2012 February

Cold Thermogenesis 4: The Holy Trinity

I just want to thank Sean Croxton for asking me to present at Paleo Summit today. The ideas discussed began with a podcast I did with Jimmy Moore, #474. Before I begin here today, I strongly suggest you listen to the Jimmy Moore podcast I did in May of 2011 as a primer for this blog post. It’s going to be a long one, so open a glass of wine as the sun sets tonight. However, I think you need to hear it all tonight since I have your attention from the Paleo Summit. I have planned for this day for some time. I am humbled to share this with you all. It was hard for me to write. If any of you remember when I first gave my initial thoughts on leptin publicly, it was on a podcast I did with Jimmy Moore in May 2011. I discussed the things that transformed my thinking back then. Most of the time I spent with Jimmy, we talked about leptin. In the beginning of the podcast, I mentioned a person who saw me injure myself as I stood up to give a lecture, and told me she knew precisely why I hurt my knee. At the time, I thought I had a good handle on these modern medicine principles she mentioned so I was a skeptical of her thoughts. She told me when I got home she was going to send me a few papers and a book to read. The book was called “The Monk Who Sold his Ferrari.” She was emphatic that I read the book before the papers. Then, she told me to read six specific papers in the order they were numbered and then reflect on what I had just read.

Cold Thermogenesis 3

Evolutionary strategy is based upon finding an environmental niche and exploiting it. Evolution is based upon change and the natural adaptations to it. Today, we are going to explore how some environmental triggers might open a “biochemical trap door.” Why is circadian biology critical? For evolution to work, a cell first must adapt to its environment. So the first thing any living cell would see in an earth day is a period of day and night. It also has to find food to make energy (ATP). In addition, it has to control its own cellular division. The epic battle for the cell is the circadian cycle has to “yoke” the metabolic cycle to its growth cycle. Most people know that the suprachiasmatic nucleus (SCN), is the circadian pacemaker that monitors this dance between darkness and light and the seasonal cold and hot temperatures in our environment. Evolution apparently agreed with this assessment, because we now know it to be true. What most people do not know is how leptin plays a massive role in regulating it. Research has revealed that leptin can induce expression of a neuropeptide gene called vasoactive intestinal peptide (VIP) through the VIP cytokine response element. VIP actually is what sets the circadian pacemaker to light. Leptin yokes metabolism and sleep to the light and dark cycle. When temperature becomes the dominant environmental trigger and not light cycles, leptin induces endothelial nitric oxide synthetase (eNOS), that shuts down the photic effects of VIP on the SCN. This means that leptin forces the SCN not to be able to use light any longer to yoke circadian cycles! Once temperature begins to yoke the circadian rhythms, some very special things happen to our biochemistry that normally does not occur in other environments. These are ancient epigenetic programs that are hardwired into the DNA of every descendant of a eutherian mammal. We are descended from these animals.

By Jack Kruse|February 23rd, 2012|Cancer, Circadian Cycle, Cold Thermogenesis, Colon Cancer, Diabetes, Epi Paleo, Epigenetics, Leaky Gut / Grain Brain, Mitochondria, Optimal Pillar 1, Optimal Pillar 4, Series: Cold Thermogenesis, The Importance of Sleep, The Leptin Prescription, The Optimal Paleo Diet|234 Comments

