thyroid issues when all the time they have been leptin resistant. One becomes leptin resistant when the brain no longer recognizes the leptin signal sent from our fat cells. Testing leptin is easy to do but rarely done in medicine today. The easiest way is to look in the mirror. If you're way too fat or way too thin guess what? You are leptin resistant, most likely. Biochemically we can also assess it with a test called a reverse T3 level. This is rarely ordered because many docs don't know about the test and because it is not covered by insurance. Reverse T3 is a competitive inhibitor to T3 and T4. Those are your thyroid hormones. So yes, leptin resistance completely turns off your thyroid gland! That does not allow you to burn fat in your muscles because it down regulates your basal metabolic rate. Now you know what controls your metabolism too! That process is called peripheral (muscle) leptin resistance. That is why some fat people can not burn fat with exercise. That is why your thyroid test are close to worthless clinically in leptin resistance. I bet many of you just had an epiphany!

By Jack Kruse|June 3rd, 2011|Anorexia and Bulimia, Breast Cancer, Cancer, Diabetes, Endometriosis and PCOS, Epi Paleo, Hormones & Methylation, Inflammation, Leaky Gut / Grain Brain, Optimal Pillar 5, Osteoporosis, Pancreatic Cancer, Series: Leptin, The Leptin Prescription, Thyroid, Thyroid Cancer|71 Comments