The Leptin Prescription

Brain Gut 9: What Really Killed Michael Jackson

Today, we are going to dive into the gut flora story a bit deeper than we did in our first gut flora post to help you understand how a a change in gut flora might lead to changes in your health by altering your hormone panel. Obesity is an inflammatory brain condition. Where does the infection come from? The gut flora actually is what causes humans to become fat. It has to due with shear numbers and the species of bacteria in our gut. There is a particular flora that produces adiposity and obesity in humans. These bacteria make something called FIAF (Fasting induced adipose factor) that control this process. This factor blocks lipoprotein lipase (LPL) in fat cells. LPL allows us to convert dietary Free Fatty Acids carried in lipoproteins into neutral fats that are stored in adipocytes. Non Geeks: Our gut bacteria makes humans fat. Geek Alert: The FIAF is made by our liver, muscles, and our small bowel wall when food sources are in short supply. This is the signal to stop storing fat in our fat cells when food is scarce. What is not well appreciated by many is that the FIAF in our intestinal wall is controlled 100{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} by our gut flora. When we have a simplified gut flora it favors fat cell creation. When our gut flora is complex and healthy, it has 100 trillion cells with 250 species. We tend not to make fat in this instance either! Moreover, when the bacteria are active metabolically due to the presence of simple sugars, production of FIAF ceases, and fat creation is signaled. This implies that our gut flora is directly tied to fat creation in humans. The gut flora’s action is directly signaled to the brain via the afferent nerve fibers in the vagus nerve. In those newly created fat cells, a protein called leptin is also produced, and acts as a score keeper for the brain of how much fat is stored in the body. This messenger is sent to the brain around midnight when we are sleeping allowing the brain to assess total energy balance in the body.

Brain Gut 8: Their Trip Down the Rabbit Hole

READERS SUMMARY: 1. What is a day in the life of a vacationing doctor like? 2. Accept that your epigenome is a loaded gun, and your lifestyle is the trigger. Your lifestyle can't change you. It reveals who you really are. 3. Is there an important difference between giving up on somethings and letting go to [...]

BRAIN GUT 7: INTRO TO YOUR GUT MICROBIOME

Many of you know I believe obesity if an inflammatory disease of the brain. Where this disease begins may surprise some of you. It begins in our gut flora. How does this happen? Read this link! Sub optimal bacteria which contain bacterial toxins called lipopolysaccharides (LPS) which are found in bacterial cell membranes. As gut LPS rises, it has been shown to cause a rise in serum leptin levels. Once leptin levels are raised high enough it stimulates SOCS 3 signaling in the hypothalamus to cause LR.

Brain Gut #5: Paradigm Drifts Paradigm Shifts–Epi-Paleo Rx

Geeks: The implications of Brain Gut 4 mean that to develop a brain seafood is required part of the program to maintain it. Nutrients and many other environmental factors have also been found to influence epigenetic programing of our DNA either directly or indirectly via metabolic sensors. Peroxisomal proliferator-activated receptors (PPAR's), the vitamin D receptors, and the retinoid X receptors (RXR), and the retinoic acid receptors (RAR) are all examples of the nuclear receptors that interact with the brain cell membranes to control inflammation and metabolism all over our bodies. It turns out that PPAR's are the receptors that are at the crossroads of where inflammation and metabolism actually cross. These are specialized lipid sensors that pay attention to our balance of omega 6 and 3 levels. 3{a7b724a0454d92c70890dedf5ec22a026af4df067c7b55aa6009b4d34d5da3c6} of the human genome is directly or indirectly controlled by the endocrine functions of the Vitamin D system. This shows you how environmental signals are intertwined into the expression of DNA in humans. The Epi-Paleo Rx controls inflammation at a hormonal level in the brain better than the more famous paleo diet. Non Geeks: What we eat is really damn important when you have 3 lbs of lipid in your head called a brain. If you eat outside our design you get sick.

Brain Gut 4: What was Homo’s Solution?

The paleo community has the "Paleo Solution", and it is a great introductory book to a lifestyle that will improve people to a higher plane of health than we have while eating a standard American diet found in our western world. It is clear from fossil data humans were in better physical shape in the late paleolithic before the Younger Dryas occurred as well. It appears that this deep freeze caused massive dietary change in the homo species from predominate hunter gatherers culture to and agrarian culture because of rapid climate change and elimination of the great megafauna from our food chains. The focus of this series, however, is focused upon when we jumped from purely primate to mainly homo species and to see what diet is really best for the rapid encephalization of our species. I am not convinced the modern paleolithic diet that is quite popular now fits that bill at all. The reason I bring this forth, is because I treat very sick and ill homo sapiens every day. 'Eating paleo' may just not reverse their health. The proof of this is found on every single popular paleo forum you can visit. As a surgeon, I need something that really works in the most resistant cases. That is where I discovered the Epi-Paleo Rx. In my specialty of spine surgery, this is especially true when we are dealing with cranial and spinal pathology. As a neurosurgeon these neolithic diseases are the ones I am most focused in on in my clinic. Evolution is in large part about epigenetic to cellular communication; it's comparing notes and copying and pasting new genetic recipes to create a new dish. When we understand how that dish was created we gain deep insight of how to to keep that dish tasting crisp and fresh every time we replicate it.

Brain Gut 2: Viral Marketing

READERS SUMMARY: 1. To discover the unknown we must use the known to guide our thoughts to see the future. 2. How should we think about evolution and health now? Counterintuitive is an axiomatic cognitive ability required for neurosurgical residency training and that is why I chose to tackle this problem in this fashion. 3. [...]