Cold Thermogensis 2

Now that you understand that I believe cold environments were how life first evolved, what implications does this hold for all life and humans today? I think with this thought experiment we need to begin to talk about another aspect of evolution to fully conceptualize how cold works for biology. Let’s talk about sleep for 4 short minutes. First, I want you to watch this video before you proceed. Recently, one of my readers pointed out he was confused by Dr. Gamble when she said the normal pattern of sleep in a natural environment had two cycles. He wanted to know why her version and my version for sleep as written in my post “Rx for the Leptin Rx” were not congruent. It was a great question that really opens the discussion to the idea of evolutionary mismatches. These mismatches occur in many modern systems of biology, and they are actually increasing in frequency and severity as time elapses. The reason is quite simple. Evolution is constantly getting faster as time goes on, relative to the current state of our genome. This is really how the “cellular theory of relativity” is currently affecting our own genome today. The speed of evolutionary change has far out stripped the ability of our paleolithic genes to catch up. This mismatch causes major problems for modern humans. When they further exacerbate the system with choices not congruent with our biology, the results are magnified in disease incidence and prevalence. She also mentioned in passing, early in her talk, that people who went deep into the ground have been found to be “very productive” while in a cold dark environment. She did not expand on this concept at all, but I would strongly suggest you remember this as the cold thermogenesis series progresses on. There is a deep biologic reason this occurs. As we use this pathway, lots of things improve that we do not expect.

By Jack Kruse|February 22nd, 2012|Alzheimer’s, Circadian Cycle, Cold Thermogenesis, Diabetes, Epi Paleo, Epigenetics, Heart Disease, Inflammation, Leaky Gut / Grain Brain, Optimal Pillar 1, Optimal Pillar 4, Series: Cold Thermogenesis, The Importance of Sleep, The Leptin Prescription, The Optimal Paleo Diet|Comments Off

Cold Thermogenesis 1: Theory To Practice Begins

Today, we are going to bend your mind a bit by explaining to you many of the things you might be believe as biologic truths published in biochemistry books today are in fact truths, when certain environmental truths are held within a constant range. Yet, they change tremendously when certain factors are altered. Often the biophysical changes do not even have to affect the thermal coefficients of the biochemistry in the hypothalamus. Just the perception of the environmental change from the brain is enough to alter the chemistry as is the enzyme and proteins existed on the top of Mount Everest or on the ocean floor in the coldest environments on earth. When biochemistry was observed in living cells and described, the scientists rarely considered these effects on our biochemistry and how it may alter the cellular terror. Our hypothalamus rewires too many stimuli, and it appears that temperature is a major factor in the rewiring protocol of our brain. Evolution has clearly needed to use this in the past for some reason. Our job as enquiring primal bio-hackers, is to figure out why and how this might have happened. In essence, they looked at the complex biologic machinery from a standard Newtonian platform. Most scientists know that Newtonian physics explain much of what we observe in the physical sciences here on earth, and that quantum mechanics best describes the physics of subatomic matter of matter in space on a universal scale. When QM theory is adapted to many biologic systems, some puzzling things emerge that are hard to explain. Complicating matters, we have few ways to measure the quantum effects within biologic systems to test how they may affect living cells. This does not imply in any way that quantum mechanics does not apply to biologic systems, because it clearly does. It is often buried in the biochemistry equations that biochemists use to describe how living cells make order from the complete chaos that rules matter. This implies the effects might be difficult to discern or measure with current techniques we have, and this is why we have yet to uncover them in biologic systems. The brain clearly uses quantum mechanics to operate. This is not a controversial point at all in the scientific world.

By Jack Kruse|February 21st, 2012|Cold Thermogenesis, Epigenetics, Optimal Pillar 2, Optimal Pillar 4, Series: Cold Thermogenesis, The Importance of Sleep|68 Comments

PERI-OPERATIVE OPTIMAL SURGICAL CONSIDERATIONS

READERS SUMMARY: What might you consider pre and post op before your surgery? These all need to be cleared with your surgeon before starting! In an ideal situation, patients undergoing surgery will have adequate time before the operation to prepare themselves emotionally and physically. This preparation will likely include dietary supplementation, as well as mental [...]