By Jack Kruse|June 22nd, 2012|ADD / ADHD, Cancer, Cold Thermogenesis, Colon Cancer, Diabetes, Epi Paleo, Epigenetics, Hormones & Methylation, Leaky Gut / Grain Brain, Optimal Pillar 2, Optimal Pillar 3, Optimal Pillar 4, Optimal Pillar 5, Series: Brain Gut, The Leptin Prescription, The Optimal Paleo Diet|132 Comments

Cold Thermogenesis 13: The FAQ’s

The readers of my forum asked for a FAQ's on CT and I decided it would be a good idea to make a short blog about this. They picked their top 25 questions and I decided to answer them for this blog. If you have any others, just ask in the comments section. I answer them all when I have time.

By Jack Kruse|June 2nd, 2012|Cold Thermogenesis, HCG, Hormones & Methylation, Inflammation, Longevity Principles, Menopause / Andropause, Mitochondria, Nutrients and Supplements, Optimal Pillar 2, Optimal Pillar 4, Series: Cold Thermogenesis, Series: How To, The Importance of Sleep, The Leptin Prescription|82 Comments

Cold Thermogenesis 12: Getting Back “On Board” With My Message

Well, it has been a very interesting last few days but I am not the kind of person who looks in the rear view mirror to run my race. What happened happened and it will all come out in the wash eventually. I am a person who runs their own race by looking forward via the windshield as I step on the accelerator pedal to live my life. If we focus on the past we lose sight of where we are headed and the road to Optimal. A reader of mine, Dan K, sent this gem to me, "I heard the Dalai Lama once say in a lecture that our worst enemies are your greatest teachers because they allow you to examine the emotions of anger and revenge and then to transcend them. They give you the exact tools you need to elevate yourself to the spiritual energies that eliminate problems and provide solutions." So today, I am moving toward the Paleo template and away from the "Paleo Radical Insurgency" who is steering the community into an abyss. There are too many people who need help and not the surrounding drama. The time has come to become, Epi-paleo, a term I mentioned at my Paleo fx speech, and that is what I will be building here on my blog and forum from here on out. An event that appears to be a tragedy to one, might reveal the seeds of unlimited opportunity for another. On the Low Carb cruise I was going to present some of the things that happened in my mind at the base of Michelangelo's David in help me realize that the missing piece to the obesity and insulin resistant story was the "off switch" in how we make fat and how we continue to make fat cells. Gary Taubes was scheduled to be the featured speaker for the cruise, but he could not attend, so Jimmy Moore asked me to step in his role. Gary wrote a book called, "Why we get Fat" but I clearly am not Gary Taubes, and I was not here to tell them why we get fat…I was going to tell you how to reverse being fat and insulin resistant…because unlike, Mr. Taubes, I have done it myself and pretty successfully. Obese humans have a difficult life to live. I know the life they live because I was one of them for close to decade. It is very hard to take advice from someone who has never had obesity. To understand the mindset one has to have walked in the shoes. Most of the people giving out advice however have not had a successful track history of losing the weight and keeping it off. The reason for this is they are prisoners to modern dogma of fatness.

By Jack Kruse|May 8th, 2012|Cold Thermogenesis, Diabetes, Epi Paleo, Epigenetics, Inflammation, Longevity Principles, Optimal Pillar 2, Optimal Pillar 4, Optimal Pillar 5, Series: Cold Thermogenesis, The Leptin Prescription, The Optimal Paleo Diet|Comments Off

Cold Thermogenesis 11: Paleo FX To Practice

Today, I want to introduce you to someone who is a true 'Paleo leader' by stepping up to the the challenge I put to our community at PaleoFx conference recently held in Austin, Tx. Kevin Cottrell is one of the co founders of Paleo Fx. The leaders of Paleo fx have to be commended because the conference they were able to put on in 150 days of prep time was nothing short of remarkable. The conference exceeded all my expectations and the reviews of many attendees have been stellar. The future of this community is tied to clinical application of what the science continues to show in the literature. For assimilation of the Ancestral Lifestyle to become mainstream we need to have more clinical conferences like Paleo fx, and we need to take them globally. Today, I am breaking new ground and presenting to you my first guest blog written by Mr. Kevin Cottrell, who has agreed to share his personal story and personal medical history with all of you so that he may help you in some way. I think what he has agreed to do here is the most noble and worthy things to do to help our community and mankind. I am indebted to him for this chance to publish his story for you to consider. The following post is written by Kevin, in his words, to share with you and yours, to help open your eyes and challenge your "own dogma and current intuition' to help you reach for optimal health.

CPC #3: Do You Need a Gallbladder?

You must become aware of the high cost of low living by cheap thinking. In biology, we often get what we deserve when we forget this. Today’s CPC will illustrate that point for you. Wasting your time doing things that do not get you to Optimal is losing opportunity to improve yourself. Today.......and every day from here become very aware of time. Be wise in the use of time. The question for living an Optimal life is never how much time do I really have...it is in how you use the time you have. And when you realize that…….you can begin to reverse the errors you made in that time. There is a great lesson here for those willing to think. I hope the sharpness of this message strikes you in the correct fashion. When you think average you get average. Reject mediocre...demand optimal from me, your loved ones, and most importantly yourself. When you get this lesson.........you will understand why there is much harm in wasting your most valuable asset. TIME The more sand that has escaped from the hourglass of your life, the clearer we should see through it. If you continue to think the way you do your life's hour glass will remain opaque. Think, adapt, learn, become what you can only envision now through the actions those thoughts bring to you.