By Jack Kruse|February 20th, 2012|Cold Thermogenesis, Diabetes, EMF, Heart Disease, Longevity Principles, Nutrients and Supplements, Optimal Pillar 2, Optimal Pillar 3, Optimal Pillar 4, Osteoporosis, Series: Miscellaneous, The Importance of Sleep|Comments Off

The Rewarding Feeling of Safe Starches

READERS SUMMARY: WHY SHOULD WE QUESTION EVERYTHING? WHAT IS THE SOURCE OF ALL CHOICE? WHERE MIGHT THE REWARD IN SAFE STARCHES TRULY LIE? HOW GOOD IS YOUR NEOLITHIC BRAIN AT SENSING YOUR PALEOLITHIC BRAIN? DOES QUANTUM MECHANICS PROVIDE AN EXPLANATION FOR THE PARADOX OF CHOICE? I took a stroll through some of my favorite [...]

By Jack Kruse|February 19th, 2012|Uncategorized|98 Comments

The Paleo Summit: Is The Paleo Diet The Answer?

So what is the Paleo Summit to me? For me, it is where unconventional thoughts lead to stunning results! Come and listen to what we put together for free! Sean Croxton, of Underground Wellness, called upon me to talk about some stunning results. When Sean and I spoke, I was putting the finishing touches on a pretty [...]

By Jack Kruse|February 14th, 2012|Epi Paleo, Leaky Gut / Grain Brain, Longevity Principles, Optimal Pillar 4, Paleo News, Series: Miscellaneous, The Leptin Prescription, The Optimal Paleo Diet|88 Comments

The Cold Thermogenesis Protocol

The Cold Thermogenesis Protocol should be added gradually to the Leptin Rx rest protocol. This blog post is additive to the Leptin Rx, and is an evolution extension of it for those who need it. I hope you all realize that not everyone will need it. Some will need it because they have special needs that they face. This blog is designed for those who have been previously left out of the reset protocol. Those people are gastric bypass patients, HCG users, those on exogenous steroids, chronic pain patients, and those with T2D and metabolic syndrome, as a few examples. Prolonged and controlled local peripheral skin cooling can induce selective “damage,” and increased hypothalamic signaling by forcing adipocyte apoptosis and subsequent loss of subcutaneous fat without damaging the overlying skin or the underlying muscle layers. This means that acute cold cause rapid leptin sensitivity! It means that fat is forced to liberate leptin from fat cells to slowly lower its serum levels as long as the cold stimulus is applied safely. This is new scientific information that was first carried out in pigs in 2008, and subsequently tested in humans and found to be quite effective for fat removal in certain selected areas of the body.

Rewiring The Leptin Rx Reset

Evolutionary strategy is based upon finding an environmental niche and exploiting it. Evolution is based upon change and the natural adaptations to it. Today, we are going to explore how some environmental triggers might open a “biochemical trap door” that will allow me to add a new recommendation for you to consider adding to the Leptin Rx reset protocol for those who are LR. I am beginning a series on circadian biology to show you how this all ties in together. Today, I will give you a very cursory review of why circadian biology, leptin, and environment are critical to using the Quilt to obtain your Optimal life. Why is circadian biology critical to humans? For evolution to work Optimally, a cell first must adapt to its environment. The first situation any living cell would be subjected to in an earth day is a period of day and night. Over time it would also be subject to the seasons in our environment because of the earth’s revolution, tilt, and angulations of the sun. As time continued on, further life would have been subjected to solar variations and would have had to account for it. It also has to find food to make energy (ATP) to survive, and it also has to control its own cellular division. The epic battle for the cell is to have the regularly expected circadian cycles found in our environment and ”yoke” those signals to its metabolic cycle and to its growth cycle. Most people know that the suprachiasmatic nucleus (SCN) in the brain is where the circadian pacemaker lies in humans. It monitors this dance between darkness and light, and the seasonal cold and hot temperatures in our environment to help control and monitor our own growth and development. Evolution apparently agreed to use these signals in all living things because this is what it uses for all life on earth today. What most people do not know is how leptin plays a massive role in regulating it. Many people and physicians think it plays a small role. Recent research has revealed that leptin can induce expression of a neuropeptide called vasoactive intestinal peptide (VIP) through the VIP cytokine response element. This is an epigenetic modification from our environment directly signaling the master hormone in our body. So what does VIP actually do?

Monthly Archives: February 2012